PE20211207A1 - Formas solidas de 3-((1r,3r)-1-(2,6-difluoro-4-((1- (3-fluoropropil)azetidin-3-il)amino)fenil)-3-metil-1,3,4,9-tetrahidro-2h-pirido[3,4-b]indol-2-il)-2,2-difluoropropan-1-ol y procesos para preparar compuestos triciclicos fusionados que comprenden un resto fenilo o piridinilo sustituido, incluidos metodos para su uso - Google Patents

Formas solidas de 3-((1r,3r)-1-(2,6-difluoro-4-((1- (3-fluoropropil)azetidin-3-il)amino)fenil)-3-metil-1,3,4,9-tetrahidro-2h-pirido[3,4-b]indol-2-il)-2,2-difluoropropan-1-ol y procesos para preparar compuestos triciclicos fusionados que comprenden un resto fenilo o piridinilo sustituido, incluidos metodos para su uso

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Publication number
PE20211207A1
PE20211207A1 PE2020001888A PE2020001888A PE20211207A1 PE 20211207 A1 PE20211207 A1 PE 20211207A1 PE 2020001888 A PE2020001888 A PE 2020001888A PE 2020001888 A PE2020001888 A PE 2020001888A PE 20211207 A1 PE20211207 A1 PE 20211207A1
Authority
PE
Peru
Prior art keywords
phenyl
difluoropropan
fluoropropyl
indol
difluoro
Prior art date
Application number
PE2020001888A
Other languages
English (en)
Inventor
Jie Xu
Hans Iding
Kyle Clagg
Michael Dalziel
Alec Fettes
Francis Gosselin
Ngiap-Kie Lim
Andrew Mcclory
Haiming Zhang
Paroma Chakravarty
Karthik Nagapudi
Sarah Robinson
Cheol Keun Chung
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20211207A1 publication Critical patent/PE20211207A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

La presente invencion se refiere al compuesto (2R,3R)-2,3-dihidroxisuccinato de 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropil)azetidin-3-il)amino)fenil)-3-metil-1,3,4,9-tetrahidro-2H-pirido[3,4-b]indol-2-il)-2,2-difluoropropan-1-ol (compuesto B) o una forma cristalina del mismo que tiene un patron de difraccion de polvo de rayos X que comprende picos en 19,32, 20,26, 21,63, 23,28 o 24,81 ±0,1º 2 theta (± 0,1 °2 theta). Tambien se refiere a composiciones farmaceuticas y procesos de sintesis. Dichos compuestos son utiles en el tratamiento del cancer.
PE2020001888A 2018-06-21 2019-06-17 Formas solidas de 3-((1r,3r)-1-(2,6-difluoro-4-((1- (3-fluoropropil)azetidin-3-il)amino)fenil)-3-metil-1,3,4,9-tetrahidro-2h-pirido[3,4-b]indol-2-il)-2,2-difluoropropan-1-ol y procesos para preparar compuestos triciclicos fusionados que comprenden un resto fenilo o piridinilo sustituido, incluidos metodos para su uso PE20211207A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862687930P 2018-06-21 2018-06-21
US201862719896P 2018-08-20 2018-08-20
PCT/US2019/037492 WO2019245974A1 (en) 2018-06-21 2019-06-17 Solid forms of 3-((1r,3r)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2h-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use

Publications (1)

Publication Number Publication Date
PE20211207A1 true PE20211207A1 (es) 2021-07-05

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EP (2) EP3810283B1 (es)
JP (4) JP6916969B1 (es)
KR (2) KR20230117761A (es)
CN (1) CN112437685A (es)
AU (3) AU2019290545B2 (es)
BR (1) BR112020024073A2 (es)
CA (1) CA3098203A1 (es)
CL (1) CL2020003022A1 (es)
CO (1) CO2020014604A2 (es)
CR (2) CR20200621A (es)
DK (1) DK3810283T3 (es)
ES (1) ES2951829T3 (es)
FI (1) FI3810283T3 (es)
HR (1) HRP20230859T1 (es)
HU (1) HUE064542T2 (es)
IL (1) IL278063A (es)
LT (1) LT3810283T (es)
MX (3) MX2020011531A (es)
PE (1) PE20211207A1 (es)
PH (1) PH12020500676A1 (es)
PL (1) PL3810283T3 (es)
PT (1) PT3810283T (es)
RS (1) RS64429B1 (es)
SG (1) SG11202012171SA (es)
SI (1) SI3810283T1 (es)
TW (1) TW202016098A (es)
UA (1) UA128114C2 (es)
WO (1) WO2019245974A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS64429B1 (sr) 2018-06-21 2023-09-29 Hoffmann La Roche Čvrsti oblici soli tartarata 3-((1r,3r)-1-(2,6-difluor-4-((1-(3-fluorpropil)azetidin-3-il)amino)fenil)-3-metil-1,3,4,9-tetrahidro-2h-pirido[3,4-b]indol-2-il)-2,2-difluorpropan-1-ola, proces za njihovu pripremu i postupci za njihovu upotrebu u lečenju kancera
KR20230007360A (ko) * 2020-05-07 2023-01-12 리커리엄 아이피 홀딩스, 엘엘씨 복합제
CA3182018A1 (en) 2020-05-12 2021-11-18 Genentech, Inc. Treatment of breast cancer using combination therapies comprising gdc-9545 and a cdk4/6 inhibitor
WO2021228210A1 (zh) 2020-05-15 2021-11-18 江苏先声药业有限公司 吡咯烷类化合物及其应用
WO2022001971A1 (zh) 2020-06-28 2022-01-06 南京明德新药研发有限公司 并环吲唑类化合物
AU2021299200A1 (en) 2020-06-30 2023-02-23 F. Hoffmann-La Roche Ag Processes for making SERD tricyclic compounds having a substituted phenyl or pyridinyl moiety
WO2022140744A1 (en) 2020-12-23 2022-06-30 Recurium Ip Holdings, Llc Estrogen receptor modulators
IL304911A (en) * 2021-02-16 2023-10-01 Genentech Inc Breast cancer treatment using combination therapies including GDC-9545 and abemciclib or ribociclib
WO2022177835A1 (en) * 2021-02-16 2022-08-25 Genentech, Inc. Treatment of breast cancer using combination therapies comprising gdc-9545 and ipatasertib
CN117813288A (zh) 2021-07-15 2024-04-02 西藏海思科制药有限公司 芳氨基衍生物雌激素受体调节剂及其用途
CN114656444A (zh) * 2022-03-04 2022-06-24 河北松辰医药科技有限公司 一种2,2-二氟-1,3-丙基磺酸内酯的合成方法
TW202400141A (zh) 2022-04-28 2024-01-01 瑞士商赫孚孟拉羅股份公司 ３－（（１ｒ，３ｒ）－１－（２，６－二氟－４－（（１－（３－氟丙基）四氫吖唉－３－基）胺基）苯基）－３－甲基－１，３，４，９－四氫－２ｈ－吡啶并［３，４－ｂ］吲哚－２－基）－２，２－二氟丙－１－醇酒石酸鹽之固體形式
CN115872996B (zh) * 2023-02-21 2023-05-05 山东绿叶制药有限公司 一种雌激素受体降解剂化合物及其制备方法和应用

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7414572L (es) 1973-12-06 1975-06-09 Endo Lab
SE455604B (sv) 1982-06-29 1988-07-25 Stiftelsen Ind Organisk Elektr Sett att framstella fenetylaminer medelst elektrokemisk reduktion
DE3639329C1 (de) 1986-11-18 1988-02-25 Heesemann Karl Masch Bandschleifmaschine
US5206377A (en) 1991-12-05 1993-04-27 Whitby Research, Inc. Compounds useful as antiproliferative agents
EP0620222A3 (en) 1993-04-14 1995-04-12 Lilly Co Eli Tetrahydro-beta-carbolines.
RU14873U1 (ru) 2000-06-26 2000-09-10 Закрытое акционерное общество "Патентные услуги" Комбинированная машина непрерывного литья заготовок
JP2004532816A (ja) 2000-12-08 2004-10-28 スミスクライン・ビーチャム・コーポレイション 抗菌性化合物
DE60112974T2 (de) 2001-02-12 2006-02-16 Lilly Icos Llc, Wilmington Carbolinderivate
US6951961B2 (en) 2002-05-17 2005-10-04 Marina Nikolaevna Protopopova Methods of use and compositions for the diagnosis and treatment of infectious disease
TWI329111B (en) 2002-05-24 2010-08-21 X Ceptor Therapeutics Inc Azepinoindole and pyridoindole derivatives as pharmaceutical agents
EP1615698B1 (en) 2003-04-11 2010-09-29 High Point Pharmaceuticals, LLC New amide derivatives and pharmaceutical use thereof
WO2005034857A2 (en) 2003-09-05 2005-04-21 Sequella, Inc. Methods and compositions comprising diamines as new anti-tubercular therapeutics
DE602005006539D1 (de) 2004-03-11 2008-06-19 Actelion Pharmaceuticals Ltd Tetrahydropyridoindolderivate
US7767689B2 (en) 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
AU2005222632B2 (en) 2004-03-15 2012-02-09 Ptc Therapeutics, Inc. Carboline derivatives useful in the inhibition of angiogenesis
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
JP2008508356A (ja) 2004-08-02 2008-03-21 スミスクライン ビーチャム コーポレーション Ｈｐｖ感染に有用な化合物
WO2007002051A1 (en) 2005-06-22 2007-01-04 Smithkline Beecham Corporation Carboline derivatives and their use as inhibitors of flaviviridae infections
WO2007077570A1 (en) 2006-01-02 2007-07-12 Hetero Drugs Limited Process for obtaining pure oseltamivir
US20100158858A1 (en) 2007-04-13 2010-06-24 Liangxian Cao Administration of carboline derivatives useful in the treatment of cancer and other diseases
SI2285808T1 (sl) 2008-04-29 2014-03-31 Novartis Ag Spiro-indolni derivati za zdravljenje parazitskih bolezni
US9292307B2 (en) 2008-07-30 2016-03-22 Kyocera Corporation User interface generation apparatus
WO2010015815A2 (en) 2008-08-05 2010-02-11 Summit Corporation Plc Compounds for the treatment of flaviviral infections
WO2010015816A2 (en) 2008-08-06 2010-02-11 Summit Corporation Plc Treatment of lysosomal storage disorders and other proteostatic diseases
WO2010029313A1 (en) 2008-09-11 2010-03-18 Summit Corporation Plc. Antiinfective compounds
WO2010049678A2 (en) 2008-10-31 2010-05-06 Summit Corporation Plc Treatment of energy utilization diseases
WO2010075282A1 (en) 2008-12-22 2010-07-01 University Of Washington Molecular inhibitors of the wnt/beta-catenin pathway
US20120046242A1 (en) 2008-12-24 2012-02-23 Massachusetts Institute Of Technology Molecular activators of the wnt/beta-catenin pathway
DE102009006545B4 (de) 2009-01-29 2017-08-17 Epcos Ag Überspannungsableiter und Anordnung von mehreren Überspannungsableitern zu einem Array
WO2010107485A1 (en) 2009-03-17 2010-09-23 The Trustees Of Columbia University In The City Of New York E3 ligase inhibitors
CA2756808A1 (en) 2009-03-31 2010-10-07 Arqule, Inc. Substituted indolo-piperidine compounds
US20120202801A1 (en) 2009-05-27 2012-08-09 Liangxian Cao Methods for treating breast cancer
US20120157402A1 (en) 2009-05-27 2012-06-21 Liangxian Cao Methods for treating brain tumors
US20120157401A1 (en) 2009-05-27 2012-06-21 Ptc Therapeutics, Inc. Methods for treating neurofibromatosis
WO2010138685A1 (en) 2009-05-27 2010-12-02 Ptc Therapeutics, Inc. Methods for treating prostate conditions
TWI574961B (zh) 2009-05-27 2017-03-21 Ｐｔｃ治療公司 治療癌症及非腫瘤病症之方法
WO2010138652A1 (en) 2009-05-27 2010-12-02 Ptc Therapeutics, Inc. Methods for treating kaposi sarcoma
WO2011150162A1 (en) 2010-05-27 2011-12-01 Ptc Therapeutics, Inc. Methods for treating viral conditions
CA2800673A1 (en) 2010-06-10 2011-12-15 Aragon Pharmaceuticals, Inc. Estrogen receptor modulators and uses thereof
WO2011159769A2 (en) 2010-06-17 2011-12-22 Aragon Pharmaceuticals, Inc. Indane estrogen receptor modulators and uses thereof
US9540361B2 (en) 2010-12-24 2017-01-10 Merck Sharp & Dohme B.V. N-substituted azetidine derivatives
US9187460B2 (en) 2011-12-14 2015-11-17 Seragon Pharmaceuticals, Inc. Estrogen receptor modulators and uses thereof
ES2748460T3 (es) 2012-03-23 2020-03-16 Novartis Ag Procesos químicos para preparar espiroindolonas y compuestos intermedios correspondientes
WO2013142770A1 (en) 2012-03-23 2013-09-26 Codexis, Inc. Biocatalysts and methods for synthesizing derivatives of tryptamine and tryptamine analogs
EP2682119A1 (en) 2012-07-03 2014-01-08 Université Libre de Bruxelles Aromatic N-heterocycle derivatives for use as medicine
EP2738173A1 (en) 2012-11-28 2014-06-04 Commissariat A L'energie Atomique Et Aux Energies Alternatives Heterocyclic compounds as inhibitors of the sodium iodide symporter
DK2997033T3 (da) 2013-05-17 2018-01-29 Merck Sharp & Dohme Kondenserede tricykliske heterocykliske forbindelser som hiv- integrasehæmmere
PE20160874A1 (es) 2013-05-28 2016-09-04 Astrazeneca Ab Compuestos quimicos
CA2912853A1 (en) 2013-06-19 2014-12-24 Seragon Pharmaceuticals, Inc. Estrogen receptor modulator and uses thereof
BR112015030595A2 (pt) 2013-06-19 2017-07-25 Seragon Pharmaceuticals Inc moduladores de receptor de estrogênio de azetidina e usos dos mesmos
WO2015039348A1 (en) 2013-09-23 2015-03-26 Merck Sharp & Dohme Corp. Tetracyclic heterocycle compounds useful as hiv integrase inhibitors
WO2015066019A1 (en) 2013-10-28 2015-05-07 Drexel University Novel treatments for attention and cognitive disorders, and for dementia associated with a neurodegenerative disorder
KR20160085915A (ko) 2013-12-06 2016-07-18 에프. 호프만-라 로슈 아게 국소 진행성 또는 전이성 에스트로겐 수용체 양성 유방암을 치료하기 위한 에스트로겐 수용체 조절자
CA2941161A1 (en) 2014-03-13 2015-09-17 F.Hoffmann-La Roche Ag Methods and compositions for modulating estrogen receptor mutants
MA39741A (fr) 2014-03-13 2017-01-18 Hoffmann La Roche Combinaisons thérapeutiques avec des modulateurs du récepteur des œstrogènes
MX2017000135A (es) 2014-06-27 2017-04-10 Nogra Pharma Ltd Moduladores del receptor arilo y metodos para elaborar y usar los mismos.
EP3233818A1 (en) 2014-12-18 2017-10-25 F. Hoffmann-La Roche AG Derivatives of 2,3-diphenylchromene useful for the treatment of cancer
US9845291B2 (en) 2014-12-18 2017-12-19 Genentech, Inc. Estrogen receptor modulators and uses thereof
CN112457310A (zh) * 2014-12-18 2021-03-09 豪夫迈·罗氏有限公司 四氢-吡啶并[3,4-b]吲哚雌激素受体调节剂及其用途
HUE055321T2 (hu) 2015-10-01 2021-11-29 Olema Pharmaceuticals Inc Tetrahidro-1H-pirido[3,4-b]indol anti-ösztrogén hatóanyagok
HUE057240T2 (hu) * 2016-02-01 2022-04-28 Takeda Pharmaceuticals Co Kokristály
KR102479822B1 (ko) 2016-02-05 2022-12-21 인벤티스바이오 엘엘씨 선택적 에스트로겐 수용체 분해제 및 이들의 용도
WO2017216279A1 (en) * 2016-06-16 2017-12-21 F. Hoffmann-La Roche Ag Heteroaryl estrogen receptor modulators and uses thereof
EP3472159A1 (en) * 2016-06-16 2019-04-24 F. Hoffmann-La Roche AG TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
RS64429B1 (sr) 2018-06-21 2023-09-29 Hoffmann La Roche Čvrsti oblici soli tartarata 3-((1r,3r)-1-(2,6-difluor-4-((1-(3-fluorpropil)azetidin-3-il)amino)fenil)-3-metil-1,3,4,9-tetrahidro-2h-pirido[3,4-b]indol-2-il)-2,2-difluorpropan-1-ola, proces za njihovu pripremu i postupci za njihovu upotrebu u lečenju kancera

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JP2021522312A (ja) 2021-08-30
BR112020024073A2 (pt) 2021-02-17
AU2019290545A1 (en) 2020-11-19
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JP6916969B1 (ja) 2021-08-11
JP2021191751A (ja) 2021-12-16
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CA3098203A1 (en) 2019-12-26
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US20220041587A1 (en) 2022-02-10
PH12020500676A1 (en) 2021-06-14
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TW202016098A (zh) 2020-05-01
PL3810283T3 (pl) 2023-10-16
US10954234B2 (en) 2021-03-23
HUE064542T2 (hu) 2024-03-28
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EP3810283A1 (en) 2021-04-28
CN112437685A (zh) 2021-03-02
WO2019245974A1 (en) 2019-12-26
CL2020003022A1 (es) 2021-06-04
US20200002331A1 (en) 2020-01-02
MX2022016065A (es) 2023-02-02
JP2021191750A (ja) 2021-12-16
KR20210022701A (ko) 2021-03-03
RS64429B1 (sr) 2023-09-29
HRP20230859T1 (hr) 2023-11-10
UA128114C2 (uk) 2024-04-10
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