MX350510B - Aminación (r)-selectiva. - Google Patents
Aminación (r)-selectiva.Info
- Publication number
- MX350510B MX350510B MX2013000494A MX2013000494A MX350510B MX 350510 B MX350510 B MX 350510B MX 2013000494 A MX2013000494 A MX 2013000494A MX 2013000494 A MX2013000494 A MX 2013000494A MX 350510 B MX350510 B MX 350510B
- Authority
- MX
- Mexico
- Prior art keywords
- mycobacterium
- group
- proteins
- general formula
- burkholderia
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y206/00—Transferases transferring nitrogenous groups (2.6)
- C12Y206/01—Transaminases (2.6.1)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
La presente invención se refiere a un procedimiento para la síntesis enzimática de (R)-aminas enantioméricamente enriquecidas de fórmula general [1] [c] (ver Fórmula) a partir de las cetonas correspondientes de la fórmula general [1] [a] (ver Fórmula) usando transaminasas novedosas. Estas transaminasas novedosas están seleccionadas de dos grupos diferentes: tanto de un grupo de algunas 20 proteínas con secuencias como se especifican en el presente documento como de un grupo de proteínas que tienen actividad de transaminasa y aisladas de un microorganismo seleccionado del grupo de organismos que consiste en Rahnella aquatilis, Ochrobactrum anthropi, Ochrobactrum tritici, Sinorhizobium morelense, Curtobacterium pusillum, Paecilomyces lilacinus, Microbacterium ginsengisoli, Microbacteriurn trichothecenolyticum, Pseudomonas citronellolis, Yersinia kristensenii, Achromobacter spanius, Achromobacter insolitus, Mycobacterium fortuitum, Mycobacterium frederiksbergense, Mycobacterium sacrum, Mycobacterium fluoranthenivorans, .Burkholderia sp., Burkholderia tropica, Cosmospora episphaeria y Fusarium oxysporum.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10169573 | 2010-07-14 | ||
PCT/EP2011/062056 WO2012007548A1 (en) | 2010-07-14 | 2011-07-14 | (r)-selective amination |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013000494A MX2013000494A (es) | 2013-02-15 |
MX350510B true MX350510B (es) | 2017-09-08 |
Family
ID=43844620
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013000494A MX350510B (es) | 2010-07-14 | 2011-07-14 | Aminación (r)-selectiva. |
Country Status (8)
Country | Link |
---|---|
US (2) | US20140199734A1 (es) |
EP (1) | EP2593556B1 (es) |
JP (1) | JP5999565B2 (es) |
CN (1) | CN103189519B (es) |
ES (1) | ES2650245T3 (es) |
MX (1) | MX350510B (es) |
PT (1) | PT2593556T (es) |
WO (1) | WO2012007548A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT2593556T (pt) | 2010-07-14 | 2017-12-11 | Dpx Holdings Bv | Método enzimático de (r)-aminação seletiva |
KR102057590B1 (ko) * | 2012-03-23 | 2019-12-19 | 노파르티스 아게 | 스피로인돌론을 제조하기 위한 화학적 방법 및 그의 중간체 |
CN104185634B (zh) * | 2012-03-23 | 2017-05-03 | 诺华股份有限公司 | 制备螺旋吲哚酮和其中间体的化学工艺 |
WO2014037376A1 (en) | 2012-09-04 | 2014-03-13 | C5 Ligno Technologies In Lund Ab | Stereoselective biosynthesis in microbial host cells |
WO2014060571A1 (en) * | 2012-10-18 | 2014-04-24 | Sandoz Ag | A process for preparing indoline derivatives |
US9777301B2 (en) * | 2012-12-13 | 2017-10-03 | Industry-Academic Cooperation Foundation, Yonsei University | Method for producing optically active amine compounds by deracemization |
KR101493311B1 (ko) | 2012-12-13 | 2015-02-16 | 연세대학교 산학협력단 | 광학 활성 아민 및 호모알라닌의 제조방법 |
GB201316410D0 (en) * | 2013-09-13 | 2013-10-30 | Bial Portela & Ca Sa | Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein |
CN104630170A (zh) * | 2013-11-08 | 2015-05-20 | 中国科学院天津工业生物技术研究所 | 一种来源于里氏木霉的新(r)-转氨酶及其应用 |
US10131926B2 (en) * | 2013-11-26 | 2018-11-20 | Asymchem Laboratories (Tianjin) Co., Ltd | Transaminase and uses thereof |
CN105018440B (zh) * | 2014-04-24 | 2018-06-05 | 上海弈柯莱生物医药科技有限公司 | 一种转氨酶及其在合成西他列汀中间体中的应用 |
CN105734089A (zh) * | 2014-12-11 | 2016-07-06 | 南京博优康远生物医药科技有限公司 | 一种不对称合成(r)-3-氨基哌啶衍生物的方法 |
EP3283622B1 (en) * | 2015-04-16 | 2019-07-03 | H. Hoffnabb-La Roche Ag | Mutant transaminases as well as methods and uses relating thereto |
CN107384887B (zh) * | 2017-07-05 | 2020-08-21 | 浙江工业大学 | 一种氨基转移酶、突变体及其制备西他列汀的应用 |
US10853439B2 (en) | 2017-08-08 | 2020-12-01 | Nice Ltd. | Systems and methods for fast play back of recorded data |
ES2816102T3 (es) * | 2017-11-17 | 2021-03-31 | Enzymicals Ag | Procedimiento de preparación de aminas a partir de compuestos de carbonilo mediante reacción de transaminasa bajo precipitación de sal |
CN108866021B (zh) * | 2018-05-30 | 2021-06-08 | 浙江工业大学 | 一种转氨酶突变体及在制备西他列汀中间体中的应用 |
CN111748590B (zh) * | 2019-03-29 | 2024-05-28 | 弈柯莱(台州)药业有限公司 | 转氨酶在制备Sacubitril中间体中的应用 |
CN111117979B (zh) * | 2020-01-14 | 2020-08-21 | 中国科学院苏州生物医学工程技术研究所 | 转氨酶突变体、酶制剂、重组载体、重组细胞及其制备方法和应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69841075D1 (de) * | 1997-04-23 | 2009-10-01 | Kaneka Corp | Deoxynukleinsäure welche ein Polypeptid mit stereoselektiver Transaminase Aktivität kodiert, sowie die Deoxynukleinsäure enthaltende Transformanden |
EP1038953B1 (en) | 1999-03-19 | 2004-09-22 | Sumitomo Chemical Company, Limited | Stereoselective transaminase, gene encoding said protein and use thereof |
JP4496593B2 (ja) * | 1999-03-19 | 2010-07-07 | 住友化学株式会社 | 蛋白質、その遺伝子及びその利用 |
DE60313866T2 (de) | 2002-06-14 | 2008-04-17 | Dsm Ip Assets B.V. | Polypeptide mit alpha-h alpha amino acid amide racemase aktivitität und nukleinsäuren kodierend dafür |
EP2035561A1 (en) | 2006-06-29 | 2009-03-18 | DSMIP Assets B.V. | A method for achieving improved polypeptide expression |
EP1897956A1 (en) * | 2006-09-06 | 2008-03-12 | Lonza AG | Process for preparation of optically active amines by optical resolution of racemic amines employing a bacterial omega-transaminase |
CN103472093A (zh) | 2009-09-02 | 2013-12-25 | 罗扎股份公司 | 用于分析(R)-特异性ω-转氨酶的方法 |
PT2593556T (pt) | 2010-07-14 | 2017-12-11 | Dpx Holdings Bv | Método enzimático de (r)-aminação seletiva |
-
2011
- 2011-07-14 PT PT117338376T patent/PT2593556T/pt unknown
- 2011-07-14 CN CN201180034658.9A patent/CN103189519B/zh active Active
- 2011-07-14 US US13/810,004 patent/US20140199734A1/en not_active Abandoned
- 2011-07-14 WO PCT/EP2011/062056 patent/WO2012007548A1/en active Application Filing
- 2011-07-14 ES ES11733837.6T patent/ES2650245T3/es active Active
- 2011-07-14 MX MX2013000494A patent/MX350510B/es active IP Right Grant
- 2011-07-14 JP JP2013519103A patent/JP5999565B2/ja active Active
- 2011-07-14 EP EP11733837.6A patent/EP2593556B1/en active Active
-
2015
- 2015-10-16 US US14/885,622 patent/US10023886B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CN103189519A (zh) | 2013-07-03 |
MX2013000494A (es) | 2013-02-15 |
US10023886B2 (en) | 2018-07-17 |
WO2012007548A1 (en) | 2012-01-19 |
CN103189519B (zh) | 2018-01-26 |
US20160032335A1 (en) | 2016-02-04 |
ES2650245T3 (es) | 2018-01-17 |
JP5999565B2 (ja) | 2016-09-28 |
PT2593556T (pt) | 2017-12-11 |
EP2593556B1 (en) | 2017-08-30 |
JP2013530713A (ja) | 2013-08-01 |
EP2593556A1 (en) | 2013-05-22 |
US20140199734A1 (en) | 2014-07-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX350510B (es) | Aminación (r)-selectiva. | |
WO2007107789A3 (en) | Treatment of cns conditions | |
MX2018013367A (es) | Metodos para etiquetar bibliotecas codificadas por adn. | |
HK1146053A1 (en) | Substituted n-phenyl-bipyrrolidine carboxamides and therapeutic use thereof | |
TN2010000148A1 (en) | Amide compound | |
MX2007007919A (es) | Nuevos derivados de bencilaminas como inhibidores de la proteina de transferencia de colesteril-ester(cetp). | |
TW200716647A (en) | Synthesis of (R)-N-methylnaltrexone | |
WO2008143668A3 (en) | Indoleamine-2, 3-dioxygenase-2 | |
UA99936C2 (en) | Biaryl substituted azabicyclic alkane derivatives | |
HK1146054A1 (en) | Substituted n-phenyl-bipyrrolidine carboxamides and therapeutic use thereof | |
MX2012002272A (es) | Dominios cataliticos de lisil oxidasa y loxl2. | |
WO2009089263A3 (en) | Novel compositions and methods of use | |
MY148807A (en) | Substituted n-phenyl-bipyrrolidine ureas and therapeutic use thereof | |
WO2011160052A3 (en) | Methods and compositions for sequence specific rna endonucleases | |
MX2009011215A (es) | Derivados de triazolopiridina carboxamida, su preparacion y su aplicacion terapeutica. | |
MX346019B (es) | Kit para detectar el virus de la leucemia bovina (blv), y uso del mismo. | |
WO2006020348A3 (en) | Polymorphs of atomoxetine hydrochloride | |
WO2007109288A3 (en) | Enantiomerically pure r-etifoxine, pharmaceutical compositions thereof and methods of their use | |
UA104880C2 (uk) | Заміщені тетрагідропіранспіропіролідинон і тетрагідропіранспіропіперидинон, спосіб їх одержання й застосування в лікувальних цілях | |
BR112012024232A8 (pt) | "aptâmero de 73 nucleotídeos ou menos, complexo, composição farmacêutica e medicamento anti-dor" | |
MX349698B (es) | Metodo para la produccion de nitrilos de terpeno a partir de terpeno-oximas utilizando un aldoxima deshidratasa. | |
AU2013212209A8 (en) | (1R,4R) 7-oxo-2-azabicyclo[2.2.2]oct-5-ene and derivatives thereof | |
WO2011130426A3 (en) | Compositions and methods for treatment of melanoma | |
DE602006020869D1 (de) | Verfahren zum züchten von bakterien der familie der streptococcaceae | |
EP2562267A3 (en) | Method and kit for identifying Phalaenopsis varieties |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
GB | Transfer or assignment |
Owner name: PATHEON AUSTRIA GMBH & CO KG |
|
HC | Change of company name or juridical status |
Owner name: PATHEON AUSTRIA GMBH & CO KG |
|
FG | Grant or registration | ||
PD | Change of proprietorship |
Owner name: PATHEON AUSTRIA GMBH & CO KG |