JP2021530442A5 - - Google Patents

Info

Publication number
JP2021530442A5
JP2021530442A5 JP2020570791A JP2020570791A JP2021530442A5 JP 2021530442 A5 JP2021530442 A5 JP 2021530442A5 JP 2020570791 A JP2020570791 A JP 2020570791A JP 2020570791 A JP2020570791 A JP 2020570791A JP 2021530442 A5 JP2021530442 A5 JP 2021530442A5
Authority
JP
Japan
Prior art keywords
alkyl
group
heterocyclyl
cycloalkyl
heteroaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2020570791A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021530442A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/039860 external-priority patent/WO2020006432A1/en
Publication of JP2021530442A publication Critical patent/JP2021530442A/ja
Publication of JP2021530442A5 publication Critical patent/JP2021530442A5/ja
Pending legal-status Critical Current

Links

JP2020570791A 2018-06-28 2019-06-28 縮合三環系複素環化合物およびその治療上の使用 Pending JP2021530442A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862691208P 2018-06-28 2018-06-28
US62/691,208 2018-06-28
PCT/US2019/039860 WO2020006432A1 (en) 2018-06-28 2019-06-28 Fused tricyclic heterocycle compounds and therapeutic uses thereof

Publications (2)

Publication Number Publication Date
JP2021530442A JP2021530442A (ja) 2021-11-11
JP2021530442A5 true JP2021530442A5 (enExample) 2022-06-22

Family

ID=68987618

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020570791A Pending JP2021530442A (ja) 2018-06-28 2019-06-28 縮合三環系複素環化合物およびその治療上の使用

Country Status (7)

Country Link
US (1) US11535633B2 (enExample)
EP (1) EP3813827A4 (enExample)
JP (1) JP2021530442A (enExample)
KR (1) KR20210025016A (enExample)
CN (1) CN112351778B (enExample)
TW (1) TW202019408A (enExample)
WO (1) WO2020006432A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3802534B1 (en) 2018-05-25 2022-07-13 Incyte Corporation Tricyclic heterocyclic compounds as sting activators
US10875872B2 (en) 2018-07-31 2020-12-29 Incyte Corporation Heteroaryl amide compounds as sting activators
WO2020028565A1 (en) 2018-07-31 2020-02-06 Incyte Corporation Tricyclic heteraryl compounds as sting activators
AU2019326633B2 (en) * 2018-08-24 2022-09-08 Adlai Nortye Biopharma Co., Ltd. High activity sting protein agonist
CA3110474C (en) * 2018-08-29 2024-04-23 Adlai Nortye Biopharma Co., Ltd. Highly active sting protein agonist compound
US11596692B1 (en) 2018-11-21 2023-03-07 Incyte Corporation PD-L1/STING conjugates and methods of use
CN113195473B (zh) * 2018-12-14 2022-11-22 江苏恒瑞医药股份有限公司 三环化合物作为sting激动剂及其制备方法和医药用途
WO2020146237A1 (en) 2019-01-07 2020-07-16 Incyte Corporation Heteroaryl amide compounds as sting activators
KR20220056176A (ko) 2019-08-02 2022-05-04 메르사나 테라퓨틱스, 인코포레이티드 암 치료를 위한 sting(인터페론 유전자의 자극인자) 작용제로서의 비스-[n-((5-카바모일)-1h-벤조[d]이미다졸-2-일)-피라졸-5-카복사미드] 유도체 및 관련 화합물
CN116196435B (zh) 2020-04-02 2025-12-02 梅尔莎纳医疗公司 包含sting激动剂的抗体药物缀合物
US20230141284A1 (en) 2020-04-10 2023-05-11 Ono Pharmaceutical Co., Ltd. Cancer therapeutic method
CN115554303B (zh) * 2021-09-18 2024-07-09 上海科技大学 一种三环类化合物、其制备方法及其应用
WO2023158862A2 (en) * 2022-02-21 2023-08-24 Geode Therapeutics Inc. Stimulator of interferon genes (sting) modulators, and compositions and methods thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2731708B1 (fr) * 1995-03-13 1997-04-30 Synthelabo Derives de piperidine, leur procede de preparation et leur application en therapeutique
FR2747678B1 (fr) * 1996-04-22 1998-05-22 Synthelabo Composes derives d'imidazobenzoxazine, leurs procedes de preparation et leurs utilisations en therapeutique
CA2332239A1 (en) * 1998-05-15 1999-11-25 Guilford Pharmaceuticals Inc. Fused tricyclic compounds which inhibit parp activity
ECSP003637A (es) 1999-08-31 2002-03-25 Agouron Pharma Inhibidores triciclicos de poli (adp-ribosa) polimerasas
CA2324090A1 (en) 1999-10-25 2001-04-25 Leviton Manufacturing Co., Inc. Electrical wiring device with multiple types of wire terminations
MX2008001152A (es) * 2005-08-05 2008-04-02 Astrazeneca Ab Benzimidazoles triciclicos y su uso como moduladores del receptor de glutamato metabotropico.
EP2324044A4 (en) 2008-08-04 2012-04-25 Univ Miami STING (STIMULATOR OF INTERFERON GENES) AS A REGULATOR OF BORROWING IMMUNE REACTIONS
US8653089B2 (en) * 2011-02-09 2014-02-18 F. Hoffmann-La Roche Ag Heterocyclic compounds and methods of use
AU2013256468A1 (en) 2012-04-30 2014-12-04 Glen N. Barber Modulating immune responses
JP6599979B2 (ja) * 2014-09-15 2019-10-30 インサイト・コーポレイション Ｂｅｔタンパク質阻害剤として用いるための三環式複素環化合物
SG10201900628RA (en) 2016-04-07 2019-02-27 Glaxosmithkline Ip Dev Ltd Heterocyclic amides useful as protein modulators
WO2017175156A1 (en) * 2016-04-07 2017-10-12 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides useful as protein modulators

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