|
US4911920A
(en)
*
|
1986-07-30 |
1990-03-27 |
Alcon Laboratories, Inc. |
Sustained release, comfort formulation for glaucoma therapy
|
|
FR2588189B1
(fr)
*
|
1985-10-03 |
1988-12-02 |
Merck Sharp & Dohme |
Composition pharmaceutique de type a transition de phase liquide-gel
|
|
US4801575A
(en)
*
|
1986-07-30 |
1989-01-31 |
The Regents Of The University Of California |
Chimeric peptides for neuropeptide delivery through the blood-brain barrier
|
|
US4902505A
(en)
|
1986-07-30 |
1990-02-20 |
Alkermes |
Chimeric peptides for neuropeptide delivery through the blood-brain barrier
|
|
US5624898A
(en)
*
|
1989-12-05 |
1997-04-29 |
Ramsey Foundation |
Method for administering neurologic agents to the brain
|
|
US6407061B1
(en)
*
|
1989-12-05 |
2002-06-18 |
Chiron Corporation |
Method for administering insulin-like growth factor to the brain
|
|
DK0495421T3
(da)
*
|
1991-01-15 |
1996-12-09 |
Alcon Lab Inc |
Anvendelse af carragenaner i topiske ophthalmiske sammensætninger
|
|
US5212162A
(en)
*
|
1991-03-27 |
1993-05-18 |
Alcon Laboratories, Inc. |
Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
|
|
US6287792B1
(en)
*
|
1991-06-17 |
2001-09-11 |
The Regents Of The University Of California |
Drug delivery of antisense oligonucleotides and peptides to tissues in vivo and to cells using avidin-biotin technology
|
|
TW282460B
(enExample)
|
1993-12-28 |
1996-08-01 |
Yamanouchi Pharma Co Ltd |
|
|
US6309853B1
(en)
|
1994-08-17 |
2001-10-30 |
The Rockfeller University |
Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
|
|
US5728718A
(en)
*
|
1994-12-20 |
1998-03-17 |
The United States Of America As Represented By The Department Of Health And Human Services |
2,5-diamino-3,4-disubstituted-1,6-diphenylhexane isosteres comprising benzamide, sulfonamide and anthranilamide subunits and methods of using same
|
|
US6545127B1
(en)
*
|
1999-06-28 |
2003-04-08 |
Oklahoma Medical Research Foundation |
Catalytically active recombinant memapsin and methods of use thereof
|
|
JP4850379B2
(ja)
*
|
1999-12-16 |
2012-01-11 |
エミスフェアー・テクノロジーズ・インク |
活性剤を輸送するための化合物及び組成物
|
|
EP1272221A2
(en)
*
|
2000-04-12 |
2003-01-08 |
Implyx Ltd. |
Peptide conjugates for drug delivery
|
|
US6372250B1
(en)
*
|
2000-04-25 |
2002-04-16 |
The Regents Of The University Of California |
Non-invasive gene targeting to the brain
|
|
US6846813B2
(en)
|
2000-06-30 |
2005-01-25 |
Pharmacia & Upjohn Company |
Compounds to treat alzheimer's disease
|
|
AU2001273094A1
(en)
|
2000-06-30 |
2002-01-14 |
Elan Pharmaceuticals, Inc. |
Compounds to treat alzheimer's disease
|
|
PE20020276A1
(es)
*
|
2000-06-30 |
2002-04-06 |
Elan Pharm Inc |
COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
|
|
CA2433446A1
(en)
|
2000-12-28 |
2002-07-11 |
Oklahoma Medical Research Foundation |
Inhibitors of memapsin 2 and use thereof
|
|
US20040121947A1
(en)
*
|
2000-12-28 |
2004-06-24 |
Oklahoma Medical Research Foundation |
Compounds which inhibit beta-secretase activity and methods of use thereof
|
|
WO2002064558A2
(en)
|
2001-02-14 |
2002-08-22 |
Sankyo Company, Limited |
Oxazole derivatives, their preparation and their use as cytokine inhibitors
|
|
US20060234944A1
(en)
*
|
2001-10-23 |
2006-10-19 |
Oklahoma Medical Reseach Foundation |
Beta-secretase inhibitors and methods of use
|
|
JP4547152B2
(ja)
|
2001-10-23 |
2010-09-22 |
オクラホマ メディカル リサーチ ファウンデーション |
β−セクレターゼ阻害剤および使用方法
|
|
KR20050044407A
(ko)
|
2001-11-08 |
2005-05-12 |
엘란 파마슈티칼스, 인크. |
N,n'-치환-1,3-디아미노-2-히드록시프로판 유도체
|
|
JP2005511735A
(ja)
*
|
2001-12-06 |
2005-04-28 |
イーラン ファーマスーティカルズ、インコーポレイテッド |
置換ヒドロキシエチルアミン
|
|
IL163652A0
(en)
|
2002-02-27 |
2005-12-18 |
Upjohn Co |
Substituted hydroxyethylamines
|
|
WO2003100031A2
(en)
*
|
2002-05-20 |
2003-12-04 |
Board Of Regents, The University Of Texas System |
Methods and compositions for delivering enzymes and nucleic acid molecules to brain, bone, and other tissues
|
|
US7294642B2
(en)
|
2002-09-06 |
2007-11-13 |
Elan Pharmaceuticals, Inc. |
1,3-Diamino-2-hydroxypropane pro-drug derivatives
|
|
US7109217B2
(en)
|
2002-11-12 |
2006-09-19 |
Merck & Co., Inc. |
Phenylcarboxamide beta-secretase inhibitors for the treatment of Alzheimer's disease
|
|
US7388079B2
(en)
*
|
2002-11-27 |
2008-06-17 |
The Regents Of The University Of California |
Delivery of pharmaceutical agents via the human insulin receptor
|
|
US20040102369A1
(en)
*
|
2002-11-27 |
2004-05-27 |
The Regents Of The University Of California |
Transport of basic fibroblast growth factor across the blood brain barrier
|
|
GB0228410D0
(en)
|
2002-12-05 |
2003-01-08 |
Glaxo Group Ltd |
Novel Compounds
|
|
GB0305918D0
(en)
|
2003-03-14 |
2003-04-23 |
Glaxo Group Ltd |
Novel compounds
|
|
KR20060058104A
(ko)
|
2003-08-08 |
2006-05-29 |
쉐링 코포레이션 |
벤즈아미드 치환체를 갖는 사이클릭 아민 ｂａｃｅ-1억제제
|
|
KR100793095B1
(ko)
|
2003-10-01 |
2008-01-10 |
주식회사 프로메디텍 |
Ｂａｃｅ 저해효능을 가진 신규한 술폰 아미드 유도체
|
|
US7550481B2
(en)
|
2003-12-19 |
2009-06-23 |
Merck & Co., Inc. |
Phenylamide and pyridylamide beta-secretase inhibitors for the treatment of Alzheimer's disease
|
|
JP2007533741A
(ja)
|
2004-04-22 |
2007-11-22 |
イーライ リリー アンド カンパニー |
Ｂａｃｅ阻害剤
|
|
US7585885B2
(en)
*
|
2004-04-22 |
2009-09-08 |
Eli Lilly And Company |
Pyrrolidine derivatives useful as BACE inhibitors
|
|
CN1968924B
(zh)
|
2004-06-15 |
2011-08-03 |
默沙东公司 |
作为β-分泌酶抑制剂用于治疗阿尔茨海默氏病的吡咯烷-3-基化合物
|
|
US8436006B2
(en)
*
|
2004-08-06 |
2013-05-07 |
Jansssen Pharmaceutica N.V. |
2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
|
|
CA2580238A1
(en)
*
|
2004-09-17 |
2006-03-30 |
Comentis, Inc. |
Bicyclic compounds which inhibit beta-secretase activity and methods of use thereof
|
|
AU2005286774A1
(en)
*
|
2004-09-17 |
2006-03-30 |
Comentis, Inc |
Amino-containing compounds which inhibit memapsin 2 beta-secretase activity and methods of use thereof
|
|
CN100475786C
(zh)
*
|
2005-02-18 |
2009-04-08 |
中国科学院上海药物研究所 |
一类4-羟基戊酰胺类化合物及其制备方法和用途
|
|
US7745470B2
(en)
*
|
2005-03-10 |
2010-06-29 |
Bristol-Myers Squibb Company |
Isophthalates as beta-secretase inhibitors
|
|
AU2006235344B2
(en)
*
|
2005-04-08 |
2012-07-26 |
Comentis, Inc. |
Compounds which inhibit beta-secretase activity and methods of use thereof
|
|
MY158766A
(en)
|
2005-04-11 |
2016-11-15 |
Xenon Pharmaceuticals Inc |
Spiro-oxindole compounds and their uses as therapeutic agents
|
|
AR054044A1
(es)
|
2005-05-23 |
2007-05-30 |
Astrazeneca Ab |
Derivados de cromano y tetrahidronaftaleno como moduladores del receptor 5 - ht6; intermediarios en su preparacion; composiciones farmaceuticas que los contienen y su empelo en la fabricacion de medicamentos para el tratamiento de enfermedades del snc y de la obesidad.
|
|
AR054363A1
(es)
|
2005-05-23 |
2007-06-20 |
Astrazeneca Ab |
Compuestos que exhiben actividad moduladora en el receptor 5-hidroxi-triptamina 6
|
|
GB0513886D0
(en)
|
2005-07-06 |
2005-08-10 |
Glaxo Group Ltd |
Novel compounds
|
|
US7476764B2
(en)
*
|
2005-08-04 |
2009-01-13 |
Bristol-Myers Squibb Company |
Phenylcarboxyamides as beta-secretase inhibitors
|
|
US7790745B2
(en)
|
2005-10-21 |
2010-09-07 |
Bristol-Myers Squibb Company |
Tetrahydroisoquinoline LXR Modulators
|
|
TW200804290A
(en)
|
2005-11-15 |
2008-01-16 |
Astrazeneca Ab |
Compounds and uses thereof
|
|
CA2664130A1
(en)
|
2006-09-21 |
2008-03-27 |
Merck & Co., Inc. |
Piperidine and pyrrolidine beta-secretase inhibitors for the treatment of alzheimer's disease
|
|
CN101821238A
(zh)
|
2007-07-26 |
2010-09-01 |
科门蒂斯公司 |
抑制β-分泌酶(BETA-SECRETASE)活性的间苯二酰胺衍生物
|
|
JP5055432B2
(ja)
|
2007-09-24 |
2012-10-24 |
コメンティス，インコーポレーテッド |
治療のためのβ−セクレターゼ阻害剤としての（３−ヒドロキシ−４−アミノブタン−２−イル）−３−（２−チアゾール−２−イル−ピロリジン−１−カルボニル）ベンズアミド誘導体及び関連する化合物
|
|
WO2010002994A1
(en)
|
2008-07-01 |
2010-01-07 |
Purdue Research Foundation |
Nonpeptide hiv-1 protease inhibitors
|
|
WO2010042892A1
(en)
|
2008-10-10 |
2010-04-15 |
Comentis, Inc. |
Pyrrolidine compounds which inhibit beta-secretase activity and methods of use thereof
|
|
WO2010042796A1
(en)
|
2008-10-10 |
2010-04-15 |
Purdue Research Foundation |
Compounds for treatment of alzheimer's disease
|
|
US8394807B2
(en)
|
2008-11-20 |
2013-03-12 |
Purdue Research Foundation |
Quinazoline inhibitors of BACE 1 and methods of using
|
|
WO2010065861A2
(en)
|
2008-12-05 |
2010-06-10 |
Purdue Research Foundation |
Inhibitors of bace 1 and methods for treating alzheimer's disease
|
|
US20120214802A1
(en)
|
2009-03-25 |
2012-08-23 |
Bilcer Geoffrey M |
Pyrrolidine compounds which inhibit beta-secretase activity and methods of use thereof
|
|
JP2013506713A
(ja)
|
2009-10-05 |
2013-02-28 |
コメンティス，インコーポレーテッド |
β−セクレターゼ活性を阻害するスルホンアミドピロリジン化合物及びその使用方法
|