JP6495908B2 - ピリジノン - Google Patents
ピリジノン Download PDFInfo
- Publication number
- JP6495908B2 JP6495908B2 JP2016533909A JP2016533909A JP6495908B2 JP 6495908 B2 JP6495908 B2 JP 6495908B2 JP 2016533909 A JP2016533909 A JP 2016533909A JP 2016533909 A JP2016533909 A JP 2016533909A JP 6495908 B2 JP6495908 B2 JP 6495908B2
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- mmol
- substituted
- compound according
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CC([C@@]1N(*)c2cc(*)c(*)cc2N1)=I*N(*)C(C(*)=C)=O Chemical compound CC([C@@]1N(*)c2cc(*)c(*)cc2N1)=I*N(*)C(C(*)=C)=O 0.000 description 15
- ZSIUXTUVHIYRKJ-UHFFFAOYSA-N CC(C1)C(N)=NNC1=O Chemical compound CC(C1)C(N)=NNC1=O ZSIUXTUVHIYRKJ-UHFFFAOYSA-N 0.000 description 2
- WSSJEINFFUTORW-UHFFFAOYSA-N CC(C1)C(c(cc2)cc(N)c2NCc2ccccc2)=NNC1=O Chemical compound CC(C1)C(c(cc2)cc(N)c2NCc2ccccc2)=NNC1=O WSSJEINFFUTORW-UHFFFAOYSA-N 0.000 description 1
- JPKADUBXIMIGGU-UHFFFAOYSA-N CC(c(cc1NCc2ccccn2)ncc1[N+]([O-])=O)=C Chemical compound CC(c(cc1NCc2ccccn2)ncc1[N+]([O-])=O)=C JPKADUBXIMIGGU-UHFFFAOYSA-N 0.000 description 1
- AWNBPGRFIZUPKD-UHFFFAOYSA-N CC(c1ncccc1)[n]1c(C(C=C2C)=CN(C)C2=O)nc(cn2)c1cc2OCC1CC1 Chemical compound CC(c1ncccc1)[n]1c(C(C=C2C)=CN(C)C2=O)nc(cn2)c1cc2OCC1CC1 AWNBPGRFIZUPKD-UHFFFAOYSA-N 0.000 description 1
- UBHABGPIPKAICI-UHFFFAOYSA-N CC1=CC(c([n](Cc2ccccc2)c2c3)nc2ccc3N)=CN(C)C1=O Chemical compound CC1=CC(c([n](Cc2ccccc2)c2c3)nc2ccc3N)=CN(C)C1=O UBHABGPIPKAICI-UHFFFAOYSA-N 0.000 description 1
- RGZCKPXTNJAWMR-UHFFFAOYSA-N CN(C=C(C=C1)C(O)=O)C1=O Chemical compound CN(C=C(C=C1)C(O)=O)C1=O RGZCKPXTNJAWMR-UHFFFAOYSA-N 0.000 description 1
- ITRUWWKXJNZPFX-UHFFFAOYSA-N CN(CC1)CCN1c(cc1)nc(NCc2ccccc2)c1N Chemical compound CN(CC1)CCN1c(cc1)nc(NCc2ccccc2)c1N ITRUWWKXJNZPFX-UHFFFAOYSA-N 0.000 description 1
- KQBMBZGNIPGFCG-UHFFFAOYSA-N CN(CC1)CCN1c1ccc2nc(C(C=C3)=CN(C)C3=O)[n](Cc3ccccc3)c2n1 Chemical compound CN(CC1)CCN1c1ccc2nc(C(C=C3)=CN(C)C3=O)[n](Cc3ccccc3)c2n1 KQBMBZGNIPGFCG-UHFFFAOYSA-N 0.000 description 1
- OYGPOBCNKHZOPZ-UHFFFAOYSA-N Nc(c(NCc1ccccc1)c1)cnc1N1CCOCC1 Chemical compound Nc(c(NCc1ccccc1)c1)cnc1N1CCOCC1 OYGPOBCNKHZOPZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13180404 | 2013-08-14 | ||
| EP13180404.9 | 2013-08-14 | ||
| PCT/EP2014/067263 WO2015022332A1 (en) | 2013-08-14 | 2014-08-12 | Pyridinones |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016530259A JP2016530259A (ja) | 2016-09-29 |
| JP2016530259A5 JP2016530259A5 (enExample) | 2017-09-21 |
| JP6495908B2 true JP6495908B2 (ja) | 2019-04-03 |
Family
ID=48951412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016533909A Active JP6495908B2 (ja) | 2013-08-14 | 2014-08-12 | ピリジノン |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20150051208A1 (enExample) |
| EP (1) | EP3033335B1 (enExample) |
| JP (1) | JP6495908B2 (enExample) |
| WO (1) | WO2015022332A1 (enExample) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9266891B2 (en) | 2012-11-16 | 2016-02-23 | Boehringer Ingelheim International Gmbh | Substituted [1,2,4]triazolo[4,3-A]pyrazines that are BRD4 inhibitors |
| US9271978B2 (en) | 2012-12-21 | 2016-03-01 | Zenith Epigenetics Corp. | Heterocyclic compounds as bromodomain inhibitors |
| WO2015004533A2 (en) | 2013-06-21 | 2015-01-15 | Zenith Epigenetics Corp. | Novel substituted bicyclic compounds as bromodomain inhibitors |
| SG11201510409QA (en) | 2013-06-21 | 2016-01-28 | Zenith Epigenetics Corp | Novel bicyclic bromodomain inhibitors |
| GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| AU2014298051B2 (en) | 2013-07-31 | 2018-11-15 | Zenith Epigenetics Ltd. | Novel quinazolinones as bromodomain inhibitors |
| DK3290407T3 (da) | 2013-10-18 | 2020-03-23 | Celgene Quanticel Res Inc | Bromodomæneinhibitorer |
| AU2013406206B2 (en) * | 2013-11-26 | 2017-07-20 | Gilead Sciences, Inc. | Quinoline derivatives as bromodomain inhibitors |
| GB201321737D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic Agents |
| WO2015086519A1 (en) * | 2013-12-09 | 2015-06-18 | Ucb Biopharma Sprl | Imidazopyridine derivatives as modulators of tnf activity |
| US20180228907A1 (en) | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| WO2016087942A1 (en) | 2014-12-01 | 2016-06-09 | Zenith Epigenetics Corp. | Substituted pyridines as bromodomain inhibitors |
| WO2016087936A1 (en) | 2014-12-01 | 2016-06-09 | Zenith Epigenetics Corp. | Substituted pyridinones as bromodomain inhibitors |
| CN107207474B (zh) | 2014-12-11 | 2021-05-07 | 恒翼生物医药科技(上海)有限公司 | 被取代的杂环作为溴结构域抑制剂 |
| CA2966450A1 (en) | 2014-12-17 | 2016-06-23 | Olesya KHARENKO | Inhibitors of bromodomains |
| GB201503720D0 (en) * | 2015-03-05 | 2015-04-22 | Glaxosmithkline Ip No 2 Ltd | Chemical compound |
| JP7269731B2 (ja) | 2015-03-18 | 2023-05-09 | アルビナス・オペレーションズ・インコーポレイテッド | 標的タンパク質の分解向上のための化合物および方法 |
| GB201504694D0 (en) | 2015-03-19 | 2015-05-06 | Glaxosmithkline Ip Dev Ltd | Covalent conjugates |
| GB201504689D0 (en) | 2015-03-19 | 2015-05-06 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
| GB201506660D0 (en) * | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| CN108137507A (zh) | 2015-07-10 | 2018-06-08 | 阿尔维纳斯股份有限公司 | 基于mdm2的蛋白水解调节剂和相关的使用方法 |
| AU2016301196B2 (en) | 2015-08-06 | 2022-09-08 | Dana-Farber Cancer Institute, Inc. | Tunable endogenous protein degradation |
| WO2017024406A1 (en) | 2015-08-11 | 2017-02-16 | Neomed Institute | N-substituted bicyclic lactams, their preparation and their use as pharmaceuticals |
| EP3334717B1 (en) | 2015-08-11 | 2020-07-01 | Neomed Institute | Aryl-substituted dihydroquinolinones, their preparation and their use as pharmaceuticals |
| CA2994478C (en) * | 2015-08-12 | 2023-10-03 | Neomed Institute | Substituted benzimidazoles, their preparation and their use as pharmaceuticals |
| EP3337476A4 (en) | 2015-08-19 | 2019-09-04 | Arvinas, Inc. | Compounds and methods for the targeted degradation of bromodomain-containing proteins |
| WO2017066876A1 (en) | 2015-10-21 | 2017-04-27 | Neomed Institute | Substituted imidazopyridines, their preparation and their use as pharmaceuticals |
| CA3007168A1 (en) * | 2015-12-14 | 2017-06-22 | Zenith Epigenetics Ltd. | 1h-imidazo[4,5-b]pyridinyl and 2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridinyl heterocyclic bet bromodomain inhibitors |
| WO2017127930A1 (en) * | 2016-01-28 | 2017-08-03 | Neomed Institute | Substituted [1,2,4]triazolo[4,3-a]pyridines, their preparation and their use as pharmaceuticals |
| ES3037659T3 (en) | 2016-03-30 | 2025-10-03 | Wisconsin Alumni Res Found | Methods and compositions for modulating frataxin expression |
| US20170281784A1 (en) | 2016-04-05 | 2017-10-05 | Arvinas, Inc. | Protein-protein interaction inducing technology |
| CN109641874A (zh) | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
| EP4483875A3 (en) | 2016-05-10 | 2025-04-02 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
| CN109562107A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的杂环降解决定子体 |
| EP3455219A4 (en) | 2016-05-10 | 2019-12-18 | C4 Therapeutics, Inc. | AMINE-RELATED C3-GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
| GB201614940D0 (en) * | 2016-09-02 | 2016-10-19 | Glaxosmithkline Intellectual Property (No 2) Ltd | Chemical compounds |
| GB201614939D0 (en) * | 2016-09-02 | 2016-10-19 | Glaxosmithkline Ip Dev Ltd | Crystalline hydrate |
| WO2018106667A1 (en) * | 2016-12-05 | 2018-06-14 | Microbiotix, Inc. | Broad-spectrum inhibitors of filoviruses |
| EP3577109A4 (en) | 2017-01-31 | 2020-11-18 | Arvinas Operations, Inc. | CEREMONY LIGANDS AND BIFUNCTIONAL COMPOUNDS CONTAINING THEM |
| EP3580212A4 (en) | 2017-02-08 | 2021-03-17 | Dana Farber Cancer Institute, Inc. | REGULATION OF CHEMERIC ANTIGEN RECEPTORS |
| WO2018183679A1 (en) | 2017-03-29 | 2018-10-04 | Wisconsin Alumni Research Foundation | Methods and compositions for modulating gene expression |
| EP3641762B1 (en) | 2017-06-20 | 2026-02-18 | C4 Therapeutics, Inc. | N/o-linked degrons and degronimers for protein degradation |
| CN109111437B (zh) * | 2017-06-22 | 2022-03-04 | 中国科学院广州生物医药与健康研究院 | 一种苯并[d]异恶唑类化合物及其制备方法和应用 |
| CN109280046B (zh) * | 2017-07-21 | 2021-02-02 | 浙江海正药业股份有限公司 | 苯并咪唑类衍生物及其制备方法及其在医药上的用途 |
| CN110997656B (zh) * | 2017-08-04 | 2023-04-14 | 百时美施贵宝公司 | 用作tlr7/8/9抑制剂的取代的吲哚化合物 |
| WO2019145410A1 (en) * | 2018-01-25 | 2019-08-01 | Boehringer Ingelheim International Gmbh | Combination treatment of acute myeloid leukemia |
| JP2021512153A (ja) | 2018-01-26 | 2021-05-13 | イエール ユニバーシティ | タンパク質分解のイミド系モジュレーターおよび使用方法 |
| US10442799B1 (en) | 2018-04-07 | 2019-10-15 | Fuqiang Ruan | Heterocyclic compounds and uses thereof |
| EP3774772A1 (en) | 2018-04-13 | 2021-02-17 | Arvinas Operations, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| CN120698983A (zh) | 2018-12-20 | 2025-09-26 | C4医药公司 | 靶向蛋白降解 |
| JP2022053557A (ja) * | 2019-02-08 | 2022-04-06 | マルホ株式会社 | ピリドン誘導体 |
| EP3958867B1 (en) * | 2019-04-24 | 2024-06-26 | Convergene Llc | Small molecule bromodomain inhibitors and uses thereof |
| TW202126638A (zh) | 2019-09-30 | 2021-07-16 | 日商協和麒麟股份有限公司 | Bet分解劑 |
| EP4077309A1 (en) | 2019-12-19 | 2022-10-26 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
| WO2021175432A1 (en) | 2020-03-04 | 2021-09-10 | Boehringer Ingelheim International Gmbh | Method for administration of an anti cancer agent |
| WO2024050016A1 (en) | 2022-08-31 | 2024-03-07 | Oerth Bio Llc | Compositions and methods for targeted inhibition and degradation of proteins in an insect cell |
| WO2025049555A1 (en) | 2023-08-31 | 2025-03-06 | Oerth Bio Llc | Compositions and methods for targeted inhibition and degradation of proteins in an insect cell |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004010207A1 (de) * | 2004-03-02 | 2005-09-15 | Aventis Pharma S.A. | Neue 4-Benzimidazol-2-yl-pyridazin-3-on-Derivate |
| KR20080107466A (ko) * | 2006-03-09 | 2008-12-10 | 파마코페이아, 인코포레이티드 | 대사 장애 치료용 8-헤테로아릴퓨린 ｍｎｋ2 억제제 |
| CL2007002867A1 (es) * | 2006-10-04 | 2008-06-27 | Pharmacopeia Inc | Compuestos derivados de 2-(bencimidazolil)purina, inhibidores de janus quinasa 3; composicion farmaceutica que los contiene; y su uso para tratar enfermedades autoinmune, inflamatorias, cardiovasculares, rechazo de implante, entre otras. |
| US8975247B2 (en) * | 2009-03-18 | 2015-03-10 | The Board Of Trustees Of The Leland Stanford Junion University | Methods and compositions of treating a flaviviridae family viral infection |
| EP2439197A1 (en) * | 2010-10-07 | 2012-04-11 | Santhera Pharmaceuticals (Schweiz) AG | Substituted benzimidazole derivatives as melanocortin 4 receptor antagonists |
-
2014
- 2014-08-11 US US14/456,038 patent/US20150051208A1/en not_active Abandoned
- 2014-08-12 WO PCT/EP2014/067263 patent/WO2015022332A1/en not_active Ceased
- 2014-08-12 JP JP2016533909A patent/JP6495908B2/ja active Active
- 2014-08-12 EP EP14750485.6A patent/EP3033335B1/en active Active
-
2015
- 2015-05-18 US US14/714,521 patent/US9296748B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US9296748B2 (en) | 2016-03-29 |
| WO2015022332A1 (en) | 2015-02-19 |
| US20150246919A1 (en) | 2015-09-03 |
| JP2016530259A (ja) | 2016-09-29 |
| US20150051208A1 (en) | 2015-02-19 |
| EP3033335A1 (en) | 2016-06-22 |
| EP3033335B1 (en) | 2020-04-15 |
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