CY1122087T1 - Χημικη διεργασια για την παρασκευη σπειροϊνδολονων και ενδιαμεσων αυτων - Google Patents

Χημικη διεργασια για την παρασκευη σπειροϊνδολονων και ενδιαμεσων αυτων

Info

Publication number
CY1122087T1
CY1122087T1 CY20191101024T CY191101024T CY1122087T1 CY 1122087 T1 CY1122087 T1 CY 1122087T1 CY 20191101024 T CY20191101024 T CY 20191101024T CY 191101024 T CY191101024 T CY 191101024T CY 1122087 T1 CY1122087 T1 CY 1122087T1
Authority
CY
Cyprus
Prior art keywords
intermediates
spiroindolones
preparation
chemical process
tetrahydrospiro
Prior art date
Application number
CY20191101024T
Other languages
English (en)
Inventor
Michael Crowe
Michael Foulkes
Giancarlo Francese
Ernst Kuesters
Kurt Laumen
Yunzhong Li
Changxue LIN
Jovana Nazor
Thomas Ruch
Derek Smith
Shiwei Song
Shangjun TENG
Dominique Grimler
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY1122087T1 publication Critical patent/CY1122087T1/el

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται σε διεργασίες και ενδιάμεσα χρήσιμα για την παραγωγή ενώσεων σπειροϊνδολόνης όπως (1'R,3'S)-5,7'-διχλωρο-6'-φθορο-3'-μεθυλ-2',3',4',9'-τετραϋδροσπειρο[ινδολινο-3,1'-πυριδο[3,4-ο]ινδολ]-2-όνη και άλατα και ένυδρα άλατα και διαλυτώματα αυτών.
CY20191101024T 2012-03-23 2019-10-02 Χημικη διεργασια για την παρασκευη σπειροϊνδολονων και ενδιαμεσων αυτων CY1122087T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2012000359 2012-03-23
PCT/EP2013/056170 WO2013139987A1 (en) 2012-03-23 2013-03-22 Chemical process for preparing spiroindolones and intermediates thereof

Publications (1)

Publication Number Publication Date
CY1122087T1 true CY1122087T1 (el) 2020-11-25

Family

ID=48048006

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20191101024T CY1122087T1 (el) 2012-03-23 2019-10-02 Χημικη διεργασια για την παρασκευη σπειροϊνδολονων και ενδιαμεσων αυτων

Country Status (21)

Country Link
US (1) US9598712B2 (el)
EP (2) EP2828256B1 (el)
JP (1) JP6117906B2 (el)
KR (1) KR102057590B1 (el)
AP (1) AP2014007906A0 (el)
AU (1) AU2013237330C1 (el)
BR (1) BR112014022909B1 (el)
CA (1) CA2866222C (el)
CY (1) CY1122087T1 (el)
DK (1) DK2828256T5 (el)
ES (2) ES2962530T3 (el)
HK (1) HK1202289A1 (el)
HR (1) HRP20191632T1 (el)
HU (1) HUE046421T2 (el)
LT (1) LT2828256T (el)
MX (1) MX354023B (el)
PL (1) PL2828256T3 (el)
PT (1) PT2828256T (el)
RU (1) RU2662815C2 (el)
SI (1) SI2828256T1 (el)
WO (1) WO2013139987A1 (el)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA53837A (fr) 2014-12-18 2021-11-10 Hoffmann La Roche Tetrahydro-pyrido[3,4-b]indoles modulateurs des récepteurs des oestrogènes et leurs utilisations
JP2017024992A (ja) * 2015-07-15 2017-02-02 公益財団法人微生物化学研究会 化合物の製造方法
JP6916969B1 (ja) 2018-06-21 2021-08-11 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト ３−（（１Ｒ，３Ｒ）−１−（２，６−ジフルオロ−４−（（１−（３−フルオロプロピル）アゼチジン−３−イル）アミノ）フェニル）−３−メチル−１，３，４，９−テトラヒドロ−２Ｈ−ピリド［３，４−ｂ］インドール−２−イル）−２，２−ジフルオロプロパン−１−オールの固体形態及び置換されたフェニル又はピリジニル部分を含む縮合三環式化合物を調製するための方法とそれらの使用方法
CA3179751A1 (en) * 2020-04-10 2021-10-14 Codexis, Inc. Engineered transaminase polypeptides
US20240026401A1 (en) * 2020-09-28 2024-01-25 Codexis, Inc. Engineered biocatalysts and methods for synthesizing chiral amines

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Also Published As

Publication number Publication date
JP6117906B2 (ja) 2017-04-19
BR112014022909B1 (pt) 2021-11-03
HRP20191632T1 (hr) 2019-12-13
EP2828256A1 (en) 2015-01-28
AU2013237330B2 (en) 2015-12-03
KR102057590B1 (ko) 2019-12-19
MX2014011489A (es) 2015-05-11
ES2962530T3 (es) 2024-03-19
RU2014142621A (ru) 2016-05-20
PL2828256T3 (pl) 2019-12-31
AU2013237330C1 (en) 2016-08-25
PT2828256T (pt) 2019-10-18
LT2828256T (lt) 2019-09-25
US9598712B2 (en) 2017-03-21
HK1202289A1 (en) 2015-09-25
RU2662815C2 (ru) 2018-07-31
WO2013139987A1 (en) 2013-09-26
AP2014007906A0 (en) 2014-08-31
KR20140137374A (ko) 2014-12-02
EP3578557B1 (en) 2023-09-20
US20150045562A1 (en) 2015-02-12
MX354023B (es) 2018-02-08
AU2013237330A1 (en) 2014-09-25
DK2828256T5 (da) 2019-12-09
DK2828256T3 (da) 2019-10-07
ES2748460T3 (es) 2020-03-16
HUE046421T2 (hu) 2020-02-28
EP2828256B1 (en) 2019-07-03
JP2015512381A (ja) 2015-04-27
EP3578557A1 (en) 2019-12-11
SI2828256T1 (sl) 2019-11-29
CA2866222C (en) 2022-01-11
BR112014022909A2 (pt) 2017-07-18
CA2866222A1 (en) 2013-09-26

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