JP2021500394A5 - - Google Patents
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- Publication number
- JP2021500394A5 JP2021500394A5 JP2020523748A JP2020523748A JP2021500394A5 JP 2021500394 A5 JP2021500394 A5 JP 2021500394A5 JP 2020523748 A JP2020523748 A JP 2020523748A JP 2020523748 A JP2020523748 A JP 2020523748A JP 2021500394 A5 JP2021500394 A5 JP 2021500394A5
- Authority
- JP
- Japan
- Prior art keywords
- halogen
- alkyl
- ring members
- compound according
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052736 halogen Inorganic materials 0.000 claims 23
- 150000002367 halogens Chemical class 0.000 claims 23
- 150000001875 compounds Chemical class 0.000 claims 22
- 229910052760 oxygen Inorganic materials 0.000 claims 17
- 229910052717 sulfur Inorganic materials 0.000 claims 16
- 125000003545 alkoxy group Chemical group 0.000 claims 15
- 125000001424 substituent group Chemical group 0.000 claims 15
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 14
- 125000005842 heteroatom Chemical group 0.000 claims 11
- 229910052805 deuterium Inorganic materials 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 229940002612 prodrug Drugs 0.000 claims 5
- 239000000651 prodrug Substances 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 4
- -1 C1-C4alkoxyl Chemical group 0.000 claims 4
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000006413 ring segment Chemical group 0.000 claims 4
- 125000003282 alkyl amino group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 125000001188 haloalkyl group Chemical group 0.000 claims 3
- 208000019423 liver disease Diseases 0.000 claims 3
- 125000006677 (C1-C3) haloalkoxy group Chemical group 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- 241000700721 Hepatitis B virus Species 0.000 claims 2
- 125000004423 acyloxy group Chemical group 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000004438 haloalkoxy group Chemical group 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 2
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 2
- 125000002861 (C1-C4) alkanoyl group Chemical group 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 241000711549 Hepacivirus C Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 125000003302 alkenyloxy group Chemical group 0.000 claims 1
- 125000000033 alkoxyamino group Chemical group 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000005754 cellular signaling Effects 0.000 claims 1
- 125000005265 dialkylamine group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000000262 haloalkenyl group Chemical group 0.000 claims 1
- 239000012678 infectious agent Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 244000045947 parasite Species 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023169347A JP2023182695A (ja) | 2017-10-27 | 2023-09-29 | αタンパク質キナーゼ１を活性化することによって免疫応答をモジュレートするための組成物および方法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2017/107962 | 2017-10-27 | ||
| CNPCT/CN2017/107962 | 2017-10-27 | ||
| CNPCT/CN2018/083153 | 2018-04-16 | ||
| CNPCT/CN2018/083153 | 2018-04-16 | ||
| CNPCT/CN2018/100871 | 2018-08-16 | ||
| CNPCT/CN2018/100871 | 2018-08-16 | ||
| PCT/CN2018/111885 WO2019080898A1 (en) | 2017-10-27 | 2018-10-25 | COMPOSITIONS AND METHODS FOR MODULATION OF IMMUNE RESPONSE BY ACTIVATION OF PROTEIN KINASE ALPHA 1 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023169347A Division JP2023182695A (ja) | 2017-10-27 | 2023-09-29 | αタンパク質キナーゼ１を活性化することによって免疫応答をモジュレートするための組成物および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021500394A JP2021500394A (ja) | 2021-01-07 |
| JP2021500394A5 true JP2021500394A5 (enExample) | 2021-12-02 |
Family
ID=66246202
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020523748A Pending JP2021500394A (ja) | 2017-10-27 | 2018-10-25 | αタンパク質キナーゼ１を活性化することによって免疫応答をモジュレートするための組成物および方法 |
| JP2023169347A Pending JP2023182695A (ja) | 2017-10-27 | 2023-09-29 | αタンパク質キナーゼ１を活性化することによって免疫応答をモジュレートするための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023169347A Pending JP2023182695A (ja) | 2017-10-27 | 2023-09-29 | αタンパク質キナーゼ１を活性化することによって免疫応答をモジュレートするための組成物および方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US11186606B2 (enExample) |
| EP (1) | EP3700536A4 (enExample) |
| JP (2) | JP2021500394A (enExample) |
| KR (1) | KR102733555B1 (enExample) |
| CN (1) | CN111565726A (enExample) |
| AU (1) | AU2018355487B2 (enExample) |
| CA (1) | CA3078267C (enExample) |
| WO (1) | WO2019080898A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| CN105939767B (zh) | 2014-01-08 | 2018-04-06 | 弗洛设计声能学公司 | 具有双声电泳腔的声电泳装置 |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| KR102669985B1 (ko) | 2015-06-30 | 2024-05-29 | 샌포드 번햄 프레비즈 메디컬 디스커버리 인스티튜트 | Btla 융합 단백질 작용제 및 이의 용도 |
| CN111565726A (zh) | 2017-10-27 | 2020-08-21 | 上海药苑生物科技有限公司 | 通过激活α蛋白激酶1调节免疫应答的组合物和方法 |
| CA3103724A1 (en) | 2018-06-14 | 2019-12-19 | National Institute Of Biological Sciences, Beijing | Promoting immune responses |
| EP3958870A1 (en) * | 2019-04-26 | 2022-03-02 | Shanghai Yao Yuan Biotechnology Co., Ltd. | Derivatives of glycero-manno-heptose adp for use in modulating immune response |
| WO2021231436A1 (en) * | 2020-05-11 | 2021-11-18 | The Board Of Trustees Of The Leland Stanford Junior University | Therapeutic methods for treating covid-19 infections |
| EP4196131A1 (en) * | 2020-08-14 | 2023-06-21 | Merck Sharp & Dohme LLC | Synthesis of fluorinated nucleotides |
| WO2022127914A1 (en) | 2020-12-18 | 2022-06-23 | Pyrotech (Beijing) Biotechnology Co., Ltd. | Nucleoside-thiodiphosphate-heptose compounds for treating conditions associated with alpk1 activity |
| CN118055936A (zh) * | 2021-09-30 | 2024-05-17 | 北京炎明生物科技有限公司 | 用于治疗与alpk1活性相关的病症的核苷-双磷酸-庚糖化合物 |
| CN116808216A (zh) * | 2022-07-06 | 2023-09-29 | 四川大学 | Alpk1基因作为脑缺血导致的中枢神经系统疾病的防治靶点的应用 |
| WO2025113626A2 (en) | 2023-11-30 | 2025-06-05 | Pyrotech (Beijing) Biotechnology Co., Ltd. | Salt forms of alpk1 activators |
| CN117517657B (zh) * | 2024-01-08 | 2024-04-09 | 中国农业科学院北京畜牧兽医研究所 | Lnx1基因或蛋白在调控禽类先天免疫应答反应中的应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE7611930U1 (de) | 1976-04-15 | 1977-01-13 | Filterwerk Mann & Hummel Gmbh, 7140 Ludwigsburg | Vorrichtung zum mischen von koernigem oder pulverfoermigem material mit einem oder mehreren zusatzstoffen |
| ES2389203T3 (es) | 2004-01-12 | 2012-10-24 | Ym Biosciences Australia Pty Ltd | Inhibidores de quinasa selectivos |
| US20070167408A1 (en) * | 2005-12-19 | 2007-07-19 | Zentaris Gmbh | Novel alkyl phospholipid derivatives with reduced cytotoxicity and uses thereof |
| US20100016250A1 (en) | 2006-04-14 | 2010-01-21 | Kyowa Hakko Kirin Co., Ltd. | Toll-like receptor 9 agonists |
| US20090098056A1 (en) | 2007-09-10 | 2009-04-16 | National Health Research Institute | Alpk1 gene variants in diagnosis risk of gout |
| US8071636B2 (en) | 2008-06-09 | 2011-12-06 | Allergan, Inc. | Methods of treating alpha adrenergic mediated conditions |
| CN201735264U (zh) | 2010-05-27 | 2011-02-09 | 蓝星化工有限责任公司 | 一种尘降器 |
| CN202590724U (zh) | 2010-12-20 | 2012-12-12 | 西安磁林电气有限公司 | 一种加料装置 |
| WO2013023084A2 (en) | 2011-08-09 | 2013-02-14 | Fred Hutchinson Cancer Research Center | Methods and compositions for inhibiting the growth and/or proliferation of myc-driven tumor cells |
| JP6272846B2 (ja) | 2012-06-27 | 2018-01-31 | ４エスツェー ディスカバリー ゲゼルシャフト ミット ベシュレンクテル ハフツング | 癌、自己免疫性炎症及びｃｎｓ疾患の処置のためのビフルオロジオキサラン−アミノ−ベンゾイミダゾールキナーゼ阻害剤 |
| GB201408100D0 (en) | 2014-05-07 | 2014-06-18 | Sec Dep For Health The | Detection method |
| CN204182373U (zh) | 2014-09-30 | 2015-03-04 | 天津博弘化工有限责任公司 | 流化床下料斗排气装置 |
| EP3204014B1 (en) | 2014-10-10 | 2020-07-01 | The Governing Council of the University of Toronto | Methods of modulating immune system responses |
| CN204973750U (zh) | 2015-05-26 | 2016-01-20 | 柳州钢铁股份有限公司 | 圆筒混合机刮料器 |
| EP3190062A1 (en) * | 2016-01-07 | 2017-07-12 | Pont Packaging B.V. | A cap construction with a storage space and a container provided therewith as well as a method of using same |
| CN105536635A (zh) | 2016-02-02 | 2016-05-04 | 珠海格力智能装备有限公司 | 一种车用尿素加料装置 |
| CN106582336B (zh) | 2016-12-13 | 2022-09-13 | 珠海格力智能装备有限公司 | 吸料装置及具有其的尿素机 |
| CN206366365U (zh) | 2016-12-13 | 2017-08-01 | 珠海格力智能装备有限公司 | 吸料装置及具有其的尿素机 |
| CN111565726A (zh) | 2017-10-27 | 2020-08-21 | 上海药苑生物科技有限公司 | 通过激活α蛋白激酶1调节免疫应答的组合物和方法 |
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2018
- 2018-10-25 CN CN201880081664.1A patent/CN111565726A/zh active Pending
- 2018-10-25 CA CA3078267A patent/CA3078267C/en active Active
- 2018-10-25 EP EP18869754.4A patent/EP3700536A4/en active Pending
- 2018-10-25 AU AU2018355487A patent/AU2018355487B2/en active Active
- 2018-10-25 KR KR1020207012233A patent/KR102733555B1/ko active Active
- 2018-10-25 JP JP2020523748A patent/JP2021500394A/ja active Pending
- 2018-10-25 US US16/759,426 patent/US11186606B2/en active Active
- 2018-10-25 WO PCT/CN2018/111885 patent/WO2019080898A1/en not_active Ceased
-
2019
- 2019-04-26 US US16/395,463 patent/US11149051B2/en active Active
-
2021
- 2021-08-16 US US17/445,122 patent/US11840551B2/en active Active
- 2021-08-16 US US17/445,113 patent/US11773131B2/en active Active
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2023
- 2023-09-29 JP JP2023169347A patent/JP2023182695A/ja active Pending
- 2023-10-30 US US18/497,384 patent/US20240124511A1/en not_active Abandoned