AR055273A1 - Pi3-quinasas, sus usos y composiciones farmaceuticas que los contienen - Google Patents

Pi3-quinasas, sus usos y composiciones farmaceuticas que los contienen

Info

Publication number
AR055273A1
AR055273A1 ARP050104225A ARP050104225A AR055273A1 AR 055273 A1 AR055273 A1 AR 055273A1 AR P050104225 A ARP050104225 A AR P050104225A AR P050104225 A ARP050104225 A AR P050104225A AR 055273 A1 AR055273 A1 AR 055273A1
Authority
AR
Argentina
Prior art keywords
alkyl
het
alkenyl
aryl
nitrogen
Prior art date
Application number
ARP050104225A
Other languages
English (en)
Inventor
Steffen Breitfelder
Udo Maier
Trixi Brandl
Christoph Hoenke
Matthias Grauert
Alexander Pautsch
Matthias Hoffmann
Frank Kalkbrenner
Anne Joergensen
Gerhard Schaenzle
Stefan Petters
Eckhart Bauer
Frank Buettner
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102004048877A external-priority patent/DE102004048877A1/de
Priority claimed from DE102005005813A external-priority patent/DE102005005813A1/de
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR055273A1 publication Critical patent/AR055273A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/84—Naphthothiazoles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Debido a su accion farmacéutica como moduladores de la PI3-quinasa pueden utilizarse en el área terapéutica para el tratamiento de enfermedades inflamatorias o alérgicas. A modo de ejemplo, se mencionan enfermedades inflamatorias o alérgicas de las vías respiratorias, enfermedades inflamatorias del tracto gastro-intestinal, artritis reumatoidea, patologías dérmicas inflamatorias y alérgicas, patologías oftálmicas inflamatorias, patologías de la mucosa nasal, estados patologicas inflamatorios o alérgicos, en los cuales inciden reacciones autoinmunes o inflamaciones renales. Reivindicacion 1: Compuestos de formula (1), con la condicion, que la línea circular identificada con A significa un sistema aromático; donde Y significa carbono, átomo de nitrogeno, azufre; de preferencial carbono, nitrogeno; Z significa carbono, nitrogeno, azufre; de preferencia carbono, nitrogeno; j 1, 2 o 3; k 0 o 1; Ra es H, COR8, NR9R10, NO2, OR8, SR11, SOR11, SO2R11, NHCO-alquiloC1-6-NH2, o un radical seleccionado del grupo que incluye alquilo C1-6, alquenilo C2-6, cicloalquilo C3-8, cicloalquenilo C3-8, haloalquilo C1-6, arilo, aralquilo C7-11, espiro, Het, heteroarilo y CH2-O-arilo, que en su caso puede estar sustituido; R8 significa alquilo C1- 6, cicloalquilo C3-6, NH2, hetarilo o arilo, en su caso sustituido con uno o varios halogenos o alquilo C1-4; R9 significa H, COOR12, CONR12 o alquilo C1-6, en su caso sustituido con uno o varios COOH, N(alquilo C1-6)2 o Het, en su caso sustituido con uno o varios alquilo C1-6; o R9 significa Het, en su caso sustituido con uno o varios alquilo C1-4; R10 significa H, alquilo C1-6, CO-alquiloC1-6 o alquinilo C2-6; R11 significa alquilo C1-6, en su caso sustituido con uno o varios N(alquilo C1- 4)2; Rb es R4, OR4, -CH2OR4, COR4, COOR4, CONR4R5, NR4R5, NR5COR4, NR5COOR4, NR5CONR4R5, NR5SOR4 o NR5SO2R4; R4, R5 significan H, alquilo C1-6, haloalquilo C1-6, alquileno C1-6-OH, alquenilo C2-6, aralquilo C7-11, alqueniloC2-4-arilo, alquiniloC2-4- arilo, alquiloC1-4-hetarilo, alqueniloC2-4-hetarilo, alquiniloC2-4-hetarilo, alquinilo C2-6, en su caso sustituido con Si(alquilo C1-4)3, o R4 significa un radical seleccionado del grupo que incluye arilo, Het, Hetarilo y en su caso alquilo C1-4; o R4 y R5 forman conjuntamente un anillo de cinco, seis o siete miembros que se compone de átomo de carbono y en su caso un heteroátomo seleccionado del grupo que se compone de oxígeno, nitrogeno y azufre; Rc significa NHR6 o un radical seleccionado del grupo que incluye la formula (2) donde: B significa un enlace, alquilo C1-6, alquenilo C2-6 o alquinilo C2-6; R6 es H o un radical seleccionado del grupo alquilo C1-4, alquenilo C2-4, alquinilo C2-4, cicloalquilo C3-6, cicloalquenilo C3-6, Het, arilo, hetarilo en su caso sustituido con uno o varios radicales R6,1; R6,1 es halogeno, CF3, OH, CN, OMe, SO2(alquilo C1-4); R7 significa H, alquilo C1-4, alquenilo C2-4, alquinilo C2-4, cicloalquilo C3-6, NR7,1R7,2, OR7,2, SR7,2, hetarilo, Het, en su caso sustituido con alquilo C1-4 o CONH2; R7,1 significa H, alquilo C1-6, (CH2)2-4R7,1,1 o COO-butilo; R7,2 significa H, alquilo C1-6, en su caso sustituido con uno o varios OH; R7,1,1NR7,1,1,1R7,1,1,2, Het o 1-imidazolilo, 2-(N-etilpirrolidina); R7,1,1,1 es H o alquilo C1-6; R7,1,1,2 es H o alquilo C1-6; así como sales aceptables para uso farmacéuticos, diaesteromeros, enantiomeros, racematos, hidratos o solvatos de éstos, con la condicion, que Ra no puede ser H o Me, cuando significan Y = nitrogeno; Z = nitrogeno; j = 2; k = 0; Rb= H y Rc = NHCONH-Et.
ARP050104225A 2004-10-07 2005-10-07 Pi3-quinasas, sus usos y composiciones farmaceuticas que los contienen AR055273A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004048877A DE102004048877A1 (de) 2004-10-07 2004-10-07 PI3-Kinasen
DE102005005813A DE102005005813A1 (de) 2005-02-09 2005-02-09 PI3-Kinasen

Publications (1)

Publication Number Publication Date
AR055273A1 true AR055273A1 (es) 2007-08-15

Family

ID=35583390

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050104225A AR055273A1 (es) 2004-10-07 2005-10-07 Pi3-quinasas, sus usos y composiciones farmaceuticas que los contienen

Country Status (14)

Country Link
US (4) US7691888B2 (es)
EP (2) EP2343303A1 (es)
JP (1) JP5122287B2 (es)
KR (1) KR20070064660A (es)
CN (1) CN101048418A (es)
AR (1) AR055273A1 (es)
AU (1) AU2005293607A1 (es)
BR (1) BRPI0516557A (es)
CA (1) CA2579279C (es)
IL (1) IL182398A0 (es)
MX (1) MX2007004051A (es)
RU (2) RU2007116861A (es)
TW (1) TW200628475A (es)
WO (1) WO2006040279A1 (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050096332A1 (en) * 2003-10-30 2005-05-05 Boehringer Ingelheim International Gmbh Use of tyrosine kinase inhibitors for the treatment of inflammatory processes
US7691888B2 (en) * 2004-10-07 2010-04-06 Boehringer Ingelheim International Gmbh Thiazolyl-dihydro-indazole
US7517995B2 (en) * 2006-04-06 2009-04-14 Boehringer Ingelheim International Gmbh Thiazolyl-dihydro-cyclopentapyrazole
US20070259855A1 (en) * 2006-04-06 2007-11-08 Udo Maier Thiazolyl-dihydro-indazole
US20070238718A1 (en) * 2006-04-06 2007-10-11 Matthias Grauert Thiazolyl-dihydro-indazole
US7691868B2 (en) 2006-04-06 2010-04-06 Boehringer Ingelheim International Gmbh Thiazolyl-dihydro-quinazoline
BRPI0710843A2 (pt) * 2006-04-06 2011-08-23 Boehringer Ingelheim Int tiazolil-di-hidro-indazóis
US20070238746A1 (en) * 2006-04-06 2007-10-11 Trixi Brandl Thiazolyl-dihydro-chinazoline
DE602006002385D1 (de) * 2006-06-26 2008-10-02 Helm Ag Verfahren zur Herstellung von Pramipexole
JP5258563B2 (ja) * 2006-06-29 2013-08-07 日産化学工業株式会社 αアミノ酸誘導体及びそれを有効成分として含む医薬
US8779154B2 (en) * 2006-09-26 2014-07-15 Qinglin Che Fused ring compounds for inflammation and immune-related uses
GB0619611D0 (en) 2006-10-04 2006-11-15 Ark Therapeutics Ltd Compounds and their use
EP2217590A4 (en) * 2007-09-17 2011-12-14 Glaxosmithkline Llc Pyridopyrimidine derivatives as PI3-kinase inhibitors
JP2011509261A (ja) * 2008-01-07 2011-03-24 シンタ ファーマシューティカルズ コーポレーション 炎症および免疫関連用途向けの化合物
UY31700A (es) 2008-03-13 2009-11-10 Boehringer Ingelheim Int Tiazolil-dihidro-indazoles
WO2009120826A1 (en) * 2008-03-27 2009-10-01 Wyeth 2-aryl- and 2-heteroarylthiazolyl compounds, methods for their preparation and use thereof
ES2480994T3 (es) * 2008-03-31 2014-07-29 Genentech, Inc. Compuestos de tipo benzopirano y benzoxepina inhibidores de PI3K y métodos de uso
WO2010007943A1 (ja) * 2008-07-17 2010-01-21 旭化成ファーマ株式会社 含窒素複素環化合物
WO2010024258A1 (ja) * 2008-08-29 2010-03-04 塩野義製薬株式会社 Ｐｉ３ｋ阻害活性を有する縮環アゾール誘導体
JP5579724B2 (ja) * 2008-10-17 2014-08-27 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ホスファチジルイノシトール−３−キナーゼ（ｐｉ−３キナーゼ）阻害剤としてのテトラ−アザ−複素環
GB0900404D0 (en) 2009-01-12 2009-02-11 Addex Pharmaceuticals Sa New compounds 4
US8278302B2 (en) 2009-04-08 2012-10-02 Boehringer Ingelheim International Gmbh Substituted piperidines as CCR3 antagonists
US8288379B2 (en) 2009-04-22 2012-10-16 Boehringer Ingelheim International Gmbh Thia-triaza-cyclopentazulenes
EP2421872B1 (en) * 2009-04-22 2015-06-10 Boehringer Ingelheim International GmbH Thia-triaza-as-indacenes as pi3-kinases inhibitors for the treatment of cancer
EP2448946B1 (en) * 2009-07-02 2013-07-24 Novartis AG 2-carboxamide cycloamino ureas useful as pi3k inhibitors
NZ598220A (en) * 2009-08-17 2014-02-28 Intellikine Llc Heterocyclic compounds and uses thereof
WO2011036280A1 (en) * 2009-09-28 2011-03-31 F. Hoffmann-La Roche Ag Benzoxazepin pi3k inhibitor compounds and methods of use
UA108863C2 (ru) 2009-09-28 2015-06-25 Ф. Хоффманн-Ля Рош Аг Бензоксепиновые ингибиторы pi3 и их применение
AU2010317883B2 (en) 2009-11-13 2015-08-06 Merck Serono S.A. Tricyclic pyrazol amine derivatives
CN103153062B (zh) 2010-05-24 2015-07-15 因特利凯有限责任公司 杂环化合物及其用途
WO2012009000A2 (en) * 2010-07-14 2012-01-19 Addex Pharma S.A. Novel fused pyrazole derivatives and their use as allosteric modulators of metabotropic glutamate receptors
GB201011831D0 (en) 2010-07-14 2010-09-01 Addex Pharmaceuticals Sa New compounds 5
US8466162B2 (en) 2011-01-26 2013-06-18 Boehringer Ingelheim International Gmbh 5-alkynyl-pyridines
TW201245176A (en) 2011-01-26 2012-11-16 Boehringer Ingelheim Int New 5-alkynyl-pyridines
EP2546249A1 (en) 2011-07-15 2013-01-16 Boehringer Ingelheim International Gmbh 5-Alkynyl-pyridines
TWI592411B (zh) 2011-02-23 2017-07-21 英特爾立秦有限責任公司 激酶抑制劑之組合及其用途
JP5808826B2 (ja) 2011-02-23 2015-11-10 インテリカイン， エルエルシー 複素環化合物およびその使用
MX340013B (es) 2011-03-21 2016-06-22 Hoffmann La Roche Compuestos de benzoxazepina selectivos para fosfatidilinositol 3-cinasa (pi3k) p110 delta y metodos de uso.
RU2014128386A (ru) * 2012-02-06 2016-03-27 ГлаксоСмитКлайн Интеллекчуал Проперти (N 2) Лимитед Ингибиторы PI3K для лечения кашля
US10722484B2 (en) 2016-03-09 2020-07-28 K-Gen, Inc. Methods of cancer treatment
KR20210117261A (ko) 2018-12-31 2021-09-28 바이오메아 퓨전, 인크. 메닌-mll 상호작용의 비가역적 억제제
US11174263B2 (en) 2018-12-31 2021-11-16 Biomea Fusion, Inc. Inhibitors of menin-MLL interaction
AU2022331496A1 (en) 2021-08-20 2024-02-29 Biomea Fusion, Inc. Crystalline form of n-[4-[4-(4-morpholinyl)-7h-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(r)-[(1-oxo -2-propen-1-yl)amino]-1-piperidinyl]methyl]-2-pyridinecarboxamide, an irreversible menin-mll inhibitor for the treatment of cancer

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5533405A (en) 1978-08-29 1980-03-08 Teijin Ltd Hexahydronaphtho(1',2':4,5)imidazo(2,1-b)thiazole and its preparation
WO1979001080A1 (en) 1978-05-17 1979-12-13 Teijin Ltd Hexahydronaphtoimidazothiazoles and process for preparing same
DE3572485D1 (en) 1984-12-22 1989-09-28 Thomae Gmbh Dr K Tetrahydro-benzothiazoles, their production and their use as intermediates or drugs
US5358949A (en) * 1986-03-05 1994-10-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives
US5182290A (en) * 1991-08-27 1993-01-26 Neurogen Corporation Certain oxazoloquinolinones; a new class of GABA brain receptor ligands
TW260664B (es) * 1993-02-15 1995-10-21 Otsuka Pharma Factory Inc
NO941135L (no) 1993-04-01 1994-10-03 Daiichi Seiyaku Co Tiazolpyrimidin derivater
JP3670309B2 (ja) 1993-04-01 2005-07-13 第一製薬株式会社 二環性複素環化合物
AU727654B2 (en) * 1997-06-13 2000-12-21 Yamanouchi Pharmaceutical Co., Ltd. Tricyclic pyrazole derivative
MXPA02007632A (es) * 2000-02-07 2004-08-23 Abbott Gmbh & Co Kg Derivados de 2-benzotiazolil urea y su uso como inhibidores de proteina cinasa.
AU2001242629B2 (en) 2000-03-29 2005-08-11 Cyclacel Limited 2-substituted 4-heteroaryl-pyrimidines and their use in the treatment of proliferative disorders
US6608053B2 (en) * 2000-04-27 2003-08-19 Yamanouchi Pharmaceutical Co., Ltd. Fused heteroaryl derivatives
KR100423899B1 (ko) 2000-05-10 2004-03-24 주식회사 엘지생명과학 세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸
US6908932B2 (en) 2001-10-24 2005-06-21 Iconix Pharmaceuticals, Inc. Modulators of phosphoinositide 3-kinase
TWI314928B (en) * 2002-02-28 2009-09-21 Novartis A 5-phenylthiazole derivatives and use as pi3 kinase inhibitors
EP1349179A1 (en) 2002-03-18 2003-10-01 ATOFINA Research Conductive polyolefins with good mechanical properties
RS115904A (en) 2002-07-10 2006-12-15 Applied Research Systems Ars Holding N.V. Azolidinone-vinyl fused benzene derivatives
UA82205C2 (en) 2002-09-30 2008-03-25 Байер Фармасьютикалз Корпорейшн Fused azole-pyrimidine derivatives
AU2003280188A1 (en) 2002-12-06 2004-06-30 Warner-Lambert Company Llc Benzoxazin-3-ones and derivatives thereof as inhibitors of pi3k
AU2003303231A1 (en) 2002-12-20 2004-07-14 Warner-Lambert Company Llc Benzoxazines and derivatives thereof as inhibitors of pi3ks
GB0315966D0 (en) * 2003-07-08 2003-08-13 Cyclacel Ltd Compounds
NO20041733L (no) * 2004-04-28 2005-10-31 Thin Film Electronics Asa Organisk elektronisk krets med funksjonelt mellomsjikt og fremgangsmate til dens fremstilling.
US7691888B2 (en) 2004-10-07 2010-04-06 Boehringer Ingelheim International Gmbh Thiazolyl-dihydro-indazole
FR2887993B1 (fr) * 2005-07-01 2007-08-03 Commissariat Energie Atomique Dispositif de detection de rayonnements a electrodes empilees et methode de detection de rayonnements ionisants mettant en oeuvre un tel dispositif
US20070259855A1 (en) * 2006-04-06 2007-11-08 Udo Maier Thiazolyl-dihydro-indazole
AU2007233729A1 (en) * 2006-04-06 2007-10-11 Boehringer Ingelheim International Gmbh Thiazolyldihydroindazole derivatives as protein kinase inhibitors

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JP2008515852A (ja) 2008-05-15
CA2579279A1 (en) 2006-04-20
EP1802636B1 (de) 2013-03-27
EP2343303A1 (de) 2011-07-13
US8207349B2 (en) 2012-06-26
RU2007116861A (ru) 2009-03-20
MX2007004051A (es) 2007-05-24
TW200628475A (en) 2006-08-16
RU2007116858A (ru) 2008-12-27
AU2005293607A1 (en) 2006-04-20
RU2403258C2 (ru) 2010-11-10
US8232286B2 (en) 2012-07-31
US20060106013A1 (en) 2006-05-18
EP1802636A1 (de) 2007-07-04
WO2006040279A1 (de) 2006-04-20
US20090156554A1 (en) 2009-06-18
CA2579279C (en) 2013-10-01
IL182398A0 (en) 2007-07-24
BRPI0516557A (pt) 2008-09-09
US20100113414A1 (en) 2010-05-06
US20060100254A1 (en) 2006-05-11
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JP5122287B2 (ja) 2013-01-16
US7691888B2 (en) 2010-04-06

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