RU2006120486A - Гидроксиалкилзамещенные пиридо-7-пиримидин-7-оны - Google Patents
Гидроксиалкилзамещенные пиридо-7-пиримидин-7-оны Download PDFInfo
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- RU2006120486A RU2006120486A RU2006120486/04A RU2006120486A RU2006120486A RU 2006120486 A RU2006120486 A RU 2006120486A RU 2006120486/04 A RU2006120486/04 A RU 2006120486/04A RU 2006120486 A RU2006120486 A RU 2006120486A RU 2006120486 A RU2006120486 A RU 2006120486A
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- Prior art keywords
- formula
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- hydroxyalkyl
- kinase
- alkyl
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (9)
1. Соединение формулы I
в которой Х1 обозначает О, С=O или S(O)n, где n равно 0, 1 или 2;
Ar1 обозначает арил или гетероарил;
R1 обозначает алкоксиалкил, алкил, циклоалкил, циклоалкилалкил, гетероциклил, гидроксиалкил или гидроксициклоалкил; и
R2 обозначает гидроксиалкил, оксоалкил или гидроксициклоалкил.
2. Соединение формулы I по п.1, имеющее формулу II
в которой m равно от 0 до 4;
все R3 обозначают алкил, галоген, алкоксигруппу или галогеналкил; и
R1 и R2 являются такими, как определено в п.1.
3. Соединение по п.1, предназначенное для применения в качестве терапевтически активного вещества.
4. Способ получения соединения формулы I по п.1, включающий реакцию соединения формулы If
в которой R обозначает C1-С6алкил, а X1, Ar1 и R2 имеют значения, определенные в п.1, с амином формулы R1-NH2.
5. Соединение формулы I по п.1, полученное способом по п.4.
6. Применение соединения формулы I по п.1 для приготовления лекарственного средства, предназначенного для борьбы с нарушением, опосредуемым киназой р38, или его предупреждения.
7. Композиция, содержащая фармацевтически приемлемый наполнитель и соединение формулы I по п.1.
8. Способ лечения нарушения, опосредуемого киназой р38, включающий введение пациенту терапевтически эффективного количества соединения по п.1.
9. Способ по п.8, в котором указанное нарушение, опосредуемое киназой р38, представляет собой артрит, болезнь Крона, синдром раздраженной толстой кишки, респираторный дистресс-синдром взрослых, хроническое обструктивное заболевание легких или болезнь Альцгеймера.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51978903P | 2003-11-13 | 2003-11-13 | |
| US60/519,789 | 2003-11-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2006120486A true RU2006120486A (ru) | 2008-01-20 |
| RU2348632C2 RU2348632C2 (ru) | 2009-03-10 |
Family
ID=34590444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006120486/04A RU2348632C2 (ru) | 2003-11-13 | 2004-11-04 | Гидроксиалкилзамещенные пиридо-7-пиримидин-7-оны |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US7348331B2 (ru) |
| EP (1) | EP1685131B1 (ru) |
| JP (1) | JP4616839B2 (ru) |
| KR (1) | KR100816321B1 (ru) |
| CN (1) | CN100455582C (ru) |
| AR (1) | AR046705A1 (ru) |
| AT (1) | ATE356124T1 (ru) |
| AU (1) | AU2004289428B2 (ru) |
| BR (1) | BRPI0416030A (ru) |
| CA (1) | CA2544247A1 (ru) |
| CO (1) | CO5690600A2 (ru) |
| DE (1) | DE602004005238T2 (ru) |
| DK (1) | DK1685131T3 (ru) |
| ES (1) | ES2281843T3 (ru) |
| HK (1) | HK1099021A1 (ru) |
| HR (1) | HRP20070132T3 (ru) |
| IL (1) | IL175284A0 (ru) |
| MY (1) | MY141011A (ru) |
| NO (1) | NO20062256L (ru) |
| NZ (1) | NZ546634A (ru) |
| PL (1) | PL1685131T3 (ru) |
| PT (1) | PT1685131E (ru) |
| RU (1) | RU2348632C2 (ru) |
| SI (1) | SI1685131T1 (ru) |
| TW (1) | TWI349670B (ru) |
| WO (1) | WO2005047284A1 (ru) |
| ZA (1) | ZA200603829B (ru) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11078199B2 (en) | 2014-02-07 | 2021-08-03 | Principia Biopharma, Inc. | Quinolone derivatives as fibroblast growth factor receptor inhibitors |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008011032A1 (en) | 2006-07-17 | 2008-01-24 | Amgen Inc. | Quinazoline and pyridopyrimidine derivatives as p38 kinase inhibitors |
| CA2672848A1 (en) * | 2006-12-22 | 2008-07-03 | F. Hoffmann-La Roche Ag | Compounds and methods for amino-alkylenediol synthesis |
| EP2158182A2 (en) * | 2007-06-15 | 2010-03-03 | F. Hoffmann-Roche AG | A novel process for the preparation of 3-amino-pentan-1,5-diol |
| KR101754664B1 (ko) * | 2009-12-18 | 2017-07-06 | 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | 치환된 피리도〔2,3-ｄ〕피리미딘-7(8ｈ)-온스 및 이의 치료 용도 |
| JP6940480B2 (ja) | 2015-08-11 | 2021-09-29 | プリンシピア バイオファーマ インコーポレイテッド | Ｆｇｆｒ阻害剤の合成方法 |
| CN105418609B (zh) * | 2015-12-31 | 2017-06-23 | 山东大学 | 4‑(1,2,3‑三氮唑取代苯胺基)‑吡啶骈嘧啶酮衍生物及其制备方法与应用 |
| WO2017151409A1 (en) | 2016-02-29 | 2017-09-08 | University Of Florida Research Foundation, Incorporated | Chemotherapeutic methods |
| KR20220119529A (ko) | 2016-06-02 | 2022-08-29 | 애브비 인코포레이티드 | 글루코코르티코이드 수용체 작용제 및 이의 면역접합체 |
| PE20190376A1 (es) | 2016-06-08 | 2019-03-08 | Support Venture Gmbh | Combinaciones farmaceuticas para el tratamiento del cancer |
| EA201990220A1 (ru) | 2016-08-17 | 2019-08-30 | Суппорт-Венче Гмбх | Способ предотвращения или лечения потери слуха |
| US11576916B2 (en) * | 2017-04-04 | 2023-02-14 | Kinarus Ag | Methods of preventing or treating ophthalmic diseases |
| WO2019071147A1 (en) | 2017-10-05 | 2019-04-11 | Fulcrum Therapeutics, Inc. | INHIBITORS OF KINASE P38 REDUCING EXPRESSION OF DUX4 GENE AND DOWNSTREAM GENES FOR THE TREATMENT OF FSHD |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| WO2019106609A1 (en) | 2017-12-01 | 2019-06-06 | Abbvie Inc. | Glucocorticoid receptor agonist and immunoconjugates thereof |
| WO2019224096A1 (en) | 2018-05-21 | 2019-11-28 | Nerviano Medical Sciences S.R.L. | Heterocondensed pyridones compounds and their use as idh inhibitors |
| WO2020011661A1 (en) | 2018-07-13 | 2020-01-16 | Kinarus Ag | Combinations of ppar agonists and p38 kinase inhibitors for preventing or treating fibrotic diseases |
| EP4055015A1 (en) | 2019-11-08 | 2022-09-14 | Nerviano Medical Sciences S.r.l. | Gem-disubstituted heterocyclic compounds and their use as idh inhibitors |
| US20230263803A1 (en) | 2020-08-11 | 2023-08-24 | Kinarus Ag | Methods of preventing or treating covid-19 and related viral diseases or disorders |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4215216A (en) * | 1979-04-18 | 1980-07-29 | American Home Products Corporation | 7,8-Dihydro-2,5,8-trisubstituted-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxylic acid derivatives |
| US5037826A (en) * | 1986-10-15 | 1991-08-06 | Schering Corporation | 1-substituted naphthyridine and pyridopyrazine derivatives |
| EP0278686A1 (en) | 1987-02-07 | 1988-08-17 | The Wellcome Foundation Limited | Pyridopyrimidines methods for their preparation and pharmaceutical formulations thereof |
| WO1993017682A1 (en) | 1992-03-04 | 1993-09-16 | Abbott Laboratories | Angiotensin ii receptor antagonists |
| MD1861G2 (ru) | 1994-11-14 | 2002-09-30 | Уорнер-Ламберт Кампэни | Производные 6-арилпиридо [2,3-d] пиримидинов и нафтиридинов, фармацевтические композиции на их основе, способы лечения и ингибирования пролиферации и миграции клеток рецепторов тирозин киназы |
| IL115256A0 (en) * | 1994-11-14 | 1995-12-31 | Warner Lambert Co | 6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use |
| IL117923A (en) | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
| US5620981A (en) * | 1995-05-03 | 1997-04-15 | Warner-Lambert Company | Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation |
| WO1998033798A2 (en) | 1997-02-05 | 1998-08-06 | Warner Lambert Company | Pyrido[2,3-d]pyrimidines and 4-amino-pyrimidines as inhibitors of cell proliferation |
| US5945422A (en) * | 1997-02-05 | 1999-08-31 | Warner-Lambert Company | N-oxides of amino containing pyrido 2,3-D! pyrimidines |
| BR9911590A (pt) | 1998-05-26 | 2001-02-13 | Warner Lambert Co | Pirimidinas bicìclicas e 3,4-diidropirimidinas bicìclicas como inibidores da proliferação celular |
| US7053070B2 (en) * | 2000-01-25 | 2006-05-30 | Warner-Lambert Company | Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors |
| SK10772002A3 (sk) | 2000-01-27 | 2004-01-08 | Warner-Lambert Company | Pyridopyrimidinónové deriváty na liečbu neurodegeneratívnych ochorení |
| AP2002002643A0 (en) | 2000-03-06 | 2002-12-31 | Warner Lambert Co | 5-alkylpyrido[2,3-d]pyrimidines tyrosine kinase inhibitors |
| US6518276B2 (en) * | 2000-08-31 | 2003-02-11 | Syntex (U.S.A.) Llc | 7-oxo-pyridopyrimidines (II) |
| CN1275964C (zh) * | 2000-08-31 | 2006-09-20 | 霍夫曼-拉罗奇有限公司 | 作为细胞增殖抑制剂的7－氧代吡啶并嘧啶 |
| WO2002064594A2 (en) * | 2001-02-12 | 2002-08-22 | F. Hoffmann-La Roche Ag | 6-substituted pyrido-pyrimidines |
| GEP20063909B (en) * | 2002-01-22 | 2006-08-25 | Warner Lambert Co | 2-(PYRIDIN-2-YLAMINO)-PYRIDO[2,3d] PYRIMIDIN-7-ONES |
| FR2897336B1 (fr) | 2006-02-10 | 2010-07-30 | Ranger France | Support d'aile pour vehicule automobile |
-
2004
- 2004-11-04 ES ES04797601T patent/ES2281843T3/es active Active
- 2004-11-04 AU AU2004289428A patent/AU2004289428B2/en not_active Ceased
- 2004-11-04 AT AT04797601T patent/ATE356124T1/de active
- 2004-11-04 CA CA002544247A patent/CA2544247A1/en not_active Abandoned
- 2004-11-04 SI SI200430261T patent/SI1685131T1/sl unknown
- 2004-11-04 PT PT04797601T patent/PT1685131E/pt unknown
- 2004-11-04 DK DK04797601T patent/DK1685131T3/da active
- 2004-11-04 DE DE602004005238T patent/DE602004005238T2/de active Active
- 2004-11-04 EP EP04797601A patent/EP1685131B1/en active Active
- 2004-11-04 RU RU2006120486/04A patent/RU2348632C2/ru not_active IP Right Cessation
- 2004-11-04 PL PL04797601T patent/PL1685131T3/pl unknown
- 2004-11-04 JP JP2006538744A patent/JP4616839B2/ja not_active Expired - Fee Related
- 2004-11-04 NZ NZ546634A patent/NZ546634A/en not_active IP Right Cessation
- 2004-11-04 BR BRPI0416030-4A patent/BRPI0416030A/pt not_active IP Right Cessation
- 2004-11-04 CN CNB2004800337221A patent/CN100455582C/zh not_active Expired - Fee Related
- 2004-11-04 WO PCT/EP2004/012475 patent/WO2005047284A1/en active IP Right Grant
- 2004-11-04 KR KR1020067009146A patent/KR100816321B1/ko not_active IP Right Cessation
- 2004-11-09 MY MYPI20044668A patent/MY141011A/en unknown
- 2004-11-10 TW TW093134375A patent/TWI349670B/zh not_active IP Right Cessation
- 2004-11-10 AR ARP040104138A patent/AR046705A1/es not_active Application Discontinuation
- 2004-11-12 US US10/987,656 patent/US7348331B2/en not_active Expired - Fee Related
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2006
- 2006-04-27 IL IL175284A patent/IL175284A0/en unknown
- 2006-05-12 CO CO06045585A patent/CO5690600A2/es not_active Application Discontinuation
- 2006-05-12 ZA ZA200603829A patent/ZA200603829B/en unknown
- 2006-05-19 NO NO20062256A patent/NO20062256L/no not_active Application Discontinuation
-
2007
- 2007-03-30 HR HR20070132T patent/HRP20070132T3/xx unknown
- 2007-06-18 HK HK07106518.3A patent/HK1099021A1/xx not_active IP Right Cessation
- 2007-11-19 US US11/985,821 patent/US7750016B2/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11078199B2 (en) | 2014-02-07 | 2021-08-03 | Principia Biopharma, Inc. | Quinolone derivatives as fibroblast growth factor receptor inhibitors |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20121105 |