AU2013212209A8 - (1R,4R) 7-oxo-2-azabicyclo[2.2.2]oct-5-ene and derivatives thereof - Google Patents
(1R,4R) 7-oxo-2-azabicyclo[2.2.2]oct-5-ene and derivatives thereofInfo
- Publication number
- AU2013212209A8 AU2013212209A8 AU2013212209A AU2013212209A AU2013212209A8 AU 2013212209 A8 AU2013212209 A8 AU 2013212209A8 AU 2013212209 A AU2013212209 A AU 2013212209A AU 2013212209 A AU2013212209 A AU 2013212209A AU 2013212209 A8 AU2013212209 A8 AU 2013212209A8
- Authority
- AU
- Australia
- Prior art keywords
- azabicyclo
- ene
- oxo
- oct
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- SCEMXAFQSIHIMR-NTSWFWBYSA-N (1r,4r)-5-azabicyclo[2.2.2]oct-2-en-8-one Chemical compound C1N[C@]2([H])C=C[C@@]1([H])CC2=O SCEMXAFQSIHIMR-NTSWFWBYSA-N 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/20—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
This invention provides novel (1R,4R) 7-oxo-2-azabicyclo[2.2.2]oct-5-ene and derivatives thereof, preferably in substantially enantiomerically enriched forms, intermediates thereto, and processes of their synthesis.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261741798P | 2012-01-25 | 2012-01-25 | |
US61/741,798 | 2012-01-25 | ||
PCT/US2013/022797 WO2013112622A1 (en) | 2012-01-25 | 2013-01-23 | (1r,4r) 7-oxo-2-azabicyclo[2.2.2]oct-5-ene and derivatives thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2013212209A1 AU2013212209A1 (en) | 2014-06-26 |
AU2013212209A8 true AU2013212209A8 (en) | 2014-07-10 |
Family
ID=48873876
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2013212209A Abandoned AU2013212209A1 (en) | 2012-01-25 | 2013-01-23 | (1R,4R) 7-oxo-2-azabicyclo[2.2.2]oct-5-ene and derivatives thereof |
Country Status (11)
Country | Link |
---|---|
US (2) | US20130267710A1 (en) |
EP (1) | EP2807158A4 (en) |
JP (1) | JP2015506371A (en) |
KR (1) | KR20140117380A (en) |
CN (2) | CN108912117A (en) |
AU (1) | AU2013212209A1 (en) |
CA (1) | CA2857969A1 (en) |
HK (1) | HK1204615A1 (en) |
IL (1) | IL233055A (en) |
RU (1) | RU2014124531A (en) |
WO (1) | WO2013112622A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014143201A1 (en) | 2013-03-15 | 2014-09-18 | Demerx, Inc. | Method for noribogaine treatment of addiction in patients on methadone |
US9561232B2 (en) | 2014-02-18 | 2017-02-07 | Demerx, Inc. | Low dose noribogaine for treating nicotine addiction and preventing relapse of nicotine use |
US9591978B2 (en) | 2014-03-13 | 2017-03-14 | Demerx, Inc. | Methods and compositions for pre-screening patients for treatment with noribogaine |
WO2015195673A2 (en) * | 2014-06-18 | 2015-12-23 | Demerx, Inc. | Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them |
US9549935B2 (en) | 2014-07-14 | 2017-01-24 | Demerx, Inc. | Methods and compositions for treating migraines using noribogaine |
EP4279134A1 (en) | 2014-11-26 | 2023-11-22 | DemeRx, Inc. | Methods and compostions for potentiating the action of opioid analgesics using iboga alkaloids |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5929247A (en) * | 1994-10-24 | 1999-07-27 | Eli Lilly And Company | Heterocyclic compounds and their preparation and use |
FR2884516B1 (en) * | 2005-04-15 | 2007-06-22 | Cerep Sa | NPY ANTAGONISTS, PREPARATION AND USES |
JP2010229097A (en) * | 2009-03-27 | 2010-10-14 | Tohoku Univ | New oxazolidine derivative, new oxazolidine derivative salt and method for producing optically active compound using the oxazolidine derivative salt as asymmetric organic molecular catalyst |
JP5622019B2 (en) * | 2009-09-25 | 2014-11-12 | 国立大学法人東北大学 | Asymmetric organic molecular catalyst having amino alcohol derivative salt structure and method for producing optically active compound using said asymmetric organic molecular catalyst |
WO2013028999A1 (en) * | 2011-08-24 | 2013-02-28 | The Trustees Of Columbia University In The City Of New York | Small molecule inducers of gdnf as potential new therapeutics for neuropsychiatric disorders |
-
2013
- 2013-01-23 EP EP13741387.8A patent/EP2807158A4/en not_active Withdrawn
- 2013-01-23 CN CN201810010846.1A patent/CN108912117A/en active Pending
- 2013-01-23 JP JP2014554804A patent/JP2015506371A/en active Pending
- 2013-01-23 CN CN201380004353.2A patent/CN104169279A/en active Pending
- 2013-01-23 CA CA2857969A patent/CA2857969A1/en not_active Abandoned
- 2013-01-23 KR KR1020147018193A patent/KR20140117380A/en not_active Application Discontinuation
- 2013-01-23 RU RU2014124531A patent/RU2014124531A/en not_active Application Discontinuation
- 2013-01-23 WO PCT/US2013/022797 patent/WO2013112622A1/en active Application Filing
- 2013-01-23 AU AU2013212209A patent/AU2013212209A1/en not_active Abandoned
- 2013-01-24 US US13/749,592 patent/US20130267710A1/en not_active Abandoned
-
2014
- 2014-06-10 IL IL233055A patent/IL233055A/en active IP Right Grant
-
2015
- 2015-06-01 HK HK15105207.1A patent/HK1204615A1/en unknown
-
2017
- 2017-11-13 US US15/811,549 patent/US20180319800A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN108912117A (en) | 2018-11-30 |
CN104169279A (en) | 2014-11-26 |
KR20140117380A (en) | 2014-10-07 |
CA2857969A1 (en) | 2013-08-01 |
EP2807158A4 (en) | 2015-11-18 |
RU2014124531A (en) | 2016-04-10 |
US20130267710A1 (en) | 2013-10-10 |
JP2015506371A (en) | 2015-03-02 |
AU2013212209A1 (en) | 2014-06-26 |
EP2807158A1 (en) | 2014-12-03 |
US20180319800A1 (en) | 2018-11-08 |
HK1204615A1 (en) | 2015-11-27 |
WO2013112622A1 (en) | 2013-08-01 |
IL233055A (en) | 2017-02-28 |
IL233055A0 (en) | 2014-08-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TH | Corrigenda |
Free format text: IN VOL 28 , NO 25 , PAGE(S) 3335 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE - NAME INDEX UNDER THE NAME DEMERX, INC., APPLICATION NO.2013212209, UNDER INID (54) CORRECT THE TITLE TO READ (1R,4R) 7-OXO-2-AZABICYCLO(2.2.2)OCT-5-ENE AND DERIVATIVES THEREOF |
|
MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |