JP2011037901A5 - - Google Patents
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- Publication number
- JP2011037901A5 JP2011037901A5 JP2010261857A JP2010261857A JP2011037901A5 JP 2011037901 A5 JP2011037901 A5 JP 2011037901A5 JP 2010261857 A JP2010261857 A JP 2010261857A JP 2010261857 A JP2010261857 A JP 2010261857A JP 2011037901 A5 JP2011037901 A5 JP 2011037901A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- hydrochloride
- tandospirone
- buspirone
- amd
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- WVHBEIJGAINUBW-UHFFFAOYSA-N Xaliproden hydrochloride Chemical compound Cl.FC(F)(F)C1=CC=CC(C=2CCN(CCC=3C=C4C=CC=CC4=CC=3)CC=2)=C1 WVHBEIJGAINUBW-UHFFFAOYSA-N 0.000 claims 4
- 206010064930 age-related macular degeneration Diseases 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 208000002780 macular degeneration Diseases 0.000 claims 4
- IGKYREHZJIHPML-UNTBIKODSA-N 2-[4-[[(2r)-3,4-dihydro-2h-chromen-2-yl]methylamino]butyl]-1,1-dioxo-1,2-benzothiazol-3-one;hydron;chloride Chemical compound Cl.O=S1(=O)C2=CC=CC=C2C(=O)N1CCCCNC[C@@H]1OC2=CC=CC=C2CC1 IGKYREHZJIHPML-UNTBIKODSA-N 0.000 claims 2
- QWCRAEMEVRGPNT-UHFFFAOYSA-N buspirone Chemical compound C1C(=O)N(CCCCN2CCN(CC2)C=2N=CC=CN=2)C(=O)CC21CCCC2 QWCRAEMEVRGPNT-UHFFFAOYSA-N 0.000 claims 2
- 229960002495 buspirone Drugs 0.000 claims 2
- 239000003723 serotonin 1A agonist Substances 0.000 claims 2
- CEIJFEGBUDEYSX-FZDBZEDMSA-N tandospirone Chemical compound O=C([C@@H]1[C@H]2CC[C@H](C2)[C@@H]1C1=O)N1CCCCN(CC1)CCN1C1=NC=CC=N1 CEIJFEGBUDEYSX-FZDBZEDMSA-N 0.000 claims 2
- 229950000505 tandospirone Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19027900P | 2000-03-17 | 2000-03-17 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001568420A Division JP4789231B2 (ja) | 2000-03-17 | 2001-02-23 | 網膜外縁部障害の処置に有用な５−ｈｔ１ａ活性を有する化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011037901A JP2011037901A (ja) | 2011-02-24 |
| JP2011037901A5 true JP2011037901A5 (enExample) | 2012-01-05 |
Family
ID=22700682
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001568421A Pending JP2003527423A (ja) | 2000-03-17 | 2001-02-20 | 緑内障処置用の５−ｈｔ２および５−ｈｔ１ａアゴニスト活性を有する化合物 |
| JP2001568428A Withdrawn JP2003527427A (ja) | 2000-03-17 | 2001-02-23 | 視野損失を抑制するのに有用な５−ｈｔ活性を有する化合物 |
| JP2001568420A Expired - Fee Related JP4789231B2 (ja) | 2000-03-17 | 2001-02-23 | 網膜外縁部障害の処置に有用な５−ｈｔ１ａ活性を有する化合物 |
| JP2010261857A Withdrawn JP2011037901A (ja) | 2000-03-17 | 2010-11-24 | 網膜外縁部障害の処置に有用な５−ｈｔ１ａ活性を有する化合物 |
| JP2011108785A Withdrawn JP2011153158A (ja) | 2000-03-17 | 2011-05-13 | 網膜外縁部障害の処置に有用な５−ｈｔ１ａ活性を有する化合物 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001568421A Pending JP2003527423A (ja) | 2000-03-17 | 2001-02-20 | 緑内障処置用の５−ｈｔ２および５−ｈｔ１ａアゴニスト活性を有する化合物 |
| JP2001568428A Withdrawn JP2003527427A (ja) | 2000-03-17 | 2001-02-23 | 視野損失を抑制するのに有用な５−ｈｔ活性を有する化合物 |
| JP2001568420A Expired - Fee Related JP4789231B2 (ja) | 2000-03-17 | 2001-02-23 | 網膜外縁部障害の処置に有用な５−ｈｔ１ａ活性を有する化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011108785A Withdrawn JP2011153158A (ja) | 2000-03-17 | 2011-05-13 | 網膜外縁部障害の処置に有用な５−ｈｔ１ａ活性を有する化合物 |
Country Status (18)
| Country | Link |
|---|---|
| EP (3) | EP1263434A1 (enExample) |
| JP (5) | JP2003527423A (enExample) |
| KR (3) | KR20030016239A (enExample) |
| CN (2) | CN1418100A (enExample) |
| AR (1) | AR028258A1 (enExample) |
| AT (1) | ATE247507T1 (enExample) |
| AU (5) | AU2001238552A1 (enExample) |
| BR (3) | BR0109193A (enExample) |
| CA (3) | CA2400637A1 (enExample) |
| DE (1) | DE60100625T2 (enExample) |
| DK (1) | DK1263504T3 (enExample) |
| ES (1) | ES2204848T3 (enExample) |
| MX (3) | MXPA02009071A (enExample) |
| PL (1) | PL203709B1 (enExample) |
| PT (1) | PT1263504E (enExample) |
| TW (1) | TWI268777B (enExample) |
| WO (3) | WO2001070223A1 (enExample) |
| ZA (1) | ZA200206350B (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6960579B1 (en) | 1998-05-19 | 2005-11-01 | Alcon Manufacturing, Ltd. | Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders |
| EP1263434A1 (en) * | 2000-03-17 | 2002-12-11 | Alcon, Inc | Compounds with 5-ht 2 and 5-ht 1a agonist activity for treating glaucoma |
| US20030207890A1 (en) | 2001-02-23 | 2003-11-06 | Collier Robert J | Compounds with 5-ht1a activity useful for treating disorders of the outer retina |
| TW593302B (en) | 2001-12-20 | 2004-06-21 | Alcon Inc | Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma |
| AU2003300915B2 (en) | 2002-12-13 | 2008-08-28 | Alcon, Inc. | Novel benzopyran analogs and their use for the treatment of glaucoma |
| JP2004262812A (ja) * | 2003-02-28 | 2004-09-24 | Rohto Pharmaceut Co Ltd | 眼圧低下剤 |
| CA2520813C (en) * | 2003-04-25 | 2009-10-27 | Mitsubishi Pharma Corporation | Sustained release formulations of alkylene dioxybenzene derivatives useful as 5-ht1a agonists |
| WO2005053688A1 (en) | 2003-11-26 | 2005-06-16 | Alcon, Inc. | Substituted furo[2,3-g] indazoles for the treatment of glaucoma |
| US7338972B1 (en) | 2003-12-15 | 2008-03-04 | Alcon, Inc. | Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma |
| US7129257B1 (en) | 2003-12-15 | 2006-10-31 | Alcon, Inc. | Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma |
| AR046890A1 (es) | 2003-12-15 | 2005-12-28 | Alcon Inc | [1,4] oxazino [2,3-g] indazoles sustituidos para el tratamiento del glaucoma. |
| US20050244463A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular vasculopathies |
| EP2400300A1 (en) | 2004-08-25 | 2011-12-28 | Takeda Pharmaceutical Company Limited | Method of screening preventives/remedies for stress urinary incontinence |
| WO2006062839A1 (en) | 2004-12-08 | 2006-06-15 | Alcon, Inc. | Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma |
| WO2007132841A1 (ja) | 2006-05-16 | 2007-11-22 | Takeda Pharmaceutical Company Limited | 縮合複素環化合物およびその用途 |
| WO2008024846A2 (en) * | 2006-08-25 | 2008-02-28 | Allergan, Inc. | Brimonidine and timolol compositions |
| EP2896624B1 (en) | 2007-03-28 | 2016-07-13 | Atir Holding S.A. | Heterotricyclic compounds as serotonergic and/or dopaminergic agents and uses thereof |
| JP5520051B2 (ja) | 2007-11-15 | 2014-06-11 | 武田薬品工業株式会社 | 縮合ピリジン誘導体およびその用途 |
| TW201010727A (en) * | 2008-09-03 | 2010-03-16 | Alcon Res Ltd | Pharmaceutical composition having relatively low ionic strength |
| US20110124736A1 (en) | 2009-11-09 | 2011-05-26 | Allergan, Inc. | Compositions and methods for stimulating hair growth |
| JPWO2011071136A1 (ja) | 2009-12-11 | 2013-04-22 | アステラス製薬株式会社 | 線維筋痛症治療剤 |
| RU2641021C2 (ru) | 2013-02-15 | 2018-01-17 | Аллерган, Инк. | Имплантат для пролонгированной доставки лекарственного средства |
| WO2018064465A1 (en) | 2016-09-29 | 2018-04-05 | The Regents Of The University Of California | Compounds for increasing neural plasticity |
| US20210052600A1 (en) | 2017-12-27 | 2021-02-25 | Takeda Pharmaceutical Company Limited | Therapeutic agents for stress urinary incontinence and incotinence of feces |
| CA3130770A1 (en) | 2019-02-27 | 2020-09-03 | The Regents Of The University Of California | Azepino-indoles and other heterocycles for treating brain disorders |
| KR20210134928A (ko) | 2019-02-27 | 2021-11-11 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 뇌 장애를 치료하기 위한 n-치환된 인돌 및 다른 헤테로사이클 |
| TW202333668A (zh) | 2021-12-15 | 2023-09-01 | 美商德利克斯醫療公司 | 經苯氧基及苄氧基取代之精神成形素(psychoplastogen)及其用途 |
| JP2024546180A (ja) * | 2021-12-23 | 2024-12-17 | シルケア ディーイーヴィ | 聴覚疾患の治療のための４－フェニル－テトラヒドロピリジン誘導体 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02262518A (ja) * | 1989-04-03 | 1990-10-25 | Kaken Pharmaceut Co Ltd | 眼圧調整剤 |
| JP2824863B2 (ja) * | 1989-07-12 | 1998-11-18 | エーザイ株式会社 | α▲下１▼―ブロッカー点眼剤 |
| TW270114B (enExample) * | 1993-10-22 | 1996-02-11 | Hoffmann La Roche | |
| US5521183A (en) * | 1994-08-30 | 1996-05-28 | Allergan | Use of 5-HT ligands as anti-pruritic agents |
| US5998467A (en) * | 1995-10-25 | 1999-12-07 | Mitsubishi Chemical Corporation | Medicine for oculopathy |
| JP3958391B2 (ja) * | 1995-10-25 | 2007-08-15 | 三菱化学株式会社 | 眼疾患用薬剤 |
| WO1998018458A1 (en) * | 1996-10-31 | 1998-05-07 | Alcon Laboratories, Inc. | Opthalmological compositions containing serotonin 5-ht1a receptor agonist and their use in the treatment of glaucoma |
| DE19751949A1 (de) * | 1997-11-24 | 1999-05-27 | Bayer Ag | Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration |
| GB9819033D0 (en) * | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds VI |
| EP1263434A1 (en) * | 2000-03-17 | 2002-12-11 | Alcon, Inc | Compounds with 5-ht 2 and 5-ht 1a agonist activity for treating glaucoma |
-
2001
- 2001-02-20 EP EP01911005A patent/EP1263434A1/en not_active Withdrawn
- 2001-02-20 AU AU2001238552A patent/AU2001238552A1/en not_active Abandoned
- 2001-02-20 JP JP2001568421A patent/JP2003527423A/ja active Pending
- 2001-02-20 KR KR1020027012169A patent/KR20030016239A/ko not_active Withdrawn
- 2001-02-20 BR BR0109193-0A patent/BR0109193A/pt not_active Application Discontinuation
- 2001-02-20 MX MXPA02009071A patent/MXPA02009071A/es unknown
- 2001-02-20 WO PCT/US2001/005432 patent/WO2001070223A1/en not_active Ceased
- 2001-02-20 CA CA002400637A patent/CA2400637A1/en not_active Abandoned
- 2001-02-23 AU AU2001245310A patent/AU2001245310B2/en not_active Ceased
- 2001-02-23 WO PCT/US2001/005740 patent/WO2001070230A2/en not_active Ceased
- 2001-02-23 ES ES01918208T patent/ES2204848T3/es not_active Expired - Lifetime
- 2001-02-23 JP JP2001568428A patent/JP2003527427A/ja not_active Withdrawn
- 2001-02-23 AU AU4531001A patent/AU4531001A/xx active Pending
- 2001-02-23 JP JP2001568420A patent/JP4789231B2/ja not_active Expired - Fee Related
- 2001-02-23 AU AU2001239836A patent/AU2001239836A1/en not_active Abandoned
- 2001-02-23 CN CN01806620A patent/CN1418100A/zh active Pending
- 2001-02-23 DE DE60100625T patent/DE60100625T2/de not_active Expired - Lifetime
- 2001-02-23 KR KR1020027012171A patent/KR20030009390A/ko not_active Withdrawn
- 2001-02-23 KR KR1020027012170A patent/KR100749191B1/ko not_active Expired - Fee Related
- 2001-02-23 EP EP01918208A patent/EP1263504B1/en not_active Expired - Lifetime
- 2001-02-23 BR BR0109211-1A patent/BR0109211A/pt not_active Application Discontinuation
- 2001-02-23 DK DK01918208T patent/DK1263504T3/da active
- 2001-02-23 EP EP01914447A patent/EP1267878A2/en not_active Withdrawn
- 2001-02-23 BR BR0109230-8A patent/BR0109230A/pt not_active Application Discontinuation
- 2001-02-23 AT AT01918208T patent/ATE247507T1/de active
- 2001-02-23 PT PT01918208T patent/PT1263504E/pt unknown
- 2001-02-23 CA CA002399985A patent/CA2399985A1/en not_active Abandoned
- 2001-02-23 PL PL358306A patent/PL203709B1/pl not_active IP Right Cessation
- 2001-02-23 CA CA2400639A patent/CA2400639C/en not_active Expired - Fee Related
- 2001-02-23 MX MXPA02009072A patent/MXPA02009072A/es active IP Right Grant
- 2001-02-23 CN CNB018067646A patent/CN1198605C/zh not_active Expired - Fee Related
- 2001-02-23 MX MXPA02009073A patent/MXPA02009073A/es unknown
- 2001-02-23 WO PCT/US2001/005700 patent/WO2001070222A2/en not_active Ceased
- 2001-03-15 AR ARP010101211A patent/AR028258A1/es not_active Application Discontinuation
- 2001-03-16 TW TW090106235A patent/TWI268777B/zh not_active IP Right Cessation
-
2002
- 2002-08-08 ZA ZA200206350A patent/ZA200206350B/en unknown
-
2005
- 2005-06-15 AU AU2005202600A patent/AU2005202600B2/en not_active Ceased
-
2010
- 2010-11-24 JP JP2010261857A patent/JP2011037901A/ja not_active Withdrawn
-
2011
- 2011-05-13 JP JP2011108785A patent/JP2011153158A/ja not_active Withdrawn
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