JP2010513494A5 - - Google Patents

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Publication number
JP2010513494A5
JP2010513494A5 JP2009542841A JP2009542841A JP2010513494A5 JP 2010513494 A5 JP2010513494 A5 JP 2010513494A5 JP 2009542841 A JP2009542841 A JP 2009542841A JP 2009542841 A JP2009542841 A JP 2009542841A JP 2010513494 A5 JP2010513494 A5 JP 2010513494A5
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JP
Japan
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alkyl
solvate
pharmaceutically acceptable
nhso
cycloalkyl
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JP2009542841A
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English (en)
Japanese (ja)
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JP2010513494A (ja
JP5211068B2 (ja
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Priority claimed from PCT/US2007/025765 external-priority patent/WO2008082488A1/en
Publication of JP2010513494A publication Critical patent/JP2010513494A/ja
Publication of JP2010513494A5 publication Critical patent/JP2010513494A5/ja
Application granted granted Critical
Publication of JP5211068B2 publication Critical patent/JP5211068B2/ja
Expired - Fee Related legal-status Critical Current
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JP2009542841A 2006-12-22 2007-12-17 Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体 Expired - Fee Related JP5211068B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87661306P 2006-12-22 2006-12-22
US60/876,613 2006-12-22
PCT/US2007/025765 WO2008082488A1 (en) 2006-12-22 2007-12-17 4, 5-ring annulated indole derivatives for treating or preventing of hcv and related viral infections

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2013009837A Division JP2013100331A (ja) 2006-12-22 2013-01-23 Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体
JP2013009838A Division JP2013121970A (ja) 2006-12-22 2013-01-23 Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体

Publications (3)

Publication Number Publication Date
JP2010513494A JP2010513494A (ja) 2010-04-30
JP2010513494A5 true JP2010513494A5 (enExample) 2013-03-14
JP5211068B2 JP5211068B2 (ja) 2013-06-12

Family

ID=39185892

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2009542841A Expired - Fee Related JP5211068B2 (ja) 2006-12-22 2007-12-17 Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体
JP2013009838A Pending JP2013121970A (ja) 2006-12-22 2013-01-23 Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体
JP2013009837A Pending JP2013100331A (ja) 2006-12-22 2013-01-23 Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2013009838A Pending JP2013121970A (ja) 2006-12-22 2013-01-23 Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体
JP2013009837A Pending JP2013100331A (ja) 2006-12-22 2013-01-23 Hcvおよび関連するウイルス疾患の治療または予防のための4,5−環インドール誘導体

Country Status (14)

Country Link
US (1) US8546420B2 (enExample)
EP (1) EP2064181A1 (enExample)
JP (3) JP5211068B2 (enExample)
KR (1) KR20090106539A (enExample)
CN (1) CN101611002A (enExample)
AR (1) AR064429A1 (enExample)
AU (1) AU2007339386B8 (enExample)
CA (1) CA2673254C (enExample)
CL (1) CL2007003685A1 (enExample)
MX (1) MX2009006878A (enExample)
PE (1) PE20081567A1 (enExample)
TW (1) TW200833662A (enExample)
WO (1) WO2008082488A1 (enExample)
ZA (1) ZA200904334B (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110104109A1 (en) * 2005-07-13 2011-05-05 Frank Bennett Tetracyclic indole derivatives and their use for treating or preventing viral infections
MX2009006878A (es) 2006-12-22 2009-07-07 Schering Corp Derivados indolicos con anillo unido en las posiciones 4,5 para tratar o prevenir infecciones virales por virus de la hepatitis c e infecciones virales relacionadas.
KR20090094154A (ko) 2006-12-22 2009-09-03 쉐링 코포레이션 Hcv 및 관련 바이러스 감염을 치료 또는 예방하기 위한 4,5-환 환상 인돌 유도체
US8268803B2 (en) 2006-12-22 2012-09-18 Merck Sharp & Dohme Corp. 5, 6-ring annulated indole derivatives and use thereof
CN101821252A (zh) * 2007-08-29 2010-09-01 先灵公司 取代的吲哚衍生物及其使用方法
KR20100065167A (ko) * 2007-08-29 2010-06-15 쉐링 코포레이션 바이러스 감염 치료용 2,3-치환된 아자인돌 유도체
US8765757B2 (en) * 2007-11-16 2014-07-01 Merck Sharp & Dohme Corp. 3-heterocyclic substituted indole derivatives and methods of use thereof
MX2010005355A (es) * 2007-11-16 2010-06-02 Schering Corp Derivados de indol sustituidos con 3-aminosulfonilo y metodos de uso de los mismos.
MX2010013630A (es) * 2008-06-13 2010-12-21 Schering Corp Derivados triciclicos de indol y metodos de uso de los mismos.
JP2011528686A (ja) * 2008-07-23 2011-11-24 エフ.ホフマン−ラ ロシュ アーゲー ヘテロ環式抗ウイルス性化合物
US8178547B2 (en) 2008-12-22 2012-05-15 Roche Palo Alto Llc Heterocyclic antiviral compounds
EP2435424B1 (en) 2009-05-29 2015-01-21 Merck Sharp & Dohme Corp. Antiviral compounds composed of three linked aryl moieties to treat diseases such as hepatitis c
US20120276047A1 (en) 2009-11-25 2012-11-01 Rosenblum Stuart B Fused tricyclic compounds and derivatives thereof useful for the treatment of viral diseases
EP2516430B1 (en) 2009-12-22 2014-11-05 Merck Sharp & Dohme Corp. Fused tricyclic compounds and methods of use thereof for the treatment of viral diseases
BR112012022125A2 (pt) 2010-03-09 2016-11-01 Merck Sharp & Dhme Corp composto, sal de dicloridrato, composição farmacêutica, uso do composto, e, método para tratar um paciente
KR101213495B1 (ko) * 2010-06-03 2013-01-14 삼성디스플레이 주식회사 유기 발광 소자
JP2013541499A (ja) 2010-07-26 2013-11-14 メルク・シャープ・エンド・ドーム・コーポレイション 置換されたビフェニレン化合物およびウイルス性疾患の治療のためのその使用方法
AU2011314168A1 (en) 2010-09-29 2013-04-04 Merck Sharp & Dohme Corp. Fused tetracycle derivatives and methods of use thereof for the treatment of viral diseases
EA201391519A1 (ru) 2011-04-13 2014-03-31 Мерк Шарп И Доум Корп. 2'-замещенные нуклеозидные производные и способы их применения для лечения вирусных заболеваний
WO2012142075A1 (en) 2011-04-13 2012-10-18 Merck Sharp & Dohme Corp. 2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
WO2013033900A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases
WO2013033901A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases
WO2013033899A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases
EP2755981A4 (en) 2011-09-14 2015-03-25 Merck Sharp & Dohme SILICULAR HETEROCYCLIC DERIVATIVES AND METHOD FOR THEIR USE FOR THE TREATMENT OF VIRUS DISEASES
AR092959A1 (es) 2012-10-17 2015-05-06 Merck Sharp & Dohme Derivados de nucleosidos 2-metil sustituidos y metodos de uso de los mismos para el tratamiento de enfermedades virales
WO2014059901A1 (en) 2012-10-17 2014-04-24 Merck Sharp & Dohme Corp. 2'-cyano substituted nucleoside derivatives and methods of use thereof for treatment of viral diseases
WO2014059902A1 (en) 2012-10-17 2014-04-24 Merck Sharp & Dohme Corp. 2'-disubstituted substituted nucleoside derivatives and methods of use thereof for treatment of viral diseases
RU2015123641A (ru) 2012-11-19 2017-01-10 Мерк Шарп И Доум Корп. 2-алкинилзамещенные производные нуклеозидов, предназначенные для лечения вирусных заболеваний
EP3010512B1 (en) 2013-06-18 2017-12-27 Merck Sharp & Dohme Corp. Cyclic phosphonate substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
WO2014205593A1 (en) 2013-06-24 2014-12-31 Merck Sharp & Dohme Corp. Substituted benzofuran compounds and methods of use thereof for treatment of viral diseases
WO2014205592A1 (en) 2013-06-24 2014-12-31 Merck Sharp & Dohme Corp. Heterocyclic compounds and methods of use thereof for treatment of hepatitis c
US10167298B2 (en) 2013-10-30 2019-01-01 Merck Sharp & Dohme Corp. Pseudopolymorphs of an HCV NS5A inhibitor and uses thereof
CN109790143A (zh) 2016-05-10 2019-05-21 C4医药公司 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体
WO2017197046A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. C3-carbon linked glutarimide degronimers for target protein degradation
EP4491236A3 (en) 2016-05-10 2025-04-02 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
EP4483875A3 (en) 2016-05-10 2025-04-02 C4 Therapeutics, Inc. Spirocyclic degronimers for target protein degradation
EP3471737B1 (en) 2016-06-20 2025-06-04 Merck Sharp & Dohme LLC Cyclic phosphate substituted nucleoside compounds and methods of use thereof for the treatment of viral diseases
CN106619731B (zh) * 2016-12-30 2020-06-12 昆明赛诺制药股份有限公司 一种治疗丙型肝炎的药物
WO2018237026A1 (en) 2017-06-20 2018-12-27 C4 Therapeutics, Inc. N/o-linked degrons and degronimers for protein degradation

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE648639C (de) 1935-05-19 1937-08-05 I G Farbenindustrie Akt Ges Verfahren zur Darstellung von Dipyrrolen
US3632805A (en) 1967-12-08 1972-01-04 Sumitomo Chemical Co Process for producing 1-aminoalkyl-benzodiazepine derivatives
AU575854B2 (en) 1983-10-04 1988-08-11 Shionogi & Co., Ltd. 7beta-(carboxyalkenamido) cephalosporins
NZ220764A (en) 1986-07-02 1989-09-27 Shionogi & Co Crystalline form of 7beta((z)-2-(2-aminothiazol-4-yl)-4- carboxybut-2-enoylamino)-3-cephem-4-carboxylic acid and pharmaceutical compositions
US5017380A (en) 1986-07-02 1991-05-21 Shionogi & Co., Ltd. Gelatin hard capsule containing crystalline hydrate of oral cephalosporin
CA2038925A1 (en) 1990-03-26 1991-09-27 Takashi Sohda Indole derivatives, their production and use
JPH04149429A (ja) 1990-10-12 1992-05-22 Fuji Photo Film Co Ltd ハロゲン化銀カラー反転写真感光材料およびそれを用いた画像形成方法
ZA939516B (en) * 1992-12-22 1994-06-06 Smithkline Beecham Corp Endothelin receptor antagonists
JPH0753558A (ja) * 1993-08-10 1995-02-28 Shionogi & Co Ltd デュオカルマイシンsa及びその誘導体の製造法
JPH10501532A (ja) * 1994-06-09 1998-02-10 スミスクライン・ビーチャム・コーポレイション エンドセリン受容体拮抗物質
US6075037A (en) * 1994-06-09 2000-06-13 Smithkline Beecham Corporation Endothelin receptor antagonists
JPH10510538A (ja) * 1994-12-13 1998-10-13 スミスクライン・ビーチャム・コーポレイション 新規化合物
IT1278077B1 (it) 1995-05-25 1997-11-17 Angeletti P Ist Richerche Bio Metodologia per riprodurre in vitro le attivita' di rna polimerasi rna-dipendente e di nucleotidiltransferasi terminale codificate dal
GB9526495D0 (en) * 1995-12-23 1996-02-28 Knoll Ag Therapeutic agents
US5922757A (en) 1996-09-30 1999-07-13 The Regents Of The University Of California Treatment and prevention of hepatic disorders
IN183120B (enExample) 1996-10-18 1999-09-11 Vertex Pharma
GB9623908D0 (en) 1996-11-18 1997-01-08 Hoffmann La Roche Amino acid derivatives
PT1012180E (pt) 1997-08-11 2005-04-29 Boehringer Ingelheim Ca Ltd Analogos de peptidos inibidores da hepatite c
FR2768146B1 (fr) 1997-09-05 2000-05-05 Oreal Nouveaux composes de la famille des indole-carboxyliques et leur utilisation
NZ521455A (en) 2000-04-05 2004-06-25 Schering Corp Macrocyclic NS3-Serine protease inhibitors of hepatitis C virus comprising N-Cyclic P2 Moieties
BR0110104A (pt) 2000-04-19 2003-01-07 Schering Corp Inibidores de ns-3 serina rotease macrocìclica do vìrus da hepatite c compreendendo porções de alquil e aril alanina p2
AR034127A1 (es) 2000-07-21 2004-02-04 Schering Corp Imidazolidinonas como inhibidores de ns3-serina proteasa del virus de hepatitis c, composicion farmaceutica, un metodo para su preparacion, y el uso de las mismas para la manufactura de un medicamento
AR029851A1 (es) 2000-07-21 2003-07-16 Dendreon Corp Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c
MY139078A (en) 2000-07-21 2009-08-28 Schering Corp Peptides as ns3-serine protease inhibitors of hepatitis c virus
WO2002008187A1 (en) 2000-07-21 2002-01-31 Schering Corporation Novel peptides as ns3-serine protease inhibitors of hepatitis c virus
HUP0302477A2 (hu) * 2000-10-10 2003-12-29 Smithkline Beecham Corp. Szubsztituált indolszármazékok, ezeket tartalmazó gyógyszerkészítmények és ezek alkalmazása PPAR-gamma kötő szerként
EP1343807B1 (en) 2000-12-12 2009-04-29 Schering Corporation Diaryl peptides as ns3-serine protease inhibitors of hepatits c virus
CA2430808A1 (en) 2000-12-18 2002-06-27 Eli Lilly And Company Cycloalkylfused [g]-indole compounds as spla2-inhibitors in the treatment of inflammatory diseases
DE60223544T2 (de) * 2001-02-22 2008-09-25 University Of Bradford, Bradford Pyrrolo-indol- und pyrrolo-chinolin-derivate als prodrugs zur tumorbehandlung
EP2335700A1 (en) 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
JP2003342276A (ja) * 2002-05-24 2003-12-03 Mitsui Chemicals Inc ピロロキナゾリン誘導体及び農園芸用有害生物防除剤ならびにその使用方法
JP2006505571A (ja) 2002-10-15 2006-02-16 リゲル ファーマシューテイカルズ、インコーポレイテッド 置換されたインドール及びhcv阻害剤としてのその使用
US20050075331A1 (en) 2003-10-06 2005-04-07 Pratt John K. Anti-infective agents
PT1644363E (pt) 2003-05-30 2012-05-18 Gemin X Pharmaceuticals Canada Inc Compostos tri-heterocíclicos, composições e métodos para tratamento de cancro ou doenças virais
GB0323845D0 (en) 2003-10-10 2003-11-12 Angeletti P Ist Richerche Bio Chemical compounds,compositions and uses
PE20090047A1 (es) 2003-11-10 2009-01-26 Schering Corp Anticuerpo recombinante humanizado anti-interleuquina 10
ATE470660T1 (de) 2004-02-27 2010-06-15 Schering Corp Schwefelverbindungen als inhibitoren der ns3- serinprotease des hepatitis-c-virus
MXPA06009881A (es) 2004-03-01 2007-11-20 Viropharma Inc Derivados de piranoindol y el uso de los mismos para el tratamiento de infeccion o enfermedad de virus de hepatitis c.
AR049635A1 (es) 2004-05-06 2006-08-23 Schering Corp (1r,2s,5s)-n-((1s)-3-amino-1-(ciclobutilmetil)-2,3-dioxopropil)-3-((2s)-2-((((1,1-dimetiletil)amino)carbonil)amino)-3,3-dimetil-1-oxobutil)-6,6-dimetil-3-azabiciclo(3.1.0)hexan-2-carboxamida como inhibidor de la ns3/ns4a serina proteasa del virus de la hepatitis c
EP1604988A1 (en) 2004-05-18 2005-12-14 Sanofi-Aventis Deutschland GmbH Pyridazinone derivatives, methods for producing them and their use as pharmaceuticals
WO2007084413A2 (en) 2004-07-14 2007-07-26 Ptc Therapeutics, Inc. Methods for treating hepatitis c
US7153848B2 (en) 2004-08-09 2006-12-26 Bristol-Myers Squibb Company Inhibitors of HCV replication
WO2006034337A2 (en) 2004-09-23 2006-03-30 Wyeth Carbazole and cyclopentaindole derivatives to treat infection with hepatitis c virus
DE102004047272A1 (de) 2004-09-24 2006-04-06 Schering Ag Inhibitoren der löslichen Adenylatzyklase
JP2008517986A (ja) 2004-10-26 2008-05-29 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー 抗ウイルス薬としての四環式インドール誘導体
JP4149429B2 (ja) 2004-10-26 2008-09-10 本田技研工業株式会社 車両の走行安全装置
CA2593450A1 (en) 2005-01-14 2006-07-20 Genelabs Technologies, Inc. Indole derivatives for treating viral infections
US20110104109A1 (en) 2005-07-13 2011-05-05 Frank Bennett Tetracyclic indole derivatives and their use for treating or preventing viral infections
GB0518390D0 (en) 2005-09-09 2005-10-19 Angeletti P Ist Richerche Bio Therapeutic compounds
WO2007038209A2 (en) 2005-09-23 2007-04-05 Schering Corporation Fused tetracyclic mglur1 antagonists as therapeutic agents
WO2007084435A2 (en) 2006-01-13 2007-07-26 Ptc Therapeutics, Inc. Methods for treating hepatitis c
AR059429A1 (es) 2006-02-09 2008-04-09 Schering Corp Combinaciones que involucran el (los) inhibidor(es) de la protesa hcv y metodos de tratamiento relacionados al (los) mismo (s)
KR20090094154A (ko) 2006-12-22 2009-09-03 쉐링 코포레이션 Hcv 및 관련 바이러스 감염을 치료 또는 예방하기 위한 4,5-환 환상 인돌 유도체
US8268803B2 (en) 2006-12-22 2012-09-18 Merck Sharp & Dohme Corp. 5, 6-ring annulated indole derivatives and use thereof
MX2009006878A (es) 2006-12-22 2009-07-07 Schering Corp Derivados indolicos con anillo unido en las posiciones 4,5 para tratar o prevenir infecciones virales por virus de la hepatitis c e infecciones virales relacionadas.
CN101821252A (zh) 2007-08-29 2010-09-01 先灵公司 取代的吲哚衍生物及其使用方法
TW200924751A (en) 2007-08-29 2009-06-16 Schering Corp 2,3-substituted indole derivatives and methods of use thereof
KR20100065167A (ko) 2007-08-29 2010-06-15 쉐링 코포레이션 바이러스 감염 치료용 2,3-치환된 아자인돌 유도체
US8765757B2 (en) 2007-11-16 2014-07-01 Merck Sharp & Dohme Corp. 3-heterocyclic substituted indole derivatives and methods of use thereof
MX2010005355A (es) 2007-11-16 2010-06-02 Schering Corp Derivados de indol sustituidos con 3-aminosulfonilo y metodos de uso de los mismos.

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