JP2020533288A5 - - Google Patents
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- Publication number
- JP2020533288A5 JP2020533288A5 JP2020513331A JP2020513331A JP2020533288A5 JP 2020533288 A5 JP2020533288 A5 JP 2020533288A5 JP 2020513331 A JP2020513331 A JP 2020513331A JP 2020513331 A JP2020513331 A JP 2020513331A JP 2020533288 A5 JP2020533288 A5 JP 2020533288A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- heterocycle
- inhibitor
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023089900A JP7607969B2 (ja) | 2017-09-08 | 2023-05-31 | Ｅｎｐｐ１阻害剤及びがんの治療のためのそれらの使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762556117P | 2017-09-08 | 2017-09-08 | |
| US62/556,117 | 2017-09-08 | ||
| PCT/US2018/050018 WO2019051269A1 (en) | 2017-09-08 | 2018-09-07 | ENPP1 INHIBITORS AND THEIR USE FOR THE TREATMENT OF CANCER |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023089900A Division JP7607969B2 (ja) | 2017-09-08 | 2023-05-31 | Ｅｎｐｐ１阻害剤及びがんの治療のためのそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020533288A JP2020533288A (ja) | 2020-11-19 |
| JP2020533288A5 true JP2020533288A5 (enExample) | 2021-10-14 |
| JP7292740B2 JP7292740B2 (ja) | 2023-06-19 |
Family
ID=63714052
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020513331A Active JP7292740B2 (ja) | 2017-09-08 | 2018-09-07 | Ｅｎｐｐ１阻害剤及びがんの治療のためのそれらの使用 |
| JP2023089900A Active JP7607969B2 (ja) | 2017-09-08 | 2023-05-31 | Ｅｎｐｐ１阻害剤及びがんの治療のためのそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023089900A Active JP7607969B2 (ja) | 2017-09-08 | 2023-05-31 | Ｅｎｐｐ１阻害剤及びがんの治療のためのそれらの使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US11701371B2 (enExample) |
| EP (2) | EP3678668B1 (enExample) |
| JP (2) | JP7292740B2 (enExample) |
| KR (2) | KR20240151869A (enExample) |
| CN (2) | CN111372587B (enExample) |
| AU (3) | AU2018330188C1 (enExample) |
| BR (1) | BR112020004559A2 (enExample) |
| CA (1) | CA3074268A1 (enExample) |
| DK (1) | DK3678668T3 (enExample) |
| EA (1) | EA202090595A1 (enExample) |
| ES (1) | ES2975183T3 (enExample) |
| HU (1) | HUE066413T2 (enExample) |
| IL (3) | IL272948B2 (enExample) |
| MA (1) | MA50082A (enExample) |
| MX (2) | MX2020002646A (enExample) |
| PL (1) | PL3678668T3 (enExample) |
| SG (1) | SG11202001728YA (enExample) |
| WO (1) | WO2019051269A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220056052A1 (en) * | 2018-12-28 | 2022-02-24 | Riboscience Llc | Quinazoline derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors |
| ES2960987T3 (es) | 2019-04-12 | 2024-03-07 | Riboscience Llc | Derivados de heteroarilo bicíclicos como inhibidores de la ectonucleótido pirofosfatasa fosfodiesterasa 1 |
| CA3151277A1 (en) | 2019-09-16 | 2021-03-25 | Aten Porus Lifesciences Pvt. Ltd. | 2-amino-s6-substituted thiopurine compounds as inhibitors of the enpp1 protein |
| WO2021061803A1 (en) * | 2019-09-23 | 2021-04-01 | Nanjing Zhengxiang Pharmaceuticals Co., Ltd. | Phosphodiesterase inhibitors and use |
| EP4100394B1 (en) * | 2020-02-04 | 2026-04-08 | Stingray Therapeutics, Inc. | Inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 1 (enpp1) and methods of use thereof |
| TWI775313B (zh) | 2020-02-18 | 2022-08-21 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| KR20250133471A (ko) | 2020-02-18 | 2025-09-05 | 길리애드 사이언시즈, 인코포레이티드 | 항바이러스 화합물 |
| TWI794742B (zh) | 2020-02-18 | 2023-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| WO2021203772A1 (en) * | 2020-04-09 | 2021-10-14 | Betta Pharmaceuticals Co., Ltd | Ectonucleotide pyrophosphatase-phosphodiesterase 1 inhibitors,compositions and uses thereof |
| WO2021225969A1 (en) * | 2020-05-04 | 2021-11-11 | Volastra Therapeutics, Inc. | Imino sulfanone inhibitors of enpp1 |
| US11834512B2 (en) * | 2020-05-04 | 2023-12-05 | The Regents Of The University Of California | Inhibiting anti-ENPP1 antibodies |
| KR102682428B1 (ko) | 2020-05-08 | 2024-07-05 | 주식회사 티씨노바이오사이언스 | 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 프탈라진 유도체 및 이들의 용도 |
| US20230159469A1 (en) | 2020-05-08 | 2023-05-25 | Txinno Bioscience Inc. | Novel phthalazine derivative having ectonucloeotide pyrophosphatase/phosphodieste rase inhibitory activity, and use thereof |
| TW202214640A (zh) | 2020-06-16 | 2022-04-16 | 美商佛拉斯托醫療公司 | Ｅｎｐｐ１之雜環抑制劑 |
| US11873291B2 (en) * | 2020-09-03 | 2024-01-16 | Immunesensor Therapeutics, Inc. | Quinoline cGAS antagonist compounds |
| WO2022091048A1 (en) | 2020-10-30 | 2022-05-05 | Integral Biosciences Private Limited | Ectonucleotide pyrophosphatase-phosphodiesterase-1 (enpp1) inhibitors and uses thereof |
| CN116600813A (zh) * | 2020-12-09 | 2023-08-15 | 斯汀格瑞治疗股份有限公司 | 作为enpp1和cdnp抑制剂的膦酸盐 |
| WO2022125613A1 (en) * | 2020-12-09 | 2022-06-16 | Stingray Therapeutics, Inc. | Phosphonates as inhibitors of enpp1 and cdnp |
| AU2021412688B2 (en) | 2020-12-29 | 2025-06-12 | Txinno Bioscience Inc. | Novel naphthyridinone derivative having inhibitory activity against ectonucleotide pyrophosphatase-phosphodiesterase and use thereof |
| KR102720206B1 (ko) | 2020-12-29 | 2024-10-21 | 주식회사 티씨노바이오사이언스 | 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 나프티리딘온 유도체 및 이들의 용도 |
| KR102686866B1 (ko) | 2021-01-29 | 2024-07-19 | 주식회사 티씨노바이오사이언스 | 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 벤조트리아졸 유도체 및 이들의 용도 |
| CA3204409C (en) | 2021-01-29 | 2026-04-28 | Txinno Bioscience Inc. | Benzotriazole derivative having inhibitory activity against ectonucleotide pyrophosphatase-phosphodiesterase, and use thereof |
| WO2022197734A1 (en) * | 2021-03-16 | 2022-09-22 | Riboscience Llc | Bicyclic heteroaryl boronate derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors |
| WO2022212488A1 (en) * | 2021-03-31 | 2022-10-06 | Riboscience Llc | Bicyclic heteroaryl phosphonate derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors |
| AU2022256476B2 (en) | 2021-04-16 | 2025-06-05 | Gilead Sciences, Inc. | Methods of preparing carbanucleosides using amides |
| CN115536696B (zh) * | 2021-06-29 | 2023-07-14 | 上海齐鲁制药研究中心有限公司 | Enpp1抑制剂 |
| CA3228162A1 (en) | 2021-08-18 | 2023-02-23 | Gilead Sciences, Inc. | Phospholipid compounds and methods of making and using the same |
| EP4395786A4 (en) * | 2021-09-03 | 2025-07-23 | Angarus Therapeutics Inc | ENPP1 INHIBITORS AND IMMUNE CELLS EXPRESSING CHIMERIC ANTIGEN RECEPTORS |
| WO2023077083A1 (en) * | 2021-10-29 | 2023-05-04 | Angarus Therapeutics, Inc. | Enpp1 inhibitors as inhibitors of metastasis |
| EP4486734A1 (en) | 2022-03-02 | 2025-01-08 | Immunesensor Therapeutics, Inc. | Quinoline cgas antagonist compounds |
| CN118488950A (zh) * | 2022-04-11 | 2024-08-13 | 上海齐鲁制药研究中心有限公司 | Enpp1抑制剂 |
| EP4514331A1 (en) | 2022-04-29 | 2025-03-05 | Petragen, Inc. | Inhibitors of enpp1 and modulation of bone growth |
| CN114767863B (zh) * | 2022-04-29 | 2024-01-30 | 西北工业大学 | 一种enpp2基因或蛋白在调控结直肠癌细胞中的应用 |
| WO2024028727A1 (en) * | 2022-08-01 | 2024-02-08 | Sravathi Ai Technology Private Limited | Novel ectonucleotide pyrophosphatase / phosphodiesterase 1 (enpp-1) inhibitors and uses thereof |
| WO2024213932A1 (en) * | 2023-04-11 | 2024-10-17 | The Hong Kong University Of Science And Technology | Driving axon regeneration by novel enpp1 inhibitors |
| WO2024216211A2 (en) * | 2023-04-14 | 2024-10-17 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of inhibiting tumor progression and metastasis by inhibition of enpp1 |
| CN118108720B (zh) * | 2023-12-28 | 2026-03-10 | 河南大学 | 一种苝酰亚胺衍生物pdic-ns及应用 |
| WO2025207514A1 (en) * | 2024-03-25 | 2025-10-02 | Riboscience Llc | Bicyclic heteroaryl sulfanediimine derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA228044A (en) | 1923-01-16 | Thomas Noble Boughton | Die for forming bolts | |
| CA190896A (en) | 1919-02-24 | 1919-06-17 | Josephat C. Bergeron | Advertising device |
| DE3319795A1 (de) | 1983-06-01 | 1984-12-06 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von phosphonsaeureestern |
| US5599902A (en) | 1994-11-10 | 1997-02-04 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Cancer inhibitory peptides |
| EP0831100B1 (en) | 1995-04-21 | 2000-10-11 | Teikoku Hormone Mfg. Co., Ltd. | Novel peptide derivatives |
| US6323315B1 (en) | 1999-09-10 | 2001-11-27 | Basf Aktiengesellschaft | Dolastatin peptides |
| WO2002072578A2 (en) | 2001-03-08 | 2002-09-19 | Millennium Pharmaceuticals | (homo) piperazine substituted quinolines for inhibiting the phosphorylation of kinases |
| US20040101840A1 (en) * | 2001-04-27 | 2004-05-27 | Chung Leland W.K. | Identification, cloning and characterization of a novel pc-1 gene differentially expressed in prostate cells and tissues |
| EP1391213A1 (en) | 2002-08-21 | 2004-02-25 | Boehringer Ingelheim International GmbH | Compositions and methods for treating cancer using maytansinoid CD44 antibody immunoconjugates and chemotherapeutic agents |
| UA83814C2 (ru) | 2002-12-24 | 2008-08-26 | Астразенека Аб | Производные фосфонооксихиназолина и их фармацевтическое применение |
| US20070004763A1 (en) | 2005-06-10 | 2007-01-04 | Nand Baindur | Aminoquinoline and aminoquinazoline kinase modulators |
| US10543207B2 (en) | 2008-12-31 | 2020-01-28 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| KR101676062B1 (ko) * | 2009-04-11 | 2016-11-14 | 어레이 바이오파마 인크. | Ｄｎａ 손상제를 강화시키기 위한 체크포인트 키나제 1 억제제 |
| ES2624845T3 (es) | 2010-09-29 | 2017-07-17 | Intervet International B.V. | Compuestos de N-heteroarilo con unidad de puente cíclico para el tratamiento de enfermedades parasitarias |
| EP2794630A4 (en) | 2011-12-22 | 2015-04-01 | Alios Biopharma Inc | SUBSTITUTED PHOSPHORTHIOAT NUCLEOTIDE ANALOGUE |
| CN105377867B (zh) | 2013-05-03 | 2019-11-12 | 加利福尼亚大学董事会 | I型干扰素的环状二核苷酸诱导 |
| CU24377B1 (es) | 2013-05-18 | 2018-12-05 | Aduro Biotech Inc | Dinucléotidos de purina cíclicos y composiciones de los mismos útiles para inducir la producción de interferón de tipo i dependientes de sting |
| CA2962329C (en) * | 2014-09-22 | 2023-12-19 | Yu-Sheng Chao | Heterocyclic compounds and use thereof |
| US10011600B2 (en) * | 2014-09-25 | 2018-07-03 | Araxes Pharma Llc | Methods and compositions for inhibition of Ras |
| EP3233089A4 (en) * | 2014-12-17 | 2018-11-14 | Lipogen LLC | Method of treating cancer with cgamp or cgasmp |
| CN105153153A (zh) | 2015-08-31 | 2015-12-16 | 吉林奥来德光电材料股份有限公司 | 一种新的芳香族胺类化合物及其制备与应用 |
| TWI659949B (zh) | 2016-05-16 | 2019-05-21 | 臺北醫學大學 | 組蛋白去乙醯酶6抑制劑及其用途 |
| CA3047579A1 (en) | 2016-12-22 | 2018-06-28 | Abbvie Inc. | Compositions and methods of enhancing or augmenting type i ifn production |
| CN110312424A (zh) | 2017-01-09 | 2019-10-08 | 澳大利亚国立大学 | 用于改善杀虫剂的增效剂 |
| US10518257B2 (en) | 2017-05-04 | 2019-12-31 | Exxonmobil Research And Engineering Company | Metal organic frameworks, their synthesis and use |
| WO2018229139A1 (en) | 2017-06-14 | 2018-12-20 | Fundación Para La Investigación Médica Aplicada | Novel compounds for use in cancer |
| AU2018325445A1 (en) | 2017-08-31 | 2020-03-19 | Abbvie Inc. | Ectonucleotide pyrophosphatase-phosphodiesterase 1 (ENPP-1) inhibitors and uses thereof |
| MX2021009269A (es) | 2019-02-01 | 2021-08-24 | Univ Leland Stanford Junior | Inhibidores de enpp1 y metodos para modular una respuesta inmunitaria. |
| CN114437128B (zh) * | 2022-01-28 | 2023-12-19 | 中国科学院长春应用化学研究所 | 一种胆碱磷酸修饰的紫杉醇药物及其制备方法和应用 |
-
2018
- 2018-09-07 EA EA202090595A patent/EA202090595A1/ru unknown
- 2018-09-07 IL IL272948A patent/IL272948B2/en unknown
- 2018-09-07 BR BR112020004559-4A patent/BR112020004559A2/pt not_active Application Discontinuation
- 2018-09-07 IL IL311010A patent/IL311010A/en unknown
- 2018-09-07 SG SG11202001728YA patent/SG11202001728YA/en unknown
- 2018-09-07 KR KR1020247033122A patent/KR20240151869A/ko active Pending
- 2018-09-07 MA MA050082A patent/MA50082A/fr unknown
- 2018-09-07 MX MX2020002646A patent/MX2020002646A/es unknown
- 2018-09-07 HU HUE18779884A patent/HUE066413T2/hu unknown
- 2018-09-07 IL IL302338A patent/IL302338B2/en unknown
- 2018-09-07 DK DK18779884.8T patent/DK3678668T3/da active
- 2018-09-07 US US16/645,300 patent/US11701371B2/en active Active
- 2018-09-07 ES ES18779884T patent/ES2975183T3/es active Active
- 2018-09-07 EP EP18779884.8A patent/EP3678668B1/en active Active
- 2018-09-07 AU AU2018330188A patent/AU2018330188C1/en active Active
- 2018-09-07 CA CA3074268A patent/CA3074268A1/en active Pending
- 2018-09-07 PL PL18779884.8T patent/PL3678668T3/pl unknown
- 2018-09-07 JP JP2020513331A patent/JP7292740B2/ja active Active
- 2018-09-07 WO PCT/US2018/050018 patent/WO2019051269A1/en not_active Ceased
- 2018-09-07 CN CN201880063793.8A patent/CN111372587B/zh active Active
- 2018-09-07 KR KR1020207007008A patent/KR102715420B1/ko active Active
- 2018-09-07 EP EP24150802.7A patent/EP4327882A3/en not_active Withdrawn
- 2018-09-07 CN CN202311760294.3A patent/CN117883449A/zh active Pending
-
2020
- 2020-03-06 MX MX2023007193A patent/MX2023007193A/es unknown
-
2022
- 2022-09-30 US US17/957,392 patent/US11707471B2/en active Active
-
2023
- 2023-05-16 US US18/197,877 patent/US20230277570A1/en active Pending
- 2023-05-31 JP JP2023089900A patent/JP7607969B2/ja active Active
-
2024
- 2024-01-10 AU AU2024200148A patent/AU2024200148B2/en active Active
-
2026
- 2026-01-30 AU AU2026200707A patent/AU2026200707A1/en active Pending
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