JP2015512381A5 - - Google Patents
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- Publication number
- JP2015512381A5 JP2015512381A5 JP2015500948A JP2015500948A JP2015512381A5 JP 2015512381 A5 JP2015512381 A5 JP 2015512381A5 JP 2015500948 A JP2015500948 A JP 2015500948A JP 2015500948 A JP2015500948 A JP 2015500948A JP 2015512381 A5 JP2015512381 A5 JP 2015512381A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- salt
- hydrate
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- VECSRFWOHMDQCJ-UHFFFAOYSA-N CC(Cc1c[nH]c(cc2Cl)c1cc2F)=O Chemical compound CC(Cc1c[nH]c(cc2Cl)c1cc2F)=O VECSRFWOHMDQCJ-UHFFFAOYSA-N 0.000 description 2
- NTPLXRHDUXRPNE-UHFFFAOYSA-N CC(c(cc1)ccc1OC)=O Chemical compound CC(c(cc1)ccc1OC)=O NTPLXRHDUXRPNE-UHFFFAOYSA-N 0.000 description 1
- JYAQYXOVOHJRCS-UHFFFAOYSA-N CC(c1cccc(Br)c1)=O Chemical compound CC(c1cccc(Br)c1)=O JYAQYXOVOHJRCS-UHFFFAOYSA-N 0.000 description 1
- GYLDXXLJMRTVSS-UHFFFAOYSA-N CCCCNC(C)=O Chemical compound CCCCNC(C)=O GYLDXXLJMRTVSS-UHFFFAOYSA-N 0.000 description 1
- FNXVEILQGNGZNE-UHFFFAOYSA-N CS(c(cc1)ccc1OC(F)(F)F)(=O)=O Chemical compound CS(c(cc1)ccc1OC(F)(F)F)(=O)=O FNXVEILQGNGZNE-UHFFFAOYSA-N 0.000 description 1
- NLRUCNFHLCYFCM-LURJTMIESA-N C[C@@H](Cc(c1c2)c[nH]c1cc(Cl)c2F)N Chemical compound C[C@@H](Cc(c1c2)c[nH]c1cc(Cl)c2F)N NLRUCNFHLCYFCM-LURJTMIESA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012000359 | 2012-03-23 | ||
| CNPCT/CN2012/000359 | 2012-03-23 | ||
| PCT/EP2013/056170 WO2013139987A1 (en) | 2012-03-23 | 2013-03-22 | Chemical process for preparing spiroindolones and intermediates thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015512381A JP2015512381A (ja) | 2015-04-27 |
| JP2015512381A5 true JP2015512381A5 (enExample) | 2017-02-16 |
| JP6117906B2 JP6117906B2 (ja) | 2017-04-19 |
Family
ID=48048006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015500948A Active JP6117906B2 (ja) | 2012-03-23 | 2013-03-22 | スピロインドロンおよびこれらの中間体を調製するための化学プロセス |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9598712B2 (enExample) |
| EP (2) | EP3578557B1 (enExample) |
| JP (1) | JP6117906B2 (enExample) |
| KR (1) | KR102057590B1 (enExample) |
| CN (1) | CN104185634B (enExample) |
| AP (1) | AP2014007906A0 (enExample) |
| AU (1) | AU2013237330C1 (enExample) |
| BR (1) | BR112014022909B1 (enExample) |
| CA (1) | CA2866222C (enExample) |
| CY (1) | CY1122087T1 (enExample) |
| DK (1) | DK2828256T5 (enExample) |
| ES (2) | ES2962530T3 (enExample) |
| HR (1) | HRP20191632T1 (enExample) |
| HU (1) | HUE046421T2 (enExample) |
| LT (1) | LT2828256T (enExample) |
| MX (1) | MX354023B (enExample) |
| PL (1) | PL2828256T3 (enExample) |
| PT (1) | PT2828256T (enExample) |
| RU (1) | RU2662815C2 (enExample) |
| SI (1) | SI2828256T1 (enExample) |
| WO (1) | WO2013139987A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI784255B (zh) | 2014-12-18 | 2022-11-21 | 瑞士商赫孚孟拉羅股份公司 | 四氫-吡啶并[3,4-b]吲哚雌激素受體調節劑及其用途 |
| JP2017024992A (ja) * | 2015-07-15 | 2017-02-02 | 公益財団法人微生物化学研究会 | 化合物の製造方法 |
| LT3810283T (lt) | 2018-06-21 | 2023-08-25 | F. Hoffmann-La Roche Ag | 3-((1r,3r)-1-(2,6-difluor-4-((1-(3-fluorpropil)azetidin-3- il)amino) fenil)-3-metil-1,3,4,9-tetrahidro-2h-pirido[3,4-b]indol-2-il)- 2,2- difluorpropan-1-olio tartrato druskos kietosios formos, jų paruošimo procesas ir jų naudojimo būdai vėžiui gydyti |
| CN111041015B (zh) * | 2019-12-31 | 2022-03-18 | 浙江工业大学 | 一种高温下制备(r)-(+)-n-乙酰基-1-甲基-3-苯丙胺的方法 |
| US11788071B2 (en) | 2020-04-10 | 2023-10-17 | Codexis, Inc. | Engineered transaminase polypeptides |
| CN116209754A (zh) * | 2020-09-28 | 2023-06-02 | 科德克希思公司 | 用于合成手性胺的工程化生物催化剂及方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2947758A (en) * | 1959-04-28 | 1960-08-02 | Searle & Co | 3-(omega-hydrazino) alkylindoles |
| GB974895A (en) * | 1961-04-06 | 1964-11-11 | Parke Davis & Co | Process for the production of amine compounds |
| GB974893A (en) * | 1961-04-06 | 1964-11-11 | Parke Davis & Co | Amine compounds and means of producing the same |
| US3183170A (en) * | 1961-10-03 | 1965-05-11 | Sanraku Ocean Kabushiki Kaisha | Method of l-amino acid manufacture |
| BE795457A (fr) * | 1972-02-16 | 1973-08-16 | Clin Midy | Amines indoliques, leur preparation et leur application en therapeutiques |
| US4073795A (en) * | 1976-06-22 | 1978-02-14 | Hoffmann-La Roche Inc. | Synthesis of tryptophans |
| US4331818A (en) * | 1980-03-19 | 1982-05-25 | The Procter & Gamble Company | Chiral phospine ligand |
| DE3307095A1 (de) * | 1983-03-01 | 1984-09-06 | Degussa Ag, 6000 Frankfurt | Mikrobiologisch hergestellte l-phenylalanin-dehydrogenase, verfahren zu ihrer gewinnung und ihre verwendung |
| US4518692A (en) * | 1983-09-01 | 1985-05-21 | Genetics Institute, Inc. | Production of L-amino acids by transamination |
| DE3482982D1 (de) * | 1983-09-01 | 1990-09-20 | Genetics Inst | Herstellung von l-aminosaeuren durch transaminierung. |
| US4859591A (en) * | 1984-07-05 | 1989-08-22 | W. R. Grace & Co.-Conn. | Transamination process for producing amino acids |
| US4826766A (en) * | 1985-09-23 | 1989-05-02 | Genetics Institute, Inc. | Production of amino acids using coupled aminotransferases |
| US7629157B2 (en) | 2003-08-11 | 2009-12-08 | Codexis, Inc. | Ketoreductase polypeptides and related polynucleotides |
| US7541091B2 (en) | 2004-05-18 | 2009-06-02 | M & G Usa Corporation | Compartmentalized resin pellets for oxygen scavenging |
| JPWO2006038520A1 (ja) * | 2004-10-05 | 2008-05-15 | 味の素株式会社 | ヒドロキシイミノ酸からのアミノ酸誘導体製造方法 |
| WO2008050207A1 (en) * | 2006-10-25 | 2008-05-02 | Pfizer Limited | Heterocyclic compounds useful as anabolic agents for livestock animals |
| EP2132322A4 (en) | 2007-03-02 | 2013-02-20 | Richmond Chemical Corp | METHOD FOR INCREASING YIELD AND IMPROVING PURIFICATION OF PRODUCTS FROM REACTIONS WITH TRANSAMINASE |
| EP2285808B1 (en) * | 2008-04-29 | 2013-11-20 | Novartis AG | Spiro-indole derivatives for the treatment of parasitic diseases |
| AT507050B1 (de) * | 2008-06-17 | 2010-06-15 | Angewandte Biokatalyse Kompete | Verfahren zur herstellung von aminen unter verwendung von omega-transaminasen |
| HUE036104T2 (hu) | 2009-01-08 | 2018-06-28 | Codexis Inc | Transzamináz polipeptidek |
| JP5999565B2 (ja) * | 2010-07-14 | 2016-09-28 | ディーピーエックス ホールディングス ビー．ブイ． | （ｒ）−選択的アミノ化 |
| WO2013142770A1 (en) * | 2012-03-23 | 2013-09-26 | Codexis, Inc. | Biocatalysts and methods for synthesizing derivatives of tryptamine and tryptamine analogs |
-
2013
- 2013-03-22 EP EP19182727.8A patent/EP3578557B1/en active Active
- 2013-03-22 CA CA2866222A patent/CA2866222C/en active Active
- 2013-03-22 HU HUE13714246A patent/HUE046421T2/hu unknown
- 2013-03-22 US US14/384,233 patent/US9598712B2/en active Active
- 2013-03-22 AU AU2013237330A patent/AU2013237330C1/en active Active
- 2013-03-22 LT LTEP13714246.9T patent/LT2828256T/lt unknown
- 2013-03-22 MX MX2014011489A patent/MX354023B/es active IP Right Grant
- 2013-03-22 WO PCT/EP2013/056170 patent/WO2013139987A1/en not_active Ceased
- 2013-03-22 SI SI201331580T patent/SI2828256T1/sl unknown
- 2013-03-22 HR HRP20191632 patent/HRP20191632T1/hr unknown
- 2013-03-22 KR KR1020147026392A patent/KR102057590B1/ko active Active
- 2013-03-22 BR BR112014022909-0A patent/BR112014022909B1/pt active IP Right Grant
- 2013-03-22 CN CN201380016114.9A patent/CN104185634B/zh active Active
- 2013-03-22 RU RU2014142621A patent/RU2662815C2/ru active
- 2013-03-22 PL PL13714246T patent/PL2828256T3/pl unknown
- 2013-03-22 EP EP13714246.9A patent/EP2828256B1/en active Active
- 2013-03-22 JP JP2015500948A patent/JP6117906B2/ja active Active
- 2013-03-22 PT PT137142469T patent/PT2828256T/pt unknown
- 2013-03-22 DK DK13714246T patent/DK2828256T5/da active
- 2013-03-22 AP AP2014007906A patent/AP2014007906A0/xx unknown
- 2013-03-22 ES ES19182727T patent/ES2962530T3/es active Active
- 2013-03-22 ES ES13714246T patent/ES2748460T3/es active Active
-
2019
- 2019-10-02 CY CY20191101024T patent/CY1122087T1/el unknown
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