|
US4911920A
(en)
|
1986-07-30 |
1990-03-27 |
Alcon Laboratories, Inc. |
Sustained release, comfort formulation for glaucoma therapy
|
|
FR2588189B1
(fr)
|
1985-10-03 |
1988-12-02 |
Merck Sharp & Dohme |
Composition pharmaceutique de type a transition de phase liquide-gel
|
|
US4801575A
(en)
|
1986-07-30 |
1989-01-31 |
The Regents Of The University Of California |
Chimeric peptides for neuropeptide delivery through the blood-brain barrier
|
|
US4902505A
(en)
|
1986-07-30 |
1990-02-20 |
Alkermes |
Chimeric peptides for neuropeptide delivery through the blood-brain barrier
|
|
US5624898A
(en)
|
1989-12-05 |
1997-04-29 |
Ramsey Foundation |
Method for administering neurologic agents to the brain
|
|
US6407061B1
(en)
|
1989-12-05 |
2002-06-18 |
Chiron Corporation |
Method for administering insulin-like growth factor to the brain
|
|
JP2594486B2
(ja)
|
1991-01-15 |
1997-03-26 |
アルコン ラボラトリーズ インコーポレイテッド |
局所的眼薬組成物
|
|
US5212162A
(en)
|
1991-03-27 |
1993-05-18 |
Alcon Laboratories, Inc. |
Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
|
|
US6287792B1
(en)
|
1991-06-17 |
2001-09-11 |
The Regents Of The University Of California |
Drug delivery of antisense oligonucleotides and peptides to tissues in vivo and to cells using avidin-biotin technology
|
|
TW282460B
(enExample)
|
1993-12-28 |
1996-08-01 |
Yamanouchi Pharma Co Ltd |
|
|
US6309853B1
(en)
|
1994-08-17 |
2001-10-30 |
The Rockfeller University |
Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
|
|
US5728718A
(en)
|
1994-12-20 |
1998-03-17 |
The United States Of America As Represented By The Department Of Health And Human Services |
2,5-diamino-3,4-disubstituted-1,6-diphenylhexane isosteres comprising benzamide, sulfonamide and anthranilamide subunits and methods of using same
|
|
JP4484410B2
(ja)
|
1999-06-28 |
2010-06-16 |
オクラホマ メディカル リサーチ ファウンデーション |
メマプシン2のインヒビターおよびその使用
|
|
JP4850379B2
(ja)
|
1999-12-16 |
2012-01-11 |
エミスフェアー・テクノロジーズ・インク |
活性剤を輸送するための化合物及び組成物
|
|
IL151909A0
(en)
|
2000-04-12 |
2003-04-10 |
Implyx Ltd |
Peptide conjugates for drug delivery
|
|
US6372250B1
(en)
|
2000-04-25 |
2002-04-16 |
The Regents Of The University Of California |
Non-invasive gene targeting to the brain
|
|
ATE314343T1
(de)
|
2000-06-30 |
2006-01-15 |
Elan Pharm Inc |
Verbindungen zur behandlung der alzheimerischen krankheit
|
|
PE20020276A1
(es)
|
2000-06-30 |
2002-04-06 |
Elan Pharm Inc |
COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
|
|
US6846813B2
(en)
|
2000-06-30 |
2005-01-25 |
Pharmacia & Upjohn Company |
Compounds to treat alzheimer's disease
|
|
JP4344518B2
(ja)
|
2000-12-28 |
2009-10-14 |
オクラホマ メディカル リサーチ ファウンデーション |
メマプシン2のインヒビターおよびその使用
|
|
US20040121947A1
(en)
|
2000-12-28 |
2004-06-24 |
Oklahoma Medical Research Foundation |
Compounds which inhibit beta-secretase activity and methods of use thereof
|
|
WO2002064558A2
(en)
|
2001-02-14 |
2002-08-22 |
Sankyo Company, Limited |
Oxazole derivatives, their preparation and their use as cytokine inhibitors
|
|
JP4547152B2
(ja)
|
2001-10-23 |
2010-09-22 |
オクラホマ メディカル リサーチ ファウンデーション |
β−セクレターゼ阻害剤および使用方法
|
|
US20060234944A1
(en)
|
2001-10-23 |
2006-10-19 |
Oklahoma Medical Reseach Foundation |
Beta-secretase inhibitors and methods of use
|
|
RS50504A
(sr)
|
2001-11-08 |
2007-04-10 |
Elan Pharmaceuticals Inc., |
Derivati n,n'-supstituisanog-1,3- diamino-2-hidroksipropana
|
|
BR0214736A
(pt)
|
2001-12-06 |
2004-11-23 |
Elan Pharm Inc |
Composto e seus sais farmaceuticamente aceitáveis, composição farmacêutica e método de tratar seres humanos ou animais que sofrem de doenças ou condições
|
|
MXPA04008317A
(es)
|
2002-02-27 |
2005-06-08 |
Upjohn Co |
Hidroxietilaminas sustituidas.
|
|
AU2003220115A1
(en)
|
2002-05-20 |
2003-12-12 |
Board Of Regents, The University Of Texas System |
Methods and compositions for delivering enzymes and nucleic acid molecules to brain, bone, and other tissues
|
|
EP1534693A2
(en)
|
2002-09-06 |
2005-06-01 |
Elan Pharmaceuticals, Inc. |
1, 3-diamino-2-hydroxypropane prodrug derivatives
|
|
EP1562897B1
(en)
|
2002-11-12 |
2009-09-16 |
Merck & Co., Inc. |
Phenylcarboxamide beta-secretase inhibitors for the treatment of alzheimer s disease
|
|
US20040102369A1
(en)
|
2002-11-27 |
2004-05-27 |
The Regents Of The University Of California |
Transport of basic fibroblast growth factor across the blood brain barrier
|
|
US7388079B2
(en)
|
2002-11-27 |
2008-06-17 |
The Regents Of The University Of California |
Delivery of pharmaceutical agents via the human insulin receptor
|
|
GB0228410D0
(en)
|
2002-12-05 |
2003-01-08 |
Glaxo Group Ltd |
Novel Compounds
|
|
GB0305918D0
(en)
|
2003-03-14 |
2003-04-23 |
Glaxo Group Ltd |
Novel compounds
|
|
CN1863797A
(zh)
|
2003-08-08 |
2006-11-15 |
先灵公司 |
具有苯甲酰胺取代基的环胺bace-1抑制剂
|
|
KR100793095B1
(ko)
|
2003-10-01 |
2008-01-10 |
주식회사 프로메디텍 |
Bace 저해효능을 가진 신규한 술폰 아미드 유도체
|
|
WO2005065195A2
(en)
|
2003-12-19 |
2005-07-21 |
Merck & Co., Inc. |
Phenylamide and pyridylamide beta-secretase inhibitors for the treatment of alzheimer's disease
|
|
US7585885B2
(en)
|
2004-04-22 |
2009-09-08 |
Eli Lilly And Company |
Pyrrolidine derivatives useful as BACE inhibitors
|
|
EP1740573A1
(en)
|
2004-04-22 |
2007-01-10 |
Eli Lilly And Company |
Amides as bace inhibitors
|
|
EP1758854B1
(en)
|
2004-06-15 |
2014-07-16 |
Merck Sharp & Dohme Corp. |
Pyrrolidin-3-yl compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease
|
|
US8436006B2
(en)
|
2004-08-06 |
2013-05-07 |
Jansssen Pharmaceutica N.V. |
2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
|
|
JP2008513497A
(ja)
|
2004-09-17 |
2008-05-01 |
コメンティス,インコーポレーテッド |
メマプシン2βセクレターゼ活性を阻害するアミノ含有化合物およびその使用方法
|
|
EP1797052A1
(en)
|
2004-09-17 |
2007-06-20 |
Comentis, Inc. |
Bicyclic compounds which inhibit beta-secretase activity and methods of use thereof
|
|
CN100475786C
(zh)
*
|
2005-02-18 |
2009-04-08 |
中国科学院上海药物研究所 |
一类4-羟基戊酰胺类化合物及其制备方法和用途
|
|
US7745470B2
(en)
|
2005-03-10 |
2010-06-29 |
Bristol-Myers Squibb Company |
Isophthalates as beta-secretase inhibitors
|
|
WO2006110668A1
(en)
*
|
2005-04-08 |
2006-10-19 |
Comentis, Inc. |
Compounds which inhibit beta-secretase activity and methods of use thereof
|
|
MY158766A
(en)
|
2005-04-11 |
2016-11-15 |
Xenon Pharmaceuticals Inc |
Spiro-oxindole compounds and their uses as therapeutic agents
|
|
AR054363A1
(es)
|
2005-05-23 |
2007-06-20 |
Astrazeneca Ab |
Compuestos que exhiben actividad moduladora en el receptor 5-hidroxi-triptamina 6
|
|
AR054044A1
(es)
|
2005-05-23 |
2007-05-30 |
Astrazeneca Ab |
Derivados de cromano y tetrahidronaftaleno como moduladores del receptor 5 - ht6; intermediarios en su preparacion; composiciones farmaceuticas que los contienen y su empelo en la fabricacion de medicamentos para el tratamiento de enfermedades del snc y de la obesidad.
|
|
GB0513886D0
(en)
|
2005-07-06 |
2005-08-10 |
Glaxo Group Ltd |
Novel compounds
|
|
US7476764B2
(en)
|
2005-08-04 |
2009-01-13 |
Bristol-Myers Squibb Company |
Phenylcarboxyamides as beta-secretase inhibitors
|
|
US7790745B2
(en)
|
2005-10-21 |
2010-09-07 |
Bristol-Myers Squibb Company |
Tetrahydroisoquinoline LXR Modulators
|
|
TW200804290A
(en)
|
2005-11-15 |
2008-01-16 |
Astrazeneca Ab |
Compounds and uses thereof
|
|
CA2664130A1
(en)
|
2006-09-21 |
2008-03-27 |
Merck & Co., Inc. |
Piperidine and pyrrolidine beta-secretase inhibitors for the treatment of alzheimer's disease
|
|
WO2009015369A2
(en)
|
2007-07-26 |
2009-01-29 |
Comentis, Inc. |
Compounds which inhibit beta-secretase activity and methods of use thereof
|
|
KR20100059919A
(ko)
|
2007-09-24 |
2010-06-04 |
코멘티스, 인코포레이티드 |
치료를 위한 베타-세크레타제 억제제로서 (3-히드록시-4-아미노-부탄-2일)-3-(2-티아졸-2-일-피롤리딘-1-카르보닐) 벤즈아미드 유도체 및 관련 화합물
|
|
US8791135B2
(en)
|
2008-07-01 |
2014-07-29 |
Purdue Research Foundation |
Nonpeptide HIV-1 protease inhibitors
|
|
EP2349244A4
(en)
|
2008-10-10 |
2012-09-19 |
Comentis Inc |
PYRROLIDINE COMPOUNDS THAT PREVENT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF
|
|
EP2349308A4
(en)
|
2008-10-10 |
2012-09-12 |
Purdue Research Foundation |
COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
|
|
EP2376083A4
(en)
|
2008-11-20 |
2012-06-20 |
Purdue Research Foundation |
QUINAZOLIN-BASED BACE-1 INHIBITORS AND METHODS OF USE
|
|
US8859590B2
(en)
|
2008-12-05 |
2014-10-14 |
Purdue Research Foundation |
Inhibitors of BACE1 and methods for treating Alzheimer's disease
|
|
JP2012521421A
(ja)
|
2009-03-25 |
2012-09-13 |
コメンティス,インコーポレーテッド |
β−セクレターゼ活性を阻害するピロリジン化合物及びその使用方法
|
|
JP2013506713A
(ja)
|
2009-10-05 |
2013-02-28 |
コメンティス,インコーポレーテッド |
β−セクレターゼ活性を阻害するスルホンアミドピロリジン化合物及びその使用方法
|