WO2013072933A3 - Process for preparation of 2-acetamido-n-benzyl-3-methoxypropionamide - Google Patents

Process for preparation of 2-acetamido-n-benzyl-3-methoxypropionamide Download PDF

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Publication number
WO2013072933A3
WO2013072933A3 PCT/IN2012/000655 IN2012000655W WO2013072933A3 WO 2013072933 A3 WO2013072933 A3 WO 2013072933A3 IN 2012000655 W IN2012000655 W IN 2012000655W WO 2013072933 A3 WO2013072933 A3 WO 2013072933A3
Authority
WO
WIPO (PCT)
Prior art keywords
methoxypropionamide
acetamido
benzyl
preparation
enantiomer
Prior art date
Application number
PCT/IN2012/000655
Other languages
French (fr)
Other versions
WO2013072933A2 (en
Inventor
Milind Gharpure
Sachin Srivastava
Anthony CRASTO
Tarun Kant Sharma
Suresh Babu Narayanan
Shekhar Bhaskar Bhirud
Sunil Kumar Singh
Sushanta Kumar MISHRA
Premkumar Ramraj YADAV
Deepak Shantaram PATEKAR
Original Assignee
Glenmark Generics Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Generics Limited filed Critical Glenmark Generics Limited
Publication of WO2013072933A2 publication Critical patent/WO2013072933A2/en
Publication of WO2013072933A3 publication Critical patent/WO2013072933A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/20—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Abstract

Disclosed are processes for the preparation and purification of 2-acetamido-N-benzyl-3-methoxypropionamide or enantiomer thereof.
PCT/IN2012/000655 2011-10-03 2012-09-28 Process for preparation of 2-acetamido-n-benzyl-3-methoxypropionamide WO2013072933A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2813/MUM/2011 2011-10-03
IN2813MU2011 2011-10-03

Publications (2)

Publication Number Publication Date
WO2013072933A2 WO2013072933A2 (en) 2013-05-23
WO2013072933A3 true WO2013072933A3 (en) 2013-08-08

Family

ID=48430298

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2012/000655 WO2013072933A2 (en) 2011-10-03 2012-09-28 Process for preparation of 2-acetamido-n-benzyl-3-methoxypropionamide

Country Status (1)

Country Link
WO (1) WO2013072933A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3659997A1 (en) * 2015-11-13 2020-06-03 API Corporation Method for producing lacosamide and intermediate thereof
US11370761B2 (en) 2017-01-23 2022-06-28 Nippon Chemiphar Co., Ltd. Voltage-dependent T-type calcium channel inhibitor
ES2908646T3 (en) * 2017-03-01 2022-05-03 Api Corp Method for producing N-benzyl-2-bromo-3-methoxypropionamide and intermediates thereof
US11447448B2 (en) * 2018-08-14 2022-09-20 Glenmark Life Sciences Limited Process for the preparation of solriamfetol and salt thereof
CN114685317A (en) * 2020-12-25 2022-07-01 成都硕德药业有限公司 Preparation method of medicine for treating epilepsy
CN114524746B (en) * 2022-01-21 2022-11-11 河北广祥制药有限公司 Preparation method of lacosamide crystal form

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080027137A1 (en) * 2004-10-02 2008-01-31 Schwarz Pharma Ag Synthesis Scheme for Lacosamide
CN101591300A (en) * 2009-02-19 2009-12-02 成都伊诺达博医药科技有限公司 The novel method of synthesizing lacosamide
US20110034731A1 (en) * 2009-08-06 2011-02-10 Medichem, S.A. Solid Forms Of An N-(Phenylmethyl)Propanamide Derivative And Processes Of Preparation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080027137A1 (en) * 2004-10-02 2008-01-31 Schwarz Pharma Ag Synthesis Scheme for Lacosamide
CN101591300A (en) * 2009-02-19 2009-12-02 成都伊诺达博医药科技有限公司 The novel method of synthesizing lacosamide
US20110034731A1 (en) * 2009-08-06 2011-02-10 Medichem, S.A. Solid Forms Of An N-(Phenylmethyl)Propanamide Derivative And Processes Of Preparation

Also Published As

Publication number Publication date
WO2013072933A2 (en) 2013-05-23

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