JP2015512381A5 - - Google Patents
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- Publication number
- JP2015512381A5 JP2015512381A5 JP2015500948A JP2015500948A JP2015512381A5 JP 2015512381 A5 JP2015512381 A5 JP 2015512381A5 JP 2015500948 A JP2015500948 A JP 2015500948A JP 2015500948 A JP2015500948 A JP 2015500948A JP 2015512381 A5 JP2015512381 A5 JP 2015512381A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- salt
- hydrate
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- VECSRFWOHMDQCJ-UHFFFAOYSA-N CC(Cc1c[nH]c(cc2Cl)c1cc2F)=O Chemical compound CC(Cc1c[nH]c(cc2Cl)c1cc2F)=O VECSRFWOHMDQCJ-UHFFFAOYSA-N 0.000 description 2
- NTPLXRHDUXRPNE-UHFFFAOYSA-N CC(c(cc1)ccc1OC)=O Chemical compound CC(c(cc1)ccc1OC)=O NTPLXRHDUXRPNE-UHFFFAOYSA-N 0.000 description 1
- JYAQYXOVOHJRCS-UHFFFAOYSA-N CC(c1cccc(Br)c1)=O Chemical compound CC(c1cccc(Br)c1)=O JYAQYXOVOHJRCS-UHFFFAOYSA-N 0.000 description 1
- GYLDXXLJMRTVSS-UHFFFAOYSA-N CCCCNC(C)=O Chemical compound CCCCNC(C)=O GYLDXXLJMRTVSS-UHFFFAOYSA-N 0.000 description 1
- FNXVEILQGNGZNE-UHFFFAOYSA-N CS(c(cc1)ccc1OC(F)(F)F)(=O)=O Chemical compound CS(c(cc1)ccc1OC(F)(F)F)(=O)=O FNXVEILQGNGZNE-UHFFFAOYSA-N 0.000 description 1
- NLRUCNFHLCYFCM-LURJTMIESA-N C[C@@H](Cc(c1c2)c[nH]c1cc(Cl)c2F)N Chemical compound C[C@@H](Cc(c1c2)c[nH]c1cc(Cl)c2F)N NLRUCNFHLCYFCM-LURJTMIESA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2012/000359 | 2012-03-23 | ||
| CN2012000359 | 2012-03-23 | ||
| PCT/EP2013/056170 WO2013139987A1 (en) | 2012-03-23 | 2013-03-22 | Chemical process for preparing spiroindolones and intermediates thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015512381A JP2015512381A (ja) | 2015-04-27 |
| JP2015512381A5 true JP2015512381A5 (enExample) | 2017-02-16 |
| JP6117906B2 JP6117906B2 (ja) | 2017-04-19 |
Family
ID=48048006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015500948A Active JP6117906B2 (ja) | 2012-03-23 | 2013-03-22 | スピロインドロンおよびこれらの中間体を調製するための化学プロセス |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9598712B2 (enExample) |
| EP (2) | EP3578557B1 (enExample) |
| JP (1) | JP6117906B2 (enExample) |
| KR (1) | KR102057590B1 (enExample) |
| AP (1) | AP2014007906A0 (enExample) |
| AU (1) | AU2013237330C1 (enExample) |
| BR (1) | BR112014022909B1 (enExample) |
| CA (1) | CA2866222C (enExample) |
| CY (1) | CY1122087T1 (enExample) |
| DK (1) | DK2828256T5 (enExample) |
| ES (2) | ES2748460T3 (enExample) |
| HR (1) | HRP20191632T1 (enExample) |
| HU (1) | HUE046421T2 (enExample) |
| LT (1) | LT2828256T (enExample) |
| MX (1) | MX354023B (enExample) |
| PL (1) | PL2828256T3 (enExample) |
| PT (1) | PT2828256T (enExample) |
| RU (1) | RU2662815C2 (enExample) |
| SI (1) | SI2828256T1 (enExample) |
| WO (1) | WO2013139987A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117865872A (zh) | 2014-12-18 | 2024-04-12 | 豪夫迈·罗氏有限公司 | 四氢-吡啶并[3,4-b]吲哚雌激素受体调节剂及其用途 |
| JP2017024992A (ja) * | 2015-07-15 | 2017-02-02 | 公益財団法人微生物化学研究会 | 化合物の製造方法 |
| TWI915239B (zh) | 2018-06-21 | 2026-02-11 | 瑞士商赫孚孟拉羅股份公司 | 3-((1r,3r)-1-(2,6-二氟-4-((1-(3-氟丙基)氮雜環丁-3-基)胺基)苯基)-3-甲基-1,3,4,9-四氫-2h-吡啶并[3,4-b]吲哚-2-基)-2,2-二氟丙-1-醇之固體形式及用於製備包含經取代苯基或吡啶基部分之稠合三環化合物之製程，包括其使用方法 |
| CN115427557A (zh) * | 2020-04-10 | 2022-12-02 | 科德克希思公司 | 工程化转氨酶多肽 |
| WO2022066534A1 (en) * | 2020-09-28 | 2022-03-31 | Codexis, Inc. | Engineered biocatalysts and methods for synthesizing chiral amines |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2947758A (en) * | 1959-04-28 | 1960-08-02 | Searle & Co | 3-(omega-hydrazino) alkylindoles |
| GB974893A (en) * | 1961-04-06 | 1964-11-11 | Parke Davis & Co | Amine compounds and means of producing the same |
| GB974895A (en) * | 1961-04-06 | 1964-11-11 | Parke Davis & Co | Process for the production of amine compounds |
| US3183170A (en) | 1961-10-03 | 1965-05-11 | Sanraku Ocean Kabushiki Kaisha | Method of l-amino acid manufacture |
| BE795457A (fr) * | 1972-02-16 | 1973-08-16 | Clin Midy | Amines indoliques, leur preparation et leur application en therapeutiques |
| US4073795A (en) * | 1976-06-22 | 1978-02-14 | Hoffmann-La Roche Inc. | Synthesis of tryptophans |
| US4331818A (en) * | 1980-03-19 | 1982-05-25 | The Procter & Gamble Company | Chiral phospine ligand |
| DE3307095A1 (de) * | 1983-03-01 | 1984-09-06 | Degussa Ag, 6000 Frankfurt | Mikrobiologisch hergestellte l-phenylalanin-dehydrogenase, verfahren zu ihrer gewinnung und ihre verwendung |
| EP0135846B1 (en) * | 1983-09-01 | 1990-08-16 | Genetics Institute, Inc. | Production of l-amino acids by transamination |
| US4518692A (en) * | 1983-09-01 | 1985-05-21 | Genetics Institute, Inc. | Production of L-amino acids by transamination |
| US4859591A (en) * | 1984-07-05 | 1989-08-22 | W. R. Grace & Co.-Conn. | Transamination process for producing amino acids |
| US4826766A (en) * | 1985-09-23 | 1989-05-02 | Genetics Institute, Inc. | Production of amino acids using coupled aminotransferases |
| JP2007502124A (ja) | 2003-08-11 | 2007-02-08 | コデクシス， インコーポレイテッド | 改良ケトレダクターゼポリペプチドおよび関連ポリヌクレオチド |
| US7541091B2 (en) | 2004-05-18 | 2009-06-02 | M & G Usa Corporation | Compartmentalized resin pellets for oxygen scavenging |
| KR20070062542A (ko) * | 2004-10-05 | 2007-06-15 | 아지노모토 가부시키가이샤 | 하이드록시이미노산으로부터 아미노산 유도체의 제조방법 |
| WO2008050207A1 (en) * | 2006-10-25 | 2008-05-02 | Pfizer Limited | Heterocyclic compounds useful as anabolic agents for livestock animals |
| US7588923B2 (en) | 2007-03-02 | 2009-09-15 | Richmond Chemical Corporation | Method to increase the yield and improve purification of products from transaminase reactions |
| NZ588217A (en) * | 2008-04-29 | 2012-10-26 | Novartis Ag | Spiro-indole derivatives for treating malaria, leishmaniasis and Chagas disease |
| AT507050B1 (de) * | 2008-06-17 | 2010-06-15 | Angewandte Biokatalyse Kompete | Verfahren zur herstellung von aminen unter verwendung von omega-transaminasen |
| ES2840000T3 (es) | 2009-01-08 | 2021-07-06 | Codexis Inc | Polipéptidos de transaminasa |
| PT2593556T (pt) * | 2010-07-14 | 2017-12-11 | Dpx Holdings Bv | Método enzimático de (r)-aminação seletiva |
| US9139821B2 (en) * | 2012-03-23 | 2015-09-22 | Codexis, Inc. | Biocatalysts and methods for synthesizing derivatives of tryptamine and tryptamine analogs |
-
2013
- 2013-03-22 DK DK13714246T patent/DK2828256T5/da active
- 2013-03-22 US US14/384,233 patent/US9598712B2/en active Active
- 2013-03-22 EP EP19182727.8A patent/EP3578557B1/en active Active
- 2013-03-22 LT LTEP13714246.9T patent/LT2828256T/lt unknown
- 2013-03-22 AP AP2014007906A patent/AP2014007906A0/xx unknown
- 2013-03-22 MX MX2014011489A patent/MX354023B/es active IP Right Grant
- 2013-03-22 HR HRP20191632 patent/HRP20191632T1/hr unknown
- 2013-03-22 ES ES13714246T patent/ES2748460T3/es active Active
- 2013-03-22 PT PT137142469T patent/PT2828256T/pt unknown
- 2013-03-22 CA CA2866222A patent/CA2866222C/en active Active
- 2013-03-22 KR KR1020147026392A patent/KR102057590B1/ko active Active
- 2013-03-22 EP EP13714246.9A patent/EP2828256B1/en active Active
- 2013-03-22 JP JP2015500948A patent/JP6117906B2/ja active Active
- 2013-03-22 HU HUE13714246A patent/HUE046421T2/hu unknown
- 2013-03-22 WO PCT/EP2013/056170 patent/WO2013139987A1/en not_active Ceased
- 2013-03-22 BR BR112014022909-0A patent/BR112014022909B1/pt active IP Right Grant
- 2013-03-22 ES ES19182727T patent/ES2962530T3/es active Active
- 2013-03-22 AU AU2013237330A patent/AU2013237330C1/en active Active
- 2013-03-22 SI SI201331580T patent/SI2828256T1/sl unknown
- 2013-03-22 PL PL13714246T patent/PL2828256T3/pl unknown
- 2013-03-22 RU RU2014142621A patent/RU2662815C2/ru active
-
2019
- 2019-10-02 CY CY20191101024T patent/CY1122087T1/el unknown
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