HUE058257T2 - Eljárások oxatiazin-jellegû vegyületek elõállítására - Google Patents
Eljárások oxatiazin-jellegû vegyületek elõállításáraInfo
- Publication number
- HUE058257T2 HUE058257T2 HUE15821172A HUE15821172A HUE058257T2 HU E058257 T2 HUE058257 T2 HU E058257T2 HU E15821172 A HUE15821172 A HU E15821172A HU E15821172 A HUE15821172 A HU E15821172A HU E058257 T2 HUE058257 T2 HU E058257T2
- Authority
- HU
- Hungary
- Prior art keywords
- processes
- preparation
- oxathiazine compounds
- oxathiazine
- compounds
- Prior art date
Links
- AZHVQJLDOFKHPZ-UHFFFAOYSA-N oxathiazine Chemical class O1SN=CC=C1 AZHVQJLDOFKHPZ-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
- C07C303/04—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof by substitution of hydrogen atoms by sulfo or halosulfonyl groups
- C07C303/12—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof by substitution of hydrogen atoms by sulfo or halosulfonyl groups by reaction with thionylhalides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/78—Halides of sulfonic acids
- C07C309/79—Halides of sulfonic acids having halosulfonyl groups bound to acyclic carbon atoms
- C07C309/82—Halides of sulfonic acids having halosulfonyl groups bound to acyclic carbon atoms of a carbon skeleton substituted by singly-bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
- C07C303/18—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof by reaction of sulfides with compounds having functional groups with formation of sulfo or halosulfonyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
- C07C303/22—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof from sulfonic acids, by reactions not involving the formation of sulfo or halosulfonyl groups; from sulfonic halides by reactions not involving the formation of halosulfonyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/32—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/07—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton
- C07C309/09—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing etherified hydroxy groups bound to the carbon skeleton
- C07C309/10—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing etherified hydroxy groups bound to the carbon skeleton with the oxygen atom of at least one of the etherified hydroxy groups further bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/07—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton
- C07C309/12—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing esterified hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
- C07C311/24—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
- C07C311/27—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D291/00—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms
- C07D291/02—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms not condensed with other rings
- C07D291/06—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D419/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462094580P | 2014-12-19 | 2014-12-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE058257T2 true HUE058257T2 (hu) | 2022-07-28 |
Family
ID=55077556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE15821172A HUE058257T2 (hu) | 2014-12-19 | 2015-12-17 | Eljárások oxatiazin-jellegû vegyületek elõállítására |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US10392355B2 (enExample) |
| EP (2) | EP4011871A3 (enExample) |
| JP (4) | JP6746605B2 (enExample) |
| KR (1) | KR102594322B1 (enExample) |
| CN (3) | CN107257786B (enExample) |
| AU (2) | AU2015365348B2 (enExample) |
| CA (1) | CA2971570A1 (enExample) |
| CY (1) | CY1125047T1 (enExample) |
| DK (1) | DK3233813T3 (enExample) |
| ES (1) | ES2907592T3 (enExample) |
| HR (1) | HRP20220313T1 (enExample) |
| HU (1) | HUE058257T2 (enExample) |
| IL (1) | IL252912B (enExample) |
| LT (1) | LT3233813T (enExample) |
| MX (2) | MX369462B (enExample) |
| PL (1) | PL3233813T3 (enExample) |
| PT (1) | PT3233813T (enExample) |
| RS (1) | RS62955B1 (enExample) |
| SI (1) | SI3233813T1 (enExample) |
| SM (1) | SMT202200091T1 (enExample) |
| WO (1) | WO2016098054A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107257786B (zh) * | 2014-12-19 | 2019-12-24 | 盖斯特里希医药公司 | 制备噁噻嗪样化合物的方法 |
| US11591302B2 (en) * | 2014-12-19 | 2023-02-28 | Geistlich Pharm A Ag | Processes for preparing oxathiazin-like compounds |
| BR112018070662A2 (pt) | 2016-04-07 | 2019-02-05 | Geistlich Pharma Ag | processos para preparar compostos do tipo oxatiazina |
| US10980813B2 (en) * | 2017-02-27 | 2021-04-20 | Seed Research Institute Co., Ltd. | Antifungal composition |
| CN109602744A (zh) * | 2018-12-13 | 2019-04-12 | 中国人民解放军总医院 | 荜茇酰胺在制备抗菌消炎药物中的应用 |
| WO2020234829A1 (en) * | 2019-05-22 | 2020-11-26 | Geistlich Pharma Ag | Methods and compositions for inhibiting gapdh |
| US20220323423A1 (en) * | 2019-05-22 | 2022-10-13 | Geistlich Pharma Ag | Oxathiazin_dioxide for treating, preventing, inhibiting or reducing cytokine release |
| EP3972608A1 (en) * | 2019-05-22 | 2022-03-30 | Geistlich Pharma AG | Oxathiazin compounds for inhibiting gapdh |
| CN111671758A (zh) * | 2020-07-06 | 2020-09-18 | 长春迈灵生物工程有限公司 | 牛磺罗定在制备抗hiv病毒药物中的应用 |
| CN111617086A (zh) * | 2020-07-06 | 2020-09-04 | 长春迈灵生物工程有限公司 | 牛磺罗定在制备抗hpv病毒药物中的应用 |
| WO2022007713A1 (zh) * | 2020-07-06 | 2022-01-13 | 军事科学院军事医学研究院军事兽医研究所 | 牛磺罗定在抗病毒中的应用 |
| CA3216783A1 (en) * | 2021-04-29 | 2022-11-03 | Thomas Mueller | Antimicrobial and anticancer agents |
| CN118724762A (zh) * | 2024-06-24 | 2024-10-01 | 湖南增达生物科技有限公司 | 一种牛磺酸的制备新工艺 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1160443B (de) | 1961-11-30 | 1964-01-02 | Hoechst Ag | Verfahren zur Herstellung von Tetrahydro-oxathiazin-dioxyden |
| GB1124285A (en) * | 1964-10-06 | 1968-08-21 | Geistlich Soehne Ag | Novel perhydro-1,2,4-thiadiazine dioxides-(1,1), their preparation and compositionscontaining them |
| DE1234988B (de) | 1964-11-28 | 1967-02-23 | Bayer Ag | Verfahren zur Herstellung von Copolymerisaten des Trioxans |
| DK167393B1 (da) * | 1985-12-30 | 1993-10-25 | Roussel Uclaf | 1-sulfonyl-2-oxo-pyrrolidinderivater, deres fremstilling og farmaceutiske praeparater med indhold deraf |
| GB8617482D0 (en) | 1986-07-17 | 1986-08-28 | Geistlich Soehne Ag | Pharmaceutical composition |
| IT1296926B1 (it) * | 1997-12-05 | 1999-08-03 | Zambon Spa | Procedimento per la preparazione di composti ad attivita' antimicotica |
| US7928264B2 (en) * | 2004-09-21 | 2011-04-19 | Astellas Pharma Inc. | Aminoalcohol derivatives |
| WO2008082725A1 (en) | 2006-12-29 | 2008-07-10 | Anadys Pharmaceuticals, Inc. | Pyridazinone compounds |
| JP2008222659A (ja) | 2007-03-14 | 2008-09-25 | Asahi Kasei Corp | スルホンアミド化合物の製造方法 |
| WO2008149965A1 (ja) * | 2007-06-07 | 2008-12-11 | Astellas Pharma Inc. | ピリドン化合物 |
| US8088824B2 (en) | 2007-08-15 | 2012-01-03 | Reata Pharmaceuticals Inc. | Forms of CDDO methyl ester |
| US20120142676A1 (en) * | 2010-08-18 | 2012-06-07 | Gaik-Lean Chee | Oxathiazine and dithiine oxides as inhibitors of sulfhydryl-dependent biomolecules |
| EP2643308B1 (en) * | 2010-11-23 | 2016-08-17 | Biophore India Pharmaceuticals Pvt. Ltd. | Process for the preparation of taurolidine and its intermediates thereof |
| WO2013190355A1 (en) * | 2012-06-18 | 2013-12-27 | Geistlich Pharma Ag | Oxathiazine derivatives as antibacterial and anticancer agents |
| CN107257786B (zh) | 2014-12-19 | 2019-12-24 | 盖斯特里希医药公司 | 制备噁噻嗪样化合物的方法 |
-
2015
- 2015-12-17 CN CN201580072835.0A patent/CN107257786B/zh active Active
- 2015-12-17 RS RS20220195A patent/RS62955B1/sr unknown
- 2015-12-17 CN CN201910974314.4A patent/CN110776479A/zh active Pending
- 2015-12-17 EP EP21211288.2A patent/EP4011871A3/en active Pending
- 2015-12-17 LT LTEPPCT/IB2015/059741T patent/LT3233813T/lt unknown
- 2015-12-17 MX MX2017008112A patent/MX369462B/es active IP Right Grant
- 2015-12-17 JP JP2017551388A patent/JP6746605B2/ja active Active
- 2015-12-17 ES ES15821172T patent/ES2907592T3/es active Active
- 2015-12-17 MX MX2019013194A patent/MX392353B/es unknown
- 2015-12-17 HR HRP20220313TT patent/HRP20220313T1/hr unknown
- 2015-12-17 EP EP15821172.2A patent/EP3233813B1/en active Active
- 2015-12-17 DK DK15821172.2T patent/DK3233813T3/da active
- 2015-12-17 SM SM20220091T patent/SMT202200091T1/it unknown
- 2015-12-17 PT PT158211722T patent/PT3233813T/pt unknown
- 2015-12-17 WO PCT/IB2015/059741 patent/WO2016098054A1/en not_active Ceased
- 2015-12-17 PL PL15821172T patent/PL3233813T3/pl unknown
- 2015-12-17 SI SI201531791T patent/SI3233813T1/sl unknown
- 2015-12-17 CA CA2971570A patent/CA2971570A1/en active Pending
- 2015-12-17 US US15/535,266 patent/US10392355B2/en active Active
- 2015-12-17 CN CN202310038641.5A patent/CN119454714A/zh active Pending
- 2015-12-17 KR KR1020177019296A patent/KR102594322B1/ko active Active
- 2015-12-17 AU AU2015365348A patent/AU2015365348B2/en active Active
- 2015-12-17 HU HUE15821172A patent/HUE058257T2/hu unknown
-
2017
- 2017-06-14 IL IL252912A patent/IL252912B/en active IP Right Grant
-
2019
- 2019-08-12 US US16/538,344 patent/US10968190B2/en active Active
- 2019-11-05 AU AU2019261702A patent/AU2019261702B2/en active Active
- 2019-11-15 JP JP2019206621A patent/JP7030093B2/ja active Active
-
2021
- 2021-11-12 JP JP2021184435A patent/JP7449913B2/ja active Active
-
2022
- 2022-03-04 CY CY20221100186T patent/CY1125047T1/el unknown
-
2023
- 2023-11-30 JP JP2023202330A patent/JP7688098B2/ja active Active
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