HRP20191632T1 - Kemijski postupak dobivanja spiroindolona i njihovih međuprodukata - Google Patents
Kemijski postupak dobivanja spiroindolona i njihovih međuprodukata Download PDFInfo
- Publication number
- HRP20191632T1 HRP20191632T1 HRP20191632T HRP20191632T1 HR P20191632 T1 HRP20191632 T1 HR P20191632T1 HR P20191632 T HRP20191632 T HR P20191632T HR P20191632 T1 HRP20191632 T1 HR P20191632T1
- Authority
- HR
- Croatia
- Prior art keywords
- formula
- compound
- salt
- solvate
- hydrate
- Prior art date
Links
- 238000001311 chemical methods and process Methods 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 13
- 238000000034 method Methods 0.000 claims 11
- 239000012453 solvate Substances 0.000 claims 10
- 239000011737 fluorine Substances 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 230000002255 enzymatic effect Effects 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 238000005891 transamination reaction Methods 0.000 claims 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Claims (12)
1. Postupak dobivanja spoja formule (II), ili njegove soli ili njegovog solvata ili hidrata,
naznačen time, što obuhvaća enzimsko transaminiranje spoja formule (I) u spoj formule (II), ili njegovu sol, ili njegov solvat ili hidrat, gdje je enzim SEQ ID NO: 134,
gdje:
R1 je H, -CH3,
,
,
,
ili
;
svaki od R4 i R7 neovisno je H ili -Cl;
R5 je H, -OH, -CH3, -OCH3, -F, -Cl, -CF3 ili -CN;
R6 je H, -OH, -OCH3, -F ili -Cl;
R8 je H, -CH3, -CH2CH3, -CH2OH, -CO2H, -CO2CH3, -CO2CH2CH3 ili -CF3.
2. Postupak prema patentnom zahtjevu 1, naznačen time, što R5 i R6 su fluor kada: R8 je -CH3.
3. Postupak prema patentnom zahtjevu 1, naznačen time, što R5 i R6 su fluor i klor, kada: R8 je -CH3.
4. Postupak prema patentnom zahtjevu 1, naznačen time, što R5 i R6 su vodik kada: R8 je -CH3.
5. Postupak prema patentnom zahtjevu 1, naznačen time, što R5 je fluor kada: R6 je vodik.
6. Postupak prema patentnom zahtjevu 1, naznačen time, što je spoj formule (II) prema formuli (IIA), ili njegova sol ili njegov solvat ili hidrat,
7. Postupak prema patentnom zahtjevu 1, naznačen time, što je spoj formule (I) spoj formule (IA) ili njegova sol ili njegov hidrat ili solvat,
8. Postupak dobivanja spoja formule (IVA), ili njegove soli ili njegovog solvata ili hidrata,
naznačen time, što obuhvaća
reakciju spoja formule (IIIA) ili njegove soli ili njegovog solvata ili hidrata,
sa spojem formule (IIA) ili njegovom soli ili njegovim solvatom ili hidratom,
kako bi se dobio spoj formule (IVA), ili njegova sol ili njegov solvat ili hidrat,
pri čemu je spoj formule (IIA) pripravljen enzimskom transaminacijom spoja formule (IA), ili njegove soli ili njegovog hidrata ili solvata,
i pri čemu je enzim SEQ ID NO: 134.
9. Postupak prema patentnom zahtjevu 8, naznačen time, što se spoj formule (IIA) pretvara u sol formule (IIB):
prije reakcije sa spojem formule (IIIA).
10. Postupak prema patentnom zahtjevu 8, naznačen time, što je spoj formule (IVA) izoliran kao sol formule (IVB):
11. Postupak prema patentnom zahtjevu 8, naznačen time, što se sol formule (IVB) pretvara u spoj formule (IVA) u slobodnoj bazi.
12. Spoj, naznačen time, što ima formulu (IA):
ili njegova farmaceutski prihvatljiva sol ili njegov hidrat ili solvat.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2012000359 | 2012-03-23 | ||
PCT/EP2013/056170 WO2013139987A1 (en) | 2012-03-23 | 2013-03-22 | Chemical process for preparing spiroindolones and intermediates thereof |
EP13714246.9A EP2828256B1 (en) | 2012-03-23 | 2013-03-22 | Chemical process for preparing spiroindolones and intermediates thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20191632T1 true HRP20191632T1 (hr) | 2019-12-13 |
Family
ID=48048006
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20191632 HRP20191632T1 (hr) | 2012-03-23 | 2019-09-11 | Kemijski postupak dobivanja spiroindolona i njihovih međuprodukata |
Country Status (21)
Country | Link |
---|---|
US (1) | US9598712B2 (hr) |
EP (2) | EP3578557B1 (hr) |
JP (1) | JP6117906B2 (hr) |
KR (1) | KR102057590B1 (hr) |
AP (1) | AP2014007906A0 (hr) |
AU (1) | AU2013237330C1 (hr) |
BR (1) | BR112014022909B1 (hr) |
CA (1) | CA2866222C (hr) |
CY (1) | CY1122087T1 (hr) |
DK (1) | DK2828256T5 (hr) |
ES (2) | ES2748460T3 (hr) |
HK (1) | HK1202289A1 (hr) |
HR (1) | HRP20191632T1 (hr) |
HU (1) | HUE046421T2 (hr) |
LT (1) | LT2828256T (hr) |
MX (1) | MX354023B (hr) |
PL (1) | PL2828256T3 (hr) |
PT (1) | PT2828256T (hr) |
RU (1) | RU2662815C2 (hr) |
SI (1) | SI2828256T1 (hr) |
WO (1) | WO2013139987A1 (hr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102559719B1 (ko) | 2014-12-18 | 2023-07-26 | 에프. 호프만-라 로슈 아게 | 테트라하이드로-피리도[3,4-b]인돌 에스트로겐 수용체 조절제 및 이의 용도 |
JP2017024992A (ja) * | 2015-07-15 | 2017-02-02 | 公益財団法人微生物化学研究会 | 化合物の製造方法 |
PE20211207A1 (es) | 2018-06-21 | 2021-07-05 | Hoffmann La Roche | Formas solidas de 3-((1r,3r)-1-(2,6-difluoro-4-((1- (3-fluoropropil)azetidin-3-il)amino)fenil)-3-metil-1,3,4,9-tetrahidro-2h-pirido[3,4-b]indol-2-il)-2,2-difluoropropan-1-ol y procesos para preparar compuestos triciclicos fusionados que comprenden un resto fenilo o piridinilo sustituido, incluidos metodos para su uso |
IL296841A (en) * | 2020-04-10 | 2022-11-01 | Codexis Inc | Transaminase transaminase polypeptides |
US20240026401A1 (en) * | 2020-09-28 | 2024-01-25 | Codexis, Inc. | Engineered biocatalysts and methods for synthesizing chiral amines |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
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US2947758A (en) * | 1959-04-28 | 1960-08-02 | Searle & Co | 3-(omega-hydrazino) alkylindoles |
GB974895A (en) * | 1961-04-06 | 1964-11-11 | Parke Davis & Co | Process for the production of amine compounds |
GB974893A (en) * | 1961-04-06 | 1964-11-11 | Parke Davis & Co | Amine compounds and means of producing the same |
US3183170A (en) * | 1961-10-03 | 1965-05-11 | Sanraku Ocean Kabushiki Kaisha | Method of l-amino acid manufacture |
BE795457A (fr) * | 1972-02-16 | 1973-08-16 | Clin Midy | Amines indoliques, leur preparation et leur application en therapeutiques |
US4073795A (en) * | 1976-06-22 | 1978-02-14 | Hoffmann-La Roche Inc. | Synthesis of tryptophans |
US4331818A (en) * | 1980-03-19 | 1982-05-25 | The Procter & Gamble Company | Chiral phospine ligand |
DE3307095A1 (de) * | 1983-03-01 | 1984-09-06 | Degussa Ag, 6000 Frankfurt | Mikrobiologisch hergestellte l-phenylalanin-dehydrogenase, verfahren zu ihrer gewinnung und ihre verwendung |
HU193902B (en) * | 1983-09-01 | 1987-12-28 | Genetics Inst | Process for preparing l-amino acids by means of transamination |
US4518692A (en) * | 1983-09-01 | 1985-05-21 | Genetics Institute, Inc. | Production of L-amino acids by transamination |
US4859591A (en) * | 1984-07-05 | 1989-08-22 | W. R. Grace & Co.-Conn. | Transamination process for producing amino acids |
US4826766A (en) * | 1985-09-23 | 1989-05-02 | Genetics Institute, Inc. | Production of amino acids using coupled aminotransferases |
WO2005017135A1 (en) | 2003-08-11 | 2005-02-24 | Codexis, Inc. | Improved ketoreductase polypeptides and related polynucleotides |
US7541091B2 (en) | 2004-05-18 | 2009-06-02 | M & G Usa Corporation | Compartmentalized resin pellets for oxygen scavenging |
EP1806408B1 (en) * | 2004-10-05 | 2012-04-18 | Ajinomoto Co., Inc. | Process for producing amino acid derivatives from hydroxyimino acids |
WO2008050207A1 (en) * | 2006-10-25 | 2008-05-02 | Pfizer Limited | Heterocyclic compounds useful as anabolic agents for livestock animals |
US7588923B2 (en) | 2007-03-02 | 2009-09-15 | Richmond Chemical Corporation | Method to increase the yield and improve purification of products from transaminase reactions |
EP2285808B1 (en) * | 2008-04-29 | 2013-11-20 | Novartis AG | Spiro-indole derivatives for the treatment of parasitic diseases |
AT507050B1 (de) * | 2008-06-17 | 2010-06-15 | Angewandte Biokatalyse Kompete | Verfahren zur herstellung von aminen unter verwendung von omega-transaminasen |
DK2385983T3 (en) | 2009-01-08 | 2018-02-12 | Codexis Inc | Transaminase POLYPEPTIDES |
PT2593556T (pt) | 2010-07-14 | 2017-12-11 | Dpx Holdings Bv | Método enzimático de (r)-aminação seletiva |
SG11201405990PA (en) * | 2012-03-23 | 2014-11-27 | Codexis Inc | Biocatalysts and methods for synthesizing derivatives of tryptamine and tryptamine analogs |
-
2013
- 2013-03-22 KR KR1020147026392A patent/KR102057590B1/ko active IP Right Grant
- 2013-03-22 HU HUE13714246A patent/HUE046421T2/hu unknown
- 2013-03-22 DK DK13714246T patent/DK2828256T5/da active
- 2013-03-22 AP AP2014007906A patent/AP2014007906A0/xx unknown
- 2013-03-22 RU RU2014142621A patent/RU2662815C2/ru active
- 2013-03-22 MX MX2014011489A patent/MX354023B/es active IP Right Grant
- 2013-03-22 WO PCT/EP2013/056170 patent/WO2013139987A1/en active Application Filing
- 2013-03-22 EP EP19182727.8A patent/EP3578557B1/en active Active
- 2013-03-22 BR BR112014022909-0A patent/BR112014022909B1/pt active IP Right Grant
- 2013-03-22 EP EP13714246.9A patent/EP2828256B1/en active Active
- 2013-03-22 SI SI201331580T patent/SI2828256T1/sl unknown
- 2013-03-22 ES ES13714246T patent/ES2748460T3/es active Active
- 2013-03-22 ES ES19182727T patent/ES2962530T3/es active Active
- 2013-03-22 AU AU2013237330A patent/AU2013237330C1/en active Active
- 2013-03-22 US US14/384,233 patent/US9598712B2/en active Active
- 2013-03-22 JP JP2015500948A patent/JP6117906B2/ja active Active
- 2013-03-22 CA CA2866222A patent/CA2866222C/en active Active
- 2013-03-22 LT LTEP13714246.9T patent/LT2828256T/lt unknown
- 2013-03-22 PT PT137142469T patent/PT2828256T/pt unknown
- 2013-03-22 PL PL13714246T patent/PL2828256T3/pl unknown
-
2015
- 2015-03-17 HK HK15102724.2A patent/HK1202289A1/xx unknown
-
2019
- 2019-09-11 HR HRP20191632 patent/HRP20191632T1/hr unknown
- 2019-10-02 CY CY20191101024T patent/CY1122087T1/el unknown
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