JP2013517278A5 - - Google Patents
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- JP2013517278A5 JP2013517278A5 JP2012549064A JP2012549064A JP2013517278A5 JP 2013517278 A5 JP2013517278 A5 JP 2013517278A5 JP 2012549064 A JP2012549064 A JP 2012549064A JP 2012549064 A JP2012549064 A JP 2012549064A JP 2013517278 A5 JP2013517278 A5 JP 2013517278A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- methyl
- optionally substituted
- group
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 35
- -1 2,3-dihydro-1,4-benzodioxinyl Chemical group 0.000 claims 28
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 18
- 125000000217 alkyl group Chemical group 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 16
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 15
- 125000004093 cyano group Chemical group *C#N 0.000 claims 12
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 10
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims 7
- 150000002367 halogens Chemical class 0.000 claims 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 125000001544 thienyl group Chemical group 0.000 claims 7
- 125000004429 atom Chemical group 0.000 claims 6
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 6
- 125000004076 pyridyl group Chemical group 0.000 claims 6
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 5
- 125000001153 fluoro group Chemical group F* 0.000 claims 5
- 125000004594 isoindolinyl group Chemical group C1(NCC2=CC=CC=C12)* 0.000 claims 5
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
- 125000003386 piperidinyl group Chemical group 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 4
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 3
- 125000005871 1,3-benzodioxolyl group Chemical group 0.000 claims 3
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 3
- 125000001246 bromo group Chemical group Br* 0.000 claims 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 125000002883 imidazolyl group Chemical group 0.000 claims 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 125000002971 oxazolyl group Chemical group 0.000 claims 3
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims 2
- 125000004414 alkyl thio group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 claims 2
- 125000005956 isoquinolyl group Chemical group 0.000 claims 2
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 125000001425 triazolyl group Chemical group 0.000 claims 2
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 1
- 125000006528 (C2-C6) alkyl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 125000006568 (C4-C7) heterocycloalkyl group Chemical group 0.000 claims 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- SWCAWZMNVIXNKH-UHFFFAOYSA-N 3-[1-[3-(3-methyl-1,2-oxazol-5-yl)propyl]indol-5-yl]-5-(trifluoromethyl)-1,2,4-oxadiazole Chemical compound O1N=C(C)C=C1CCCN1C2=CC=C(C=3N=C(ON=3)C(F)(F)F)C=C2C=C1 SWCAWZMNVIXNKH-UHFFFAOYSA-N 0.000 claims 1
- MFGOBRZBIXOVQL-UHFFFAOYSA-N 3-[4-(trifluoromethyl)phenyl]-n-[3-(trifluoromethyl)-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]propanamide Chemical compound O1C(C(F)(F)F)=NC(C=2C(=CC(NC(=O)CCC=3C=CC(=CC=3)C(F)(F)F)=CC=2)C(F)(F)F)=N1 MFGOBRZBIXOVQL-UHFFFAOYSA-N 0.000 claims 1
- NLUHMENALNPHJA-UHFFFAOYSA-N 3-[7-methyl-1-[3-(3-methyl-1,2-oxazol-5-yl)propyl]-2,3-dihydroindol-5-yl]-5-(trifluoromethyl)-1,2,4-oxadiazole Chemical compound O1N=C(C)C=C1CCCN1C2=C(C)C=C(C=3N=C(ON=3)C(F)(F)F)C=C2CC1 NLUHMENALNPHJA-UHFFFAOYSA-N 0.000 claims 1
- LIUHKQNWTKDRIU-UHFFFAOYSA-N 3-[7-methyl-1-[4-(3-methyl-1,2-oxazol-5-yl)butyl]indol-5-yl]-5-(trifluoromethyl)-1,2,4-oxadiazole Chemical compound O1N=C(C)C=C1CCCCN1C2=C(C)C=C(C=3N=C(ON=3)C(F)(F)F)C=C2C=C1 LIUHKQNWTKDRIU-UHFFFAOYSA-N 0.000 claims 1
- RVFHUKHEFRHUIX-UHFFFAOYSA-N 3-[7-methyl-1-[5-(3-methyl-1,2-oxazol-5-yl)pentyl]indol-5-yl]-5-(trifluoromethyl)-1,2,4-oxadiazole Chemical compound O1N=C(C)C=C1CCCCCN1C2=C(C)C=C(C=3N=C(ON=3)C(F)(F)F)C=C2C=C1 RVFHUKHEFRHUIX-UHFFFAOYSA-N 0.000 claims 1
- NVCUFLNOWZTXPQ-UHFFFAOYSA-N 3-[7-methyl-2-[4-(3-methyl-1,2-oxazol-5-yl)butyl]-1-benzofuran-5-yl]-5-(trifluoromethyl)-1,2,4-oxadiazole Chemical compound O1N=C(C)C=C1CCCCC1=CC2=CC(C=3N=C(ON=3)C(F)(F)F)=CC(C)=C2O1 NVCUFLNOWZTXPQ-UHFFFAOYSA-N 0.000 claims 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000004801 4-cyanophenyl group Chemical group [H]C1=C([H])C(C#N)=C([H])C([H])=C1* 0.000 claims 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 claims 1
- 125000005037 alkyl phenyl group Chemical group 0.000 claims 1
- 125000002393 azetidinyl group Chemical group 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- BRMIYYWPBPHSQY-UHFFFAOYSA-N n-[(4-fluorophenyl)methyl]-3-[5-(2,2,2-trifluoroacetyl)thiophen-2-yl]benzamide Chemical compound C1=CC(F)=CC=C1CNC(=O)C1=CC=CC(C=2SC(=CC=2)C(=O)C(F)(F)F)=C1 BRMIYYWPBPHSQY-UHFFFAOYSA-N 0.000 claims 1
- JQYWWORDYVNBGY-UHFFFAOYSA-N n-[(4-fluorophenyl)methyl]-4-[5-(2,2,2-trifluoroacetyl)thiophen-2-yl]benzamide Chemical compound C1=CC(F)=CC=C1CNC(=O)C1=CC=C(C=2SC(=CC=2)C(=O)C(F)(F)F)C=C1 JQYWWORDYVNBGY-UHFFFAOYSA-N 0.000 claims 1
- WVXPYMGHPGVJKO-UHFFFAOYSA-N n-benzyl-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-amine Chemical compound O1C(C(F)(F)F)=NC(C=2C(=NON=2)NCC=2C=CC=CC=2)=N1 WVXPYMGHPGVJKO-UHFFFAOYSA-N 0.000 claims 1
- 125000003566 oxetanyl group Chemical group 0.000 claims 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29457510P | 2010-01-13 | 2010-01-13 | |
| US61/294,575 | 2010-01-13 | ||
| PCT/US2011/021089 WO2011088181A1 (en) | 2010-01-13 | 2011-01-13 | Compounds and methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013517278A JP2013517278A (ja) | 2013-05-16 |
| JP2013517278A5 true JP2013517278A5 (enExample) | 2014-03-06 |
| JP6017313B2 JP6017313B2 (ja) | 2016-10-26 |
Family
ID=44304635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012549064A Expired - Fee Related JP6017313B2 (ja) | 2010-01-13 | 2011-01-13 | 化合物および方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8901156B2 (enExample) |
| EP (1) | EP2533783B8 (enExample) |
| JP (1) | JP6017313B2 (enExample) |
| KR (1) | KR101781663B1 (enExample) |
| CN (1) | CN103221047B (enExample) |
| AU (1) | AU2011205283B2 (enExample) |
| BR (1) | BR112012017441B1 (enExample) |
| CA (1) | CA2787018A1 (enExample) |
| EA (1) | EA022964B1 (enExample) |
| ES (1) | ES2560627T3 (enExample) |
| IL (1) | IL220939A (enExample) |
| MX (1) | MX341133B (enExample) |
| SG (1) | SG182401A1 (enExample) |
| WO (1) | WO2011088181A1 (enExample) |
| ZA (1) | ZA201205125B (enExample) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013517281A (ja) | 2010-01-13 | 2013-05-16 | テンペロ、ファーマシューティカルズ、インコーポレイテッド | 化合物及び方法 |
| EP2729454B1 (en) * | 2011-07-08 | 2015-09-16 | Novartis AG | Novel trifluoromethyl-oxadiazole derivatives and their use in the treatment of disease |
| WO2013066835A2 (en) * | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods |
| WO2013066833A1 (en) * | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods to inhibit histone deacetylase (hdac) enzymes |
| BR112014012815A8 (pt) * | 2011-11-28 | 2017-06-20 | Novartis Ag | derivados de trifluormetil-oxadiazol e uso dos mesmos no tratamento de doença |
| WO2013113791A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| CN104220428A (zh) | 2012-02-03 | 2014-12-17 | 巴斯夫欧洲公司 | 杀真菌嘧啶化合物 |
| WO2013113776A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113716A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113863A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113778A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113773A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113720A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| BR112015003376A8 (pt) * | 2012-08-23 | 2018-01-23 | Alios Biopharma Inc | composto ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica e usos de quantidade eficiente de composto ou sal farmaceuticamente aceitável do mesmo ou composição farmacêutica |
| CN102826985B (zh) * | 2012-09-18 | 2015-08-19 | 厦门大学 | 一种1-(3,4,5-三羟基)苯基-1-烷基酮的制备方法 |
| TW201444798A (zh) | 2013-02-28 | 2014-12-01 | 必治妥美雅史谷比公司 | 作爲強效ｒｏｃｋ１及ｒｏｃｋ２抑制劑之苯基吡唑衍生物 |
| JP6423372B2 (ja) | 2013-02-28 | 2018-11-14 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 強力なｒｏｃｋ１およびｒｏｃｋ２阻害剤としてのフェニルピラゾール誘導体 |
| CN103214327A (zh) * | 2013-03-22 | 2013-07-24 | 郑州泰基鸿诺药物科技有限公司 | 一种芳香环或芳杂环三氟甲基酮化合物及其制备方法 |
| MX2016002199A (es) * | 2013-08-21 | 2016-07-13 | Alios Biopharma Inc | Compuestos antivirales. |
| WO2015057659A1 (en) | 2013-10-14 | 2015-04-23 | Eisai R&D Management Co., Ltd. | Selectively substituted quinoline compounds |
| JP6483666B2 (ja) | 2013-10-14 | 2019-03-13 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 選択的に置換されたキノリン化合物 |
| PL226024B1 (pl) * | 2013-10-23 | 2017-06-30 | Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną | Zastosowanie N-[2-[4-(4-metoksyfenylo)-1,3-tiazol-2-ilo]etylo]- -2-okso-2,5,6,7-tetrahydrocyklopenta[b] pirydyno-3-karboksyamidu |
| UA121116C2 (uk) * | 2014-06-06 | 2020-04-10 | Басф Се | Застосування заміщених оксадіазолів для боротьби з фітопатогенними грибами |
| JP6556146B2 (ja) * | 2014-08-26 | 2019-08-07 | 武田薬品工業株式会社 | 複素環化合物 |
| US9896436B2 (en) | 2014-09-16 | 2018-02-20 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| JP6660060B2 (ja) | 2014-09-16 | 2020-03-04 | セルジーン クオンティセル リサーチ，インク． | ヒストンデメチラーゼ阻害剤 |
| CN104262281A (zh) * | 2014-10-16 | 2015-01-07 | 湖南华腾制药有限公司 | 一种2-溴-4(4-乙氧基苯基)恶唑的制备方法 |
| WO2016065583A1 (en) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Oxazole orexin receptor antagonists |
| US10183937B2 (en) * | 2014-12-09 | 2019-01-22 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
| DK3587417T3 (da) | 2014-12-09 | 2022-03-28 | Bayer Ag | 1,3-thiazol-2-yl-substituerede benzamider |
| AR103598A1 (es) | 2015-02-02 | 2017-05-24 | Forma Therapeutics Inc | Ácidos bicíclicos[4,6,0]hidroxámicos como inhibidores de hdac |
| AU2016215432B2 (en) | 2015-02-02 | 2020-07-30 | Valo Early Discovery, Inc. | 3-alkyl-4-amido-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors |
| AU2016245984B2 (en) | 2015-04-10 | 2021-03-25 | Bioresponse, L.L.C. | Self-emulsifying formulations of DIM-related indoles |
| AU2016258188B2 (en) | 2015-05-07 | 2021-08-26 | Chdi Foundation, Inc. | Histone deacetylase inhibitors and compositions and methods of use thereof |
| KR20180002730A (ko) | 2015-05-07 | 2018-01-08 | 씨에이치디아이 파운데이션, 인코포레이티드 | 히스톤 탈아세틸효소 억제제 및 그것의 조성물 및 사용 방법 |
| AU2016297362B2 (en) | 2015-07-17 | 2020-04-16 | Takeda Pharmaceutical Company Limited | Oxadiazole derivatives useful as HDAC inhibitors |
| JPWO2017014170A1 (ja) | 2015-07-17 | 2018-04-26 | 武田薬品工業株式会社 | 複素環化合物 |
| KR101799005B1 (ko) | 2015-07-27 | 2017-11-17 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 설프아마이드 유도체 화합물 및 이를 포함하는 약제학적 조성물 |
| NZ739026A (en) | 2015-07-27 | 2019-03-29 | Chong Kun Dang Pharmaceutical Corp | 1,3,4-oxadiazole sulfonamide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same |
| PL3330259T3 (pl) * | 2015-07-27 | 2021-02-08 | Chong Kun Dang Pharmaceutical Corp. | Związek pochodna amidowa 1,3,4-oksadiazolu jako inhibitor deacetylazy histonowej 6 i kompozycja farmaceutyczna go zawierająca |
| BR112018002304B1 (pt) * | 2015-08-04 | 2023-12-19 | Chong Kun Dang Pharmaceutical Corp | Compostos de derivado de 1,3,4-oxadiazol como inibidor de histona desacetilase 6 e a composição farmacêutica que compreende os mesmos |
| WO2017033946A1 (ja) | 2015-08-25 | 2017-03-02 | 武田薬品工業株式会社 | 複素環化合物 |
| MX2018003845A (es) | 2015-10-02 | 2018-06-18 | Syngenta Participations Ag | Derivados de oxadiazol microbicidas. |
| HUE050030T2 (hu) | 2015-10-02 | 2020-11-30 | Syngenta Participations Ag | Mikrobiocid oxadiazol-származékok |
| WO2017065473A1 (en) * | 2015-10-12 | 2017-04-20 | Chong Kun Dang Pharmaceutical Corp. | Oxadiazole amine derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same |
| EP3167716A1 (en) | 2015-11-10 | 2017-05-17 | Basf Se | Substituted oxadiazoles for combating phytopathogenic fungi |
| BR112018009539B1 (pt) | 2015-11-13 | 2022-05-24 | Basf Se | Uso de compostos da fórmula i, compostos, mistura, composição agroquímica, uso dos compostos e método para combater fungos nocivos fitopatogênicos |
| AR106679A1 (es) | 2015-11-13 | 2018-02-07 | Basf Se | Oxadiazoles sustituidos para combatir hongos fitopatógenos |
| US10674727B2 (en) | 2015-11-19 | 2020-06-09 | Basf Se | Substituted oxadiazoles for combating phytopathogenic fungi |
| JP6930972B2 (ja) | 2015-12-02 | 2021-09-01 | シンジェンタ パーティシペーションズ アーゲー | 殺微生物性オキサジアゾール誘導体 |
| WO2017093019A1 (en) | 2015-12-03 | 2017-06-08 | Basf Se | Substituted oxadiazoles for combating phytopathogenic fungi |
| WO2017108569A1 (en) | 2015-12-22 | 2017-06-29 | Syngenta Participations Ag | Pesticidally active pyrazole derivatives |
| UY37062A (es) | 2016-01-08 | 2017-08-31 | Syngenta Participations Ag | Derivados de aryl oxadiazol fungicidas |
| CN105503716A (zh) * | 2016-01-30 | 2016-04-20 | 天长市淳峰精细材料合成厂 | 一种2,6-二氰基吡啶的制备方法 |
| JP6970680B2 (ja) * | 2016-03-15 | 2021-11-24 | セルジーン クオンティセル リサーチ，インク． | ヒストンデメチラーゼ阻害剤 |
| JP2019514851A (ja) | 2016-03-24 | 2019-06-06 | シンジェンタ パーティシペーションズ アーゲー | 殺微生物オキサジアゾール誘導体 |
| AU2017250397A1 (en) | 2016-04-11 | 2018-10-11 | Basf Se | Substituted oxadiazoles for combating phytopathogenic fungi |
| EP3472131B1 (en) | 2016-06-17 | 2020-02-19 | Forma Therapeutics, Inc. | 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors |
| WO2017222950A1 (en) * | 2016-06-23 | 2017-12-28 | Merck Sharp & Dohme Corp. | 3-heterocyclyl substituted 5-trifluoromethyl oxadiazoles as histone deacetylase 6 (hdac6) inhibitors |
| US11066396B2 (en) | 2016-06-23 | 2021-07-20 | Merck Sharp & Dohme Corp. | 3-aryl- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histonedeacetylase 6 (HDAC6) inhibitors |
| AR109304A1 (es) | 2016-08-10 | 2018-11-21 | Sumitomo Chemical Co | Compuesto de oxadiazol y su uso |
| WO2018057933A1 (en) * | 2016-09-22 | 2018-03-29 | The Regents Of The University Of Colorado, A Body Corporate | Compounds, compositions, and methods for reducing oxidative stress in cardiomyocytes |
| WO2018165520A1 (en) | 2017-03-10 | 2018-09-13 | Vps-3, Inc. | Metalloenzyme inhibitor compounds |
| BR112019020253B1 (pt) | 2017-03-31 | 2023-04-25 | Syngenta Participations Ag | Composições fungicidas, método de controle ou prevenção de fungos fitopatogênicos e processo para a preparação de um composto de fórmula (i) |
| TW201910328A (zh) | 2017-07-31 | 2019-03-16 | 日商武田藥品工業股份有限公司 | 雜環化合物 |
| CN112351981A (zh) | 2018-06-29 | 2021-02-09 | 先正达农作物保护股份公司 | 杀微生物的噁二唑衍生物 |
| WO2020018647A1 (en) | 2018-07-17 | 2020-01-23 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods of treating pacs1 and pacs2 syndromes |
| KR102316234B1 (ko) | 2018-07-26 | 2021-10-22 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물 |
| US12010995B2 (en) | 2018-08-08 | 2024-06-18 | Nihon Nohyaku Co., Ltd. | Oxadiazoline compounds or salts thereof, agrohorticultural fungicides containing the compounds, and methods of using the same |
| AR118673A1 (es) | 2019-04-18 | 2021-10-20 | Syngenta Crop Protection Ag | Procedimiento para la preparación de derivados de oxadiazol microbiocidas |
| MX2021014315A (es) | 2019-05-31 | 2022-01-04 | Chong Kun Dang Pharmaceutical Corp | Compuestos derivados de 1,3,4-oxadiazol homoftalimida como inhibidores de histona desacetilasa 6, y la composicion farmaceutica que comprende los mismos. |
| CN110526878A (zh) * | 2019-09-16 | 2019-12-03 | 成都睿智化学研究有限公司 | 一种2-(噁唑基)乙胺的制备方法 |
| AR120040A1 (es) | 2019-09-27 | 2022-01-26 | Takeda Pharmaceuticals Co | Compuesto heterocíclico |
| WO2021090865A1 (ja) | 2019-11-07 | 2021-05-14 | 日本農薬株式会社 | オキサジアゾリン化合物又はその塩類及び該化合物を含有する農園芸用殺菌剤並びにその使用方法 |
| CN112194620B (zh) * | 2020-12-04 | 2021-02-26 | 苏州开元民生科技股份有限公司 | 一种2-乙基-4-氰基吡啶的制备方法 |
| KR20240035395A (ko) | 2021-06-14 | 2024-03-15 | 스코르피온 테라퓨틱스, 인코퍼레이티드 | 암 치료에 사용할 수 있는 요소 유도체 |
| CN116253730B (zh) * | 2023-03-06 | 2025-09-02 | 浙江大学 | 一种靶向降解hdac7蛋白的protac类化合物及其制备方法与应用 |
| CN116354897B (zh) * | 2023-03-31 | 2024-10-15 | 华东师范大学 | 一种取代的1，2，4-三氮唑、吡啶及嘧啶衍生物及其在药物中的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5523312A (en) * | 1994-09-27 | 1996-06-04 | Sterling Winthrop Inc. | Antipicornaviral agents |
| DE60034688T2 (de) | 1999-09-08 | 2008-01-17 | Sloan-Kettering Institute For Cancer Research | Kristallstruktur einer deacetylase und deren inhibitoren |
| PE20020354A1 (es) | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
| TWI319387B (en) | 2002-04-05 | 2010-01-11 | Astrazeneca Ab | Benzamide derivatives |
| WO2006061638A2 (en) * | 2004-12-10 | 2006-06-15 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Heterocycle derivatives as histone deacetylase (hdac) inhibitors |
| EP1863756A1 (en) * | 2005-03-24 | 2007-12-12 | Janssen Pharmaceutica N.V. | Biaryl derived amide modulators of vanilloid vr1 receptor |
| GB0603041D0 (en) * | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| JP2013517279A (ja) | 2010-01-13 | 2013-05-16 | テンペロ、ファーマシューティカルズ、インコーポレイテッド | 化合物及び方法 |
| JP2013517281A (ja) | 2010-01-13 | 2013-05-16 | テンペロ、ファーマシューティカルズ、インコーポレイテッド | 化合物及び方法 |
| WO2013006408A1 (en) | 2011-07-01 | 2013-01-10 | Tempero Pharmaceuticals, Inc. | Compounds and methods |
| EP2729454B1 (en) | 2011-07-08 | 2015-09-16 | Novartis AG | Novel trifluoromethyl-oxadiazole derivatives and their use in the treatment of disease |
-
2011
- 2011-01-13 KR KR1020127021121A patent/KR101781663B1/ko not_active Expired - Fee Related
- 2011-01-13 BR BR112012017441-0A patent/BR112012017441B1/pt not_active IP Right Cessation
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- 2011-01-13 CN CN201180013827.0A patent/CN103221047B/zh not_active Expired - Fee Related
- 2011-01-13 WO PCT/US2011/021089 patent/WO2011088181A1/en not_active Ceased
- 2011-01-13 EA EA201290638A patent/EA022964B1/ru not_active IP Right Cessation
- 2011-01-13 EP EP11733353.4A patent/EP2533783B8/en active Active
- 2011-01-13 CA CA2787018A patent/CA2787018A1/en not_active Abandoned
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- 2011-01-13 MX MX2012008280A patent/MX341133B/es active IP Right Grant
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