KR102733555B1 - 알파 단백질 키나제 1의 활성화에 의해 면역 반응을 조절하는 조성물 및 방법 - Google Patents

알파 단백질 키나제 1의 활성화에 의해 면역 반응을 조절하는 조성물 및 방법 Download PDF

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KR102733555B1
KR102733555B1 KR1020207012233A KR20207012233A KR102733555B1 KR 102733555 B1 KR102733555 B1 KR 102733555B1 KR 1020207012233 A KR1020207012233 A KR 1020207012233A KR 20207012233 A KR20207012233 A KR 20207012233A KR 102733555 B1 KR102733555 B1 KR 102733555B1
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delete delete
compound
virus
alpk1
mmol
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KR20200090154A (ko
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티안 수
콩 수
단양 리우
지에칭 판
얀팡 판
통루에이 레이몬드 리
샤오동 첸
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상하이 야오 유안 바이오테크놀로지 컴퍼니 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
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    • C07H19/06—Pyrimidine radicals
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
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    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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KR1020207012233A 2017-10-27 2018-10-25 알파 단백질 키나제 1의 활성화에 의해 면역 반응을 조절하는 조성물 및 방법 Active KR102733555B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CNPCT/CN2017/107962 2017-10-27
CNPCT/CN2017/107962 2017-10-27
CNPCT/CN2018/083153 2018-04-16
CNPCT/CN2018/083153 2018-04-16
CNPCT/CN2018/100871 2018-08-16
CNPCT/CN2018/100871 2018-08-16
PCT/CN2018/111885 WO2019080898A1 (en) 2017-10-27 2018-10-25 COMPOSITIONS AND METHODS FOR MODULATION OF IMMUNE RESPONSE BY ACTIVATION OF PROTEIN KINASE ALPHA 1

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KR20200090154A KR20200090154A (ko) 2020-07-28
KR102733555B1 true KR102733555B1 (ko) 2024-11-25

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US (5) US11186606B2 (enExample)
EP (1) EP3700536A4 (enExample)
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CN (1) CN111565726A (enExample)
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CN111565726A (zh) 2017-10-27 2020-08-21 上海药苑生物科技有限公司 通过激活α蛋白激酶1调节免疫应答的组合物和方法
CA3103724A1 (en) 2018-06-14 2019-12-19 National Institute Of Biological Sciences, Beijing Promoting immune responses
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WO2021231436A1 (en) * 2020-05-11 2021-11-18 The Board Of Trustees Of The Leland Stanford Junior University Therapeutic methods for treating covid-19 infections
EP4196131A1 (en) * 2020-08-14 2023-06-21 Merck Sharp & Dohme LLC Synthesis of fluorinated nucleotides
WO2022127914A1 (en) 2020-12-18 2022-06-23 Pyrotech (Beijing) Biotechnology Co., Ltd. Nucleoside-thiodiphosphate-heptose compounds for treating conditions associated with alpk1 activity
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CN116808216A (zh) * 2022-07-06 2023-09-29 四川大学 Alpk1基因作为脑缺血导致的中枢神经系统疾病的防治靶点的应用
WO2025113626A2 (en) 2023-11-30 2025-06-05 Pyrotech (Beijing) Biotechnology Co., Ltd. Salt forms of alpk1 activators
CN117517657B (zh) * 2024-01-08 2024-04-09 中国农业科学院北京畜牧兽医研究所 Lnx1基因或蛋白在调控禽类先天免疫应答反应中的应用

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AU2018355487A1 (en) 2020-04-23
US11186606B2 (en) 2021-11-30
US11773131B2 (en) 2023-10-03
US11840551B2 (en) 2023-12-12
EP3700536A1 (en) 2020-09-02
CN111565726A (zh) 2020-08-21
WO2019080898A1 (en) 2019-05-02
US20240124511A1 (en) 2024-04-18
CA3078267A1 (en) 2019-05-02
CA3078267C (en) 2024-06-18
JP2023182695A (ja) 2023-12-26
AU2018355487A2 (en) 2020-05-21
JP2021500394A (ja) 2021-01-07
KR20200090154A (ko) 2020-07-28
US11149051B2 (en) 2021-10-19
EP3700536A4 (en) 2021-11-17
US20210403501A1 (en) 2021-12-30
US20200283468A1 (en) 2020-09-10
AU2018355487B2 (en) 2023-09-21
US20190367553A1 (en) 2019-12-05
US20220017560A1 (en) 2022-01-20

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