JP7292740B2 - Ｅｎｐｐ１阻害剤及びがんの治療のためのそれらの使用 - Google Patents

Ｅｎｐｐ１阻害剤及びがんの治療のためのそれらの使用 Download PDF

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JP7292740B2
JP7292740B2 JP2020513331A JP2020513331A JP7292740B2 JP 7292740 B2 JP7292740 B2 JP 7292740B2 JP 2020513331 A JP2020513331 A JP 2020513331A JP 2020513331 A JP2020513331 A JP 2020513331A JP 7292740 B2 JP7292740 B2 JP 7292740B2
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substituted
alkyl
heterocycle
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enpp1
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JP2020533288A5 (enExample
JP2020533288A (ja
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リンイン リー，
マーク スミス，
ケルシー エリン ショー，
ジャクリーン アン カロッザ，
ヴォルカー ボーナート，
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Leland Stanford Junior University
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Leland Stanford Junior University
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    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
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    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
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    • C07F9/44—Amides thereof
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    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
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JP2020513331A 2017-09-08 2018-09-07 Ｅｎｐｐ１阻害剤及びがんの治療のためのそれらの使用 Active JP7292740B2 (ja)

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US201762556117P 2017-09-08 2017-09-08
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PCT/US2018/050018 WO2019051269A1 (en) 2017-09-08 2018-09-07 ENPP1 INHIBITORS AND THEIR USE FOR THE TREATMENT OF CANCER

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CN114767863B (zh) * 2022-04-29 2024-01-30 西北工业大学 一种enpp2基因或蛋白在调控结直肠癌细胞中的应用
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