JP2017518959A5 - - Google Patents
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- JP2017518959A5 JP2017518959A5 JP2016557019A JP2016557019A JP2017518959A5 JP 2017518959 A5 JP2017518959 A5 JP 2017518959A5 JP 2016557019 A JP2016557019 A JP 2016557019A JP 2016557019 A JP2016557019 A JP 2016557019A JP 2017518959 A5 JP2017518959 A5 JP 2017518959A5
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- Prior art keywords
- alkyl
- alkoxy
- halogen
- hydroxyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461952467P | 2014-03-13 | 2014-03-13 | |
| US61/952,467 | 2014-03-13 | ||
| US201462010025P | 2014-06-10 | 2014-06-10 | |
| US62/010,025 | 2014-06-10 | ||
| PCT/US2015/020444 WO2015138895A1 (en) | 2014-03-13 | 2015-03-13 | Hepatitis b core protein allosteric modulators |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019085742A Division JP2019151650A (ja) | 2014-03-13 | 2019-04-26 | Ｂ型肝炎コアタンパク質アロステリックモジュレーター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017518959A JP2017518959A (ja) | 2017-07-13 |
| JP2017518959A5 true JP2017518959A5 (enExample) | 2018-04-26 |
| JP6602311B2 JP6602311B2 (ja) | 2019-11-06 |
Family
ID=54072461
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016557019A Expired - Fee Related JP6602311B2 (ja) | 2014-03-13 | 2015-03-13 | Ｂ型肝炎コアタンパク質アロステリックモジュレーター |
| JP2019085742A Withdrawn JP2019151650A (ja) | 2014-03-13 | 2019-04-26 | Ｂ型肝炎コアタンパク質アロステリックモジュレーター |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019085742A Withdrawn JP2019151650A (ja) | 2014-03-13 | 2019-04-26 | Ｂ型肝炎コアタンパク質アロステリックモジュレーター |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US10183936B2 (enExample) |
| EP (3) | EP3607950A3 (enExample) |
| JP (2) | JP6602311B2 (enExample) |
| KR (1) | KR102363174B1 (enExample) |
| CN (2) | CN106413402B (enExample) |
| AP (1) | AP2016009477A0 (enExample) |
| AU (2) | AU2015229174B2 (enExample) |
| CA (1) | CA2942533C (enExample) |
| CL (1) | CL2016002269A1 (enExample) |
| DK (1) | DK3116316T3 (enExample) |
| DO (1) | DOP2016000233A (enExample) |
| ES (1) | ES2748029T3 (enExample) |
| HR (1) | HRP20191444T1 (enExample) |
| HU (1) | HUE046567T2 (enExample) |
| IL (3) | IL247575B (enExample) |
| MX (2) | MX363600B (enExample) |
| PH (2) | PH12016501762B1 (enExample) |
| PL (1) | PL3116316T3 (enExample) |
| PT (1) | PT3116316T (enExample) |
| RS (1) | RS59430B1 (enExample) |
| SG (2) | SG11201607268UA (enExample) |
| WO (1) | WO2015138895A1 (enExample) |
| ZA (1) | ZA201606209B (enExample) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX359634B (es) | 2011-12-21 | 2018-10-03 | Novira Therapeutics Inc | Agentes antivirales contra la hepatitis b. |
| EP2890688A1 (en) | 2012-08-28 | 2015-07-08 | Janssen Sciences Ireland UC | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b |
| WO2014131847A1 (en) | 2013-02-28 | 2014-09-04 | Janssen R&D Ireland | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b |
| EA027068B1 (ru) | 2013-04-03 | 2017-06-30 | Янссен Сайенсиз Айрлэнд Юси | Производные n-фенилкарбоксамида и их применение в качестве лекарственных препаратов для лечения гепатита b |
| JO3603B1 (ar) | 2013-05-17 | 2020-07-05 | Janssen Sciences Ireland Uc | مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي |
| ES2695182T3 (es) | 2013-05-17 | 2019-01-02 | Janssen Sciences Ireland Uc | Derivados de sulfamoil tiofenamida y su uso como medicamentos para tratar la hepatitis B |
| HUE039152T2 (hu) | 2013-07-25 | 2018-12-28 | Janssen Sciences Ireland Uc | Glioxamiddal szubsztituált pirrolamid-származékok és alkalmazásuk hepatitisz B kezelésére szolgáló gyógyszerként |
| JP6452119B2 (ja) | 2013-10-23 | 2019-01-16 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | カルボキサミド誘導体およびｂ型肝炎の処置のための医薬品としてのその使用 |
| US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| US10392349B2 (en) | 2014-01-16 | 2019-08-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| CA2936947A1 (en) | 2014-02-05 | 2015-08-13 | Novira Therapeutics, Inc. | Combination therapy for treatment of hbv infections |
| WO2015118057A1 (en) | 2014-02-06 | 2015-08-13 | Janssen Sciences Ireland Uc | Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| EP3607950A3 (en) | 2014-03-13 | 2020-03-18 | Indiana University Research & Technology Corporation | Hepatitis b core protein allosteric modulators |
| US9884831B2 (en) | 2015-03-19 | 2018-02-06 | Novira Therapeutics, Inc. | Azocane and azonane derivatives and methods of treating hepatitis B infections |
| US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| SG10201913958QA (en) * | 2015-07-15 | 2020-03-30 | Agency Science Tech & Res | Modulation of hepatitis b virus replication |
| TWI721016B (zh) * | 2015-09-15 | 2021-03-11 | 美商艾森伯利生物科學公司 | B型肝炎核心蛋白質調節劑 |
| US10077239B2 (en) | 2015-09-29 | 2018-09-18 | Novira Therapeutics, Inc. | Crystalline forms of a hepatitis B antiviral agent |
| AU2017248828A1 (en) | 2016-04-15 | 2018-11-01 | Janssen Sciences Ireland Uc | Combinations and methods comprising a capsid assembly inhibitor |
| CN109790143A (zh) | 2016-05-10 | 2019-05-21 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| WO2017197036A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
| WO2017197046A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | C3-carbon linked glutarimide degronimers for target protein degradation |
| EP3454856B1 (en) | 2016-05-10 | 2024-09-11 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| AU2017326356A1 (en) * | 2016-09-15 | 2019-04-11 | Assembly Biosciences, Inc. | Hepatitis B core protein modulators |
| SG11201902938TA (en) * | 2016-10-03 | 2019-05-30 | Sigilon Therapeutics Inc | Compounds, devices, and uses thereof |
| WO2018085619A1 (en) | 2016-11-07 | 2018-05-11 | Arbutus Biopharma, Inc. | Substituted pyridinone-containing tricyclic compounds, and methods using same |
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| ES2874656T3 (es) * | 2017-02-23 | 2021-11-05 | Fujian Cosunter Pharmaceutical Co Ltd | Compuesto tricíclico y aplicaciones del mismo |
| US11078170B2 (en) | 2017-03-02 | 2021-08-03 | Assembly Biosciences, Inc. | Cyclic sulfamide compounds and methods of using same |
| EP3596070A1 (en) * | 2017-03-13 | 2020-01-22 | Assembly Biosciences, Inc. | Process for making hepatitis b core protein modulators |
| WO2018172852A1 (en) | 2017-03-21 | 2018-09-27 | Arbutus Biopharma Corporation | Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same |
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| MA49623A (fr) | 2017-07-21 | 2021-03-17 | Antabio Sas | Composés chimiques |
| MA50520A (fr) | 2017-11-02 | 2020-09-09 | Aicuris Gmbh & Co Kg | Nouveaux indole-2-carboxamides à substitution pyrazolo-pipéridine hautement actifs agissant contre le virus de l'hépatite b (vhb) |
| BR112020008762A2 (pt) | 2017-11-02 | 2020-10-20 | Aicuris Gmbh & Co. Kg | indol-2-carboxamidas amino-tiazol substituídas altamente ativas inovadoras ativas contra o vírus da hepatite b (hbv) |
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| WO2019213584A1 (en) * | 2018-05-03 | 2019-11-07 | Emory University | Modulators of orphan nuclear receptors for nash and other metabolic disorders |
| CN110627752B (zh) * | 2018-06-25 | 2021-08-17 | 新发药业有限公司 | 一种3-氨甲基四氢呋喃的制备方法 |
| CN108863884B (zh) * | 2018-07-26 | 2020-07-03 | 南京富润凯德生物医药有限公司 | 一种用dast试剂作为消除试剂合成共轭硝基烯取代系列衍生物的方法 |
| TWI826492B (zh) | 2018-07-27 | 2023-12-21 | 加拿大商愛彼特生物製藥公司 | 經取代四氫環戊[c]吡咯、經取代二氫吡咯，其類似物及使用其之方法 |
| TWI742419B (zh) * | 2018-08-23 | 2021-10-11 | 大陸商福建廣生堂藥業股份有限公司 | 三并環類化合物的晶型及其應用 |
| UY38439A (es) | 2018-11-02 | 2020-05-29 | Aicuris Gmbh & Co Kg | Novedosas urea 6,7-dihidro-4h-pirazolo[4,3-c]piridinas activas contra el virus de la hepatitis b (vhb) |
| AR117189A1 (es) | 2018-11-02 | 2021-07-21 | Aicuris Gmbh & Co Kg | Derivados de 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activos contra el virus de la hepatitis b (vhb) |
| AR116948A1 (es) | 2018-11-02 | 2021-06-30 | Aicuris Gmbh & Co Kg | Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (vhb) |
| UY38437A (es) | 2018-11-02 | 2020-05-29 | Aicuris Gmbh & Co Kg | Nuevas urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (hbv) |
| UY38436A (es) | 2018-11-02 | 2020-05-29 | Aicuris Gmbh & Co Kg | Nuevas 6,7-dihidro-4h-pirazolo[1,5-a] pirazinindol-2-carboxamidas activas contra el virus de la hepatitis b (vhb) |
| TWI827760B (zh) | 2018-12-12 | 2024-01-01 | 加拿大商愛彼特生物製藥公司 | 經取代之芳基甲基脲類及雜芳基甲基脲類、其類似物及其使用方法 |
| EP3897631A4 (en) | 2018-12-20 | 2022-11-23 | C4 Therapeutics, Inc. | TARGETED PROTEIN BREAKDOWN |
| AU2020223865A1 (en) | 2019-02-22 | 2021-07-15 | Janssen Sciences Ireland Unlimited Company | Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases |
| WO2020221824A1 (en) | 2019-04-30 | 2020-11-05 | Aicuris Gmbh & Co. Kg | Novel indolizine-2-carboxamides active against the hepatitis b virus (hbv) |
| WO2020221826A1 (en) | 2019-04-30 | 2020-11-05 | Aicuris Gmbh & Co. Kg | Novel indole-2-carboxamides active against the hepatitis b virus (hbv) |
| US20220227737A1 (en) | 2019-04-30 | 2022-07-21 | Aicuris Gmbh & Co. Kg | Novel oxalyl piperazines active against the hepatitis b virus (hbv) |
| JP2022531199A (ja) | 2019-04-30 | 2022-07-06 | アイクリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | Ｂ型肝炎ウイルス（ｈｂｖ）に対し活性な新規のフェニル及びピリジル尿素 |
| TW202108576A (zh) | 2019-05-06 | 2021-03-01 | 愛爾蘭商健生科學愛爾蘭無限公司 | 用於治療ｈｂｖ感染或ｈｂｖ誘發的疾病之醯胺衍生物 |
| JP2022532935A (ja) * | 2019-05-24 | 2022-07-20 | アッセンブリー バイオサイエンシズ，インコーポレイテッド | Ｈｂｖの処置のための医薬組成物 |
| CN110526878A (zh) * | 2019-09-16 | 2019-12-03 | 成都睿智化学研究有限公司 | 一种2-(噁唑基)乙胺的制备方法 |
| CN111072551A (zh) * | 2019-12-30 | 2020-04-28 | 上海睿瓦科技有限公司 | 催化氢化一步法制取哌啶胺的方法 |
| CN113135848A (zh) * | 2021-04-26 | 2021-07-20 | 深圳市华先医药科技有限公司 | 一种巯基烯酯类化合物的制备方法 |
| CN113636960A (zh) * | 2021-08-24 | 2021-11-12 | 上海皓元医药股份有限公司 | 一种2-(氯磺酰基)环己烷-1-烯甲酸乙酯衍生物的制备方法 |
| CN113717080A (zh) * | 2021-10-09 | 2021-11-30 | 西安瑞联新材料股份有限公司 | 一种4-氯-2-氰基苯磺酰氯的合成方法 |
| CN115353479A (zh) * | 2022-07-27 | 2022-11-18 | 常州琦诺生物科技有限公司 | 一种5-溴-2-碘嘧啶的制备方法 |
| WO2024089216A1 (en) | 2022-10-27 | 2024-05-02 | Syngenta Crop Protection Ag | Novel sulfur-containing heteroaryl carboxamide compounds |
| WO2025069039A1 (en) * | 2023-09-28 | 2025-04-03 | Rajaram Samant | An in situ process for the preparation of primary amine compounds |
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-
2015
- 2015-03-13 EP EP19184535.3A patent/EP3607950A3/en not_active Withdrawn
- 2015-03-13 MX MX2016011800A patent/MX363600B/es unknown
- 2015-03-13 HU HUE15761201A patent/HUE046567T2/hu unknown
- 2015-03-13 SG SG11201607268UA patent/SG11201607268UA/en unknown
- 2015-03-13 AP AP2016009477A patent/AP2016009477A0/en unknown
- 2015-03-13 RS RSP20191187 patent/RS59430B1/sr unknown
- 2015-03-13 KR KR1020167028057A patent/KR102363174B1/ko not_active Expired - Fee Related
- 2015-03-13 CN CN201580024580.0A patent/CN106413402B/zh active Active
- 2015-03-13 EP EP15761201.1A patent/EP3116316B1/en active Active
- 2015-03-13 PL PL15761201T patent/PL3116316T3/pl unknown
- 2015-03-13 WO PCT/US2015/020444 patent/WO2015138895A1/en not_active Ceased
- 2015-03-13 CA CA2942533A patent/CA2942533C/en active Active
- 2015-03-13 US US15/125,911 patent/US10183936B2/en active Active
- 2015-03-13 PH PH1/2016/501762A patent/PH12016501762B1/en unknown
- 2015-03-13 PT PT15761201T patent/PT3116316T/pt unknown
- 2015-03-13 HR HRP20191444 patent/HRP20191444T1/hr unknown
- 2015-03-13 ES ES15761201T patent/ES2748029T3/es active Active
- 2015-03-13 JP JP2016557019A patent/JP6602311B2/ja not_active Expired - Fee Related
- 2015-03-13 SG SG10202001506UA patent/SG10202001506UA/en unknown
- 2015-03-13 DK DK15761201.1T patent/DK3116316T3/da active
- 2015-03-13 EP EP21191660.6A patent/EP3974426A1/en not_active Withdrawn
- 2015-03-13 CN CN201910710699.3A patent/CN110437153A/zh active Pending
- 2015-03-13 PH PH1/2021/553231A patent/PH12021553231A1/en unknown
- 2015-03-13 AU AU2015229174A patent/AU2015229174B2/en not_active Ceased
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2016
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2018
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2019
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2020
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2021
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