JP2008515852A5 - - Google Patents
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- Publication number
- JP2008515852A5 JP2008515852A5 JP2007535159A JP2007535159A JP2008515852A5 JP 2008515852 A5 JP2008515852 A5 JP 2008515852A5 JP 2007535159 A JP2007535159 A JP 2007535159A JP 2007535159 A JP2007535159 A JP 2007535159A JP 2008515852 A5 JP2008515852 A5 JP 2008515852A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- het
- aryl
- group selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(C*(C)c1c(C2*C(C)C(C)(*3)c4c5cccc4)[s]c(*)n1)C2C(*)C35*#I Chemical compound CC(C*(C)c1c(C2*C(C)C(C)(*3)c4c5cccc4)[s]c(*)n1)C2C(*)C35*#I 0.000 description 2
- UQFQONCQIQEYPJ-UHFFFAOYSA-N C[n]1nccc1 Chemical compound C[n]1nccc1 UQFQONCQIQEYPJ-UHFFFAOYSA-N 0.000 description 1
- BSKHPKMHTQYZBB-UHFFFAOYSA-N Cc1ncccc1 Chemical compound Cc1ncccc1 BSKHPKMHTQYZBB-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004048877.0 | 2004-10-07 | ||
| DE102004048877A DE102004048877A1 (de) | 2004-10-07 | 2004-10-07 | PI3-Kinasen |
| DE102005005813A DE102005005813A1 (de) | 2005-02-09 | 2005-02-09 | PI3-Kinasen |
| DE102005005813.2 | 2005-02-09 | ||
| PCT/EP2005/055015 WO2006040279A1 (de) | 2004-10-07 | 2005-10-05 | Pi3-kinasen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008515852A JP2008515852A (ja) | 2008-05-15 |
| JP2008515852A5 true JP2008515852A5 (enExample) | 2008-11-27 |
| JP5122287B2 JP5122287B2 (ja) | 2013-01-16 |
Family
ID=35583390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007535159A Expired - Lifetime JP5122287B2 (ja) | 2004-10-07 | 2005-10-05 | Ｐｉ３キナーゼ |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US7691888B2 (enExample) |
| EP (2) | EP2343303A1 (enExample) |
| JP (1) | JP5122287B2 (enExample) |
| KR (1) | KR20070064660A (enExample) |
| CN (1) | CN101048418A (enExample) |
| AR (1) | AR055273A1 (enExample) |
| AU (1) | AU2005293607A1 (enExample) |
| BR (1) | BRPI0516557A (enExample) |
| CA (1) | CA2579279C (enExample) |
| IL (1) | IL182398A0 (enExample) |
| MX (1) | MX2007004051A (enExample) |
| RU (2) | RU2403258C2 (enExample) |
| TW (1) | TW200628475A (enExample) |
| WO (1) | WO2006040279A1 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050096332A1 (en) * | 2003-10-30 | 2005-05-05 | Boehringer Ingelheim International Gmbh | Use of tyrosine kinase inhibitors for the treatment of inflammatory processes |
| US7691888B2 (en) * | 2004-10-07 | 2010-04-06 | Boehringer Ingelheim International Gmbh | Thiazolyl-dihydro-indazole |
| CN101443335A (zh) * | 2006-04-06 | 2009-05-27 | 贝林格尔.英格海姆国际有限公司 | 噻唑基-二氢-吲唑 |
| US7517995B2 (en) * | 2006-04-06 | 2009-04-14 | Boehringer Ingelheim International Gmbh | Thiazolyl-dihydro-cyclopentapyrazole |
| US20070238718A1 (en) * | 2006-04-06 | 2007-10-11 | Matthias Grauert | Thiazolyl-dihydro-indazole |
| US7691868B2 (en) * | 2006-04-06 | 2010-04-06 | Boehringer Ingelheim International Gmbh | Thiazolyl-dihydro-quinazoline |
| US20070259855A1 (en) * | 2006-04-06 | 2007-11-08 | Udo Maier | Thiazolyl-dihydro-indazole |
| US20070238746A1 (en) * | 2006-04-06 | 2007-10-11 | Trixi Brandl | Thiazolyl-dihydro-chinazoline |
| ATE405554T1 (de) * | 2006-06-26 | 2008-09-15 | Helm Ag | Verfahren zur herstellung von pramipexole |
| EP2045253A4 (en) * | 2006-06-29 | 2013-01-23 | Nissan Chemical Ind Ltd | alpha-amino acid derivative and pharmaceutical agent containing it as an active ingredient |
| US8779154B2 (en) * | 2006-09-26 | 2014-07-15 | Qinglin Che | Fused ring compounds for inflammation and immune-related uses |
| GB0619611D0 (en) * | 2006-10-04 | 2006-11-15 | Ark Therapeutics Ltd | Compounds and their use |
| WO2009039140A1 (en) * | 2007-09-17 | 2009-03-26 | Smithkline Beecham Corporation | Pyridopyrimidine derivatives as pi3 kinase inhibitors |
| US20110052643A1 (en) * | 2008-01-07 | 2011-03-03 | Synta Pharmaceuticals Corp. | Compounds for inflammation and immune-related uses |
| UY31700A (es) | 2008-03-13 | 2009-11-10 | Boehringer Ingelheim Int | Tiazolil-dihidro-indazoles |
| WO2009120826A1 (en) * | 2008-03-27 | 2009-10-01 | Wyeth | 2-aryl- and 2-heteroarylthiazolyl compounds, methods for their preparation and use thereof |
| CL2009000780A1 (es) * | 2008-03-31 | 2010-01-15 | Genentech Inc | Compuestos derivados de heterociclil-pirano-heterociclilo, heterociclil-oxepina-heterociclilo, benzopirano-heterociclilo y benzoxepina-heterociclilo sustituidos; composicion farmaceutica; procedimiento de preparacion de la composicion; kit farmaceutico; y su uso en el tratamiento del cancer, mediado por la inhibicion de pi3k. |
| KR20100122513A (ko) * | 2008-07-17 | 2010-11-22 | 아사히 가세이 파마 가부시키가이샤 | 질소 함유 복소환 화합물 |
| JPWO2010024258A1 (ja) * | 2008-08-29 | 2012-01-26 | 塩野義製薬株式会社 | Ｐｉ３ｋ阻害活性を有する縮環アゾール誘導体 |
| JP5579724B2 (ja) * | 2008-10-17 | 2014-08-27 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ホスファチジルイノシトール−３−キナーゼ（ｐｉ−３キナーゼ）阻害剤としてのテトラ−アザ−複素環 |
| GB0900404D0 (en) | 2009-01-12 | 2009-02-11 | Addex Pharmaceuticals Sa | New compounds 4 |
| US8278302B2 (en) | 2009-04-08 | 2012-10-02 | Boehringer Ingelheim International Gmbh | Substituted piperidines as CCR3 antagonists |
| EP2421872B1 (en) * | 2009-04-22 | 2015-06-10 | Boehringer Ingelheim International GmbH | Thia-triaza-as-indacenes as pi3-kinases inhibitors for the treatment of cancer |
| US8288379B2 (en) * | 2009-04-22 | 2012-10-16 | Boehringer Ingelheim International Gmbh | Thia-triaza-cyclopentazulenes |
| MX2012000178A (es) * | 2009-07-02 | 2012-02-28 | Novartis Ag | 2-carboxamida-cicloamino-ureas utiles como inhibidores de pi3k. |
| GEP201706639B (en) | 2009-08-17 | 2017-03-27 | Intellikine Llc | Heterocyclic compounds and uses thereof |
| RU2654068C1 (ru) * | 2009-09-28 | 2018-05-16 | Ф.Хоффманн-Ля Рош Аг | Бензоксазепиновые ингибиторы pi3 и способы применения |
| JP5546636B2 (ja) * | 2009-09-28 | 2014-07-09 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | ベンゾキセピンｐｉ３ｋ阻害剤化合物及び使用方法 |
| MX2012005518A (es) | 2009-11-13 | 2012-06-19 | Merck Serono Sa | Derivados de pirazol amina triciclica. |
| CN103153062B (zh) | 2010-05-24 | 2015-07-15 | 因特利凯有限责任公司 | 杂环化合物及其用途 |
| GB201011831D0 (en) * | 2010-07-14 | 2010-09-01 | Addex Pharmaceuticals Sa | New compounds 5 |
| WO2012009000A2 (en) * | 2010-07-14 | 2012-01-19 | Addex Pharma S.A. | Novel fused pyrazole derivatives and their use as allosteric modulators of metabotropic glutamate receptors |
| US8466162B2 (en) | 2011-01-26 | 2013-06-18 | Boehringer Ingelheim International Gmbh | 5-alkynyl-pyridines |
| EP2546249A1 (en) | 2011-07-15 | 2013-01-16 | Boehringer Ingelheim International Gmbh | 5-Alkynyl-pyridines |
| TW201245176A (en) | 2011-01-26 | 2012-11-16 | Boehringer Ingelheim Int | New 5-alkynyl-pyridines |
| JP6130305B2 (ja) | 2011-02-23 | 2017-05-17 | インテリカイン， エルエルシー | キナーゼ阻害剤の組み合わせおよびそれらの使用 |
| JP5808826B2 (ja) | 2011-02-23 | 2015-11-10 | インテリカイン， エルエルシー | 複素環化合物およびその使用 |
| MX340013B (es) | 2011-03-21 | 2016-06-22 | Hoffmann La Roche | Compuestos de benzoxazepina selectivos para fosfatidilinositol 3-cinasa (pi3k) p110 delta y metodos de uso. |
| US20150031702A1 (en) * | 2012-02-06 | 2015-01-29 | Glaxosmithkline Intellectual Property (No.2) Limited | Pi3k inhibitors for treating cough |
| WO2017156350A1 (en) | 2016-03-09 | 2017-09-14 | K-Gen, Inc. | Methods of cancer treatment |
| US12324807B2 (en) | 2018-06-01 | 2025-06-10 | Cornell University | Combination therapy for PI3K-associated disease or disorder |
| EA202191852A1 (ru) | 2018-12-31 | 2022-03-18 | Биомеа Фьюжн, Ллс | Необратимые ингибиторы взаимодействия менин-mll |
| EP3906029A4 (en) | 2018-12-31 | 2022-09-21 | Biomea Fusion, LLC | INHIBITORS OF MENIN-MLL INTERACTION |
| AU2022325861A1 (en) | 2021-08-11 | 2024-02-29 | Biomea Fusion, Inc. | Covalent inhibitors of menin-mll interaction for diabetes mellitus |
| IL310717A (en) | 2021-08-20 | 2024-04-01 | Biomea Fusion Inc | Crystalline form of N-[4-[4-(4-morpholinyl)-7H-PYRROLO[2,3-D]PYRIMIDIN-6-YL]PHENYL]-4-[[3(R)-[(1-OXO ] -2-PROPEN-1-YL)AMINO]-1-PIPERIDINYL]METHYL]-2-PYRIDINECARBOXAMIDE, IRREVERSIBLE MENIN-MLL INHIBITOR FOR CANCER TREATMENT |
| TW202430528A (zh) | 2023-01-18 | 2024-08-01 | 美商拜歐米富士恩股份有限公司 | Ｎ－［４－［４－（４－嗎啉基）－７ｈ－吡咯並［２，３－ｄ］嘧啶－６－基］苯基］－４－［［３（ｒ）－［（１－氧代－２－丙烯－１－基）氨基］－１－哌啶基］甲基］－２－吡啶甲醯胺的結晶形式作為ｍｅｎｉｎ－ｍｌｌ相互作用的共價抑制劑 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1979001080A1 (fr) | 1978-05-17 | 1979-12-13 | Teijin Ltd | Hexahydronaphtoimidazothiazoles et procede pour leur preparation |
| JPS5533405A (en) | 1978-08-29 | 1980-03-08 | Teijin Ltd | Hexahydronaphtho(1',2':4,5)imidazo(2,1-b)thiazole and its preparation |
| DE3572485D1 (en) * | 1984-12-22 | 1989-09-28 | Thomae Gmbh Dr K | Tetrahydro-benzothiazoles, their production and their use as intermediates or drugs |
| US5358949A (en) * | 1986-03-05 | 1994-10-25 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives |
| US5182290A (en) * | 1991-08-27 | 1993-01-26 | Neurogen Corporation | Certain oxazoloquinolinones; a new class of GABA brain receptor ligands |
| TW260664B (enExample) * | 1993-02-15 | 1995-10-21 | Otsuka Pharma Factory Inc | |
| JP3670309B2 (ja) | 1993-04-01 | 2005-07-13 | 第一製薬株式会社 | 二環性複素環化合物 |
| NO941135L (no) | 1993-04-01 | 1994-10-03 | Daiichi Seiyaku Co | Tiazolpyrimidin derivater |
| TW420669B (en) * | 1994-03-28 | 2001-02-01 | Nissan Chemical Ind Ltd | Pyridine type thiazolidines |
| AU727654B2 (en) * | 1997-06-13 | 2000-12-21 | Yamanouchi Pharmaceutical Co., Ltd. | Tricyclic pyrazole derivative |
| JP2003521543A (ja) * | 2000-02-07 | 2003-07-15 | アボット ゲーエムベーハー ウント カンパニー カーゲー | ２−ベンゾチアゾリル尿素誘導体およびそのプロテインキナーゼ阻害剤としての使用 |
| HUP0300382A3 (en) * | 2000-03-29 | 2006-11-28 | Cyclacel Ltd | 2-substituted 4-heteroaryl-pyrimidines and their use in the treatmetn of proliferative disorders and pharmaceutical compositions containing the compounds |
| US6608053B2 (en) * | 2000-04-27 | 2003-08-19 | Yamanouchi Pharmaceutical Co., Ltd. | Fused heteroaryl derivatives |
| KR100423899B1 (ko) * | 2000-05-10 | 2004-03-24 | 주식회사 엘지생명과학 | 세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸 |
| WO2003035618A2 (en) | 2001-10-24 | 2003-05-01 | Iconix Pharmaceuticals, Inc. | Modulators of phosphoinositide 3-kinase |
| AR038703A1 (es) | 2002-02-28 | 2005-01-26 | Novartis Ag | Derivados de 5-feniltiazol y uso como inhibidor de quinasa p i 3 |
| EP1349179A1 (en) * | 2002-03-18 | 2003-10-01 | ATOFINA Research | Conductive polyolefins with good mechanical properties |
| AU2003255528B2 (en) | 2002-07-10 | 2009-07-16 | Merck Serono Sa | Azolidinone-vinyl fused-benzene derivatives |
| ES2312843T3 (es) | 2002-09-30 | 2009-03-01 | Bayer Healthcare Ag | Derivados de azolpirimidina condensados. |
| BR0316386A (pt) | 2002-12-06 | 2005-09-27 | Warner Lambert Co | Benzoxazin-3-onas e seus derivados como inibidores de p13k |
| JP2006512357A (ja) | 2002-12-20 | 2006-04-13 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | Ｐｉ３ｋの阻害剤としてのベンゾキサジンおよびその誘導体 |
| GB0315966D0 (en) * | 2003-07-08 | 2003-08-13 | Cyclacel Ltd | Compounds |
| NO20041733L (no) * | 2004-04-28 | 2005-10-31 | Thin Film Electronics Asa | Organisk elektronisk krets med funksjonelt mellomsjikt og fremgangsmate til dens fremstilling. |
| US7691888B2 (en) * | 2004-10-07 | 2010-04-06 | Boehringer Ingelheim International Gmbh | Thiazolyl-dihydro-indazole |
| FR2887993B1 (fr) * | 2005-07-01 | 2007-08-03 | Commissariat Energie Atomique | Dispositif de detection de rayonnements a electrodes empilees et methode de detection de rayonnements ionisants mettant en oeuvre un tel dispositif |
| US20070259855A1 (en) * | 2006-04-06 | 2007-11-08 | Udo Maier | Thiazolyl-dihydro-indazole |
| CN101460506A (zh) * | 2006-04-06 | 2009-06-17 | 贝林格尔.英格海姆国际有限公司 | 用作蛋白激酶抑制剂的噻唑基-二氢-吲唑衍生物 |
-
2005
- 2005-10-05 US US11/243,796 patent/US7691888B2/en not_active Expired - Lifetime
- 2005-10-05 RU RU2007116858/04A patent/RU2403258C2/ru not_active IP Right Cessation
- 2005-10-05 MX MX2007004051A patent/MX2007004051A/es not_active Application Discontinuation
- 2005-10-05 KR KR1020077010387A patent/KR20070064660A/ko not_active Withdrawn
- 2005-10-05 CN CNA2005800344060A patent/CN101048418A/zh active Pending
- 2005-10-05 EP EP11158787A patent/EP2343303A1/de not_active Withdrawn
- 2005-10-05 JP JP2007535159A patent/JP5122287B2/ja not_active Expired - Lifetime
- 2005-10-05 CA CA2579279A patent/CA2579279C/en not_active Expired - Lifetime
- 2005-10-05 BR BRPI0516557-1A patent/BRPI0516557A/pt not_active IP Right Cessation
- 2005-10-05 AU AU2005293607A patent/AU2005293607A1/en not_active Abandoned
- 2005-10-05 EP EP05805652A patent/EP1802636B1/de not_active Expired - Lifetime
- 2005-10-05 RU RU2007116861/04A patent/RU2007116861A/ru not_active Application Discontinuation
- 2005-10-05 US US11/244,299 patent/US20060106013A1/en not_active Abandoned
- 2005-10-05 WO PCT/EP2005/055015 patent/WO2006040279A1/de not_active Ceased
- 2005-10-06 TW TW094134899A patent/TW200628475A/zh unknown
- 2005-10-07 AR ARP050104225A patent/AR055273A1/es unknown
-
2007
- 2007-04-10 IL IL182398A patent/IL182398A0/en unknown
-
2009
- 2009-02-05 US US12/366,248 patent/US8232286B2/en active Active
-
2010
- 2010-01-11 US US12/685,213 patent/US8207349B2/en not_active Expired - Lifetime