AU2003297232B2 - 1-(amino)indanes and (1,2-dihydro-3-amino)-benzofurans, benzothiophenes and indoles - Google Patents
1-(amino)indanes and (1,2-dihydro-3-amino)-benzofurans, benzothiophenes and indoles Download PDFInfo
- Publication number
- AU2003297232B2 AU2003297232B2 AU2003297232A AU2003297232A AU2003297232B2 AU 2003297232 B2 AU2003297232 B2 AU 2003297232B2 AU 2003297232 A AU2003297232 A AU 2003297232A AU 2003297232 A AU2003297232 A AU 2003297232A AU 2003297232 B2 AU2003297232 B2 AU 2003297232B2
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- Prior art keywords
- alkyl
- phenyl
- group
- optionally substituted
- halo
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- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
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- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
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- Pain & Pain Management (AREA)
- AIDS & HIV (AREA)
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- Tropical Medicine & Parasitology (AREA)
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- Vascular Medicine (AREA)
- Obesity (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43538102P | 2002-12-20 | 2002-12-20 | |
| US60/435,381 | 2002-12-20 | ||
| PCT/US2003/040129 WO2004058149A2 (en) | 2002-12-20 | 2003-12-16 | 1-(amino)indanes and (1,2-dihydro-3-amino)-benzofurans, benzothiophenes and indoles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2003297232A1 AU2003297232A1 (en) | 2004-07-22 |
| AU2003297232B2 true AU2003297232B2 (en) | 2010-02-04 |
Family
ID=32682229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003297232A Ceased AU2003297232B2 (en) | 2002-12-20 | 2003-12-16 | 1-(amino)indanes and (1,2-dihydro-3-amino)-benzofurans, benzothiophenes and indoles |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7220734B2 (enExample) |
| EP (1) | EP1581509B1 (enExample) |
| JP (1) | JP4516430B2 (enExample) |
| AT (1) | ATE496024T1 (enExample) |
| AU (1) | AU2003297232B2 (enExample) |
| CA (1) | CA2509218C (enExample) |
| DE (1) | DE60335827D1 (enExample) |
| WO (1) | WO2004058149A2 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20110140139A (ko) | 2003-08-29 | 2011-12-30 | 오노 야꾸힝 고교 가부시키가이샤 | S1p 수용체 결합능을 갖는 화합물 및 그 의약 용도 |
| JP4773972B2 (ja) | 2003-12-17 | 2011-09-14 | メルク・シャープ・エンド・ドーム・コーポレイション | S1P(Edg)受容体作働薬としての(3,4−ジ置換)プロパンカルボン酸 |
| SI1772145T1 (sl) * | 2004-07-16 | 2011-06-30 | Kyorin Seiyaku Kk | Postopek za učinkovito uporabo zdravila in postopek za preprečevanje stranskih učinkov |
| JP2008509931A (ja) | 2004-08-13 | 2008-04-03 | プレーシス ファーマスーティカルズ インコーポレイテッド | スフィンゴシン−1−ホスフェート(s1p)レセプター活性を調節するための方法および組成物 |
| PT2511262T (pt) | 2004-10-12 | 2017-03-30 | Kyorin Seiyaku Kk | Processo para a produção de cloridrato de 2-amino-2-[2-[4-(3- benziloxi-feniltio)-2-clorofenil[etil]-1,3-propanodiol |
| PT1650186E (pt) * | 2004-10-22 | 2008-09-16 | Bioprojet Soc Civ | Novos derivados de ácidos dicarboxílicos |
| PT1826197E (pt) | 2004-12-13 | 2012-03-06 | Ono Pharmaceutical Co | Derivado de ácido aminocarboxílico e sua utilização medicinal |
| US20090280100A1 (en) * | 2005-02-25 | 2009-11-12 | Redox Bioscience Inc. | Preventive or Therapeutic Agent for Inflammatory Ocular-Surface Diseases |
| TW200642683A (en) * | 2005-04-22 | 2006-12-16 | Sankyo Co | Heterocyclic compound |
| WO2007043433A1 (ja) * | 2005-10-07 | 2007-04-19 | Kyorin Pharmaceutical Co., Ltd. | 2-アミノ-1,3-プロパンジオール誘導体を有効成分とする肝臓疾患治療剤および肝臓疾患治療方法 |
| JP5035752B2 (ja) | 2006-02-03 | 2012-09-26 | 大正製薬株式会社 | トリアゾール誘導体 |
| TWI389683B (zh) * | 2006-02-06 | 2013-03-21 | Kyorin Seiyaku Kk | A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient |
| WO2007091570A1 (ja) | 2006-02-06 | 2007-08-16 | Taisho Pharmaceutical Co., Ltd. | スフィンゴシン-1-リン酸結合阻害物質 |
| WO2007099423A1 (en) * | 2006-03-02 | 2007-09-07 | Pfizer Products Inc. | 1-pyrrolidine indane derivatives as histamine-3 receptor antagonists |
| CA2648303C (en) * | 2006-04-03 | 2014-07-15 | Astellas Pharma Inc. | 5-[monocyclic(hetero)arylsubstituted-1,2,4-oxadliazol-3-yl]-(fused heteroaryl substituted) compounds and their use as s1p1 agonists |
| EP2017263A4 (en) | 2006-05-09 | 2011-11-30 | Daiichi Sankyo Co Ltd | Heteroarylamide derivative of a lower carboxylic acid |
| SG174029A1 (en) * | 2006-08-08 | 2011-09-29 | Kyorin Seiyaku Kk | Aminoalcohol derivative and immunosuppressant containing the same as active ingredient |
| SG174028A1 (en) * | 2006-08-08 | 2011-09-29 | Kyorin Seiyaku Kk | Aminophosphoric acid ester derivative and s1p receptor modulator containing the same as active ingredient |
| JP2009269819A (ja) * | 2006-08-25 | 2009-11-19 | Asahi Kasei Pharma Kk | アミン化合物 |
| EP2014653A1 (en) * | 2007-06-15 | 2009-01-14 | Bioprojet | Novel dicarboxylic acid derivatives as S1P1 receptor agonists |
| US8048898B2 (en) | 2007-08-01 | 2011-11-01 | Taisho Pharmaceutical Co., Ltd | Inhibitor of binding of S1P1 |
| BR122018001845B1 (pt) | 2007-08-13 | 2019-11-26 | Monsanto Technology Llc | compostos para controlar nematódeos, composições compreendendo os mesmos e método de controle de nematódeos |
| JP5452237B2 (ja) | 2008-02-07 | 2014-03-26 | 杏林製薬株式会社 | アミノアルコール誘導体を有効成分とする炎症性腸疾患の治療剤又は予防剤 |
| US20090298894A1 (en) * | 2008-04-21 | 2009-12-03 | Asahi Kasei Pharma Corporation | Amino acid compounds |
| EP2913326B1 (en) | 2008-05-14 | 2020-07-15 | The Scripps Research Institute | Novel modulators of sphingosine phosphate receptors |
| SI2913326T1 (sl) * | 2008-05-14 | 2020-11-30 | The Scripps Research Institute | Novi modulatorji sfingozinskih fosfatnih receptorjev |
| PT2326621T (pt) | 2008-07-23 | 2016-09-12 | Arena Pharm Inc | Derivados de ácido 1,2,3,4-tetrahidrociclopenta[b]indol-3-il) acético substituídos úteis no tratamento de distúrbios autoimunes e inflamatórios |
| PT2342205T (pt) * | 2008-08-27 | 2016-07-28 | Arena Pharm Inc | Derivados de ácido tricíclico substituído como agonistas de recetor s1p1 úteis no tratamento de distúrbios autoimunes e inflamatórios |
| JP2012515787A (ja) | 2009-01-23 | 2012-07-12 | ブリストル−マイヤーズ スクイブ カンパニー | 自己免疫疾患および炎症性疾患の処置におけるs1pアゴニストとしての置換オキサジアゾール誘導体 |
| EP2389377B1 (en) | 2009-01-23 | 2014-07-16 | Bristol-Myers Squibb Company | Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases |
| JP2012515789A (ja) | 2009-01-23 | 2012-07-12 | ブリストル−マイヤーズ スクイブ カンパニー | スフィンゴシン−1−リン酸アゴニストとしてのピラゾール−1,2,4−オキサジアゾール誘導体 |
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| KR101771755B1 (ko) * | 2009-11-13 | 2017-08-25 | 셀진 인터내셔널 Ii 에스에이알엘 | 선택적 헤테로시클릭 스핑고신 1 포스페이트 수용체 조절자 |
| BR112012014164A2 (pt) | 2009-12-14 | 2016-05-17 | Merck Patent Gmbh | inibidores da esfingosina quinase |
| JP5856980B2 (ja) | 2010-01-27 | 2016-02-10 | アリーナ ファーマシューティカルズ, インコーポレイテッド | (R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス |
| WO2011109471A1 (en) | 2010-03-03 | 2011-09-09 | Arena Pharmaceuticals, Inc. | Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof |
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| JP5869579B2 (ja) | 2010-09-24 | 2016-02-24 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 置換オキサジアゾール化合物およびそれらのs1p1アゴニストとしての使用 |
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2003
- 2003-12-16 US US10/536,730 patent/US7220734B2/en not_active Expired - Fee Related
- 2003-12-16 WO PCT/US2003/040129 patent/WO2004058149A2/en not_active Ceased
- 2003-12-16 EP EP03814075A patent/EP1581509B1/en not_active Expired - Lifetime
- 2003-12-16 CA CA2509218A patent/CA2509218C/en not_active Expired - Fee Related
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- 2003-12-16 AU AU2003297232A patent/AU2003297232B2/en not_active Ceased
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| EP1581509B1 (en) | 2011-01-19 |
| CA2509218A1 (en) | 2004-07-15 |
| JP4516430B2 (ja) | 2010-08-04 |
| AU2003297232A1 (en) | 2004-07-22 |
| DE60335827D1 (de) | 2011-03-03 |
| ATE496024T1 (de) | 2011-02-15 |
| EP1581509A2 (en) | 2005-10-05 |
| US20060161005A1 (en) | 2006-07-20 |
| EP1581509A4 (en) | 2008-04-23 |
| JP2006511579A (ja) | 2006-04-06 |
| WO2004058149A3 (en) | 2004-09-16 |
| CA2509218C (en) | 2010-09-07 |
| WO2004058149A2 (en) | 2004-07-15 |
| US7220734B2 (en) | 2007-05-22 |
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