JP6117906B2 - スピロインドロンおよびこれらの中間体を調製するための化学プロセス - Google Patents
スピロインドロンおよびこれらの中間体を調製するための化学プロセス Download PDFInfo
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- JP6117906B2 JP6117906B2 JP2015500948A JP2015500948A JP6117906B2 JP 6117906 B2 JP6117906 B2 JP 6117906B2 JP 2015500948 A JP2015500948 A JP 2015500948A JP 2015500948 A JP2015500948 A JP 2015500948A JP 6117906 B2 JP6117906 B2 JP 6117906B2
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- 0 C*(CC(*)N)Cc1c[n](*)c2c(*)c(*)c(*)c(*)c12 Chemical compound C*(CC(*)N)Cc1c[n](*)c2c(*)c(*)c(*)c(*)c12 0.000 description 7
- UMWAPELVIFUJEA-UHFFFAOYSA-N CC(CC(c(c(N1)c2)cc(F)c2Cl)(C1=O)O)=O Chemical compound CC(CC(c(c(N1)c2)cc(F)c2Cl)(C1=O)O)=O UMWAPELVIFUJEA-UHFFFAOYSA-N 0.000 description 1
- MEQFCXIZVFNTIC-UHFFFAOYSA-N CC(Cc(c1c2)c[nH]c1cc(Cl)c2[I]=C)=O Chemical compound CC(Cc(c1c2)c[nH]c1cc(Cl)c2[I]=C)=O MEQFCXIZVFNTIC-UHFFFAOYSA-N 0.000 description 1
- XRHCAHNJYOQFIZ-UHFFFAOYSA-N CC(Cc(c1c2)c[nH]c1cc([ClH+])c2F)=O Chemical compound CC(Cc(c1c2)c[nH]c1cc([ClH+])c2F)=O XRHCAHNJYOQFIZ-UHFFFAOYSA-N 0.000 description 1
- BHVFMCCLFQNHOH-UHFFFAOYSA-N CC1(CC(c(c(N2)c3)cc(F)c3Cl)(C2=O)O)OCCC1 Chemical compound CC1(CC(c(c(N2)c3)cc(F)c3Cl)(C2=O)O)OCCC1 BHVFMCCLFQNHOH-UHFFFAOYSA-N 0.000 description 1
- XHDJYQWGFIBCEP-UHFFFAOYSA-N O=C(c(cc(cc1)Cl)c1N1)C1=O Chemical compound O=C(c(cc(cc1)Cl)c1N1)C1=O XHDJYQWGFIBCEP-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2012/000359 | 2012-03-23 | ||
| CN2012000359 | 2012-03-23 | ||
| PCT/EP2013/056170 WO2013139987A1 (en) | 2012-03-23 | 2013-03-22 | Chemical process for preparing spiroindolones and intermediates thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015512381A JP2015512381A (ja) | 2015-04-27 |
| JP2015512381A5 JP2015512381A5 (enExample) | 2017-02-16 |
| JP6117906B2 true JP6117906B2 (ja) | 2017-04-19 |
Family
ID=48048006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015500948A Active JP6117906B2 (ja) | 2012-03-23 | 2013-03-22 | スピロインドロンおよびこれらの中間体を調製するための化学プロセス |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9598712B2 (enExample) |
| EP (2) | EP3578557B1 (enExample) |
| JP (1) | JP6117906B2 (enExample) |
| KR (1) | KR102057590B1 (enExample) |
| AP (1) | AP2014007906A0 (enExample) |
| AU (1) | AU2013237330C1 (enExample) |
| BR (1) | BR112014022909B1 (enExample) |
| CA (1) | CA2866222C (enExample) |
| CY (1) | CY1122087T1 (enExample) |
| DK (1) | DK2828256T5 (enExample) |
| ES (2) | ES2748460T3 (enExample) |
| HR (1) | HRP20191632T1 (enExample) |
| HU (1) | HUE046421T2 (enExample) |
| LT (1) | LT2828256T (enExample) |
| MX (1) | MX354023B (enExample) |
| PL (1) | PL2828256T3 (enExample) |
| PT (1) | PT2828256T (enExample) |
| RU (1) | RU2662815C2 (enExample) |
| SI (1) | SI2828256T1 (enExample) |
| WO (1) | WO2013139987A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2819448T3 (es) | 2014-12-18 | 2021-04-16 | Hoffmann La Roche | Tetrahidro-pirido[3,4-b]indoles como moduladores del receptor de estrógenos y usos de los mismos |
| JP2017024992A (ja) * | 2015-07-15 | 2017-02-02 | 公益財団法人微生物化学研究会 | 化合物の製造方法 |
| CR20230409A (es) | 2018-06-21 | 2023-09-25 | Hoffmann La Roche | Formas sólidas de 3-((1r,3r)-1-(2,6-difluoro-4-((1-(3-fluoropropil)azetidin-3-il)amino)fenil)-3-(metil-1,3,4,9-tetrahidro-2h-pirido[3,4-b]indol-2-il)-2,2-difluoropropan-1-ol y procesos para preparar compuestos tricíclicos fusionados que comprenden un resto fenilo o piridinilo sustituido, incluidos métodos para su uso (divisional expediente 2020-0621) |
| JP2023521772A (ja) * | 2020-04-10 | 2023-05-25 | コデクシス， インコーポレイテッド | 操作されたトランスアミナーゼポリペプチド |
| CA3193755A1 (en) * | 2020-09-28 | 2022-03-31 | Codexis, Inc. | Engineered biocatalysts and methods for synthesizing chiral amines |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2947758A (en) * | 1959-04-28 | 1960-08-02 | Searle & Co | 3-(omega-hydrazino) alkylindoles |
| GB974895A (en) * | 1961-04-06 | 1964-11-11 | Parke Davis & Co | Process for the production of amine compounds |
| GB974893A (en) * | 1961-04-06 | 1964-11-11 | Parke Davis & Co | Amine compounds and means of producing the same |
| US3183170A (en) | 1961-10-03 | 1965-05-11 | Sanraku Ocean Kabushiki Kaisha | Method of l-amino acid manufacture |
| BE795457A (fr) * | 1972-02-16 | 1973-08-16 | Clin Midy | Amines indoliques, leur preparation et leur application en therapeutiques |
| US4073795A (en) * | 1976-06-22 | 1978-02-14 | Hoffmann-La Roche Inc. | Synthesis of tryptophans |
| US4331818A (en) * | 1980-03-19 | 1982-05-25 | The Procter & Gamble Company | Chiral phospine ligand |
| DE3307095A1 (de) * | 1983-03-01 | 1984-09-06 | Degussa Ag, 6000 Frankfurt | Mikrobiologisch hergestellte l-phenylalanin-dehydrogenase, verfahren zu ihrer gewinnung und ihre verwendung |
| EP0135846B1 (en) | 1983-09-01 | 1990-08-16 | Genetics Institute, Inc. | Production of l-amino acids by transamination |
| US4518692A (en) * | 1983-09-01 | 1985-05-21 | Genetics Institute, Inc. | Production of L-amino acids by transamination |
| US4859591A (en) | 1984-07-05 | 1989-08-22 | W. R. Grace & Co.-Conn. | Transamination process for producing amino acids |
| US4826766A (en) | 1985-09-23 | 1989-05-02 | Genetics Institute, Inc. | Production of amino acids using coupled aminotransferases |
| WO2005017135A1 (en) | 2003-08-11 | 2005-02-24 | Codexis, Inc. | Improved ketoreductase polypeptides and related polynucleotides |
| US7541091B2 (en) | 2004-05-18 | 2009-06-02 | M & G Usa Corporation | Compartmentalized resin pellets for oxygen scavenging |
| EP1806408B1 (en) * | 2004-10-05 | 2012-04-18 | Ajinomoto Co., Inc. | Process for producing amino acid derivatives from hydroxyimino acids |
| WO2008050207A1 (en) * | 2006-10-25 | 2008-05-02 | Pfizer Limited | Heterocyclic compounds useful as anabolic agents for livestock animals |
| US7588923B2 (en) | 2007-03-02 | 2009-09-15 | Richmond Chemical Corporation | Method to increase the yield and improve purification of products from transaminase reactions |
| SI2285808T1 (sl) * | 2008-04-29 | 2014-03-31 | Novartis Ag | Spiro-indolni derivati za zdravljenje parazitskih bolezni |
| AT507050B1 (de) * | 2008-06-17 | 2010-06-15 | Angewandte Biokatalyse Kompete | Verfahren zur herstellung von aminen unter verwendung von omega-transaminasen |
| ES2840000T3 (es) * | 2009-01-08 | 2021-07-06 | Codexis Inc | Polipéptidos de transaminasa |
| EP2593556B1 (en) * | 2010-07-14 | 2017-08-30 | DPx Holdings B.V. | Enzymatic method for (r)-selective amination |
| DK2828385T3 (en) * | 2012-03-23 | 2018-03-12 | Codexis Inc | BIOCATALIZATORS AND METHODS FOR SYNTHETIZING DERIVATIVES AND TRYPTAMIN AND TRYPTAMINE ANALOGS |
-
2013
- 2013-03-22 HU HUE13714246A patent/HUE046421T2/hu unknown
- 2013-03-22 BR BR112014022909-0A patent/BR112014022909B1/pt active IP Right Grant
- 2013-03-22 DK DK13714246T patent/DK2828256T5/da active
- 2013-03-22 CA CA2866222A patent/CA2866222C/en active Active
- 2013-03-22 EP EP19182727.8A patent/EP3578557B1/en active Active
- 2013-03-22 KR KR1020147026392A patent/KR102057590B1/ko active Active
- 2013-03-22 SI SI201331580T patent/SI2828256T1/sl unknown
- 2013-03-22 US US14/384,233 patent/US9598712B2/en active Active
- 2013-03-22 ES ES13714246T patent/ES2748460T3/es active Active
- 2013-03-22 WO PCT/EP2013/056170 patent/WO2013139987A1/en not_active Ceased
- 2013-03-22 PL PL13714246T patent/PL2828256T3/pl unknown
- 2013-03-22 PT PT137142469T patent/PT2828256T/pt unknown
- 2013-03-22 ES ES19182727T patent/ES2962530T3/es active Active
- 2013-03-22 JP JP2015500948A patent/JP6117906B2/ja active Active
- 2013-03-22 AU AU2013237330A patent/AU2013237330C1/en active Active
- 2013-03-22 HR HRP20191632 patent/HRP20191632T1/hr unknown
- 2013-03-22 MX MX2014011489A patent/MX354023B/es active IP Right Grant
- 2013-03-22 AP AP2014007906A patent/AP2014007906A0/xx unknown
- 2013-03-22 EP EP13714246.9A patent/EP2828256B1/en active Active
- 2013-03-22 RU RU2014142621A patent/RU2662815C2/ru active
- 2013-03-22 LT LTEP13714246.9T patent/LT2828256T/lt unknown
-
2019
- 2019-10-02 CY CY20191101024T patent/CY1122087T1/el unknown
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