JP2018502909A5 - - Google Patents
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- Publication number
- JP2018502909A5 JP2018502909A5 JP2017551388A JP2017551388A JP2018502909A5 JP 2018502909 A5 JP2018502909 A5 JP 2018502909A5 JP 2017551388 A JP2017551388 A JP 2017551388A JP 2017551388 A JP2017551388 A JP 2017551388A JP 2018502909 A5 JP2018502909 A5 JP 2018502909A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- reaction mixture
- reaction
- aqueous phase
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 15
- 239000007787 solid Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims 13
- 239000011541 reaction mixture Substances 0.000 claims 12
- 238000006243 chemical reaction Methods 0.000 claims 10
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 9
- 239000008346 aqueous phase Substances 0.000 claims 7
- 229940125782 compound 2 Drugs 0.000 claims 7
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 4
- 238000001816 cooling Methods 0.000 claims 4
- 239000012071 phase Substances 0.000 claims 4
- 239000013078 crystal Substances 0.000 claims 3
- 238000010992 reflux Methods 0.000 claims 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 2
- 238000001914 filtration Methods 0.000 claims 2
- 229910052763 palladium Inorganic materials 0.000 claims 2
- NJIAKNWTIVDSDA-FQEVSTJZSA-N 7-[4-(1-methylsulfonylpiperidin-4-yl)phenyl]-n-[[(2s)-morpholin-2-yl]methyl]pyrido[3,4-b]pyrazin-5-amine Chemical compound C1CN(S(=O)(=O)C)CCC1C1=CC=C(C=2N=C(NC[C@H]3OCCNC3)C3=NC=CN=C3C=2)C=C1 NJIAKNWTIVDSDA-FQEVSTJZSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 238000001704 evaporation Methods 0.000 claims 1
- 230000008020 evaporation Effects 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- BWYYYTVSBPRQCN-UHFFFAOYSA-M sodium;ethenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C=C BWYYYTVSBPRQCN-UHFFFAOYSA-M 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462094580P | 2014-12-19 | 2014-12-19 | |
| US62/094,580 | 2014-12-19 | ||
| PCT/IB2015/059741 WO2016098054A1 (en) | 2014-12-19 | 2015-12-17 | Processes for preparing oxathiazin-like compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019206621A Division JP7030093B2 (ja) | 2014-12-19 | 2019-11-15 | オキサチアジン様化合物を作製する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018502909A JP2018502909A (ja) | 2018-02-01 |
| JP2018502909A5 true JP2018502909A5 (enExample) | 2019-12-26 |
| JP6746605B2 JP6746605B2 (ja) | 2020-08-26 |
Family
ID=55077556
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017551388A Active JP6746605B2 (ja) | 2014-12-19 | 2015-12-17 | オキサチアジン様化合物を作製する方法 |
| JP2019206621A Active JP7030093B2 (ja) | 2014-12-19 | 2019-11-15 | オキサチアジン様化合物を作製する方法 |
| JP2021184435A Active JP7449913B2 (ja) | 2014-12-19 | 2021-11-12 | オキサチアジン様化合物を作製する方法 |
| JP2023202330A Active JP7688098B2 (ja) | 2014-12-19 | 2023-11-30 | オキサチアジン様化合物を作製する方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019206621A Active JP7030093B2 (ja) | 2014-12-19 | 2019-11-15 | オキサチアジン様化合物を作製する方法 |
| JP2021184435A Active JP7449913B2 (ja) | 2014-12-19 | 2021-11-12 | オキサチアジン様化合物を作製する方法 |
| JP2023202330A Active JP7688098B2 (ja) | 2014-12-19 | 2023-11-30 | オキサチアジン様化合物を作製する方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US10392355B2 (enExample) |
| EP (2) | EP3233813B1 (enExample) |
| JP (4) | JP6746605B2 (enExample) |
| KR (1) | KR102594322B1 (enExample) |
| CN (3) | CN107257786B (enExample) |
| AU (2) | AU2015365348B2 (enExample) |
| CA (1) | CA2971570A1 (enExample) |
| CY (1) | CY1125047T1 (enExample) |
| DK (1) | DK3233813T3 (enExample) |
| ES (1) | ES2907592T3 (enExample) |
| HR (1) | HRP20220313T1 (enExample) |
| HU (1) | HUE058257T2 (enExample) |
| IL (1) | IL252912B (enExample) |
| LT (1) | LT3233813T (enExample) |
| MX (2) | MX392353B (enExample) |
| PL (1) | PL3233813T3 (enExample) |
| PT (1) | PT3233813T (enExample) |
| RS (1) | RS62955B1 (enExample) |
| SI (1) | SI3233813T1 (enExample) |
| SM (1) | SMT202200091T1 (enExample) |
| WO (1) | WO2016098054A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11591302B2 (en) * | 2014-12-19 | 2023-02-28 | Geistlich Pharm A Ag | Processes for preparing oxathiazin-like compounds |
| CA2971570A1 (en) * | 2014-12-19 | 2016-06-23 | Geistlich Pharma Ag | Processes for preparing oxathiazin-like compounds |
| US10544114B2 (en) | 2016-04-07 | 2020-01-28 | Geistlich Pharma Ag | Process for preparing oxathiazin-like compounds |
| JP7152030B2 (ja) * | 2017-02-27 | 2022-10-12 | 株式会社シード探索研究所 | 抗真菌組成物 |
| CN109602744A (zh) * | 2018-12-13 | 2019-04-12 | 中国人民解放军总医院 | 荜茇酰胺在制备抗菌消炎药物中的应用 |
| WO2020234830A1 (en) * | 2019-05-22 | 2020-11-26 | Geistlich Pharma Ag | Oxathiazin_dioxide for treating, preventing, inhibiting or reducing cytokine release |
| WO2020234829A1 (en) * | 2019-05-22 | 2020-11-26 | Geistlich Pharma Ag | Methods and compositions for inhibiting gapdh |
| CN114025766B (zh) * | 2019-05-22 | 2024-09-10 | 盖斯特里希医药公司 | 用于抑制gapdh的噁噻嗪化合物 |
| CN111671758A (zh) * | 2020-07-06 | 2020-09-18 | 长春迈灵生物工程有限公司 | 牛磺罗定在制备抗hiv病毒药物中的应用 |
| BR112023000308A2 (pt) * | 2020-07-06 | 2023-03-28 | Acad Of Military Medical Sciences | Uso de taurolidina contra vírus |
| CN111617086A (zh) * | 2020-07-06 | 2020-09-04 | 长春迈灵生物工程有限公司 | 牛磺罗定在制备抗hpv病毒药物中的应用 |
| US20240199563A1 (en) * | 2021-04-29 | 2024-06-20 | Geistlich Pharma Ag | Antimicrobial and anticancer agents |
| CN118724762A (zh) * | 2024-06-24 | 2024-10-01 | 湖南增达生物科技有限公司 | 一种牛磺酸的制备新工艺 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1160443B (de) * | 1961-11-30 | 1964-01-02 | Hoechst Ag | Verfahren zur Herstellung von Tetrahydro-oxathiazin-dioxyden |
| GB1124285A (en) * | 1964-10-06 | 1968-08-21 | Geistlich Soehne Ag | Novel perhydro-1,2,4-thiadiazine dioxides-(1,1), their preparation and compositionscontaining them |
| DE1234988B (de) | 1964-11-28 | 1967-02-23 | Bayer Ag | Verfahren zur Herstellung von Copolymerisaten des Trioxans |
| DK167393B1 (da) * | 1985-12-30 | 1993-10-25 | Roussel Uclaf | 1-sulfonyl-2-oxo-pyrrolidinderivater, deres fremstilling og farmaceutiske praeparater med indhold deraf |
| GB8617482D0 (en) | 1986-07-17 | 1986-08-28 | Geistlich Soehne Ag | Pharmaceutical composition |
| IT1296926B1 (it) | 1997-12-05 | 1999-08-03 | Zambon Spa | Procedimento per la preparazione di composti ad attivita' antimicotica |
| KR101052462B1 (ko) * | 2004-09-21 | 2011-07-28 | 아스텔라스세이야쿠 가부시키가이샤 | 아미노알콜 유도체 |
| WO2008082725A1 (en) * | 2006-12-29 | 2008-07-10 | Anadys Pharmaceuticals, Inc. | Pyridazinone compounds |
| JP2008222659A (ja) * | 2007-03-14 | 2008-09-25 | Asahi Kasei Corp | スルホンアミド化合物の製造方法 |
| EP2154130A4 (en) | 2007-06-07 | 2011-09-07 | Astellas Pharma Inc | pyridone |
| US8088824B2 (en) * | 2007-08-15 | 2012-01-03 | Reata Pharmaceuticals Inc. | Forms of CDDO methyl ester |
| US20120142676A1 (en) * | 2010-08-18 | 2012-06-07 | Gaik-Lean Chee | Oxathiazine and dithiine oxides as inhibitors of sulfhydryl-dependent biomolecules |
| EP2643308B1 (en) * | 2010-11-23 | 2016-08-17 | Biophore India Pharmaceuticals Pvt. Ltd. | Process for the preparation of taurolidine and its intermediates thereof |
| PL2861573T3 (pl) * | 2012-06-18 | 2018-02-28 | Geistlich Pharma Ag | Pochodne oksatiazyny jako środki przeciwbakteryjne i przeciwnowotworowe |
| CA2971570A1 (en) * | 2014-12-19 | 2016-06-23 | Geistlich Pharma Ag | Processes for preparing oxathiazin-like compounds |
-
2015
- 2015-12-17 CA CA2971570A patent/CA2971570A1/en active Pending
- 2015-12-17 LT LTEPPCT/IB2015/059741T patent/LT3233813T/lt unknown
- 2015-12-17 EP EP15821172.2A patent/EP3233813B1/en active Active
- 2015-12-17 KR KR1020177019296A patent/KR102594322B1/ko active Active
- 2015-12-17 DK DK15821172.2T patent/DK3233813T3/da active
- 2015-12-17 JP JP2017551388A patent/JP6746605B2/ja active Active
- 2015-12-17 WO PCT/IB2015/059741 patent/WO2016098054A1/en not_active Ceased
- 2015-12-17 SI SI201531791T patent/SI3233813T1/sl unknown
- 2015-12-17 EP EP21211288.2A patent/EP4011871A3/en active Pending
- 2015-12-17 CN CN201580072835.0A patent/CN107257786B/zh active Active
- 2015-12-17 SM SM20220091T patent/SMT202200091T1/it unknown
- 2015-12-17 ES ES15821172T patent/ES2907592T3/es active Active
- 2015-12-17 HU HUE15821172A patent/HUE058257T2/hu unknown
- 2015-12-17 PL PL15821172T patent/PL3233813T3/pl unknown
- 2015-12-17 AU AU2015365348A patent/AU2015365348B2/en active Active
- 2015-12-17 CN CN202310038641.5A patent/CN119454714A/zh active Pending
- 2015-12-17 HR HRP20220313TT patent/HRP20220313T1/hr unknown
- 2015-12-17 PT PT158211722T patent/PT3233813T/pt unknown
- 2015-12-17 MX MX2019013194A patent/MX392353B/es unknown
- 2015-12-17 MX MX2017008112A patent/MX369462B/es active IP Right Grant
- 2015-12-17 RS RS20220195A patent/RS62955B1/sr unknown
- 2015-12-17 CN CN201910974314.4A patent/CN110776479A/zh active Pending
- 2015-12-17 US US15/535,266 patent/US10392355B2/en active Active
-
2017
- 2017-06-14 IL IL252912A patent/IL252912B/en active IP Right Grant
-
2019
- 2019-08-12 US US16/538,344 patent/US10968190B2/en active Active
- 2019-11-05 AU AU2019261702A patent/AU2019261702B2/en active Active
- 2019-11-15 JP JP2019206621A patent/JP7030093B2/ja active Active
-
2021
- 2021-11-12 JP JP2021184435A patent/JP7449913B2/ja active Active
-
2022
- 2022-03-04 CY CY20221100186T patent/CY1125047T1/el unknown
-
2023
- 2023-11-30 JP JP2023202330A patent/JP7688098B2/ja active Active
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