JP2010513494A5 - - Google Patents

Download PDF

Info

Publication number
JP2010513494A5
JP2010513494A5 JP2009542841A JP2009542841A JP2010513494A5 JP 2010513494 A5 JP2010513494 A5 JP 2010513494A5 JP 2009542841 A JP2009542841 A JP 2009542841A JP 2009542841 A JP2009542841 A JP 2009542841A JP 2010513494 A5 JP2010513494 A5 JP 2010513494A5
Authority
JP
Japan
Prior art keywords
alkyl
solvate
pharmaceutically acceptable
nhso
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009542841A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010513494A (ja
JP5211068B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2007/025765 external-priority patent/WO2008082488A1/en
Publication of JP2010513494A publication Critical patent/JP2010513494A/ja
Publication of JP2010513494A5 publication Critical patent/JP2010513494A5/ja
Application granted granted Critical
Publication of JP5211068B2 publication Critical patent/JP5211068B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2009542841A 2006-12-22 2007-12-17 Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体 Expired - Fee Related JP5211068B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87661306P 2006-12-22 2006-12-22
US60/876,613 2006-12-22
PCT/US2007/025765 WO2008082488A1 (en) 2006-12-22 2007-12-17 4, 5-ring annulated indole derivatives for treating or preventing of hcv and related viral infections

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2013009838A Division JP2013121970A (ja) 2006-12-22 2013-01-23 Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体
JP2013009837A Division JP2013100331A (ja) 2006-12-22 2013-01-23 Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体

Publications (3)

Publication Number Publication Date
JP2010513494A JP2010513494A (ja) 2010-04-30
JP2010513494A5 true JP2010513494A5 (enExample) 2013-03-14
JP5211068B2 JP5211068B2 (ja) 2013-06-12

Family

ID=39185892

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2009542841A Expired - Fee Related JP5211068B2 (ja) 2006-12-22 2007-12-17 Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体
JP2013009838A Pending JP2013121970A (ja) 2006-12-22 2013-01-23 Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体
JP2013009837A Pending JP2013100331A (ja) 2006-12-22 2013-01-23 Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2013009838A Pending JP2013121970A (ja) 2006-12-22 2013-01-23 Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体
JP2013009837A Pending JP2013100331A (ja) 2006-12-22 2013-01-23 Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体

Country Status (14)

Country Link
US (1) US8546420B2 (enExample)
EP (1) EP2064181A1 (enExample)
JP (3) JP5211068B2 (enExample)
KR (1) KR20090106539A (enExample)
CN (1) CN101611002A (enExample)
AR (1) AR064429A1 (enExample)
AU (1) AU2007339386B8 (enExample)
CA (1) CA2673254C (enExample)
CL (1) CL2007003685A1 (enExample)
MX (1) MX2009006878A (enExample)
PE (1) PE20081567A1 (enExample)
TW (1) TW200833662A (enExample)
WO (1) WO2008082488A1 (enExample)
ZA (1) ZA200904334B (enExample)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110104109A1 (en) * 2005-07-13 2011-05-05 Frank Bennett Tetracyclic indole derivatives and their use for treating or preventing viral infections
JP5079818B2 (ja) 2006-12-22 2012-11-21 メルク・シャープ・アンド・ドーム・コーポレーション Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体
KR20090106539A (ko) 2006-12-22 2009-10-09 쉐링 코포레이션 Hcv 및 관련 바이러스 감염을 치료 또는 예방하기 위한 4,5-환 환상 인돌 유도체
JP5055377B2 (ja) 2006-12-22 2012-10-24 シェーリング コーポレイション [5,6−環]環形成インドール誘導体およびその使用方法
EP2195317B1 (en) * 2007-08-29 2012-01-18 Schering Corporation 2,3-substituted azaindole derivatives for treating viral infections
WO2009032124A1 (en) * 2007-08-29 2009-03-12 Schering Corporation Substituted indole derivatives and methods of use thereof
US8765757B2 (en) * 2007-11-16 2014-07-01 Merck Sharp & Dohme Corp. 3-heterocyclic substituted indole derivatives and methods of use thereof
CN102317285A (zh) * 2007-11-16 2012-01-11 先灵公司 3-氨基磺酰基取代的吲哚衍生物及其使用方法
JP5580814B2 (ja) * 2008-06-13 2014-08-27 メルク・シャープ・アンド・ドーム・コーポレーション 3環式インドール誘導体およびその使用方法
MX2011000656A (es) * 2008-07-23 2011-02-23 Hoffmann La Roche Compuestos heterociclicos antiviricos.
KR20110094352A (ko) 2008-12-22 2011-08-23 에프. 호프만-라 로슈 아게 헤테로사이클릭 항바이러스 화합물
JP2012528195A (ja) 2009-05-29 2012-11-12 メルク・シャープ・アンド・ドーム・コーポレーション C型肝炎などの疾患を処置するための3つの結合アリール部分で構成された抗菌性化合物
WO2011066241A1 (en) 2009-11-25 2011-06-03 Schering Corporation Fused tricyclic compounds and derivatives thereof useful for the treatment of viral diseases
WO2011087740A1 (en) 2009-12-22 2011-07-21 Schering Corporation Fused tricyclic compounds and methods of use thereof for the treatment of viral diseases
MA34147B1 (fr) 2010-03-09 2013-04-03 Merck Sharp & Dohme Composes tricycliques fusionnes de silyle et leurs methodes d'utilisation dans le cadre du traitement de maladies virales
KR101213495B1 (ko) * 2010-06-03 2013-01-14 삼성디스플레이 주식회사 유기 발광 소자
CA2805440A1 (en) 2010-07-26 2012-02-09 Merck Sharp & Dohme Corp. Substituted biphenylene compounds and methods of use thereof for the treatment of viral diseases
EP2621279B1 (en) 2010-09-29 2018-04-04 Merck Sharp & Dohme Corp. Fused tetracycle derivatives and methods of use thereof for the treatment of viral diseases
WO2012142085A1 (en) 2011-04-13 2012-10-18 Merck Sharp & Dohme Corp. 2'-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
EP2697242B1 (en) 2011-04-13 2018-10-03 Merck Sharp & Dohme Corp. 2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
WO2013033900A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases
WO2013033901A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases
WO2013033899A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases
US20140378416A1 (en) 2011-09-14 2014-12-25 Michael P. Dwyer Silyl-containing heterocyclic compounds and methods of use thereof for the treatment of viral diseases
EP2909209B1 (en) 2012-10-17 2022-08-03 Merck Sharp & Dohme LLC 2'-cyano substituted nucleoside derivatives and methods of use thereof for treatment of viral diseases
EP2909210A4 (en) 2012-10-17 2016-04-06 Merck Sharp & Dohme 2'-DISUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHOD FOR THE USE THEREOF FOR THE TREATMENT OF VIRUS DISEASES
AR092959A1 (es) 2012-10-17 2015-05-06 Merck Sharp & Dohme Derivados de nucleosidos 2-metil sustituidos y metodos de uso de los mismos para el tratamiento de enfermedades virales
JP2016501200A (ja) 2012-11-19 2016-01-18 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. ウイルス性疾患を処置するための2−アルキニル置換ヌクレオシド誘導体
WO2014204831A1 (en) 2013-06-18 2014-12-24 Merck Sharp & Dohme Corp. Cyclic phosphonate substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
WO2014205592A1 (en) 2013-06-24 2014-12-31 Merck Sharp & Dohme Corp. Heterocyclic compounds and methods of use thereof for treatment of hepatitis c
WO2014205593A1 (en) 2013-06-24 2014-12-31 Merck Sharp & Dohme Corp. Substituted benzofuran compounds and methods of use thereof for treatment of viral diseases
WO2015065817A1 (en) 2013-10-30 2015-05-07 Merck Sharp & Dohme Corp. Pseudopolymorphs of an hcv ns5a inhibitor and uses thereof
CN109562107A (zh) 2016-05-10 2019-04-02 C4医药公司 用于靶蛋白降解的杂环降解决定子体
CN121974842A (zh) 2016-05-10 2026-05-05 C4医药公司 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体
CN109562113A (zh) 2016-05-10 2019-04-02 C4医药公司 用于靶蛋白降解的螺环降解决定子体
WO2017197046A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. C3-carbon linked glutarimide degronimers for target protein degradation
EP3471737B1 (en) 2016-06-20 2025-06-04 Merck Sharp & Dohme LLC Cyclic phosphate substituted nucleoside compounds and methods of use thereof for the treatment of viral diseases
WO2018032467A1 (en) 2016-08-18 2018-02-22 Merck Sharp & Dohme Corp. Chromane-substitued tetracyclic compounds and uses thereof for treatment of viral diseases
WO2018032468A1 (en) 2016-08-18 2018-02-22 Merck Sharp & Dohme Corp. Heterocycle-substitued tetracyclic compounds and methods of use thereof for treatment of viral diseases
CN106619731B (zh) * 2016-12-30 2020-06-12 昆明赛诺制药股份有限公司 一种治疗丙型肝炎的药物
EP4717317A3 (en) 2017-06-20 2026-06-03 C4 Therapeutics, Inc. N/o-linked degrons and degronimers for protein degradation

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE648639C (de) 1935-05-19 1937-08-05 I G Farbenindustrie Akt Ges Verfahren zur Darstellung von Dipyrrolen
US3632805A (en) * 1967-12-08 1972-01-04 Sumitomo Chemical Co Process for producing 1-aminoalkyl-benzodiazepine derivatives
AU575854B2 (en) * 1983-10-04 1988-08-11 Shionogi & Co., Ltd. 7beta-(carboxyalkenamido) cephalosporins
US5017380A (en) * 1986-07-02 1991-05-21 Shionogi & Co., Ltd. Gelatin hard capsule containing crystalline hydrate of oral cephalosporin
NZ220764A (en) * 1986-07-02 1989-09-27 Shionogi & Co Crystalline form of 7beta((z)-2-(2-aminothiazol-4-yl)-4- carboxybut-2-enoylamino)-3-cephem-4-carboxylic acid and pharmaceutical compositions
CA2038925A1 (en) 1990-03-26 1991-09-27 Takashi Sohda Indole derivatives, their production and use
JPH04149429A (ja) 1990-10-12 1992-05-22 Fuji Photo Film Co Ltd ハロゲン化銀カラー反転写真感光材料およびそれを用いた画像形成方法
ZA939516B (en) * 1992-12-22 1994-06-06 Smithkline Beecham Corp Endothelin receptor antagonists
JPH0753558A (ja) * 1993-08-10 1995-02-28 Shionogi & Co Ltd デュオカルマイシンsa及びその誘導体の製造法
EP0766684A4 (en) * 1994-06-09 1997-07-16 Smithkline Beecham Corp ENDOTHELINE RECEPTOR ANTAGONISTS
US6075037A (en) * 1994-06-09 2000-06-13 Smithkline Beecham Corporation Endothelin receptor antagonists
EP0800389A4 (en) * 1994-12-13 1998-04-29 Smithkline Beecham Corp NEW COMPOUNDS
IT1278077B1 (it) 1995-05-25 1997-11-17 Angeletti P Ist Richerche Bio Metodologia per riprodurre in vitro le attivita' di rna polimerasi rna-dipendente e di nucleotidiltransferasi terminale codificate dal
GB9526495D0 (en) * 1995-12-23 1996-02-28 Knoll Ag Therapeutic agents
US5922757A (en) 1996-09-30 1999-07-13 The Regents Of The University Of California Treatment and prevention of hepatic disorders
NZ335276A (en) 1996-10-18 2000-09-29 Vertex Pharma Inhibitors of serine proteases, particularly hepatitis C virus (HCV) NS3 (Non Structural Protein 3) protease
GB9623908D0 (en) 1996-11-18 1997-01-08 Hoffmann La Roche Amino acid derivatives
PT1012180E (pt) 1997-08-11 2005-04-29 Boehringer Ingelheim Ca Ltd Analogos de peptidos inibidores da hepatite c
FR2768146B1 (fr) 1997-09-05 2000-05-05 Oreal Nouveaux composes de la famille des indole-carboxyliques et leur utilisation
HK1047947A1 (zh) * 2000-04-05 2003-03-14 Schering Corporation 包含n-环状p2部分的丙型肝炎病毒的大环ns3-丝氨酸蛋白酶抑制剂
AU2001253621A1 (en) * 2000-04-19 2001-11-07 Schering Corporation Macrocyclic NS3-serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties
SK742003A3 (en) * 2000-07-21 2003-06-03 Schering Corp Novel peptides as NS3-serine protease inhibitors of hepatitis C virus
AR029851A1 (es) * 2000-07-21 2003-07-16 Dendreon Corp Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c
US7012066B2 (en) * 2000-07-21 2006-03-14 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
AR034127A1 (es) * 2000-07-21 2004-02-04 Schering Corp Imidazolidinonas como inhibidores de ns3-serina proteasa del virus de hepatitis c, composicion farmaceutica, un metodo para su preparacion, y el uso de las mismas para la manufactura de un medicamento
IL154981A0 (en) * 2000-10-10 2003-10-31 Smithkline Beecham Corp Substituted indoles, pharmaceutical compositions containing such indoles and their use as ppay-y-binding agents
AU3659102A (en) * 2000-12-12 2002-06-24 Schering Corp Diaryl peptides as ns3-serine protease inhibitors of hepatits c virus
CA2430808A1 (en) * 2000-12-18 2002-06-27 Eli Lilly And Company Cycloalkylfused [g]-indole compounds as spla2-inhibitors in the treatment of inflammatory diseases
US7626026B2 (en) * 2001-02-22 2009-12-01 University Of Bradford Pyrrolo-indole and pyrrolo-quinoline derivatives as prodrugs for tumour treatment
EP2335700A1 (en) 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
JP2003342276A (ja) * 2002-05-24 2003-12-03 Mitsui Chemicals Inc ピロロキナゾリン誘導体及び農園芸用有害生物防除剤ならびにその使用方法
JP2006505571A (ja) 2002-10-15 2006-02-16 リゲル ファーマシューテイカルズ、インコーポレイテッド 置換されたインドール及びhcv阻害剤としてのその使用
US20050075331A1 (en) * 2003-10-06 2005-04-07 Pratt John K. Anti-infective agents
ES2382377T3 (es) 2003-05-30 2012-06-07 Gemin X Pharmaceuticals Canada Inc. Compuestos triheterocíclicos, composiciones, y métodos para tratar cáncer
GB0323845D0 (en) 2003-10-10 2003-11-12 Angeletti P Ist Richerche Bio Chemical compounds,compositions and uses
PE20090047A1 (es) * 2003-11-10 2009-01-26 Schering Corp Anticuerpo recombinante humanizado anti-interleuquina 10
RU2428428C9 (ru) 2004-02-27 2012-03-10 Шеринг Корпорейшн Серусодержащие соединения, действующие как ингибиторы сериновой протеазы ns3 вируса гепатита с
MXPA06009881A (es) 2004-03-01 2007-11-20 Viropharma Inc Derivados de piranoindol y el uso de los mismos para el tratamiento de infeccion o enfermedad de virus de hepatitis c.
WO2005107745A1 (en) * 2004-05-06 2005-11-17 Schering Corporation An inhibitor of hepatitis c
EP1604988A1 (en) 2004-05-18 2005-12-14 Sanofi-Aventis Deutschland GmbH Pyridazinone derivatives, methods for producing them and their use as pharmaceuticals
WO2007084413A2 (en) 2004-07-14 2007-07-26 Ptc Therapeutics, Inc. Methods for treating hepatitis c
US7153848B2 (en) 2004-08-09 2006-12-26 Bristol-Myers Squibb Company Inhibitors of HCV replication
WO2006034337A2 (en) 2004-09-23 2006-03-30 Wyeth Carbazole and cyclopentaindole derivatives to treat infection with hepatitis c virus
DE102004047272A1 (de) 2004-09-24 2006-04-06 Schering Ag Inhibitoren der löslichen Adenylatzyklase
RU2007119562A (ru) 2004-10-26 2008-12-10 Институто Ди Ричерке Ди Биолоджиа Молеколаре П Анджелетти Спа (It) Тетрациклические производные индолов в качестве противовирусных агентов
JP4149429B2 (ja) 2004-10-26 2008-09-10 本田技研工業株式会社 車両の走行安全装置
CN101103026A (zh) 2005-01-14 2008-01-09 健亚生物科技公司 用于治疗病毒感染的吲哚衍生物
US20110104109A1 (en) 2005-07-13 2011-05-05 Frank Bennett Tetracyclic indole derivatives and their use for treating or preventing viral infections
GB0518390D0 (en) 2005-09-09 2005-10-19 Angeletti P Ist Richerche Bio Therapeutic compounds
US7482360B2 (en) 2005-09-23 2009-01-27 Schering Corporation Fused tetracyclic mGluR1 antagonists as therapeutic agents
JP2009523732A (ja) 2006-01-13 2009-06-25 ピーティーシー セラピューティクス,インコーポレーテッド C型肝炎の治療方法
MX2008010355A (es) * 2006-02-09 2008-10-31 Schering Corp Combinaciones que comprenden inhibidores de proteasa del virus de la hepatitis c e inhibidores de polimerasa del virus de la hepatitis c, y metodos de tratamiento relacionados con los mismos.
JP5079818B2 (ja) 2006-12-22 2012-11-21 メルク・シャープ・アンド・ドーム・コーポレーション Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体
KR20090106539A (ko) 2006-12-22 2009-10-09 쉐링 코포레이션 Hcv 및 관련 바이러스 감염을 치료 또는 예방하기 위한 4,5-환 환상 인돌 유도체
JP5055377B2 (ja) 2006-12-22 2012-10-24 シェーリング コーポレイション [5,6−環]環形成インドール誘導体およびその使用方法
EP2195317B1 (en) 2007-08-29 2012-01-18 Schering Corporation 2,3-substituted azaindole derivatives for treating viral infections
WO2009032124A1 (en) 2007-08-29 2009-03-12 Schering Corporation Substituted indole derivatives and methods of use thereof
RU2010111550A (ru) 2007-08-29 2011-10-10 Шеринг Корпорейшн (US) 2,3-замещенные индольные производные для лечения вирусных инфекций
CN102317285A (zh) 2007-11-16 2012-01-11 先灵公司 3-氨基磺酰基取代的吲哚衍生物及其使用方法
US8765757B2 (en) 2007-11-16 2014-07-01 Merck Sharp & Dohme Corp. 3-heterocyclic substituted indole derivatives and methods of use thereof

Similar Documents

Publication Publication Date Title
JP6439050B2 (ja) Ask1阻害剤を調製するプロセス
JP6356876B2 (ja) 抗ウイルス化合物の合成
TWI460166B (zh) 製備2-亞胺基-四氫噻唑-4-酮衍生物之新穎方法
JP2010510976A5 (enExample)
JP2021536468A (ja) メチル6−(2,4−ジクロロフェニル)−5−[4−[(3s)−1−(3−フルオロプロピル)ピロリジン−3−イル]オキシフェニル]−8,9−ジヒドロ−7h−ベンゾ[7]アヌレン−2−カルボキシレートの調製方法
JP6464098B2 (ja) ボルチオキセチンの製造方法
JP2016512823A5 (enExample)
JP2010526056A (ja) イマチニブの製造方法
JP2018502909A5 (enExample)
CN104736532B (zh) 改进的生产5‑(2,6‑二‑4‑吗啉‑4‑嘧啶)‑4‑三氟甲基吡啶‑2‑胺的方法
JP2016509042A5 (enExample)
KR102266680B1 (ko) 벨리노스테트의 다형태 및 이의 제조 방법
CN114573512B (zh) 一种合成c2-二氟烷基苯并咪唑衍生物的方法
KR20100031045A (ko) 아데포비어 디피복실의 정제방법
JP2015512381A5 (enExample)
JP2010235601A5 (enExample)
ES2965478T3 (es) Protodescarboxilación catalizada por metales de transición de derivados del ácido alfa-halo-acrílico
JP2018505179A5 (enExample)
JP5335997B2 (ja) 2−ブロモ−6−フルオロナフタレンの調製方法
CN107827705A (zh) 一种二氯苯类化合物的单芳基化方法
BR112014018985B1 (pt) método para preparar um composto
JP2017525748A (ja) シクロクレアチンおよびその類似体の合成
JP6592521B2 (ja) ピラゾール誘導体の製造方法
JP2014151285A (ja) 新規光学活性イミダゾリン−リン酸触媒とその誘導体
JP2012240959A (ja) 光学活性β−アミノチオールまたは光学活性β−アミノスルホン酸誘導体の合成法