CN113365999A - 含有吡咯并杂环的衣壳蛋白装配抑制剂 - Google Patents

含有吡咯并杂环的衣壳蛋白装配抑制剂 Download PDF

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CN113365999A
CN113365999A CN202080011284.8A CN202080011284A CN113365999A CN 113365999 A CN113365999 A CN 113365999A CN 202080011284 A CN202080011284 A CN 202080011284A CN 113365999 A CN113365999 A CN 113365999A
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CN113365999B (zh
Inventor
张寅生
敖汪伟
王辉
李元
倪杰
张欢
吴杰
张立
曹凯
沈杭州
陆鹏
汪杰
赵天笑
田晓萌
卢丹丹
葛兴枫
陈硕
马雪琴
施伟
王晓金
徐宏江
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Chia Tai Tianqing Pharmaceutical Group Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

本申请属于药物化学领域，涉及一种含有吡咯并杂环的衣壳蛋白装配抑制剂，具体而言，涉及式I所示的化合物、其立体异构体或其药学上可接受的盐、其制备方法、药物组合物及医药用途，包括用于治疗受益于衣壳蛋白装配抑制的疾病的用途，尤其是乙型肝炎病毒感染引起的疾病。

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN202080011284.8A 2019-01-31 2020-01-30 含有吡咯并杂环的衣壳蛋白装配抑制剂 Active CN113365999B (zh)

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CN2019100960846 2019-01-31
CN201910096084 2019-01-31
CN2019104516892 2019-05-28
CN201910451689 2019-05-28
PCT/CN2020/074071 WO2020156494A1 (zh) 2019-01-31 2020-01-30 含有吡咯并杂环的衣壳蛋白装配抑制剂

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Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019118358A1 (en) 2017-12-11 2019-06-20 VenatoRx Pharmaceuticals, Inc. Hepatitis b capsid assembly modulators
CN111868026B (zh) 2018-03-30 2022-11-25 正大天晴药业集团股份有限公司 含有n杂五元环的衣壳蛋白装配抑制剂、其药物组合物和用途
SG11202012346YA (en) 2018-06-11 2021-01-28 Venatorx Pharmaceuticals Inc Hepatitis b capsid assembly modulators
WO2023056933A1 (zh) * 2021-10-08 2023-04-13 正大天晴药业集团股份有限公司 包含衣壳蛋白抑制剂和逆转录酶抑制剂的药物组合

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CN101743246A (zh) * 2007-05-25 2010-06-16 F2G有限公司 作为抗真菌剂的2-氧代-2-(2-苯基-5，6，7，8-四氢-中氮茚-3-基)-乙酰胺衍生物及相关化合物
WO2017156255A1 (en) * 2016-03-09 2017-09-14 Emory University Elimination of hepatitis b virus with antiviral agents
WO2018039531A1 (en) * 2016-08-26 2018-03-01 Gilead Sciences, Inc. Substituted pyrrolizine compounds and uses thereof
WO2019165374A1 (en) * 2018-02-26 2019-08-29 Gilead Sciences, Inc. Substituted pyrrolizine compounds as hbv replication inhibitors
WO2019185016A1 (zh) * 2018-03-30 2019-10-03 正大天晴药业集团股份有限公司 含有n杂五元环的衣壳蛋白装配抑制剂、其药物组合物和用途
WO2019223791A1 (zh) * 2018-05-25 2019-11-28 正大天晴药业集团股份有限公司 2,3-二氢-1h-吡咯嗪-7-甲酰胺类衍生物及其应用
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CN101743246A (zh) * 2007-05-25 2010-06-16 F2G有限公司 作为抗真菌剂的2-氧代-2-(2-苯基-5，6，7，8-四氢-中氮茚-3-基)-乙酰胺衍生物及相关化合物
WO2017156255A1 (en) * 2016-03-09 2017-09-14 Emory University Elimination of hepatitis b virus with antiviral agents
CN109153640A (zh) * 2016-03-09 2019-01-04 埃默里大学 用抗病毒剂消除乙型肝炎病毒
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CN111247151A (zh) * 2018-05-25 2020-06-05 正大天晴药业集团股份有限公司 2,3-二氢-1h-吡咯嗪-7-甲酰胺类衍生物及其应用
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CN113549079A (zh) * 2018-05-25 2021-10-26 正大天晴药业集团股份有限公司 2,3-二氢-1h-吡咯嗪-7-甲酰胺类衍生物及其应用
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WO2020156494A1 (zh) 2020-08-06

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