MX2010002938A - Derivados de (3-hidroxi-4-amino-butan-2-il)-3-(2-tiazol-2-il-pirro lidin-1-carbonil)benzamida y compuestos relacionados como inhibidores de beta-secretasa para tratar enfermedad de alzheimer. - Google Patents
Derivados de (3-hidroxi-4-amino-butan-2-il)-3-(2-tiazol-2-il-pirro lidin-1-carbonil)benzamida y compuestos relacionados como inhibidores de beta-secretasa para tratar enfermedad de alzheimer.Info
- Publication number
- MX2010002938A MX2010002938A MX2010002938A MX2010002938A MX2010002938A MX 2010002938 A MX2010002938 A MX 2010002938A MX 2010002938 A MX2010002938 A MX 2010002938A MX 2010002938 A MX2010002938 A MX 2010002938A MX 2010002938 A MX2010002938 A MX 2010002938A
- Authority
- MX
- Mexico
- Prior art keywords
- treating
- beta
- butan
- thiazol
- pyrrolidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97479307P | 2007-09-24 | 2007-09-24 | |
| PCT/US2008/077537 WO2009042694A1 (en) | 2007-09-24 | 2008-09-24 | (3-hydroxy-4-amino-butan-2-yl) -3- (2-thiazol-2-yl-pyrrolidine-1-carbonyl) benzamide derivatives and related compounds as beta-secretase inhibitors for treating |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010002938A true MX2010002938A (es) | 2010-04-01 |
Family
ID=40343545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010002938A MX2010002938A (es) | 2007-09-24 | 2008-09-24 | Derivados de (3-hidroxi-4-amino-butan-2-il)-3-(2-tiazol-2-il-pirro lidin-1-carbonil)benzamida y compuestos relacionados como inhibidores de beta-secretasa para tratar enfermedad de alzheimer. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8299267B2 (enExample) |
| EP (1) | EP2205596A1 (enExample) |
| JP (1) | JP5055432B2 (enExample) |
| KR (1) | KR20100059919A (enExample) |
| CN (1) | CN101868457B (enExample) |
| CA (1) | CA2699787A1 (enExample) |
| MX (1) | MX2010002938A (enExample) |
| WO (1) | WO2009042694A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101868457B (zh) | 2007-09-24 | 2013-02-13 | 科门蒂斯公司 | 作为β-分泌酶抑制剂用于治疗的(3-羟基-4-氨基-丁-2-基)-3-(2-噻唑-2-基-吡咯烷-1-羰基)苯甲酰胺衍生物和相关化合物 |
| MX2012002730A (es) * | 2009-09-04 | 2012-07-20 | Tactical Therapeutics Inc | Nuevas composiciones y procesos para preparar formulaciones de 1,2,3-triazoles 5-amino o amino sustituidos y triazol orotato. |
| CN102695546B (zh) | 2009-09-11 | 2014-09-10 | 前体生物药物股份公司 | 作为谷氨酰胺酰环化酶抑制剂的杂环衍生物 |
| EP2486006A4 (en) * | 2009-10-05 | 2013-05-01 | Comentis Inc | SULFONAMIDO PYRROLIDINE COMPOUNDS THAT INHIBIT BETA SECRETASE ACTIVITY AND METHODS OF USE THEREOF |
| WO2012027495A1 (en) | 2010-08-27 | 2012-03-01 | University Of The Pacific | Piperazinylpyrimidine analogues as protein kinase inhibitors |
| US20120053200A1 (en) * | 2010-09-01 | 2012-03-01 | Harald Mauser | Bace 2 inhibitors |
| KR20150021036A (ko) | 2012-06-14 | 2015-02-27 | 다이이찌 산쿄 가부시키가이샤 | 피페리디닐피라졸로피리딘 유도체 |
| CN105669365B (zh) * | 2016-03-04 | 2022-06-21 | 中国科学院上海有机化学研究所 | 含二氟烷基取代的芳基或杂芳基化合物、制备方法和应用 |
| DK3461819T3 (da) | 2017-09-29 | 2020-08-10 | Probiodrug Ag | Inhibitorer af glutaminylcyklase |
| CN110117237B (zh) * | 2018-02-05 | 2024-02-02 | 中国科学院上海有机化学研究所 | 一种芳香腈或烯基腈类化合物的制备方法 |
| CN110642789B (zh) * | 2019-11-25 | 2020-05-26 | 天津凯莱英制药有限公司 | 2-氯嘧啶-4-甲酸类化合物的连续性合成方法 |
| CN112321515A (zh) * | 2020-10-21 | 2021-02-05 | 上海馨远医药科技有限公司 | 一种手性1-叔丁基-3-甲基-6-甲基哌嗪-1,3-二甲酸酯的制备方法 |
| US20250115636A1 (en) * | 2022-02-03 | 2025-04-10 | Purdue Research Foundation | Peptidomimetic inhibitors of protein n-terminal methyltransferase 1, composition, and method of use |
| US12191004B2 (en) | 2022-06-27 | 2025-01-07 | Microsoft Technology Licensing, Llc | Machine learning system with two encoder towers for semantic matching |
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| FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
| US4801575A (en) | 1986-07-30 | 1989-01-31 | The Regents Of The University Of California | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
| US4902505A (en) | 1986-07-30 | 1990-02-20 | Alkermes | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
| US5624898A (en) | 1989-12-05 | 1997-04-29 | Ramsey Foundation | Method for administering neurologic agents to the brain |
| US6407061B1 (en) | 1989-12-05 | 2002-06-18 | Chiron Corporation | Method for administering insulin-like growth factor to the brain |
| DE69212850T2 (de) | 1991-01-15 | 1997-03-06 | Alcon Lab Inc | Verwendung von Karrageenan in topischen ophthalmologischen Zusammensetzungen |
| US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
| US6287792B1 (en) | 1991-06-17 | 2001-09-11 | The Regents Of The University Of California | Drug delivery of antisense oligonucleotides and peptides to tissues in vivo and to cells using avidin-biotin technology |
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| CN101868457B (zh) | 2007-09-24 | 2013-02-13 | 科门蒂斯公司 | 作为β-分泌酶抑制剂用于治疗的(3-羟基-4-氨基-丁-2-基)-3-(2-噻唑-2-基-吡咯烷-1-羰基)苯甲酰胺衍生物和相关化合物 |
| WO2010002994A1 (en) | 2008-07-01 | 2010-01-07 | Purdue Research Foundation | Nonpeptide hiv-1 protease inhibitors |
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| JP2012505241A (ja) | 2008-10-10 | 2012-03-01 | パーデュー・リサーチ・ファウンデーション | アルツハイマー病の治療用組成物 |
| JP2012509352A (ja) | 2008-11-20 | 2012-04-19 | パーデュー・リサーチ・ファウンデーション | Ｂａｃｅ１のキナゾリン阻害剤および使用方法 |
| US8859590B2 (en) | 2008-12-05 | 2014-10-14 | Purdue Research Foundation | Inhibitors of BACE1 and methods for treating Alzheimer's disease |
| US20120214802A1 (en) | 2009-03-25 | 2012-08-23 | Bilcer Geoffrey M | Pyrrolidine compounds which inhibit beta-secretase activity and methods of use thereof |
| EP2486006A4 (en) | 2009-10-05 | 2013-05-01 | Comentis Inc | SULFONAMIDO PYRROLIDINE COMPOUNDS THAT INHIBIT BETA SECRETASE ACTIVITY AND METHODS OF USE THEREOF |
-
2008
- 2008-09-24 CN CN2008801172385A patent/CN101868457B/zh not_active Expired - Fee Related
- 2008-09-24 US US12/677,748 patent/US8299267B2/en not_active Expired - Fee Related
- 2008-09-24 CA CA2699787A patent/CA2699787A1/en not_active Abandoned
- 2008-09-24 EP EP08834393A patent/EP2205596A1/en not_active Withdrawn
- 2008-09-24 MX MX2010002938A patent/MX2010002938A/es active IP Right Grant
- 2008-09-24 KR KR1020107006815A patent/KR20100059919A/ko not_active Withdrawn
- 2008-09-24 JP JP2010526066A patent/JP5055432B2/ja not_active Expired - Fee Related
- 2008-09-24 WO PCT/US2008/077537 patent/WO2009042694A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010540462A (ja) | 2010-12-24 |
| CA2699787A1 (en) | 2009-04-02 |
| CN101868457B (zh) | 2013-02-13 |
| CN101868457A (zh) | 2010-10-20 |
| US20100286170A1 (en) | 2010-11-11 |
| US8299267B2 (en) | 2012-10-30 |
| WO2009042694A1 (en) | 2009-04-02 |
| EP2205596A1 (en) | 2010-07-14 |
| JP5055432B2 (ja) | 2012-10-24 |
| KR20100059919A (ko) | 2010-06-04 |
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