PT2593556T - Método enzimático de (r)-aminação seletiva - Google Patents

Método enzimático de (r)-aminação seletiva

Info

Publication number
PT2593556T
PT2593556T PT117338376T PT11733837T PT2593556T PT 2593556 T PT2593556 T PT 2593556T PT 117338376 T PT117338376 T PT 117338376T PT 11733837 T PT11733837 T PT 11733837T PT 2593556 T PT2593556 T PT 2593556T
Authority
PT
Portugal
Prior art keywords
enzymatic method
selective amination
amination
selective
enzymatic
Prior art date
Application number
PT117338376T
Other languages
English (en)
Inventor
Schürmann Martin
Peter Helena Peeters Wijnand
Hubertina Johannes Smeets Natascha
Schwab Helmut
Steiner Kerstin
Mykolayivna Lypetska Kateryna
Strohmeier Gernot
Original Assignee
Dpx Holdings Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dpx Holdings Bv filed Critical Dpx Holdings Bv
Publication of PT2593556T publication Critical patent/PT2593556T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
PT117338376T 2010-07-14 2011-07-14 Método enzimático de (r)-aminação seletiva PT2593556T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10169573 2010-07-14

Publications (1)

Publication Number Publication Date
PT2593556T true PT2593556T (pt) 2017-12-11

Family

ID=43844620

Family Applications (1)

Application Number Title Priority Date Filing Date
PT117338376T PT2593556T (pt) 2010-07-14 2011-07-14 Método enzimático de (r)-aminação seletiva

Country Status (8)

Country Link
US (2) US20140199734A1 (pt)
EP (1) EP2593556B1 (pt)
JP (1) JP5999565B2 (pt)
CN (1) CN103189519B (pt)
ES (1) ES2650245T3 (pt)
MX (1) MX350510B (pt)
PT (1) PT2593556T (pt)
WO (1) WO2012007548A1 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX350510B (es) 2010-07-14 2017-09-08 Patheon Austria Gmbh & Co Kg Aminación (r)-selectiva.
CN104185634B (zh) * 2012-03-23 2017-05-03 诺华股份有限公司 制备螺旋吲哚酮和其中间体的化学工艺
RU2662815C2 (ru) * 2012-03-23 2018-07-31 Новартис Аг Химический способ получения спироиндолонов и их промежуточных соединений
WO2014037376A1 (en) 2012-09-04 2014-03-13 C5 Ligno Technologies In Lund Ab Stereoselective biosynthesis in microbial host cells
JP2015533501A (ja) * 2012-10-18 2015-11-26 サンド・アクチエンゲゼルシヤフト インドリン誘導体の調製方法
US9777301B2 (en) * 2012-12-13 2017-10-03 Industry-Academic Cooperation Foundation, Yonsei University Method for producing optically active amine compounds by deracemization
KR101493311B1 (ko) 2012-12-13 2015-02-16 연세대학교 산학협력단 광학 활성 아민 및 호모알라닌의 제조방법
GB201316410D0 (en) * 2013-09-13 2013-10-30 Bial Portela & Ca Sa Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein
CN104630170A (zh) * 2013-11-08 2015-05-20 中国科学院天津工业生物技术研究所 一种来源于里氏木霉的新(r)-转氨酶及其应用
EP3075847B1 (en) * 2013-11-26 2019-05-15 Asymchem Laboratories (Tianjin) Co., Ltd Transaminase and use thereof
CN105018440B (zh) * 2014-04-24 2018-06-05 上海弈柯莱生物医药科技有限公司 一种转氨酶及其在合成西他列汀中间体中的应用
CN105734089A (zh) * 2014-12-11 2016-07-06 南京博优康远生物医药科技有限公司 一种不对称合成(r)-3-氨基哌啶衍生物的方法
AU2016249780B2 (en) * 2015-04-16 2021-07-22 F. Hoffmann-La Roche Ag Mutant transaminases as well as methods and uses relating thereto
CN107384887B (zh) * 2017-07-05 2020-08-21 浙江工业大学 一种氨基转移酶、突变体及其制备西他列汀的应用
US10853439B2 (en) 2017-08-08 2020-12-01 Nice Ltd. Systems and methods for fast play back of recorded data
DK3486324T3 (da) 2017-11-17 2020-09-14 Enzymicals Ag Fremgangsmåde til fremstilling af aminer fra carbonylforbindelser ved transaminasereaktion under saltudfældning
CN108866021B (zh) * 2018-05-30 2021-06-08 浙江工业大学 一种转氨酶突变体及在制备西他列汀中间体中的应用
CN111748590B (zh) * 2019-03-29 2024-05-28 弈柯莱(台州)药业有限公司 转氨酶在制备Sacubitril中间体中的应用
CN111117979B (zh) * 2020-01-14 2020-08-21 中国科学院苏州生物医学工程技术研究所 转氨酶突变体、酶制剂、重组载体、重组细胞及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69841075D1 (de) * 1997-04-23 2009-10-01 Kaneka Corp Deoxynukleinsäure welche ein Polypeptid mit stereoselektiver Transaminase Aktivität kodiert, sowie die Deoxynukleinsäure enthaltende Transformanden
EP1038953B1 (en) 1999-03-19 2004-09-22 Sumitomo Chemical Company, Limited Stereoselective transaminase, gene encoding said protein and use thereof
JP4496593B2 (ja) * 1999-03-19 2010-07-07 住友化学株式会社 蛋白質、その遺伝子及びその利用
ATE362544T1 (de) 2002-06-14 2007-06-15 Dsm Ip Assets Bv Polypeptide mit alpha-h alpha amino acid amide racemase aktivitität und nukleinsäuren kodierend dafür
WO2008000632A1 (en) 2006-06-29 2008-01-03 Dsm Ip Assets B.V. A method for achieving improved polypeptide expression
EP1897956A1 (en) * 2006-09-06 2008-03-12 Lonza AG Process for preparation of optically active amines by optical resolution of racemic amines employing a bacterial omega-transaminase
ES2599644T3 (es) 2009-09-02 2017-02-02 Lonza Ag Un proceso para la identificación y preparación de una omega-transaminasa (R)-específica
MX350510B (es) 2010-07-14 2017-09-08 Patheon Austria Gmbh & Co Kg Aminación (r)-selectiva.

Also Published As

Publication number Publication date
CN103189519A (zh) 2013-07-03
CN103189519B (zh) 2018-01-26
JP2013530713A (ja) 2013-08-01
WO2012007548A1 (en) 2012-01-19
MX350510B (es) 2017-09-08
ES2650245T3 (es) 2018-01-17
US20140199734A1 (en) 2014-07-17
MX2013000494A (es) 2013-02-15
US10023886B2 (en) 2018-07-17
EP2593556B1 (en) 2017-08-30
JP5999565B2 (ja) 2016-09-28
US20160032335A1 (en) 2016-02-04
EP2593556A1 (en) 2013-05-22

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