SG11201501036RA - Compounds for the treatment of paramoxyvirus viral infections - Google Patents

Compounds for the treatment of paramoxyvirus viral infections

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Publication number
SG11201501036RA
SG11201501036RA SG11201501036RA SG11201501036RA SG11201501036RA SG 11201501036R A SG11201501036R A SG 11201501036RA SG 11201501036R A SG11201501036R A SG 11201501036RA SG 11201501036R A SG11201501036R A SG 11201501036RA SG 11201501036R A SG11201501036R A SG 11201501036RA
Authority
SG
Singapore
Prior art keywords
paramoxyvirus
compounds
treatment
viral infections
infections
Prior art date
Application number
SG11201501036RA
Inventor
Guangyi Wang
Leonid Beigelman
Anh Truong
Carmela Napolitano
Daniele Andreotti
Haiying He
Original Assignee
Alios Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alios Biopharma Inc filed Critical Alios Biopharma Inc
Publication of SG11201501036RA publication Critical patent/SG11201501036RA/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2779748T3 (en) * 2012-08-23 2020-08-19 Janssen Biopharma Inc Compounds for the treatment of paramyxovirus infections
CA2894542C (en) 2012-12-21 2023-10-31 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
CN105102448B (en) 2013-02-28 2018-03-06 百时美施贵宝公司 Phenylpyrazole derivatives as ROCK1 and ROCK2 inhibitor
AR094929A1 (en) 2013-02-28 2015-09-09 Bristol Myers Squibb Co DERIVATIVES OF PHENYLPIRAZOL AS POWERFUL INHIBITORS OF ROCK1 AND ROCK2
JP6485817B2 (en) * 2013-08-21 2019-03-20 ヤンセン バイオファーマ インク． Antiviral compound
EP3385257A1 (en) 2013-09-06 2018-10-10 Aurigene Discovery Technologies Limited 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives as immunomodulators
WO2016022464A1 (en) * 2014-08-05 2016-02-11 Alios Biopharma, Inc. Combination therapy for treating a paramyxovirus
ES2819218T3 (en) 2014-10-06 2021-04-15 Cortexyme Inc Gingipain lysine inhibitors
EP3260451A4 (en) * 2015-02-19 2018-07-18 JNC Corporation Liquid crystalline compound having benzothiophene, liquid crystal composition and liquid crystal display element
MA41614A (en) * 2015-02-25 2018-01-02 Alios Biopharma Inc ANTIVIRAL COMPOUNDS
LT3324977T (en) 2015-07-22 2022-10-25 Enanta Pharmaceuticals, Inc. Benzodiazepine derivatives as rsv inhibitors
KR102375929B1 (en) 2016-03-31 2022-03-16 온크터널 테라퓨틱스, 인코포레이티드. Indoline analogs and uses thereof
WO2018053353A1 (en) 2016-09-16 2018-03-22 Cortexyme, Inc. Ketone inhibitors of lysine gingipain
WO2019006295A1 (en) 2017-06-30 2019-01-03 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as rsv inhibitors
BR112020006334A2 (en) 2017-09-29 2020-09-24 Enanta Pharmaceuticals, Inc. combination of pharmaceutical agents such as rsv inhibitors
CA3084092A1 (en) 2017-12-06 2019-06-13 Ontario Institute For Cancer Research (Oicr) Acyl hydrazone linkers, methods and uses thereof
CA3086366A1 (en) 2017-12-22 2019-06-27 Ontario Institute For Cancer Research (Oicr) Heterocyclic acyl hydrazone linkers, methods and uses thereof
WO2019154949A1 (en) 2018-02-08 2019-08-15 Enyo Pharma Fused thiophene derivatives and their uses
CN108929273A (en) * 2018-06-27 2018-12-04 合肥医工医药有限公司 A kind of preparation method of imidazole ethyl vanillic acid ether sodium salt
UY38614A (en) 2019-03-18 2020-10-30 Enanta Pharm Inc BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS
CA3153297A1 (en) 2019-10-04 2021-04-08 Adam SZYMANIAK Antiviral heterocyclic compounds
US11505558B1 (en) 2019-10-04 2022-11-22 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
CN111004211B (en) * 2019-12-29 2021-04-02 苏州诚和医药化学有限公司 Synthetic method of brexpiprazole intermediate 4-bromobenzo [ b ] thiophene
UY39032A (en) 2020-01-24 2021-07-30 Enanta Pharm Inc HETEROCYCLIC COMPOUNDS AS ANTIVIRAL AGENTS
WO2022010882A1 (en) 2020-07-07 2022-01-13 Enanta Pharmaceuticals, Inc, Dihydroquinoxaline and dihydropyridopyrazine derivatives as rsv inhibitors
US11945824B2 (en) 2020-10-19 2024-04-02 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as anti-viral agents
MX2023009961A (en) 2021-02-26 2023-09-05 Enanta Pharm Inc Antiviral heterocyclic compounds.
EP4373506A1 (en) 2021-07-20 2024-05-29 AGS Therapeutics SAS Extracellular vesicles from microalgae, their preparation, and uses
WO2023052593A1 (en) 2021-10-01 2023-04-06 Janssen Sciences Ireland Unlimited Company Rsv inhibiting spiro bearing derivatives
WO2023144127A1 (en) 2022-01-31 2023-08-03 Ags Therapeutics Sas Extracellular vesicles from microalgae, their biodistribution upon administration, and uses
WO2023232976A1 (en) 2022-06-03 2023-12-07 Ags Therapeutics Sas Extracellular vesicles from genetically-modified microalgae containing endogenously-loaded cargo, their preparation, and uses
WO2023237730A1 (en) 2022-06-10 2023-12-14 Janssen Sciences Ireland Unlimited Company Rsv inhibiting triazolo and spiro bearing derivatives
WO2023237732A1 (en) 2022-06-10 2023-12-14 Janssen Sciences Ireland Unlimited Company Rsv inhibiting triazolo bearing derivatives
WO2024088808A1 (en) 2022-10-24 2024-05-02 Ags Therapeutics Sas Extracellular vesicles from microalgae, their biodistribution upon intranasal administration, and uses thereof

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2516098A (en) 1949-03-26 1950-07-25 Parke Davis & Co Biphenyl compounds
DE3473442D1 (en) 1983-01-21 1988-09-22 Alkaloida Vegyeszeti Gyar NEW ALKYL DIAMINE DERIVATIVES
US4876346A (en) 1985-05-02 1989-10-24 American Home Products Corporation Quinoline compounds
FI97540C (en) 1989-11-06 1997-01-10 Sanofi Sa Process for the preparation of therapeutically useful aromatically substituted piperidine and piperazine derivatives
US5716929A (en) * 1994-06-17 1998-02-10 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US5696267A (en) 1995-05-02 1997-12-09 Schering Corporation Substituted oximes, hydrazones and olefins as neurokinin antagonists
US5688960A (en) 1995-05-02 1997-11-18 Schering Corporation Substituted oximes, hydrazones and olefins useful as neurokinin antagonists
MA26487A1 (en) 1997-04-29 2004-12-20 Smithkline Beecham Corp PROTEASE INHIBITOR HETEROCYCLECETOHYDRAZIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
US6410585B1 (en) 1997-08-28 2002-06-25 Scott D. Larsen Inhibitors of protein tyrosine phosphatase
EP1064298B1 (en) 1998-03-19 2008-10-08 Vertex Pharmaceuticals Incorporated Inhibitors of caspases
KR20010025087A (en) 1998-05-22 2001-03-26 스튜어트 알. 수터 Novel 2-Alkyl Substituted Imidazole Compounds
AR018915A1 (en) * 1998-06-24 2001-12-12 Smithkline Beecham Corp INHIBITORS OF DIACIL HYDRAZINIC PROTEASES, PHARMACEUTICAL COMPOSITION THAT INCLUDE IT, USES OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT, A MANUFACTURING MANUFACTURE OF SUCH COMPOUNDS
EP1105412A1 (en) 1998-08-17 2001-06-13 Cortech, Inc. Serine protease inhibitors comprising alpha-keto heterocycles
US20100144630A1 (en) * 1999-03-05 2010-06-10 Leland Shapiro Compositions, methods and uses for inhibition and/or treatment of influenza infection
WO2000052034A2 (en) * 1999-03-05 2000-09-08 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of viral infections
IL144910A0 (en) 1999-04-15 2002-06-30 Bristol Myers Squibb Co Cyclic compounds and pharmaceutical compositions containing the same
US7125875B2 (en) 1999-04-15 2006-10-24 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
BR0011997A (en) 1999-06-28 2002-03-05 Janssen Pharmaceutica Nv Respiratory syncytial virus replication inhibitors
EP1362846A4 (en) 2001-01-26 2006-10-04 Takeda Pharmaceutical Aminoethanol derivatives
JP2002293764A (en) 2001-01-26 2002-10-09 Takeda Chem Ind Ltd Aminoethanol derivative
CA2446586A1 (en) 2001-05-11 2002-11-21 Thomas E. Barta Aromatic sulfone hydroxamates and their use as protease inhibitors
US20040024024A1 (en) 2001-05-11 2004-02-05 Freskos John N. Aromatic sulfone hydroxamates and their use as protease inhibitors
US6878743B2 (en) 2001-09-18 2005-04-12 Sunesis Pharmaceuticals, Inc. Small molecule inhibitors of caspases
KR20040041649A (en) 2001-10-01 2004-05-17 브리스톨-마이어스 스큅 컴퍼니 Spiro-hydantoin Compounds Useful as Anti-inflammatory Agents
JP2005507420A (en) 2001-11-01 2005-03-17 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Aminobenzamide derivatives as glycogen synthase kinase 3β inhibitors
GB0128415D0 (en) 2001-11-27 2002-01-16 Univ Sheffield Medicaments
DE10224888A1 (en) 2002-06-05 2003-12-24 Merck Patent Gmbh pyridazine
MXPA05002871A (en) 2002-09-20 2005-10-05 Arrow Therapeutics Ltd Benzodiazepine derivatives and pharmaceutical compositions containing them.
CA2501799C (en) * 2002-10-09 2008-06-17 Pfizer Products Inc. Pyrazole compounds for treatment of neurodegenerative disorders
JO2696B1 (en) * 2002-12-23 2013-03-03 شركة جانسين فارماسوتيكا ان. في Substituted 1-piperidin-4-yl-4-pyrrolidin-3-yl-piperazine derivatives and their use as neurokinin antagonists
JP4448134B2 (en) 2003-08-08 2010-04-07 シェーリング コーポレイション Cyclic amine BASE-1 inhibitor having a benzamide substituent
US7598250B2 (en) 2003-08-08 2009-10-06 Schering Corporation Cyclic amine BACE-1 inhibitors having a heterocyclic substituent
WO2005035514A2 (en) 2003-10-08 2005-04-21 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters containing cycloalkyl or pyranyl groups
DE10348023A1 (en) * 2003-10-15 2005-05-19 Imtm Gmbh New alanyl aminopeptidase inhibitors for the functional manipulation of different cells and for the treatment of immunological, inflammatory, neuronal and other diseases
CA2547591C (en) * 2003-10-24 2010-08-17 Aventis Pharmaceuticals Inc. Novel compounds and compositions as cathepsin inhibitors
JP2007519735A (en) 2004-01-30 2007-07-19 メルク　エンド　カムパニー　インコーポレーテッド N-benzyl-3,4-dihydroxypyridine-2-carboxamide and N-benzyl-2,3-dihydroxypyridine-4-carboxamide compounds useful as HIV integrase inhibitors
GB0406280D0 (en) 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Chemical compounds
CN1933836B (en) 2004-03-24 2011-08-17 默沙东公司 Heteroaryl piperidine glycine transporter inhibitors
WO2006044133A1 (en) * 2004-09-24 2006-04-27 Axys Pharmaceuticals, Inc. Active ketone inhibitors of tryptase
US7919487B2 (en) 2004-11-10 2011-04-05 Synta Pharmaceuticals Corporation Heteroaryl compounds
GB0425919D0 (en) 2004-11-25 2004-12-29 Prosidion Ltd Indole-2-carboxylic acid amides
DE102005024245A1 (en) 2005-05-27 2006-11-30 Merck Patent Gmbh thienopyridines
TW200800872A (en) 2005-09-07 2008-01-01 Plexxikon Inc PPAR active compounds
TWI435863B (en) 2006-03-20 2014-05-01 Nihon Nohyaku Co Ltd N-2-(hetero) arylethylcarboxamide derivative and pest controlling
CA2651043A1 (en) * 2006-05-23 2007-12-06 David C. Tully Compounds and compositions as channel activating protease inhibitors
CN101489999B (en) 2006-06-08 2012-07-04 先正达参股股份有限公司 N- (l-alkyl-2- phenylethyl) -carboxamide derivatives and usethereof as fungicides
CN101511839A (en) 2006-07-13 2009-08-19 巴斯夫欧洲公司 Fungicidal azolopyrimidines, methods for the production thereof, use thereof for controlling harmful fungi, and substances containing the same
US7834023B2 (en) 2006-09-20 2010-11-16 Portola Pharmaceuticals, Inc. Substituted dihydroquinazolines as platelet ADP receptor inhibitors
WO2008057599A2 (en) 2006-11-10 2008-05-15 Intra-Cellular Therapies, Inc. Methods for the treatment of abeta related disorders and compositions therefor
MX2009008493A (en) 2007-02-09 2009-08-20 Irm Llc Compounds and compositions as channel activating protease inhibitors.
EP2422790A1 (en) 2007-02-09 2012-02-29 Emory University Paramyxovirus family inhibitors and methods of use thereof
EP2594564B1 (en) 2007-05-31 2016-09-28 Genzyme Corporation 2-acylaminopropanol-type glucosylceramide synthase inhibitors
KR20160085917A (en) 2007-10-05 2016-07-18 젠자임 코포레이션 Method of treating polycystic kidney diseases with ceramide derivatives
US20090156509A1 (en) * 2007-12-12 2009-06-18 Accuthera, Inc. Tri-peptide Inhibitors of Serine Elastases
WO2009087379A2 (en) 2008-01-09 2009-07-16 Amura Therapeutics Limited Tetrahydrofuro (3, 2 -b) pyrrol- 3 -one derivatives as inhibitors of cysteine proteinases
JP2009209090A (en) 2008-03-04 2009-09-17 Mitsui Chemicals Inc Insecticide, compound contained in the insecticide, and method of using the compound
WO2009155362A1 (en) 2008-06-19 2009-12-23 Ligand Pharmaceuticals Inc. Small molecule hematopoietic growth factor mimetic compounds and their uses
AR073010A1 (en) 2008-08-12 2010-10-06 Takeda Pharmaceutical AMIDA COMPOUND WITH GPR52 AGONIST ACTIVITY
US9173706B2 (en) 2008-08-25 2015-11-03 Covidien Lp Dual-band dipole microwave ablation antenna
WO2010132992A1 (en) 2009-05-20 2010-11-25 UNIVERSITé LAVAL Compounds for the inhibition of herpesviruses
US8906913B2 (en) 2009-06-26 2014-12-09 Panacea Biotec Limited Azabicyclohexanes
WO2011005842A1 (en) 2009-07-09 2011-01-13 Gilead Sciences, Inc. Anti-rsv compounds
CN102656141B (en) 2009-10-13 2016-04-06 利亘制药公司 Micromolecular compound of simulation hemopoieticgrowth factor and uses thereof
AR078793A1 (en) 2009-10-27 2011-12-07 Orion Corp DERIVATIVES OF NON-STEROID CARBOXAMIDS AND ACIL HYDRAZONE MODULATORS OF ANDROGENIC RECEPTORS OF SELECTIVE FABRIC (SARM), PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE OF THE SAME IN THE TREATMENT OF PROSTATE CANCER BETWEEN OTHERS
ES2360333B1 (en) 2009-10-29 2012-05-04 Consejo Superior De Investigaciones Cientificas (Csic) (70%) DERIVATIVES OF BIS (ARALQUIL) AMINO AND AROMATICS SYSTEMS OF SIX MEMBERS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE PATHOLOGIES, INCLUDING ALZHEIMER'S DISEASE
MY159151A (en) 2009-12-04 2016-12-15 Nissan Chemical Ind Ltd 2-pyridone compounds
WO2011088181A1 (en) 2010-01-13 2011-07-21 Tempero Pharmaceuticals, Inc. Compounds and methods
WO2011097607A1 (en) * 2010-02-08 2011-08-11 Southern Research Institute Anti-viral treatment and assay to screen for anti-viral agent
CA2789474A1 (en) 2010-03-04 2011-09-09 Merck Sharp & Dohme Corp. Inhibitors of catechol o-methyl transferase and their use in the treatment of psychotic disorders
US8809377B2 (en) * 2010-09-24 2014-08-19 The Regents Of The University Of Michigan Deubiquitinase inhibitors and methods for use of the same
EP2642994A2 (en) 2010-11-18 2013-10-02 Ligand Pharmaceuticals Incorporated Use of hematopoietic growth factor mimetics
EP2548877A1 (en) 2011-07-19 2013-01-23 MSD Oss B.V. 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors
WO2013055793A1 (en) 2011-10-12 2013-04-18 University Of Pittsburg-Of The Commonwealth System Of Higher Education Small molecules targeting androgen receptor nuclear localization and/or level in prostate cancer
WO2013059119A1 (en) 2011-10-17 2013-04-25 The Regents Of The University Of Michigan Glucosylceramide synthase inhibitors and therapeutic methods using the same
US20140287916A1 (en) 2011-11-04 2014-09-25 Syngenta Participations Ag Pesticidal compounds
ES2779748T3 (en) * 2012-08-23 2020-08-19 Janssen Biopharma Inc Compounds for the treatment of paramyxovirus infections
JP6485817B2 (en) 2013-08-21 2019-03-20 ヤンセン バイオファーマ インク． Antiviral compound
MA41614A (en) 2015-02-25 2018-01-02 Alios Biopharma Inc ANTIVIRAL COMPOUNDS

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