DK3678668T3 - ENPP1-inhibitorer og deres anvendelse til behandling af kræft - Google Patents
ENPP1-inhibitorer og deres anvendelse til behandling af kræft Download PDFInfo
- Publication number
- DK3678668T3 DK3678668T3 DK18779884.8T DK18779884T DK3678668T3 DK 3678668 T3 DK3678668 T3 DK 3678668T3 DK 18779884 T DK18779884 T DK 18779884T DK 3678668 T3 DK3678668 T3 DK 3678668T3
- Authority
- DK
- Denmark
- Prior art keywords
- cancer
- treatment
- enpp1 inhibitors
- enpp1
- inhibitors
- Prior art date
Links
- 101000812677 Homo sapiens Nucleotide pyrophosphatase Proteins 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 102100039306 Nucleotide pyrophosphatase Human genes 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
- C07F9/165—Esters of thiophosphoric acids
- C07F9/1651—Esters of thiophosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3826—Acyclic unsaturated acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
- C07F9/4403—Amides thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4407—Amides of acyclic saturated acids which can have further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762556117P | 2017-09-08 | 2017-09-08 | |
| PCT/US2018/050018 WO2019051269A1 (en) | 2017-09-08 | 2018-09-07 | ENPP1 INHIBITORS AND THEIR USE FOR THE TREATMENT OF CANCER |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3678668T3 true DK3678668T3 (da) | 2024-04-08 |
Family
ID=63714052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18779884.8T DK3678668T3 (da) | 2017-09-08 | 2018-09-07 | ENPP1-inhibitorer og deres anvendelse til behandling af kræft |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US11701371B2 (da) |
| EP (2) | EP4327882A3 (da) |
| JP (2) | JP7292740B2 (da) |
| CN (2) | CN117883449A (da) |
| AU (2) | AU2018330188C1 (da) |
| BR (1) | BR112020004559A2 (da) |
| CA (1) | CA3074268A1 (da) |
| DK (1) | DK3678668T3 (da) |
| EA (1) | EA202090595A1 (da) |
| ES (1) | ES2975183T3 (da) |
| HU (1) | HUE066413T2 (da) |
| IL (3) | IL272948B2 (da) |
| MA (1) | MA50082A (da) |
| MX (2) | MX2020002646A (da) |
| PL (1) | PL3678668T3 (da) |
| SG (1) | SG11202001728YA (da) |
| WO (1) | WO2019051269A1 (da) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020140001A1 (en) * | 2018-12-28 | 2020-07-02 | Riboscience Llc | Quinazoline derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors |
| FI3952995T3 (fi) | 2019-04-12 | 2023-10-26 | Riboscience Llc | Bisyklisiä heteroaryylijohdannaisia ektonukleotidipyrofosfataasifosfodiesteraasi-1:n inhibiittoreina |
| US20230002387A1 (en) | 2019-09-16 | 2023-01-05 | Aten Porus Lifesciences Pvt. Ltd. | 2-amino-s6-substituted thiopurine compounds as inhibitors of the enpp1 protein |
| WO2021061803A1 (en) * | 2019-09-23 | 2021-04-01 | Nanjing Zhengxiang Pharmaceuticals Co., Ltd. | Phosphodiesterase inhibitors and use |
| TW202140439A (zh) * | 2020-02-04 | 2021-11-01 | 美商史汀葛瑞醫療公司 | 外核苷酸焦磷酸酶／磷酸二酯酶１（ｅｎｐｐ１）之抑制劑及其使用方法 |
| TW202245800A (zh) | 2020-02-18 | 2022-12-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| TW202322824A (zh) | 2020-02-18 | 2023-06-16 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| CN115135383B (zh) | 2020-02-18 | 2024-06-11 | 吉利德科学公司 | 抗病毒化合物 |
| CN115362150A (zh) * | 2020-04-09 | 2022-11-18 | 贝达药业股份有限公司 | Enpp1抑制剂及其组合物和用途 |
| KR20230019431A (ko) | 2020-05-04 | 2023-02-08 | 볼라스트라 쎄라퓨틱스, 인코포레이티드 | Enpp1의 이미노 설파논 억제제 |
| KR102682428B1 (ko) | 2020-05-08 | 2024-07-05 | 주식회사 티씨노바이오사이언스 | 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 프탈라진 유도체 및 이들의 용도 |
| WO2021225407A1 (ko) | 2020-05-08 | 2021-11-11 | 주식회사 티씨노바이오사이언스 | 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 프탈라진 유도체 및 이들의 용도 |
| WO2021257614A1 (en) * | 2020-06-16 | 2021-12-23 | Volastra Therapeutics, Inc. | Heterocyclic inhibitors of enpp1 |
| BR112023003948A2 (pt) | 2020-09-03 | 2023-04-11 | Immunesensor Therapeutics Inc | Compostos de antagonista de quinolina cgas |
| JP2023549738A (ja) * | 2020-10-30 | 2023-11-29 | １シーバイオ， インコーポレイテッド | エクトヌクレオチドピロホスファターゼ－ホスホジエステラーゼ－１（ｅｎｐｐ１）阻害物質及びそれらの使用 |
| CN116600813A (zh) * | 2020-12-09 | 2023-08-15 | 斯汀格瑞治疗股份有限公司 | 作为enpp1和cdnp抑制剂的膦酸盐 |
| JP2024500249A (ja) * | 2020-12-09 | 2024-01-05 | スティングレイ・セラピューティクス・インコーポレイテッド | Ｅｎｐｐ１およびｃｄｎｐの阻害剤としてのホスホネート類 |
| JP2024504285A (ja) | 2020-12-29 | 2024-01-31 | ティーエックスイノ バイオサイエンス インコーポレイテッド | エクトヌクレオチドピロホスファターゼ－ホスホジエステラーゼの阻害活性を有する新規のナフチリジノン誘導体及びこれらの用途 |
| KR20220095154A (ko) | 2020-12-29 | 2022-07-06 | 주식회사 티씨노바이오사이언스 | 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 나프티리딘온 유도체 및 이들의 용도 |
| EP4286374A1 (en) | 2021-01-29 | 2023-12-06 | Txinno Bioscience Inc. | Novel benzotriazole derivative having inhibitory activity against ectonucleotide pyrophosphatase-phosphodiesterase, and use thereof |
| KR102686866B1 (ko) | 2021-01-29 | 2024-07-19 | 주식회사 티씨노바이오사이언스 | 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 벤조트리아졸 유도체 및 이들의 용도 |
| WO2022197734A1 (en) * | 2021-03-16 | 2022-09-22 | Riboscience Llc | Bicyclic heteroaryl boronate derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors |
| AU2022256476A1 (en) | 2021-04-16 | 2023-10-12 | Gilead Sciences, Inc. | Methods of preparing carbanucleosides using amides |
| CN115536696B (zh) * | 2021-06-29 | 2023-07-14 | 上海齐鲁制药研究中心有限公司 | Enpp1抑制剂 |
| EP4395786A1 (en) * | 2021-09-03 | 2024-07-10 | Angarus Therapeutics, Inc. | Enpp1 inhibitors and immune cells expressing chimeric antigen receptors |
| EP4422639A1 (en) * | 2021-10-29 | 2024-09-04 | Angarus Therapeutics, Inc. | Enpp1 inhibitors as inhibitors of metastasis |
| WO2023168367A1 (en) | 2022-03-02 | 2023-09-07 | Immunesensor Therapeutics, Inc. | QUINOLINE cGAS ANTAGONIST COMPOUNDS |
| WO2023197987A1 (zh) * | 2022-04-11 | 2023-10-19 | 上海齐鲁制药研究中心有限公司 | Enpp1抑制剂 |
| CN114767863B (zh) * | 2022-04-29 | 2024-01-30 | 西北工业大学 | 一种enpp2基因或蛋白在调控结直肠癌细胞中的应用 |
| US20230346771A1 (en) | 2022-04-29 | 2023-11-02 | Petragen, Inc. | Inhibitors of enpp1 and modulation of bone growth |
| WO2024028727A1 (en) * | 2022-08-01 | 2024-02-08 | Sravathi Ai Technology Private Limited | Novel ectonucleotide pyrophosphatase / phosphodiesterase 1 (enpp-1) inhibitors and uses thereof |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA228044A (en) | 1923-01-16 | Thomas Noble Boughton | Die for forming bolts | |
| CA190896A (en) | 1919-02-24 | 1919-06-17 | Josephat C. Bergeron | Advertising device |
| DE3319795A1 (de) | 1983-06-01 | 1984-12-06 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von phosphonsaeureestern |
| US5599902A (en) | 1994-11-10 | 1997-02-04 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Cancer inhibitory peptides |
| KR100408909B1 (ko) | 1995-04-21 | 2004-04-29 | 데이꼬꾸 조끼 세이야꾸 가부시키가이샤 | 신규펩티드유도체 |
| US6323315B1 (en) | 1999-09-10 | 2001-11-27 | Basf Aktiengesellschaft | Dolastatin peptides |
| AU2002254152A1 (en) * | 2001-03-08 | 2002-09-24 | Millennium Pharmaceuticals | (homo) piperazine substituted quinolines for inhibiting the phosphorylation of kinases |
| EP1391213A1 (en) | 2002-08-21 | 2004-02-25 | Boehringer Ingelheim International GmbH | Compositions and methods for treating cancer using maytansinoid CD44 antibody immunoconjugates and chemotherapeutic agents |
| MY136174A (en) | 2002-12-24 | 2008-08-29 | Astrazeneca Ab | Phosphonooxy quinazoline derivatives and their pharmaceutical use |
| US20070004763A1 (en) | 2005-06-10 | 2007-01-04 | Nand Baindur | Aminoquinoline and aminoquinazoline kinase modulators |
| US10543207B2 (en) | 2008-12-31 | 2020-01-28 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| BR112013006953A2 (pt) * | 2010-09-29 | 2016-07-26 | Intervet Int Bv | composto, composições farmacêutica e anti-helmíntica, uso de um composto, kit, e, método de tratamento de uma doença |
| AU2012358804B2 (en) | 2011-12-22 | 2018-04-19 | Alios Biopharma, Inc. | Substituted phosphorothioate nucleotide analogs |
| EP2992000B1 (en) | 2013-05-03 | 2020-07-08 | The Regents of The University of California | Cyclic di-nucleotide induction of type i interferon |
| LT2996473T (lt) | 2013-05-18 | 2019-12-10 | Aduro Biotech Inc | Kompozicijos ir būdai, skirti aktyvuoti nuo "interferono geno stimuliatoriaus" priklausomą signalinį kelią |
| WO2016048861A2 (en) * | 2014-09-22 | 2016-03-31 | National Health Research Institutes | Heterocyclic compounds and use thereof |
| US10011600B2 (en) | 2014-09-25 | 2018-07-03 | Araxes Pharma Llc | Methods and compositions for inhibition of Ras |
| CN105153153A (zh) | 2015-08-31 | 2015-12-16 | 吉林奥来德光电材料股份有限公司 | 一种新的芳香族胺类化合物及其制备与应用 |
| TWI659949B (zh) | 2016-05-16 | 2019-05-21 | 臺北醫學大學 | 組蛋白去乙醯酶6抑制劑及其用途 |
| EA201991555A1 (ru) | 2016-12-22 | 2020-01-23 | Мавуфарма, Инк. | Композиции и способы усиления или увеличения продукции ifn i типа |
| CN110312424A (zh) | 2017-01-09 | 2019-10-08 | 澳大利亚国立大学 | 用于改善杀虫剂的增效剂 |
| US10518257B2 (en) | 2017-05-04 | 2019-12-31 | Exxonmobil Research And Engineering Company | Metal organic frameworks, their synthesis and use |
| WO2018229139A1 (en) | 2017-06-14 | 2018-12-20 | Fundación Para La Investigación Médica Aplicada | Novel compounds for use in cancer |
| WO2019046778A1 (en) * | 2017-08-31 | 2019-03-07 | Mavupharma, Inc. | INHIBITORS OF ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE (ENPP-1) AND USES THEREOF |
| PE20212306A1 (es) | 2019-02-01 | 2021-12-10 | Univ Leland Stanford Junior | Inhibidores de enpp1 y metodos para modular una respuesta inmunitaria |
| CN114437128B (zh) * | 2022-01-28 | 2023-12-19 | 中国科学院长春应用化学研究所 | 一种胆碱磷酸修饰的紫杉醇药物及其制备方法和应用 |
-
2018
- 2018-09-07 CN CN202311760294.3A patent/CN117883449A/zh active Pending
- 2018-09-07 SG SG11202001728YA patent/SG11202001728YA/en unknown
- 2018-09-07 WO PCT/US2018/050018 patent/WO2019051269A1/en active Application Filing
- 2018-09-07 PL PL18779884.8T patent/PL3678668T3/pl unknown
- 2018-09-07 ES ES18779884T patent/ES2975183T3/es active Active
- 2018-09-07 MX MX2020002646A patent/MX2020002646A/es unknown
- 2018-09-07 IL IL272948A patent/IL272948B2/en unknown
- 2018-09-07 CA CA3074268A patent/CA3074268A1/en active Pending
- 2018-09-07 DK DK18779884.8T patent/DK3678668T3/da active
- 2018-09-07 US US16/645,300 patent/US11701371B2/en active Active
- 2018-09-07 EA EA202090595A patent/EA202090595A1/ru unknown
- 2018-09-07 JP JP2020513331A patent/JP7292740B2/ja active Active
- 2018-09-07 BR BR112020004559-4A patent/BR112020004559A2/pt unknown
- 2018-09-07 CN CN201880063793.8A patent/CN111372587B/zh active Active
- 2018-09-07 EP EP24150802.7A patent/EP4327882A3/en active Pending
- 2018-09-07 IL IL311010A patent/IL311010A/en unknown
- 2018-09-07 MA MA050082A patent/MA50082A/fr unknown
- 2018-09-07 EP EP18779884.8A patent/EP3678668B1/en active Active
- 2018-09-07 AU AU2018330188A patent/AU2018330188C1/en active Active
- 2018-09-07 IL IL302338A patent/IL302338B2/en unknown
- 2018-09-07 HU HUE18779884A patent/HUE066413T2/hu unknown
-
2020
- 2020-03-06 MX MX2023007193A patent/MX2023007193A/es unknown
-
2022
- 2022-09-30 US US17/957,392 patent/US11707471B2/en active Active
-
2023
- 2023-05-16 US US18/197,877 patent/US20230277570A1/en active Pending
- 2023-05-31 JP JP2023089900A patent/JP2023101715A/ja active Pending
-
2024
- 2024-01-10 AU AU2024200148A patent/AU2024200148A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3678668T3 (da) | ENPP1-inhibitorer og deres anvendelse til behandling af kræft | |
| DK3558997T3 (da) | Aminotriazolopyridinforbindelser og deres anvendelse til behandling af cancer | |
| DK3307727T3 (da) | Heterocykliske inhibitorer af erk1 og erk2 og deres anvendelse i behandlingen af kræft | |
| DK3285809T3 (da) | Inhibitorer af immunkontrolpunktsmodulatorer til anvendelse i behandling af kræft og infektioner. | |
| DK3612517T3 (da) | Bicykliske forbindelser og deres anvendelse ved behandling af cancer | |
| DK3368069T3 (da) | Anvendelse af myostatininhibitorer og kombinationsterapier | |
| DK3658557T3 (da) | Tyk2-inhibitorer og anvendelser deraf | |
| DK3452485T3 (da) | Arginasehæmmere og deres terapeutiske anvendelser | |
| DK3331900T3 (da) | Peptider og kombination af peptider til anvendelse ved immunterapi mod prostatacancer og andre cancere | |
| DK3134125T3 (da) | Antistof-lægemiddel-konjugat og anvendelse deraf til behandling af cancer | |
| DK3445388T3 (da) | Materialer og fremgangsmåder til behandling af hæmoglobinopatier | |
| DK3325488T3 (da) | Chiral diaryl-makrocyklus og anvendelse deraf til behandling af cancer | |
| DK3277681T3 (da) | Imidazolonylquinoliner og deres anvendelse som atm-kinaseinhibitorer | |
| DK3322425T3 (da) | Genmodificerede anti-tredjeparts-centralhukommelse-t-celler og brug af samme i immunterapi | |
| DK3303339T3 (da) | Pde9-inhibitorer med imidazotriazinonskelet og imidazopyrazinonskelet til behandling af perifere sygdomme | |
| DK3416957T3 (da) | 6-heterocyclyl-4-morpholin-4-ylpyridin-2-on-forbindelser anvendelige ved behandlingen af cancer og diabetes | |
| DK3790879T3 (da) | Triazolopyrimidinforbindelser og deres anvendelse til behandling af kræft | |
| DK3242947T3 (da) | Genterapi og elektroporese til behandling af maligniteter | |
| DK3532459T3 (da) | Lsd1-hæmmere og medicinske anvendelser deraf | |
| DK3621694T5 (da) | Lrrc33-inhibitorer og anvendelse heraf | |
| DK3268374T3 (da) | Kv1.3-inhibitorer og deres medicinske anvendelse | |
| DK3273995T3 (da) | Kombineret anvendelse af alginatoligomerer og cftr-modulatoren lumacaftor i behandlingen af tilstande associeret med cftr-dysfunktion | |
| DK3601296T3 (da) | 2-oxo-thiazolderivater som a2a-inhibitorer og forbindelser til anvendelse ved behandling af cancere | |
| DK3374497T3 (da) | Modificerede makrofager til anvendelse i behandlingen af kræft | |
| DK3860990T3 (da) | Inhibitorer for YAP/TAZ-TEAD interaktion og disses anvendelse ved behandlingen af cancer |