JP2010513494A5 - - Google Patents

Download PDF

Info

Publication number
JP2010513494A5
JP2010513494A5 JP2009542841A JP2009542841A JP2010513494A5 JP 2010513494 A5 JP2010513494 A5 JP 2010513494A5 JP 2009542841 A JP2009542841 A JP 2009542841A JP 2009542841 A JP2009542841 A JP 2009542841A JP 2010513494 A5 JP2010513494 A5 JP 2010513494A5
Authority
JP
Japan
Prior art keywords
alkyl
solvate
pharmaceutically acceptable
nhso
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009542841A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010513494A (ja
JP5211068B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2007/025765 external-priority patent/WO2008082488A1/en
Publication of JP2010513494A publication Critical patent/JP2010513494A/ja
Publication of JP2010513494A5 publication Critical patent/JP2010513494A5/ja
Application granted granted Critical
Publication of JP5211068B2 publication Critical patent/JP5211068B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2009542841A 2006-12-22 2007-12-17 Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体 Expired - Fee Related JP5211068B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87661306P 2006-12-22 2006-12-22
US60/876,613 2006-12-22
PCT/US2007/025765 WO2008082488A1 (en) 2006-12-22 2007-12-17 4, 5-ring annulated indole derivatives for treating or preventing of hcv and related viral infections

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2013009838A Division JP2013121970A (ja) 2006-12-22 2013-01-23 Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体
JP2013009837A Division JP2013100331A (ja) 2006-12-22 2013-01-23 Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体

Publications (3)

Publication Number Publication Date
JP2010513494A JP2010513494A (ja) 2010-04-30
JP2010513494A5 true JP2010513494A5 (enExample) 2013-03-14
JP5211068B2 JP5211068B2 (ja) 2013-06-12

Family

ID=39185892

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2009542841A Expired - Fee Related JP5211068B2 (ja) 2006-12-22 2007-12-17 Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体
JP2013009838A Pending JP2013121970A (ja) 2006-12-22 2013-01-23 Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体
JP2013009837A Pending JP2013100331A (ja) 2006-12-22 2013-01-23 Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2013009838A Pending JP2013121970A (ja) 2006-12-22 2013-01-23 Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体
JP2013009837A Pending JP2013100331A (ja) 2006-12-22 2013-01-23 Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体

Country Status (14)

Country Link
US (1) US8546420B2 (enExample)
EP (1) EP2064181A1 (enExample)
JP (3) JP5211068B2 (enExample)
KR (1) KR20090106539A (enExample)
CN (1) CN101611002A (enExample)
AR (1) AR064429A1 (enExample)
AU (1) AU2007339386B8 (enExample)
CA (1) CA2673254C (enExample)
CL (1) CL2007003685A1 (enExample)
MX (1) MX2009006878A (enExample)
PE (1) PE20081567A1 (enExample)
TW (1) TW200833662A (enExample)
WO (1) WO2008082488A1 (enExample)
ZA (1) ZA200904334B (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110104109A1 (en) * 2005-07-13 2011-05-05 Frank Bennett Tetracyclic indole derivatives and their use for treating or preventing viral infections
CA2674831A1 (en) 2006-12-22 2008-11-13 Schering Corporation 5,6-ring annulated indole derivatives and methods of use thereof
JP5211068B2 (ja) 2006-12-22 2013-06-12 メルク・シャープ・アンド・ドーム・コーポレーション Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体
MX2009006880A (es) 2006-12-22 2009-07-03 Schering Corp Derivados indolicos con anillo unido en las posiciones 4,5 para tratar o prevenir infecciones virales por virus de la hepatitis c e infecciones virales relacionadas.
ES2447543T3 (es) * 2007-08-29 2014-03-12 Merck Sharp & Dohme Corp. Derivados de indol sustituidos y métodos de utilización de los mismos
CA2697500A1 (en) * 2007-08-29 2009-03-12 Schering Corporation 2,3-substituted azaindole derivatives for treating viral infections
EP2222672B1 (en) * 2007-11-16 2013-12-18 Merck Sharp & Dohme Corp. 3-aminosulfonyl substituted indole derivatives and methods of use thereof
CA2705586A1 (en) * 2007-11-16 2009-05-22 Schering Corporation 3-heterocyclic substituted indole derivatives and methods of use thereof
WO2009152200A1 (en) * 2008-06-13 2009-12-17 Schering Corporation Tricyclic indole derivatives and methods of use thereof
BRPI0916233A2 (pt) * 2008-07-23 2018-03-13 F.Hoffman-La Roche Ag compostos heterocíclicos antivirais
BRPI0924121A2 (pt) 2008-12-22 2019-09-24 Hoffmann La Roche compostos antivirais heterocíclicos
CA2763140A1 (en) 2009-05-29 2010-12-02 Schering Corporation Antiviral compounds composed of three linked aryl moieties to treat diseases such as hepatitis c
AU2010324871A1 (en) 2009-11-25 2012-06-14 Merck Sharp & Dohme Corp. Fused tricyclic compounds and derivatives thereof useful for the treatment of viral diseases
CA2785488A1 (en) 2009-12-22 2011-07-21 Merck Sharp & Dohme Corp. Fused tricyclic compounds and methods of use thereof for the treatment of viral diseases
EP2545060B1 (en) 2010-03-09 2015-11-25 Merck Sharp & Dohme Corp. Fused tricyclic silyl compounds and methods of use thereof for the treatment of viral diseases
KR101213495B1 (ko) * 2010-06-03 2013-01-14 삼성디스플레이 주식회사 유기 발광 소자
WO2012018534A2 (en) 2010-07-26 2012-02-09 Schering Corporation Substituted biphenylene compounds and methods of use thereof for the treatment of viral diseases
EP2621279B1 (en) 2010-09-29 2018-04-04 Merck Sharp & Dohme Corp. Fused tetracycle derivatives and methods of use thereof for the treatment of viral diseases
EP2696681B1 (en) 2011-04-13 2018-10-03 Merck Sharp & Dohme Corp. 2'-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
US9156872B2 (en) 2011-04-13 2015-10-13 Merck Sharp & Dohme Corp. 2′-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
WO2013033899A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases
WO2013033900A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases
WO2013033901A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases
WO2013039876A1 (en) 2011-09-14 2013-03-21 Merck Sharp & Dohme Corp. Silyl-containing heterocyclic compounds and methods of use thereof for the treatment of viral diseases
EP2909210A4 (en) 2012-10-17 2016-04-06 Merck Sharp & Dohme 2'-DISUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHOD FOR THE USE THEREOF FOR THE TREATMENT OF VIRUS DISEASES
AR092959A1 (es) 2012-10-17 2015-05-06 Merck Sharp & Dohme Derivados de nucleosidos 2-metil sustituidos y metodos de uso de los mismos para el tratamiento de enfermedades virales
WO2014059901A1 (en) 2012-10-17 2014-04-24 Merck Sharp & Dohme Corp. 2'-cyano substituted nucleoside derivatives and methods of use thereof for treatment of viral diseases
WO2014078463A1 (en) 2012-11-19 2014-05-22 Merck Sharp & Dohme Corp. 2 -alkynyl substituted nucleoside derivatives for treating viral diseases
US9765107B2 (en) 2013-06-18 2017-09-19 Merck Sharp & Dohme Corp. Cyclic phosphonate substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
WO2014205593A1 (en) 2013-06-24 2014-12-31 Merck Sharp & Dohme Corp. Substituted benzofuran compounds and methods of use thereof for treatment of viral diseases
WO2014205592A1 (en) 2013-06-24 2014-12-31 Merck Sharp & Dohme Corp. Heterocyclic compounds and methods of use thereof for treatment of hepatitis c
US10167298B2 (en) 2013-10-30 2019-01-01 Merck Sharp & Dohme Corp. Pseudopolymorphs of an HCV NS5A inhibitor and uses thereof
EP4483875A3 (en) 2016-05-10 2025-04-02 C4 Therapeutics, Inc. Spirocyclic degronimers for target protein degradation
CN109562107A (zh) 2016-05-10 2019-04-02 C4医药公司 用于靶蛋白降解的杂环降解决定子体
EP3455219A4 (en) 2016-05-10 2019-12-18 C4 Therapeutics, Inc. AMINE-RELATED C3-GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION
CN109641874A (zh) 2016-05-10 2019-04-16 C4医药公司 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
WO2017223012A1 (en) 2016-06-20 2017-12-28 Merck Sharp & Dohme Corp. Cyclic phosphate substituted nucleoside compounds and methods of use thereof for the treatment of viral diseases
CN106619731B (zh) * 2016-12-30 2020-06-12 昆明赛诺制药股份有限公司 一种治疗丙型肝炎的药物
EP3641762B1 (en) 2017-06-20 2026-02-18 C4 Therapeutics, Inc. N/o-linked degrons and degronimers for protein degradation

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE648639C (de) 1935-05-19 1937-08-05 I G Farbenindustrie Akt Ges Verfahren zur Darstellung von Dipyrrolen
US3632805A (en) * 1967-12-08 1972-01-04 Sumitomo Chemical Co Process for producing 1-aminoalkyl-benzodiazepine derivatives
AU575854B2 (en) * 1983-10-04 1988-08-11 Shionogi & Co., Ltd. 7beta-(carboxyalkenamido) cephalosporins
NZ220764A (en) * 1986-07-02 1989-09-27 Shionogi & Co Crystalline form of 7beta((z)-2-(2-aminothiazol-4-yl)-4- carboxybut-2-enoylamino)-3-cephem-4-carboxylic acid and pharmaceutical compositions
US5017380A (en) * 1986-07-02 1991-05-21 Shionogi & Co., Ltd. Gelatin hard capsule containing crystalline hydrate of oral cephalosporin
CA2038925A1 (en) 1990-03-26 1991-09-27 Takashi Sohda Indole derivatives, their production and use
JPH04149429A (ja) 1990-10-12 1992-05-22 Fuji Photo Film Co Ltd ハロゲン化銀カラー反転写真感光材料およびそれを用いた画像形成方法
ZA939516B (en) * 1992-12-22 1994-06-06 Smithkline Beecham Corp Endothelin receptor antagonists
JPH0753558A (ja) * 1993-08-10 1995-02-28 Shionogi & Co Ltd デュオカルマイシンsa及びその誘導体の製造法
WO1995033748A1 (en) * 1994-06-09 1995-12-14 Smithkline Beecham Corporation Endothelin receptor antagonists
EP0766684A4 (en) * 1994-06-09 1997-07-16 Smithkline Beecham Corp ENDOTHELINE RECEPTOR ANTAGONISTS
JPH10510538A (ja) * 1994-12-13 1998-10-13 スミスクライン・ビーチャム・コーポレイション 新規化合物
IT1278077B1 (it) 1995-05-25 1997-11-17 Angeletti P Ist Richerche Bio Metodologia per riprodurre in vitro le attivita' di rna polimerasi rna-dipendente e di nucleotidiltransferasi terminale codificate dal
GB9526495D0 (en) * 1995-12-23 1996-02-28 Knoll Ag Therapeutic agents
US5922757A (en) 1996-09-30 1999-07-13 The Regents Of The University Of California Treatment and prevention of hepatic disorders
CZ298749B6 (cs) 1996-10-18 2008-01-16 Vertex Pharmaceuticals Incorporated Inhibitory serinových proteáz a farmaceutické prostředky s jejich obsahem
GB9623908D0 (en) 1996-11-18 1997-01-08 Hoffmann La Roche Amino acid derivatives
EP1012180B1 (en) 1997-08-11 2004-12-01 Boehringer Ingelheim (Canada) Ltd. Hepatitis c inhibitor peptide analogues
FR2768146B1 (fr) * 1997-09-05 2000-05-05 Oreal Nouveaux composes de la famille des indole-carboxyliques et leur utilisation
JP4748911B2 (ja) * 2000-04-05 2011-08-17 シェーリング コーポレイション N−環状p2部分を含むc型肝炎ウイルスの大環状ns3‐セリンプロテアーゼ阻害剤
NZ521456A (en) * 2000-04-19 2004-07-30 Schering Corp Macrocyclic NS3-Serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties
WO2002008187A1 (en) * 2000-07-21 2002-01-31 Schering Corporation Novel peptides as ns3-serine protease inhibitors of hepatitis c virus
MXPA03000627A (es) * 2000-07-21 2004-07-30 Schering Corp Nuevos peptidos como inhibidores de proteasa serina-ns3 del virus de la hepatitis c.
AR029851A1 (es) * 2000-07-21 2003-07-16 Dendreon Corp Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c
AR034127A1 (es) * 2000-07-21 2004-02-04 Schering Corp Imidazolidinonas como inhibidores de ns3-serina proteasa del virus de hepatitis c, composicion farmaceutica, un metodo para su preparacion, y el uso de las mismas para la manufactura de un medicamento
JP2004529855A (ja) * 2000-10-10 2004-09-30 スミスクライン ビーチャム コーポレーション 置換インドール類、そのような置換インドール類を含む医薬組成物及びPPAR−γ結合剤としてのそれらの使用
HUP0303436A2 (hu) * 2000-12-12 2004-01-28 Schering Corp. Diaril-peptidek mint a hepatitis C vírus NS3-szerin proteáz inhibitorai, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
JP2004518658A (ja) * 2000-12-18 2004-06-24 イーライ・リリー・アンド・カンパニー 新規なsPLA2インヒビター
JP2004529887A (ja) * 2001-02-22 2004-09-30 スクール オブ ファーマシー, ユニヴァーシティ オブ ロンドン 腫瘍治療のためのプロドラッグとしてのピロロ−インドールおよびピロロ−キノリン誘導体
EP2335700A1 (en) 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
JP2003342276A (ja) * 2002-05-24 2003-12-03 Mitsui Chemicals Inc ピロロキナゾリン誘導体及び農園芸用有害生物防除剤ならびにその使用方法
JP2006505571A (ja) 2002-10-15 2006-02-16 リゲル ファーマシューテイカルズ、インコーポレイテッド 置換されたインドール及びhcv阻害剤としてのその使用
US20050075331A1 (en) * 2003-10-06 2005-04-07 Pratt John K. Anti-infective agents
US7425553B2 (en) 2003-05-30 2008-09-16 Gemin X Pharmaceuticals Canada Inc. Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases
GB0323845D0 (en) 2003-10-10 2003-11-12 Angeletti P Ist Richerche Bio Chemical compounds,compositions and uses
AR046833A1 (es) * 2003-11-10 2005-12-28 Schering Corp Anticuerpos anti-interleuquina-10
MY145081A (en) 2004-02-27 2011-12-15 Schering Corp Sulfur compounds as inhibitors of hepatitis c virus ns3 serine protease
CN101098695A (zh) 2004-03-01 2008-01-02 维洛药品公司 吡喃并吲哚衍生物及其用于治疗丙型肝炎病毒感染或者疾病的用途
AR049635A1 (es) * 2004-05-06 2006-08-23 Schering Corp (1r,2s,5s)-n-((1s)-3-amino-1-(ciclobutilmetil)-2,3-dioxopropil)-3-((2s)-2-((((1,1-dimetiletil)amino)carbonil)amino)-3,3-dimetil-1-oxobutil)-6,6-dimetil-3-azabiciclo(3.1.0)hexan-2-carboxamida como inhibidor de la ns3/ns4a serina proteasa del virus de la hepatitis c
EP1604988A1 (en) 2004-05-18 2005-12-14 Sanofi-Aventis Deutschland GmbH Pyridazinone derivatives, methods for producing them and their use as pharmaceuticals
WO2007084413A2 (en) 2004-07-14 2007-07-26 Ptc Therapeutics, Inc. Methods for treating hepatitis c
US7153848B2 (en) 2004-08-09 2006-12-26 Bristol-Myers Squibb Company Inhibitors of HCV replication
US7250441B2 (en) 2004-09-23 2007-07-31 Wyeth Carbazole and cyclopentaindole derivatives to treat infection with Hepatitis C virus
DE102004047272A1 (de) 2004-09-24 2006-04-06 Schering Ag Inhibitoren der löslichen Adenylatzyklase
CA2585084A1 (en) 2004-10-26 2006-05-04 Immacolata Conte Tetracyclic indole derivatives as antiviral agents
JP4149429B2 (ja) 2004-10-26 2008-09-10 本田技研工業株式会社 車両の走行安全装置
US20060211698A1 (en) 2005-01-14 2006-09-21 Genelabs, Inc. Bicyclic heteroaryl derivatives for treating viruses
US20110104109A1 (en) 2005-07-13 2011-05-05 Frank Bennett Tetracyclic indole derivatives and their use for treating or preventing viral infections
GB0518390D0 (en) 2005-09-09 2005-10-19 Angeletti P Ist Richerche Bio Therapeutic compounds
CA2623026A1 (en) 2005-09-23 2007-04-05 Schering Corporation Fused tetracyclic mglur1 antagonists as therapeutic agents
WO2007084435A2 (en) 2006-01-13 2007-07-26 Ptc Therapeutics, Inc. Methods for treating hepatitis c
US20070274951A1 (en) * 2006-02-09 2007-11-29 Xiao Tong Combinations comprising HCV protease inhibitor(s) and HCV polymerase inhibitor(s), and methods of treatment related thereto
JP5211068B2 (ja) 2006-12-22 2013-06-12 メルク・シャープ・アンド・ドーム・コーポレーション Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体
MX2009006880A (es) 2006-12-22 2009-07-03 Schering Corp Derivados indolicos con anillo unido en las posiciones 4,5 para tratar o prevenir infecciones virales por virus de la hepatitis c e infecciones virales relacionadas.
CA2674831A1 (en) 2006-12-22 2008-11-13 Schering Corporation 5,6-ring annulated indole derivatives and methods of use thereof
ES2447543T3 (es) 2007-08-29 2014-03-12 Merck Sharp & Dohme Corp. Derivados de indol sustituidos y métodos de utilización de los mismos
CA2697500A1 (en) 2007-08-29 2009-03-12 Schering Corporation 2,3-substituted azaindole derivatives for treating viral infections
EP2197842B1 (en) 2007-08-29 2012-05-23 Schering Corporation 2, 3-substituted indole derivatives for treating viral infections
CA2705586A1 (en) 2007-11-16 2009-05-22 Schering Corporation 3-heterocyclic substituted indole derivatives and methods of use thereof
EP2222672B1 (en) 2007-11-16 2013-12-18 Merck Sharp & Dohme Corp. 3-aminosulfonyl substituted indole derivatives and methods of use thereof

Similar Documents

Publication Publication Date Title
JP6439050B2 (ja) Ask1阻害剤を調製するプロセス
JP6356876B2 (ja) 抗ウイルス化合物の合成
TWI460166B (zh) 製備2-亞胺基-四氫噻唑-4-酮衍生物之新穎方法
JP2010510976A5 (enExample)
JP2021536468A (ja) メチル6−(2,4−ジクロロフェニル)−5−[4−[(3s)−1−(3−フルオロプロピル)ピロリジン−3−イル]オキシフェニル]−8,9−ジヒドロ−7h−ベンゾ[7]アヌレン−2−カルボキシレートの調製方法
JP6464098B2 (ja) ボルチオキセチンの製造方法
JP2016512823A5 (enExample)
JP2010526056A (ja) イマチニブの製造方法
JP2018502909A5 (enExample)
CN104736532B (zh) 改进的生产5‑(2,6‑二‑4‑吗啉‑4‑嘧啶)‑4‑三氟甲基吡啶‑2‑胺的方法
JP2016509042A5 (enExample)
KR102266680B1 (ko) 벨리노스테트의 다형태 및 이의 제조 방법
CN114573512B (zh) 一种合成c2-二氟烷基苯并咪唑衍生物的方法
KR20100031045A (ko) 아데포비어 디피복실의 정제방법
JP2010235601A5 (enExample)
JP2015512381A5 (enExample)
ES2965478T3 (es) Protodescarboxilación catalizada por metales de transición de derivados del ácido alfa-halo-acrílico
JP2018505179A5 (enExample)
JP5335997B2 (ja) 2−ブロモ−6−フルオロナフタレンの調製方法
CN107827705A (zh) 一种二氯苯类化合物的单芳基化方法
BR112014018985B1 (pt) método para preparar um composto
JP2017525748A (ja) シクロクレアチンおよびその類似体の合成
JP6592521B2 (ja) ピラゾール誘導体の製造方法
JP2014151285A (ja) 新規光学活性イミダゾリン−リン酸触媒とその誘導体
JP2012240959A (ja) 光学活性β−アミノチオールまたは光学活性β−アミノスルホン酸誘導体の合成法