CN104185634B - 制备螺旋吲哚酮和其中间体的化学工艺 - Google Patents
制备螺旋吲哚酮和其中间体的化学工艺 Download PDFInfo
- Publication number
- CN104185634B CN104185634B CN201380016114.9A CN201380016114A CN104185634B CN 104185634 B CN104185634 B CN 104185634B CN 201380016114 A CN201380016114 A CN 201380016114A CN 104185634 B CN104185634 B CN 104185634B
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- compound
- formula
- polypeptide
- salt
- amino
- Prior art date
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- 0 *C(*c1c[n](*)c2c1c(*)c(*)c(*)c2*)N Chemical compound *C(*c1c[n](*)c2c1c(*)c(*)c(*)c2*)N 0.000 description 5
- NORZCOYJQSTWNO-UHFFFAOYSA-N CC(C)(C(CC1)C2)C1(CN=O)C2=O Chemical compound CC(C)(C(CC1)C2)C1(CN=O)C2=O NORZCOYJQSTWNO-UHFFFAOYSA-N 0.000 description 1
- VECSRFWOHMDQCJ-UHFFFAOYSA-N CC(Cc(c1c2)c[nH]c1cc(Cl)c2F)=O Chemical compound CC(Cc(c1c2)c[nH]c1cc(Cl)c2F)=O VECSRFWOHMDQCJ-UHFFFAOYSA-N 0.000 description 1
- SCIGXDAEOKXMOC-UHFFFAOYSA-N CC(Cc(c1c2)c[nH]c1cc(Cl)c2F)=[O-] Chemical compound CC(Cc(c1c2)c[nH]c1cc(Cl)c2F)=[O-] SCIGXDAEOKXMOC-UHFFFAOYSA-N 0.000 description 1
- XHDJYQWGFIBCEP-UHFFFAOYSA-N O=C(c1cc(Cl)ccc1N1)C1=O Chemical compound O=C(c1cc(Cl)ccc1N1)C1=O XHDJYQWGFIBCEP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201380016114.9A CN104185634B (zh) | 2012-03-23 | 2013-03-22 | 制备螺旋吲哚酮和其中间体的化学工艺 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012000359 | 2012-03-23 | ||
| CNPCT/CN2012/000359 | 2012-03-23 | ||
| CN201380016114.9A CN104185634B (zh) | 2012-03-23 | 2013-03-22 | 制备螺旋吲哚酮和其中间体的化学工艺 |
| PCT/EP2013/056170 WO2013139987A1 (en) | 2012-03-23 | 2013-03-22 | Chemical process for preparing spiroindolones and intermediates thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104185634A CN104185634A (zh) | 2014-12-03 |
| CN104185634B true CN104185634B (zh) | 2017-05-03 |
Family
ID=48048006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380016114.9A Active CN104185634B (zh) | 2012-03-23 | 2013-03-22 | 制备螺旋吲哚酮和其中间体的化学工艺 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9598712B2 (enExample) |
| EP (2) | EP3578557B1 (enExample) |
| JP (1) | JP6117906B2 (enExample) |
| KR (1) | KR102057590B1 (enExample) |
| CN (1) | CN104185634B (enExample) |
| AP (1) | AP2014007906A0 (enExample) |
| AU (1) | AU2013237330C1 (enExample) |
| BR (1) | BR112014022909B1 (enExample) |
| CA (1) | CA2866222C (enExample) |
| CY (1) | CY1122087T1 (enExample) |
| DK (1) | DK2828256T5 (enExample) |
| ES (2) | ES2962530T3 (enExample) |
| HR (1) | HRP20191632T1 (enExample) |
| HU (1) | HUE046421T2 (enExample) |
| LT (1) | LT2828256T (enExample) |
| MX (1) | MX354023B (enExample) |
| PL (1) | PL2828256T3 (enExample) |
| PT (1) | PT2828256T (enExample) |
| RU (1) | RU2662815C2 (enExample) |
| SI (1) | SI2828256T1 (enExample) |
| WO (1) | WO2013139987A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI784255B (zh) | 2014-12-18 | 2022-11-21 | 瑞士商赫孚孟拉羅股份公司 | 四氫-吡啶并[3,4-b]吲哚雌激素受體調節劑及其用途 |
| JP2017024992A (ja) * | 2015-07-15 | 2017-02-02 | 公益財団法人微生物化学研究会 | 化合物の製造方法 |
| LT3810283T (lt) | 2018-06-21 | 2023-08-25 | F. Hoffmann-La Roche Ag | 3-((1r,3r)-1-(2,6-difluor-4-((1-(3-fluorpropil)azetidin-3- il)amino) fenil)-3-metil-1,3,4,9-tetrahidro-2h-pirido[3,4-b]indol-2-il)- 2,2- difluorpropan-1-olio tartrato druskos kietosios formos, jų paruošimo procesas ir jų naudojimo būdai vėžiui gydyti |
| CN111041015B (zh) * | 2019-12-31 | 2022-03-18 | 浙江工业大学 | 一种高温下制备(r)-(+)-n-乙酰基-1-甲基-3-苯丙胺的方法 |
| US11788071B2 (en) | 2020-04-10 | 2023-10-17 | Codexis, Inc. | Engineered transaminase polypeptides |
| CN116209754A (zh) * | 2020-09-28 | 2023-06-02 | 科德克希思公司 | 用于合成手性胺的工程化生物催化剂及方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0135846A2 (en) * | 1983-09-01 | 1985-04-03 | Genetics Institute, Inc. | Production of L-amino acids by transamination |
| WO2009132921A1 (en) * | 2008-04-29 | 2009-11-05 | Novartis Ag | Spiro-indole derivatives for the treatment of parasitic diseases |
| WO2010081053A2 (en) * | 2009-01-08 | 2010-07-15 | Codexis, Inc. | Transaminase polypeptides |
| WO2012007548A1 (en) * | 2010-07-14 | 2012-01-19 | Dsm Ip Assets B.V. | (r)-selective amination |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2947758A (en) * | 1959-04-28 | 1960-08-02 | Searle & Co | 3-(omega-hydrazino) alkylindoles |
| GB974895A (en) * | 1961-04-06 | 1964-11-11 | Parke Davis & Co | Process for the production of amine compounds |
| GB974893A (en) * | 1961-04-06 | 1964-11-11 | Parke Davis & Co | Amine compounds and means of producing the same |
| US3183170A (en) * | 1961-10-03 | 1965-05-11 | Sanraku Ocean Kabushiki Kaisha | Method of l-amino acid manufacture |
| BE795457A (fr) * | 1972-02-16 | 1973-08-16 | Clin Midy | Amines indoliques, leur preparation et leur application en therapeutiques |
| US4073795A (en) * | 1976-06-22 | 1978-02-14 | Hoffmann-La Roche Inc. | Synthesis of tryptophans |
| US4331818A (en) * | 1980-03-19 | 1982-05-25 | The Procter & Gamble Company | Chiral phospine ligand |
| DE3307095A1 (de) * | 1983-03-01 | 1984-09-06 | Degussa Ag, 6000 Frankfurt | Mikrobiologisch hergestellte l-phenylalanin-dehydrogenase, verfahren zu ihrer gewinnung und ihre verwendung |
| US4518692A (en) * | 1983-09-01 | 1985-05-21 | Genetics Institute, Inc. | Production of L-amino acids by transamination |
| US4859591A (en) * | 1984-07-05 | 1989-08-22 | W. R. Grace & Co.-Conn. | Transamination process for producing amino acids |
| US4826766A (en) * | 1985-09-23 | 1989-05-02 | Genetics Institute, Inc. | Production of amino acids using coupled aminotransferases |
| US7629157B2 (en) | 2003-08-11 | 2009-12-08 | Codexis, Inc. | Ketoreductase polypeptides and related polynucleotides |
| US7541091B2 (en) | 2004-05-18 | 2009-06-02 | M & G Usa Corporation | Compartmentalized resin pellets for oxygen scavenging |
| JPWO2006038520A1 (ja) * | 2004-10-05 | 2008-05-15 | 味の素株式会社 | ヒドロキシイミノ酸からのアミノ酸誘導体製造方法 |
| WO2008050207A1 (en) * | 2006-10-25 | 2008-05-02 | Pfizer Limited | Heterocyclic compounds useful as anabolic agents for livestock animals |
| EP2132322A4 (en) | 2007-03-02 | 2013-02-20 | Richmond Chemical Corp | METHOD FOR INCREASING YIELD AND IMPROVING PURIFICATION OF PRODUCTS FROM REACTIONS WITH TRANSAMINASE |
| AT507050B1 (de) * | 2008-06-17 | 2010-06-15 | Angewandte Biokatalyse Kompete | Verfahren zur herstellung von aminen unter verwendung von omega-transaminasen |
| WO2013142770A1 (en) * | 2012-03-23 | 2013-09-26 | Codexis, Inc. | Biocatalysts and methods for synthesizing derivatives of tryptamine and tryptamine analogs |
-
2013
- 2013-03-22 EP EP19182727.8A patent/EP3578557B1/en active Active
- 2013-03-22 CA CA2866222A patent/CA2866222C/en active Active
- 2013-03-22 HU HUE13714246A patent/HUE046421T2/hu unknown
- 2013-03-22 US US14/384,233 patent/US9598712B2/en active Active
- 2013-03-22 AU AU2013237330A patent/AU2013237330C1/en active Active
- 2013-03-22 LT LTEP13714246.9T patent/LT2828256T/lt unknown
- 2013-03-22 MX MX2014011489A patent/MX354023B/es active IP Right Grant
- 2013-03-22 WO PCT/EP2013/056170 patent/WO2013139987A1/en not_active Ceased
- 2013-03-22 SI SI201331580T patent/SI2828256T1/sl unknown
- 2013-03-22 HR HRP20191632 patent/HRP20191632T1/hr unknown
- 2013-03-22 KR KR1020147026392A patent/KR102057590B1/ko active Active
- 2013-03-22 BR BR112014022909-0A patent/BR112014022909B1/pt active IP Right Grant
- 2013-03-22 CN CN201380016114.9A patent/CN104185634B/zh active Active
- 2013-03-22 RU RU2014142621A patent/RU2662815C2/ru active
- 2013-03-22 PL PL13714246T patent/PL2828256T3/pl unknown
- 2013-03-22 EP EP13714246.9A patent/EP2828256B1/en active Active
- 2013-03-22 JP JP2015500948A patent/JP6117906B2/ja active Active
- 2013-03-22 PT PT137142469T patent/PT2828256T/pt unknown
- 2013-03-22 DK DK13714246T patent/DK2828256T5/da active
- 2013-03-22 AP AP2014007906A patent/AP2014007906A0/xx unknown
- 2013-03-22 ES ES19182727T patent/ES2962530T3/es active Active
- 2013-03-22 ES ES13714246T patent/ES2748460T3/es active Active
-
2019
- 2019-10-02 CY CY20191101024T patent/CY1122087T1/el unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0135846A2 (en) * | 1983-09-01 | 1985-04-03 | Genetics Institute, Inc. | Production of L-amino acids by transamination |
| WO2009132921A1 (en) * | 2008-04-29 | 2009-11-05 | Novartis Ag | Spiro-indole derivatives for the treatment of parasitic diseases |
| WO2010081053A2 (en) * | 2009-01-08 | 2010-07-15 | Codexis, Inc. | Transaminase polypeptides |
| WO2012007548A1 (en) * | 2010-07-14 | 2012-01-19 | Dsm Ip Assets B.V. | (r)-selective amination |
Non-Patent Citations (1)
| Title |
|---|
| spirotetrahydro β-Carbolines(spiroindoles): A New Class of potent and prally efficacious compounds for the treatment of malaria;Bryan K.S. Yeung et al.;《J.Med.Chem》;20100622;第53卷;第5155-5164页 * |
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| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |