MX350510B - Aminación (r)-selectiva. - Google Patents
Aminación (r)-selectiva.Info
- Publication number
- MX350510B MX350510B MX2013000494A MX2013000494A MX350510B MX 350510 B MX350510 B MX 350510B MX 2013000494 A MX2013000494 A MX 2013000494A MX 2013000494 A MX2013000494 A MX 2013000494A MX 350510 B MX350510 B MX 350510B
- Authority
- MX
- Mexico
- Prior art keywords
- mycobacterium
- group
- proteins
- general formula
- burkholderia
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y206/00—Transferases transferring nitrogenous groups (2.6)
- C12Y206/01—Transaminases (2.6.1)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
La presente invención se refiere a un procedimiento para la síntesis enzimática de (R)-aminas enantioméricamente enriquecidas de fórmula general [1] [c] (ver Fórmula) a partir de las cetonas correspondientes de la fórmula general [1] [a] (ver Fórmula) usando transaminasas novedosas. Estas transaminasas novedosas están seleccionadas de dos grupos diferentes: tanto de un grupo de algunas 20 proteínas con secuencias como se especifican en el presente documento como de un grupo de proteínas que tienen actividad de transaminasa y aisladas de un microorganismo seleccionado del grupo de organismos que consiste en Rahnella aquatilis, Ochrobactrum anthropi, Ochrobactrum tritici, Sinorhizobium morelense, Curtobacterium pusillum, Paecilomyces lilacinus, Microbacterium ginsengisoli, Microbacteriurn trichothecenolyticum, Pseudomonas citronellolis, Yersinia kristensenii, Achromobacter spanius, Achromobacter insolitus, Mycobacterium fortuitum, Mycobacterium frederiksbergense, Mycobacterium sacrum, Mycobacterium fluoranthenivorans, .Burkholderia sp., Burkholderia tropica, Cosmospora episphaeria y Fusarium oxysporum.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10169573 | 2010-07-14 | ||
PCT/EP2011/062056 WO2012007548A1 (en) | 2010-07-14 | 2011-07-14 | (r)-selective amination |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013000494A MX2013000494A (es) | 2013-02-15 |
MX350510B true MX350510B (es) | 2017-09-08 |
Family
ID=43844620
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013000494A MX350510B (es) | 2010-07-14 | 2011-07-14 | Aminación (r)-selectiva. |
Country Status (8)
Country | Link |
---|---|
US (2) | US20140199734A1 (es) |
EP (1) | EP2593556B1 (es) |
JP (1) | JP5999565B2 (es) |
CN (1) | CN103189519B (es) |
ES (1) | ES2650245T3 (es) |
MX (1) | MX350510B (es) |
PT (1) | PT2593556T (es) |
WO (1) | WO2012007548A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103189519B (zh) | 2010-07-14 | 2018-01-26 | DPx控股有限公司 | (r)‑选择性胺化 |
CN104185634B (zh) * | 2012-03-23 | 2017-05-03 | 诺华股份有限公司 | 制备螺旋吲哚酮和其中间体的化学工艺 |
PL2828256T3 (pl) * | 2012-03-23 | 2019-12-31 | Novartis Ag | Chemiczny sposób wytwarzania spiroindolonów i ich związków pośrednich |
WO2014037376A1 (en) | 2012-09-04 | 2014-03-13 | C5 Ligno Technologies In Lund Ab | Stereoselective biosynthesis in microbial host cells |
EP2909327A1 (en) * | 2012-10-18 | 2015-08-26 | Sandoz AG | A process for preparing indoline derivatives |
KR101493311B1 (ko) | 2012-12-13 | 2015-02-16 | 연세대학교 산학협력단 | 광학 활성 아민 및 호모알라닌의 제조방법 |
WO2014092496A1 (ko) * | 2012-12-13 | 2014-06-19 | 연세대학교 산학협력단 | 탈라세믹화를 이용한 광학 활성 아민 화합물의 제조방법 |
GB201316410D0 (en) * | 2013-09-13 | 2013-10-30 | Bial Portela & Ca Sa | Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein |
CN104630170A (zh) * | 2013-11-08 | 2015-05-20 | 中国科学院天津工业生物技术研究所 | 一种来源于里氏木霉的新(r)-转氨酶及其应用 |
ES2734579T3 (es) * | 2013-11-26 | 2019-12-10 | Asymchem Lab Tianjin Co Ltd | Transaminasa y utilización de la misma |
CN105018440B (zh) * | 2014-04-24 | 2018-06-05 | 上海弈柯莱生物医药科技有限公司 | 一种转氨酶及其在合成西他列汀中间体中的应用 |
CN105734089A (zh) * | 2014-12-11 | 2016-07-06 | 南京博优康远生物医药科技有限公司 | 一种不对称合成(r)-3-氨基哌啶衍生物的方法 |
BR112017020561B1 (pt) * | 2015-04-16 | 2024-01-16 | F. Hoffmann-La Roche Ag | Transaminase mutante, proteína de fusão, método de produção de amina e uso da transaminase mutante |
CN107384887B (zh) * | 2017-07-05 | 2020-08-21 | 浙江工业大学 | 一种氨基转移酶、突变体及其制备西他列汀的应用 |
US10853439B2 (en) | 2017-08-08 | 2020-12-01 | Nice Ltd. | Systems and methods for fast play back of recorded data |
ES2816102T3 (es) | 2017-11-17 | 2021-03-31 | Enzymicals Ag | Procedimiento de preparación de aminas a partir de compuestos de carbonilo mediante reacción de transaminasa bajo precipitación de sal |
CN108866021B (zh) * | 2018-05-30 | 2021-06-08 | 浙江工业大学 | 一种转氨酶突变体及在制备西他列汀中间体中的应用 |
CN111748590B (zh) * | 2019-03-29 | 2024-05-28 | 弈柯莱(台州)药业有限公司 | 转氨酶在制备Sacubitril中间体中的应用 |
CN111117979B (zh) * | 2020-01-14 | 2020-08-21 | 中国科学院苏州生物医学工程技术研究所 | 转氨酶突变体、酶制剂、重组载体、重组细胞及其制备方法和应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69841075D1 (de) | 1997-04-23 | 2009-10-01 | Kaneka Corp | Deoxynukleinsäure welche ein Polypeptid mit stereoselektiver Transaminase Aktivität kodiert, sowie die Deoxynukleinsäure enthaltende Transformanden |
DE60013939T2 (de) | 1999-03-19 | 2005-10-06 | Sumitomo Chemical Co. Ltd. | Stereoselektive Transaminase, deren kodierende Gen und deren Verwendungen |
JP4496593B2 (ja) * | 1999-03-19 | 2010-07-07 | 住友化学株式会社 | 蛋白質、その遺伝子及びその利用 |
DE60313866T2 (de) | 2002-06-14 | 2008-04-17 | Dsm Ip Assets B.V. | Polypeptide mit alpha-h alpha amino acid amide racemase aktivitität und nukleinsäuren kodierend dafür |
ES2534282T3 (es) | 2006-06-29 | 2015-04-21 | Dsm Ip Assets B.V. | Un método para lograr la expresión polipeptídica mejorada |
EP1897956A1 (en) * | 2006-09-06 | 2008-03-12 | Lonza AG | Process for preparation of optically active amines by optical resolution of racemic amines employing a bacterial omega-transaminase |
MX2012002561A (es) | 2009-09-02 | 2012-04-10 | Lonza Ag | Un proceso para la identificacion y preparacion de una omega-transaminasa (r)-especifica. |
CN103189519B (zh) | 2010-07-14 | 2018-01-26 | DPx控股有限公司 | (r)‑选择性胺化 |
-
2011
- 2011-07-14 CN CN201180034658.9A patent/CN103189519B/zh active Active
- 2011-07-14 WO PCT/EP2011/062056 patent/WO2012007548A1/en active Application Filing
- 2011-07-14 EP EP11733837.6A patent/EP2593556B1/en active Active
- 2011-07-14 JP JP2013519103A patent/JP5999565B2/ja active Active
- 2011-07-14 MX MX2013000494A patent/MX350510B/es active IP Right Grant
- 2011-07-14 PT PT117338376T patent/PT2593556T/pt unknown
- 2011-07-14 ES ES11733837.6T patent/ES2650245T3/es active Active
- 2011-07-14 US US13/810,004 patent/US20140199734A1/en not_active Abandoned
-
2015
- 2015-10-16 US US14/885,622 patent/US10023886B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
JP5999565B2 (ja) | 2016-09-28 |
EP2593556B1 (en) | 2017-08-30 |
US10023886B2 (en) | 2018-07-17 |
WO2012007548A1 (en) | 2012-01-19 |
CN103189519B (zh) | 2018-01-26 |
MX2013000494A (es) | 2013-02-15 |
PT2593556T (pt) | 2017-12-11 |
CN103189519A (zh) | 2013-07-03 |
US20140199734A1 (en) | 2014-07-17 |
ES2650245T3 (es) | 2018-01-17 |
EP2593556A1 (en) | 2013-05-22 |
JP2013530713A (ja) | 2013-08-01 |
US20160032335A1 (en) | 2016-02-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
GB | Transfer or assignment |
Owner name: PATHEON AUSTRIA GMBH & CO KG |
|
HC | Change of company name or juridical status |
Owner name: PATHEON AUSTRIA GMBH & CO KG |
|
FG | Grant or registration | ||
PD | Change of proprietorship |
Owner name: PATHEON AUSTRIA GMBH & CO KG |