JP2010540593A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010540593A5 JP2010540593A5 JP2010527450A JP2010527450A JP2010540593A5 JP 2010540593 A5 JP2010540593 A5 JP 2010540593A5 JP 2010527450 A JP2010527450 A JP 2010527450A JP 2010527450 A JP2010527450 A JP 2010527450A JP 2010540593 A5 JP2010540593 A5 JP 2010540593A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- asthma
- dermatitis
- syndrome
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 Cc1ccccc1-c(cc1)c([C@@](*=O)[O-])cc1C1=NC(c(cccc2)c2OC)=*=CO1 Chemical compound Cc1ccccc1-c(cc1)c([C@@](*=O)[O-])cc1C1=NC(c(cccc2)c2OC)=*=CO1 0.000 description 11
- ZECNIOSRNLMLQL-UHFFFAOYSA-N CC(C(C=C1C2=[I]COC(c(cc3C)cnc3N3C(COC)CCC3)=N2)=CCC1OC)=C Chemical compound CC(C(C=C1C2=[I]COC(c(cc3C)cnc3N3C(COC)CCC3)=N2)=CCC1OC)=C ZECNIOSRNLMLQL-UHFFFAOYSA-N 0.000 description 1
- LMEIQOZLQFASPG-UHFFFAOYSA-N CC(C)Cc(cc1)ccc1C1=NC(c2ccccc2OC)=CCO1 Chemical compound CC(C)Cc(cc1)ccc1C1=NC(c2ccccc2OC)=CCO1 LMEIQOZLQFASPG-UHFFFAOYSA-N 0.000 description 1
- FJCWNYMWFMXWIG-UHFFFAOYSA-N CC(C1)C(OC)=CC(OC)=C1c(cc1)c(C)cc1-c1nc(-c(cccc2)c2OC)n[o]1 Chemical compound CC(C1)C(OC)=CC(OC)=C1c(cc1)c(C)cc1-c1nc(-c(cccc2)c2OC)n[o]1 FJCWNYMWFMXWIG-UHFFFAOYSA-N 0.000 description 1
- RDZNOCMUKDFOEB-UHFFFAOYSA-N CC(CCCC1)N1C(C=C1)=NCC=C1c1nc(-c(cc(cc2)F)c2OC)n[o]1 Chemical compound CC(CCCC1)N1C(C=C1)=NCC=C1c1nc(-c(cc(cc2)F)c2OC)n[o]1 RDZNOCMUKDFOEB-UHFFFAOYSA-N 0.000 description 1
- HBZMDATWKNBZOL-UHFFFAOYSA-N CN(CCOC1)C1I Chemical compound CN(CCOC1)C1I HBZMDATWKNBZOL-UHFFFAOYSA-N 0.000 description 1
- PAMIQIKDUOTOBW-UHFFFAOYSA-N CN1CCCCC1 Chemical compound CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 description 1
- GJSVCUHWEJFFMO-UHFFFAOYSA-N Cc(nccc1)c1I Chemical compound Cc(nccc1)c1I GJSVCUHWEJFFMO-UHFFFAOYSA-N 0.000 description 1
- YFSLWFVIZJXFTH-UHFFFAOYSA-N Cc1c(C)[o]nc1I Chemical compound Cc1c(C)[o]nc1I YFSLWFVIZJXFTH-UHFFFAOYSA-N 0.000 description 1
- MGGZZJQVRZTTSN-UHFFFAOYSA-N Cc1cc(-c2nc(-c(cccc3)c3OC(F)(F)F)n[o]2)ccc1-c1ccccc1OC Chemical compound Cc1cc(-c2nc(-c(cccc3)c3OC(F)(F)F)n[o]2)ccc1-c1ccccc1OC MGGZZJQVRZTTSN-UHFFFAOYSA-N 0.000 description 1
- XQPLNMPHXAMKKR-UHFFFAOYSA-N Cc1cc(-c2nc(-c(cccc3)c3OC)n[o]2)ccc1C1=CCCC=C1C Chemical compound Cc1cc(-c2nc(-c(cccc3)c3OC)n[o]2)ccc1C1=CCCC=C1C XQPLNMPHXAMKKR-UHFFFAOYSA-N 0.000 description 1
- FWIGHXDJQOUOMF-UHFFFAOYSA-N Cc1ccccc1-c(cc1)c(CN(C)C)cc1-c1nc(-c(cc(C=C)cc2)c2OC)n[o]1 Chemical compound Cc1ccccc1-c(cc1)c(CN(C)C)cc1-c1nc(-c(cc(C=C)cc2)c2OC)n[o]1 FWIGHXDJQOUOMF-UHFFFAOYSA-N 0.000 description 1
- PWMQGDXVGSGAHB-UHFFFAOYSA-N Cc1ccccc1-c(cc1)c(CN)cc1-c1nc(-c2cc(F)ccc2OC)n[o]1 Chemical compound Cc1ccccc1-c(cc1)c(CN)cc1-c1nc(-c2cc(F)ccc2OC)n[o]1 PWMQGDXVGSGAHB-UHFFFAOYSA-N 0.000 description 1
- MFQWILMXHRCFDY-UHFFFAOYSA-N Cc1ccccc1-c(ccc(-c1nc(-c2cc(F)ccc2OC)n[o]1)c1)c1C(O)=O Chemical compound Cc1ccccc1-c(ccc(-c1nc(-c2cc(F)ccc2OC)n[o]1)c1)c1C(O)=O MFQWILMXHRCFDY-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07117925 | 2007-10-04 | ||
| EP07117925.3 | 2007-10-04 | ||
| US99813607P | 2007-10-09 | 2007-10-09 | |
| US60/998,136 | 2007-10-09 | ||
| PCT/EP2008/063185 WO2009043890A1 (en) | 2007-10-04 | 2008-10-01 | Oxadiazole diaryl compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014197234A Division JP2015025001A (ja) | 2007-10-04 | 2014-09-26 | オキサジアゾール・ジアリール化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010540593A JP2010540593A (ja) | 2010-12-24 |
| JP2010540593A5 true JP2010540593A5 (enExample) | 2013-10-24 |
| JP5727223B2 JP5727223B2 (ja) | 2015-06-03 |
Family
ID=38961274
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527450A Expired - Fee Related JP5727223B2 (ja) | 2007-10-04 | 2008-10-01 | オキサジアゾール・ジアリール化合物 |
| JP2014197234A Withdrawn JP2015025001A (ja) | 2007-10-04 | 2014-09-26 | オキサジアゾール・ジアリール化合物 |
| JP2016100693A Expired - Fee Related JP6224771B2 (ja) | 2007-10-04 | 2016-05-19 | オキサジアゾール・ジアリール化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014197234A Withdrawn JP2015025001A (ja) | 2007-10-04 | 2014-09-26 | オキサジアゾール・ジアリール化合物 |
| JP2016100693A Expired - Fee Related JP6224771B2 (ja) | 2007-10-04 | 2016-05-19 | オキサジアゾール・ジアリール化合物 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8404676B2 (enExample) |
| EP (1) | EP2193126B1 (enExample) |
| JP (3) | JP5727223B2 (enExample) |
| KR (1) | KR20100083814A (enExample) |
| CN (2) | CN104478821B (enExample) |
| AR (1) | AR068730A1 (enExample) |
| AU (1) | AU2008306886B2 (enExample) |
| BR (1) | BRPI0817597A2 (enExample) |
| CA (1) | CA2696829C (enExample) |
| EA (1) | EA201070423A1 (enExample) |
| ES (1) | ES2547877T3 (enExample) |
| IL (1) | IL204520A (enExample) |
| MX (1) | MX2010003614A (enExample) |
| WO (1) | WO2009043890A1 (enExample) |
| ZA (1) | ZA201001217B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2450750T3 (es) | 2007-03-16 | 2014-03-25 | Actelion Pharmaceuticals Ltd. | Derivados de amino-piridina como agonistas del receptor S1P1/EDG1 |
| US8202865B2 (en) | 2007-10-04 | 2012-06-19 | Merck Serono Sa | Oxadiazole derivatives |
| MX2010003614A (es) * | 2007-10-04 | 2010-04-21 | Merck Serono Sa | Compuestos de diarilo oxadiazol. |
| US8551463B2 (en) | 2007-10-22 | 2013-10-08 | Living Proof, Inc. | Hair care compositions and methods of treating hair |
| KR20100110834A (ko) * | 2007-12-21 | 2010-10-13 | 메르크 세로노 에스. 에이. | 트리아졸 옥사다이아졸 유도체 |
| JP5411877B2 (ja) * | 2008-03-06 | 2014-02-12 | アクテリオン ファーマシューティカルズ リミテッド | ピリジン化合物 |
| AU2009220893A1 (en) | 2008-03-07 | 2009-09-11 | Actelion Pharmaceuticals Ltd | Novel aminomethyl benzene derivatives |
| ES2405054T3 (es) | 2009-01-23 | 2013-05-30 | Bristol-Myers Squibb Company | Derivados de pirazol-1,2,4-oxadiazol como agonistas de esfingosina-1-fosfato |
| US8354398B2 (en) | 2009-01-23 | 2013-01-15 | Bristol-Myers Squibb Company | Substituted isoxazole compounds |
| US8404672B2 (en) | 2009-01-23 | 2013-03-26 | Bristol-Meyers Squibb Company | Substituted heterocyclic compounds |
| DK2454255T3 (da) | 2009-07-16 | 2013-12-16 | Actelion Pharmaceuticals Ltd | Pyridin-4-ylderivater som s1p1/edg1-agonister |
| US8399451B2 (en) | 2009-08-07 | 2013-03-19 | Bristol-Myers Squibb Company | Heterocyclic compounds |
| WO2011133734A1 (en) | 2010-04-23 | 2011-10-27 | Bristol-Myers Squibb Company | 4 - (5 - isoxazolyl or 5 - pyrrazolyl -1,2,4- oxadiazol - 3 - yl) -mandelic acid amides as sphingosin- 1 - phosphate 1 rreceptor agonists |
| WO2011136927A1 (en) * | 2010-04-27 | 2011-11-03 | Allergan, Inc. | 3-(4-((1h-imidazol-1-yl)methyl)phenyl)-5-aryl-1,2,4-oxadiazole derivatives as sphingosine-1 phosphate receptors modulators |
| EP2619190B1 (en) * | 2010-09-24 | 2015-08-12 | Bristol-Myers Squibb Company | Substituted oxadiazole compounds and their use as s1p1 agonists |
| TWI546300B (zh) | 2011-01-19 | 2016-08-21 | 艾克泰聯製藥有限公司 | ２－甲氧基－吡啶－４－基衍生物 |
| US9073881B2 (en) * | 2011-09-23 | 2015-07-07 | Hoffmann-La Roche Inc. | Benzoic acid derivatives |
| PH12017502097B1 (en) | 2015-05-20 | 2023-05-05 | Idorsia Pharmaceuticals Ltd | Crystalline form of the compound (s)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol |
| JP2023548475A (ja) * | 2020-11-09 | 2023-11-17 | アリーナ ファーマシューティカルズ， インコーポレイテッド | Ｓ１ｐ１受容体に関係する病態を治療する方法 |
| EP4050002A1 (en) * | 2021-02-26 | 2022-08-31 | First Health Pharmaceuticals B.V. | Anti-proliferative agents |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH623971B5 (de) | 1976-06-04 | 1982-01-15 | Hoechst Ag | Verfahren zur herstellung neuer benzofuranderivate und deren verwendung als optische aufheller. |
| US4135910A (en) * | 1977-05-12 | 1979-01-23 | Monsanto Company | Oxadiazol-3-yl-benzoates as plant growth regulants |
| DE4320801A1 (de) | 1993-06-23 | 1995-01-05 | Fahlberg List Pharma Gmbh | 2-Hydroxyphenylsubstituierte 1,2,4-Triazole und 1,2,4-Oxadiazole, ihre Verwendung als pharmazeutische Wirkstoffe und sie enthaltende Arzneimittel |
| DE19643037A1 (de) * | 1996-10-18 | 1998-04-23 | Boehringer Ingelheim Kg | Neue Oxadiazole, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel |
| AUPP999799A0 (en) | 1999-04-27 | 1999-05-20 | Fujisawa Pharmaceutical Co., Ltd. | New compound |
| DK1618098T3 (en) | 2003-04-11 | 2015-01-12 | Ptc Therapeutics Inc | 1,2,4-OXADIAZOLBENZOESYREFORBINDELSER AND THEIR USE FOR nonsense CONTROL AND TREATMENT OF AN ILLNESS |
| CN1788008A (zh) * | 2003-05-15 | 2006-06-14 | 麦克公司 | 作为s1p受体激动剂的3－(2－氨基－1－氮杂环基)－5－芳基－1,2,4－噁二唑 |
| JP2007528872A (ja) * | 2003-10-01 | 2007-10-18 | メルク エンド カムパニー インコーポレーテッド | Ｓ１ｐ受容体アゴニストとしての３，５−アリール置換、ヘテロアリール置換またはシクロアルキル置換された１，２，４−オキサジアゾール化合物 |
| CN1894225A (zh) | 2003-12-17 | 2007-01-10 | 默克公司 | 作为鞘氨醇1－磷酸(内皮分化基因)受体激动剂的(3,4－二取代)丙酸酯 |
| JPWO2005108370A1 (ja) * | 2004-04-16 | 2008-03-21 | 味の素株式会社 | ベンゼン化合物 |
| JP2008500991A (ja) | 2004-05-29 | 2008-01-17 | ７ティーエム ファーマ エイ／エス | 医学的使用のためのｃｒｔｈ２レセプターリガンド |
| AU2005299851B2 (en) * | 2004-10-22 | 2011-03-17 | Merck Sharp & Dohme Corp. | 2-(aryl)azacyclylmethyl carboxylates, sulfonates, phosphonates, phosphinates and heterocycles as S1P receptor agonists |
| CA2610310A1 (en) * | 2005-06-08 | 2006-12-14 | Novartis Ag | Polycyclic oxadiazoles or isoxazoles and their use as s1p receptor ligands |
| WO2007043401A1 (ja) * | 2005-10-07 | 2007-04-19 | Kissei Pharmaceutical Co., Ltd. | 含窒素複素環化合物およびそれを含有する医薬組成物 |
| TWI404706B (zh) * | 2006-01-11 | 2013-08-11 | Actelion Pharmaceuticals Ltd | 新穎噻吩衍生物 |
| JP2009269819A (ja) | 2006-08-25 | 2009-11-19 | Asahi Kasei Pharma Kk | アミン化合物 |
| MX2009003129A (es) | 2006-09-29 | 2009-04-06 | Novartis Ag | Derivados de oxadiazol con propiedades anti-inflamatorias e inmunosupresoras. |
| SG177221A1 (en) | 2006-12-15 | 2012-01-30 | Abbott Lab | Novel oxadiazole compounds |
| EP2014653A1 (en) | 2007-06-15 | 2009-01-14 | Bioprojet | Novel dicarboxylic acid derivatives as S1P1 receptor agonists |
| US8202865B2 (en) * | 2007-10-04 | 2012-06-19 | Merck Serono Sa | Oxadiazole derivatives |
| MX2010003614A (es) * | 2007-10-04 | 2010-04-21 | Merck Serono Sa | Compuestos de diarilo oxadiazol. |
-
2008
- 2008-10-01 MX MX2010003614A patent/MX2010003614A/es not_active Application Discontinuation
- 2008-10-01 ES ES08804975.4T patent/ES2547877T3/es active Active
- 2008-10-01 CN CN201410603560.6A patent/CN104478821B/zh not_active Expired - Fee Related
- 2008-10-01 BR BRPI0817597 patent/BRPI0817597A2/pt not_active IP Right Cessation
- 2008-10-01 EP EP08804975.4A patent/EP2193126B1/en active Active
- 2008-10-01 CN CN200880110507.5A patent/CN101815707B/zh not_active Expired - Fee Related
- 2008-10-01 KR KR1020107009974A patent/KR20100083814A/ko not_active Withdrawn
- 2008-10-01 WO PCT/EP2008/063185 patent/WO2009043890A1/en not_active Ceased
- 2008-10-01 EA EA201070423A patent/EA201070423A1/ru unknown
- 2008-10-01 CA CA2696829A patent/CA2696829C/en not_active Expired - Fee Related
- 2008-10-01 US US12/675,254 patent/US8404676B2/en not_active Expired - Fee Related
- 2008-10-01 AU AU2008306886A patent/AU2008306886B2/en not_active Ceased
- 2008-10-01 JP JP2010527450A patent/JP5727223B2/ja not_active Expired - Fee Related
- 2008-10-03 AR ARP080104332A patent/AR068730A1/es not_active Application Discontinuation
-
2010
- 2010-02-19 ZA ZA2010/01217A patent/ZA201001217B/en unknown
- 2010-03-16 IL IL204520A patent/IL204520A/en not_active IP Right Cessation
-
2012
- 2012-12-12 US US13/711,934 patent/US8889668B2/en not_active Expired - Fee Related
-
2014
- 2014-09-26 JP JP2014197234A patent/JP2015025001A/ja not_active Withdrawn
-
2016
- 2016-05-19 JP JP2016100693A patent/JP6224771B2/ja not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010540593A5 (enExample) | ||
| JP6506836B2 (ja) | Ｂ型肝炎ウイルス感染症の処置および予防のための新規ピリダゾンおよびトリアジノン | |
| JP2007515432A5 (enExample) | ||
| JP2006528980A5 (enExample) | ||
| JP7787063B2 (ja) | オーロラキナーゼ阻害剤およびその使用 | |
| JP2002528493A5 (enExample) | ||
| KR102212975B1 (ko) | 피리딘-４-일 유도체 | |
| JP2009534407A5 (enExample) | ||
| JP2009535307A5 (enExample) | ||
| JP2019510787A5 (enExample) | ||
| JP2019533696A (ja) | Ｂ型肝炎ウイルス感染症の処置及び予防のための新規なテトラヒドロピリドピリミジン | |
| JP2015535832A5 (enExample) | ||
| JP2013514980A5 (enExample) | ||
| JP2009532417A5 (enExample) | ||
| JP2014532716A5 (enExample) | ||
| TW200806652A (en) | N-hydroxyacrylamide compounds | |
| JP2007522142A5 (enExample) | ||
| JP6781848B2 (ja) | 新規なピロロピリジン誘導体、その製造方法及び用途 | |
| HRP20211121T1 (hr) | Supstituirani biciklični spojevi | |
| WO2023169572A1 (zh) | 一种三嗪类化合物、其中间体、其制备方法及其用途 | |
| JP2007503432A5 (enExample) | ||
| JP2022526827A (ja) | （ｅ）－３－［２－（２－チエニル）ビニル］－１ｈ－ピラゾールの固体形態 | |
| JP3539926B2 (ja) | 抗ウイルス性ピリミジンジオン誘導体及びそれらの製造方法 | |
| JP2006507347A5 (enExample) | ||
| US9340539B2 (en) | Hepatitis C inhibitor compounds |