MX2010002938A - Derivados de (3-hidroxi-4-amino-butan-2-il)-3-(2-tiazol-2-il-pirro lidin-1-carbonil)benzamida y compuestos relacionados como inhibidores de beta-secretasa para tratar enfermedad de alzheimer. - Google Patents
Derivados de (3-hidroxi-4-amino-butan-2-il)-3-(2-tiazol-2-il-pirro lidin-1-carbonil)benzamida y compuestos relacionados como inhibidores de beta-secretasa para tratar enfermedad de alzheimer.Info
- Publication number
- MX2010002938A MX2010002938A MX2010002938A MX2010002938A MX2010002938A MX 2010002938 A MX2010002938 A MX 2010002938A MX 2010002938 A MX2010002938 A MX 2010002938A MX 2010002938 A MX2010002938 A MX 2010002938A MX 2010002938 A MX2010002938 A MX 2010002938A
- Authority
- MX
- Mexico
- Prior art keywords
- treating
- beta
- butan
- thiazol
- pyrrolidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97479307P | 2007-09-24 | 2007-09-24 | |
| PCT/US2008/077537 WO2009042694A1 (en) | 2007-09-24 | 2008-09-24 | (3-hydroxy-4-amino-butan-2-yl) -3- (2-thiazol-2-yl-pyrrolidine-1-carbonyl) benzamide derivatives and related compounds as beta-secretase inhibitors for treating |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010002938A true MX2010002938A (es) | 2010-04-01 |
Family
ID=40343545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010002938A MX2010002938A (es) | 2007-09-24 | 2008-09-24 | Derivados de (3-hidroxi-4-amino-butan-2-il)-3-(2-tiazol-2-il-pirro lidin-1-carbonil)benzamida y compuestos relacionados como inhibidores de beta-secretasa para tratar enfermedad de alzheimer. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8299267B2 (enExample) |
| EP (1) | EP2205596A1 (enExample) |
| JP (1) | JP5055432B2 (enExample) |
| KR (1) | KR20100059919A (enExample) |
| CN (1) | CN101868457B (enExample) |
| CA (1) | CA2699787A1 (enExample) |
| MX (1) | MX2010002938A (enExample) |
| WO (1) | WO2009042694A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20100059919A (ko) | 2007-09-24 | 2010-06-04 | 코멘티스, 인코포레이티드 | 치료를 위한 베타-세크레타제 억제제로서 (3-히드록시-4-아미노-부탄-2일)-3-(2-티아졸-2-일-피롤리딘-1-카르보닐) 벤즈아미드 유도체 및 관련 화합물 |
| MX2012002730A (es) * | 2009-09-04 | 2012-07-20 | Tactical Therapeutics Inc | Nuevas composiciones y procesos para preparar formulaciones de 1,2,3-triazoles 5-amino o amino sustituidos y triazol orotato. |
| WO2011029920A1 (en) | 2009-09-11 | 2011-03-17 | Probiodrug Ag | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
| JP2013506713A (ja) * | 2009-10-05 | 2013-02-28 | コメンティス，インコーポレーテッド | β−セクレターゼ活性を阻害するスルホンアミドピロリジン化合物及びその使用方法 |
| WO2012027495A1 (en) | 2010-08-27 | 2012-03-01 | University Of The Pacific | Piperazinylpyrimidine analogues as protein kinase inhibitors |
| US20120053200A1 (en) * | 2010-09-01 | 2012-03-01 | Harald Mauser | Bace 2 inhibitors |
| CN104781257A (zh) | 2012-06-14 | 2015-07-15 | 第一三共株式会社 | 哌啶基吡唑并吡啶衍生物 |
| CN105669365B (zh) * | 2016-03-04 | 2022-06-21 | 中国科学院上海有机化学研究所 | 含二氟烷基取代的芳基或杂芳基化合物、制备方法和应用 |
| EP3461819B1 (en) | 2017-09-29 | 2020-05-27 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
| CN110117237B (zh) * | 2018-02-05 | 2024-02-02 | 中国科学院上海有机化学研究所 | 一种芳香腈或烯基腈类化合物的制备方法 |
| CN110642789B (zh) * | 2019-11-25 | 2020-05-26 | 天津凯莱英制药有限公司 | 2-氯嘧啶-4-甲酸类化合物的连续性合成方法 |
| CN112321515A (zh) * | 2020-10-21 | 2021-02-05 | 上海馨远医药科技有限公司 | 一种手性1-叔丁基-3-甲基-6-甲基哌嗪-1,3-二甲酸酯的制备方法 |
| US20250115636A1 (en) * | 2022-02-03 | 2025-04-10 | Purdue Research Foundation | Peptidomimetic inhibitors of protein n-terminal methyltransferase 1, composition, and method of use |
| US12191004B2 (en) | 2022-06-27 | 2025-01-07 | Microsoft Technology Licensing, Llc | Machine learning system with two encoder towers for semantic matching |
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| US4801575A (en) | 1986-07-30 | 1989-01-31 | The Regents Of The University Of California | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
| US4902505A (en) | 1986-07-30 | 1990-02-20 | Alkermes | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
| US5624898A (en) | 1989-12-05 | 1997-04-29 | Ramsey Foundation | Method for administering neurologic agents to the brain |
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| AR054044A1 (es) | 2005-05-23 | 2007-05-30 | Astrazeneca Ab | Derivados de cromano y tetrahidronaftaleno como moduladores del receptor 5 - ht6; intermediarios en su preparacion; composiciones farmaceuticas que los contienen y su empelo en la fabricacion de medicamentos para el tratamiento de enfermedades del snc y de la obesidad. |
| GB0513886D0 (en) | 2005-07-06 | 2005-08-10 | Glaxo Group Ltd | Novel compounds |
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| TW200804290A (en) | 2005-11-15 | 2008-01-16 | Astrazeneca Ab | Compounds and uses thereof |
| CA2664130A1 (en) | 2006-09-21 | 2008-03-27 | Merck & Co., Inc. | Piperidine and pyrrolidine beta-secretase inhibitors for the treatment of alzheimer's disease |
| WO2009015369A2 (en) | 2007-07-26 | 2009-01-29 | Comentis, Inc. | Compounds which inhibit beta-secretase activity and methods of use thereof |
| KR20100059919A (ko) | 2007-09-24 | 2010-06-04 | 코멘티스, 인코포레이티드 | 치료를 위한 베타-세크레타제 억제제로서 (3-히드록시-4-아미노-부탄-2일)-3-(2-티아졸-2-일-피롤리딘-1-카르보닐) 벤즈아미드 유도체 및 관련 화합물 |
| US8791135B2 (en) | 2008-07-01 | 2014-07-29 | Purdue Research Foundation | Nonpeptide HIV-1 protease inhibitors |
| EP2349244A4 (en) | 2008-10-10 | 2012-09-19 | Comentis Inc | PYRROLIDINE COMPOUNDS THAT PREVENT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF |
| EP2349308A4 (en) | 2008-10-10 | 2012-09-12 | Purdue Research Foundation | COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE |
| EP2376083A4 (en) | 2008-11-20 | 2012-06-20 | Purdue Research Foundation | QUINAZOLIN-BASED BACE-1 INHIBITORS AND METHODS OF USE |
| US8859590B2 (en) | 2008-12-05 | 2014-10-14 | Purdue Research Foundation | Inhibitors of BACE1 and methods for treating Alzheimer's disease |
| JP2012521421A (ja) | 2009-03-25 | 2012-09-13 | コメンティス，インコーポレーテッド | β−セクレターゼ活性を阻害するピロリジン化合物及びその使用方法 |
| JP2013506713A (ja) | 2009-10-05 | 2013-02-28 | コメンティス，インコーポレーテッド | β−セクレターゼ活性を阻害するスルホンアミドピロリジン化合物及びその使用方法 |
-
2008
- 2008-09-24 KR KR1020107006815A patent/KR20100059919A/ko not_active Withdrawn
- 2008-09-24 JP JP2010526066A patent/JP5055432B2/ja not_active Expired - Fee Related
- 2008-09-24 EP EP08834393A patent/EP2205596A1/en not_active Withdrawn
- 2008-09-24 US US12/677,748 patent/US8299267B2/en not_active Expired - Fee Related
- 2008-09-24 CA CA2699787A patent/CA2699787A1/en not_active Abandoned
- 2008-09-24 CN CN2008801172385A patent/CN101868457B/zh not_active Expired - Fee Related
- 2008-09-24 MX MX2010002938A patent/MX2010002938A/es active IP Right Grant
- 2008-09-24 WO PCT/US2008/077537 patent/WO2009042694A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP2205596A1 (en) | 2010-07-14 |
| JP2010540462A (ja) | 2010-12-24 |
| KR20100059919A (ko) | 2010-06-04 |
| CN101868457B (zh) | 2013-02-13 |
| US8299267B2 (en) | 2012-10-30 |
| WO2009042694A1 (en) | 2009-04-02 |
| US20100286170A1 (en) | 2010-11-11 |
| CN101868457A (zh) | 2010-10-20 |
| CA2699787A1 (en) | 2009-04-02 |
| JP5055432B2 (ja) | 2012-10-24 |
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