MX350510B - Aminación (r)-selectiva. - Google Patents

Aminación (r)-selectiva.

Info

Publication number
MX350510B
MX350510B MX2013000494A MX2013000494A MX350510B MX 350510 B MX350510 B MX 350510B MX 2013000494 A MX2013000494 A MX 2013000494A MX 2013000494 A MX2013000494 A MX 2013000494A MX 350510 B MX350510 B MX 350510B
Authority
MX
Mexico
Prior art keywords
mycobacterium
group
proteins
general formula
burkholderia
Prior art date
Application number
MX2013000494A
Other languages
English (en)
Other versions
MX2013000494A (es
Inventor
Schürmann Martin
Peter Helena Peeters Wijnand
Hubertina Johannes Smeets Natascha
Schwab Helmut
Steiner Kerstin
Mykolayivna Kateryna
Strohmeier Gernot
Original Assignee
Patheon Austria Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Patheon Austria Gmbh & Co Kg filed Critical Patheon Austria Gmbh & Co Kg
Publication of MX2013000494A publication Critical patent/MX2013000494A/es
Publication of MX350510B publication Critical patent/MX350510B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La presente invención se refiere a un procedimiento para la síntesis enzimática de (R)-aminas enantioméricamente enriquecidas de fórmula general [1] [c] (ver Fórmula) a partir de las cetonas correspondientes de la fórmula general [1] [a] (ver Fórmula) usando transaminasas novedosas. Estas transaminasas novedosas están seleccionadas de dos grupos diferentes: tanto de un grupo de algunas 20 proteínas con secuencias como se especifican en el presente documento como de un grupo de proteínas que tienen actividad de transaminasa y aisladas de un microorganismo seleccionado del grupo de organismos que consiste en Rahnella aquatilis, Ochrobactrum anthropi, Ochrobactrum tritici, Sinorhizobium morelense, Curtobacterium pusillum, Paecilomyces lilacinus, Microbacterium ginsengisoli, Microbacteriurn trichothecenolyticum, Pseudomonas citronellolis, Yersinia kristensenii, Achromobacter spanius, Achromobacter insolitus, Mycobacterium fortuitum, Mycobacterium frederiksbergense, Mycobacterium sacrum, Mycobacterium fluoranthenivorans, .Burkholderia sp., Burkholderia tropica, Cosmospora episphaeria y Fusarium oxysporum.
MX2013000494A 2010-07-14 2011-07-14 Aminación (r)-selectiva. MX350510B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10169573 2010-07-14
PCT/EP2011/062056 WO2012007548A1 (en) 2010-07-14 2011-07-14 (r)-selective amination

Publications (2)

Publication Number Publication Date
MX2013000494A MX2013000494A (es) 2013-02-15
MX350510B true MX350510B (es) 2017-09-08

Family

ID=43844620

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013000494A MX350510B (es) 2010-07-14 2011-07-14 Aminación (r)-selectiva.

Country Status (8)

Country Link
US (2) US20140199734A1 (es)
EP (1) EP2593556B1 (es)
JP (1) JP5999565B2 (es)
CN (1) CN103189519B (es)
ES (1) ES2650245T3 (es)
MX (1) MX350510B (es)
PT (1) PT2593556T (es)
WO (1) WO2012007548A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2593556T (pt) 2010-07-14 2017-12-11 Dpx Holdings Bv Método enzimático de (r)-aminação seletiva
KR102057590B1 (ko) * 2012-03-23 2019-12-19 노파르티스 아게 스피로인돌론을 제조하기 위한 화학적 방법 및 그의 중간체
CN104185634B (zh) * 2012-03-23 2017-05-03 诺华股份有限公司 制备螺旋吲哚酮和其中间体的化学工艺
WO2014037376A1 (en) 2012-09-04 2014-03-13 C5 Ligno Technologies In Lund Ab Stereoselective biosynthesis in microbial host cells
WO2014060571A1 (en) * 2012-10-18 2014-04-24 Sandoz Ag A process for preparing indoline derivatives
US9777301B2 (en) * 2012-12-13 2017-10-03 Industry-Academic Cooperation Foundation, Yonsei University Method for producing optically active amine compounds by deracemization
KR101493311B1 (ko) 2012-12-13 2015-02-16 연세대학교 산학협력단 광학 활성 아민 및 호모알라닌의 제조방법
GB201316410D0 (en) * 2013-09-13 2013-10-30 Bial Portela & Ca Sa Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein
CN104630170A (zh) * 2013-11-08 2015-05-20 中国科学院天津工业生物技术研究所 一种来源于里氏木霉的新(r)-转氨酶及其应用
US10131926B2 (en) * 2013-11-26 2018-11-20 Asymchem Laboratories (Tianjin) Co., Ltd Transaminase and uses thereof
CN105018440B (zh) * 2014-04-24 2018-06-05 上海弈柯莱生物医药科技有限公司 一种转氨酶及其在合成西他列汀中间体中的应用
CN105734089A (zh) * 2014-12-11 2016-07-06 南京博优康远生物医药科技有限公司 一种不对称合成(r)-3-氨基哌啶衍生物的方法
EP3283622B1 (en) * 2015-04-16 2019-07-03 H. Hoffnabb-La Roche Ag Mutant transaminases as well as methods and uses relating thereto
CN107384887B (zh) * 2017-07-05 2020-08-21 浙江工业大学 一种氨基转移酶、突变体及其制备西他列汀的应用
US10853439B2 (en) 2017-08-08 2020-12-01 Nice Ltd. Systems and methods for fast play back of recorded data
ES2816102T3 (es) * 2017-11-17 2021-03-31 Enzymicals Ag Procedimiento de preparación de aminas a partir de compuestos de carbonilo mediante reacción de transaminasa bajo precipitación de sal
CN108866021B (zh) * 2018-05-30 2021-06-08 浙江工业大学 一种转氨酶突变体及在制备西他列汀中间体中的应用
CN111748590B (zh) * 2019-03-29 2024-05-28 弈柯莱(台州)药业有限公司 转氨酶在制备Sacubitril中间体中的应用
CN111117979B (zh) * 2020-01-14 2020-08-21 中国科学院苏州生物医学工程技术研究所 转氨酶突变体、酶制剂、重组载体、重组细胞及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69841075D1 (de) * 1997-04-23 2009-10-01 Kaneka Corp Deoxynukleinsäure welche ein Polypeptid mit stereoselektiver Transaminase Aktivität kodiert, sowie die Deoxynukleinsäure enthaltende Transformanden
EP1038953B1 (en) 1999-03-19 2004-09-22 Sumitomo Chemical Company, Limited Stereoselective transaminase, gene encoding said protein and use thereof
JP4496593B2 (ja) * 1999-03-19 2010-07-07 住友化学株式会社 蛋白質、その遺伝子及びその利用
DE60313866T2 (de) 2002-06-14 2008-04-17 Dsm Ip Assets B.V. Polypeptide mit alpha-h alpha amino acid amide racemase aktivitität und nukleinsäuren kodierend dafür
EP2035561A1 (en) 2006-06-29 2009-03-18 DSMIP Assets B.V. A method for achieving improved polypeptide expression
EP1897956A1 (en) * 2006-09-06 2008-03-12 Lonza AG Process for preparation of optically active amines by optical resolution of racemic amines employing a bacterial omega-transaminase
CN103472093A (zh) 2009-09-02 2013-12-25 罗扎股份公司 用于分析(R)-特异性ω-转氨酶的方法
PT2593556T (pt) 2010-07-14 2017-12-11 Dpx Holdings Bv Método enzimático de (r)-aminação seletiva

Also Published As

Publication number Publication date
CN103189519A (zh) 2013-07-03
MX2013000494A (es) 2013-02-15
US10023886B2 (en) 2018-07-17
WO2012007548A1 (en) 2012-01-19
CN103189519B (zh) 2018-01-26
US20160032335A1 (en) 2016-02-04
ES2650245T3 (es) 2018-01-17
JP5999565B2 (ja) 2016-09-28
PT2593556T (pt) 2017-12-11
EP2593556B1 (en) 2017-08-30
JP2013530713A (ja) 2013-08-01
EP2593556A1 (en) 2013-05-22
US20140199734A1 (en) 2014-07-17

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Legal Events

Date Code Title Description
GB Transfer or assignment

Owner name: PATHEON AUSTRIA GMBH & CO KG

HC Change of company name or juridical status

Owner name: PATHEON AUSTRIA GMBH & CO KG

FG Grant or registration
PD Change of proprietorship

Owner name: PATHEON AUSTRIA GMBH & CO KG