JP2006511579A5 - - Google Patents
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- JP2006511579A5 JP2006511579A5 JP2004563642A JP2004563642A JP2006511579A5 JP 2006511579 A5 JP2006511579 A5 JP 2006511579A5 JP 2004563642 A JP2004563642 A JP 2004563642A JP 2004563642 A JP2004563642 A JP 2004563642A JP 2006511579 A5 JP2006511579 A5 JP 2006511579A5
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- JP
- Japan
- Prior art keywords
- alkyl
- group
- halo
- alkoxy
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 claims 77
- 125000005843 halogen group Chemical group 0.000 claims 34
- 125000003545 alkoxy group Chemical group 0.000 claims 28
- 150000001875 compounds Chemical class 0.000 claims 27
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 24
- 125000003342 alkenyl group Chemical group 0.000 claims 17
- 125000000304 alkynyl group Chemical group 0.000 claims 17
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 125000001424 substituent group Chemical group 0.000 claims 17
- 230000008938 immune dysregulation Effects 0.000 claims 11
- 208000006673 asthma Diseases 0.000 claims 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 9
- -1 1H-tetrazol-5-yl Chemical group 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 208000023504 respiratory system disease Diseases 0.000 claims 5
- 201000004624 Dermatitis Diseases 0.000 claims 4
- 206010034277 Pemphigoid Diseases 0.000 claims 4
- 230000001684 chronic effect Effects 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 208000014674 injury Diseases 0.000 claims 4
- 210000000056 organ Anatomy 0.000 claims 4
- 206010018364 Glomerulonephritis Diseases 0.000 claims 3
- 206010019663 Hepatic failure Diseases 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 3
- 201000004681 Psoriasis Diseases 0.000 claims 3
- 206010046851 Uveitis Diseases 0.000 claims 3
- 206010006451 bronchitis Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000003779 hair growth Effects 0.000 claims 3
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- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
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- 208000011231 Crohn disease Diseases 0.000 claims 2
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- 208000009329 Graft vs Host Disease Diseases 0.000 claims 2
- 208000015023 Graves' disease Diseases 0.000 claims 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
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- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
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- 208000027418 Wounds and injury Diseases 0.000 claims 2
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- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 2
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- 229910052760 oxygen Inorganic materials 0.000 claims 2
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- 230000008733 trauma Effects 0.000 claims 2
- 125000001425 triazolyl group Chemical group 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 1
- 125000006545 (C1-C9) alkyl group Chemical group 0.000 claims 1
- 125000001766 1,2,4-oxadiazol-3-yl group Chemical group [H]C1=NC(*)=NO1 0.000 claims 1
- BBVIDBNAYOIXOE-UHFFFAOYSA-N 1,2,4-oxadiazole Chemical group C=1N=CON=1 BBVIDBNAYOIXOE-UHFFFAOYSA-N 0.000 claims 1
- HXEIGYFSDRZEJG-UHFFFAOYSA-N 1-[5-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]-2,3-dihydro-1h-inden-1-yl]azetidine-3-carboxylic acid Chemical compound C1=CC(CC(C)C)=CC=C1C1=NC(C=2C=C3CCC(C3=CC=2)N2CC(C2)C(O)=O)=NO1 HXEIGYFSDRZEJG-UHFFFAOYSA-N 0.000 claims 1
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- 208000032116 Autoimmune Experimental Encephalomyelitis Diseases 0.000 claims 1
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- HXEIGYFSDRZEJG-JOCHJYFZSA-N C1=CC(CC(C)C)=CC=C1C1=NC(C=2C=C3CC[C@H](C3=CC=2)N2CC(C2)C(O)=O)=NO1 Chemical compound C1=CC(CC(C)C)=CC=C1C1=NC(C=2C=C3CC[C@H](C3=CC=2)N2CC(C2)C(O)=O)=NO1 HXEIGYFSDRZEJG-JOCHJYFZSA-N 0.000 claims 1
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- 206010011224 Cough Diseases 0.000 claims 1
- 206010012335 Dependence Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 206010012442 Dermatitis contact Diseases 0.000 claims 1
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- 206010014561 Emphysema Diseases 0.000 claims 1
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- 206010016654 Fibrosis Diseases 0.000 claims 1
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- 206010018687 Granulocytopenia Diseases 0.000 claims 1
- 208000035895 Guillain-Barré syndrome Diseases 0.000 claims 1
- 208000001204 Hashimoto Disease Diseases 0.000 claims 1
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 1
- 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 claims 1
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- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010020850 Hyperthyroidism Diseases 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 claims 1
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 1
- 201000003838 Idiopathic interstitial pneumonia Diseases 0.000 claims 1
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims 1
- 208000032571 Infant acute respiratory distress syndrome Diseases 0.000 claims 1
- 201000002287 Keratoconus Diseases 0.000 claims 1
- 206010069698 Langerhans' cell histiocytosis Diseases 0.000 claims 1
- 208000001244 Linear IgA Bullous Dermatosis Diseases 0.000 claims 1
- 208000012309 Linear IgA disease Diseases 0.000 claims 1
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- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
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- 208000001106 Takayasu Arteritis Diseases 0.000 claims 1
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
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- GFZWHAAOIVMHOI-UHFFFAOYSA-N azetidine-3-carboxylic acid Chemical compound OC(=O)C1CNC1 GFZWHAAOIVMHOI-UHFFFAOYSA-N 0.000 claims 1
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- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
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- 0 *[n]1nccc1 Chemical compound *[n]1nccc1 0.000 description 3
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43538102P | 2002-12-20 | 2002-12-20 | |
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| DE (1) | DE60335827D1 (enExample) |
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2003
- 2003-12-16 EP EP03814075A patent/EP1581509B1/en not_active Expired - Lifetime
- 2003-12-16 JP JP2004563642A patent/JP4516430B2/ja not_active Expired - Fee Related
- 2003-12-16 US US10/536,730 patent/US7220734B2/en not_active Expired - Fee Related
- 2003-12-16 AU AU2003297232A patent/AU2003297232B2/en not_active Ceased
- 2003-12-16 WO PCT/US2003/040129 patent/WO2004058149A2/en not_active Ceased
- 2003-12-16 DE DE60335827T patent/DE60335827D1/de not_active Expired - Lifetime
- 2003-12-16 AT AT03814075T patent/ATE496024T1/de not_active IP Right Cessation
- 2003-12-16 CA CA2509218A patent/CA2509218C/en not_active Expired - Fee Related
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