KR101781663B1 - 히스톤 데아세틸라제 효소를 억제하기 위한 화합물 및 이를 제조하는 방법 - Google Patents

히스톤 데아세틸라제 효소를 억제하기 위한 화합물 및 이를 제조하는 방법 Download PDF

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KR101781663B1
KR101781663B1 KR1020127021121A KR20127021121A KR101781663B1 KR 101781663 B1 KR101781663 B1 KR 101781663B1 KR 1020127021121 A KR1020127021121 A KR 1020127021121A KR 20127021121 A KR20127021121 A KR 20127021121A KR 101781663 B1 KR101781663 B1 KR 101781663B1
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trifluoromethyl
oxadiazol
alkyl
methyl
benzamide
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KR20130036093A (ko
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어칸 발로글루
쇼미르 고쉬
메르세데스 로베라
다르비 슈미트
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템페로 파마슈티칼즈, 인크.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
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KR1020127021121A 2010-01-13 2011-01-13 히스톤 데아세틸라제 효소를 억제하기 위한 화합물 및 이를 제조하는 방법 Expired - Fee Related KR101781663B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29457510P 2010-01-13 2010-01-13
US61/294,575 2010-01-13
PCT/US2011/021089 WO2011088181A1 (en) 2010-01-13 2011-01-13 Compounds and methods

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KR20130036093A KR20130036093A (ko) 2013-04-10
KR101781663B1 true KR101781663B1 (ko) 2017-09-25

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US (2) US8901156B2 (enExample)
EP (1) EP2533783B8 (enExample)
JP (1) JP6017313B2 (enExample)
KR (1) KR101781663B1 (enExample)
CN (1) CN103221047B (enExample)
AU (1) AU2011205283B2 (enExample)
BR (1) BR112012017441B1 (enExample)
CA (1) CA2787018A1 (enExample)
EA (1) EA022964B1 (enExample)
ES (1) ES2560627T3 (enExample)
IL (1) IL220939A (enExample)
MX (1) MX341133B (enExample)
SG (1) SG182401A1 (enExample)
WO (1) WO2011088181A1 (enExample)
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