ATE356124T1 - Hydroxyalkylsubstituierte pyrido-7-pyrimidin-7- one - Google Patents

Hydroxyalkylsubstituierte pyrido-7-pyrimidin-7- one

Info

Publication number
ATE356124T1
ATE356124T1 AT04797601T AT04797601T ATE356124T1 AT E356124 T1 ATE356124 T1 AT E356124T1 AT 04797601 T AT04797601 T AT 04797601T AT 04797601 T AT04797601 T AT 04797601T AT E356124 T1 ATE356124 T1 AT E356124T1
Authority
AT
Austria
Prior art keywords
pyrimidine
hydroxyalkyl substituted
substituted pyrido
pyrido
hydroxyalkyl
Prior art date
Application number
AT04797601T
Other languages
English (en)
Inventor
David Michael Goldstein
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE356124T1 publication Critical patent/ATE356124T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
AT04797601T 2003-11-13 2004-11-04 Hydroxyalkylsubstituierte pyrido-7-pyrimidin-7- one ATE356124T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51978903P 2003-11-13 2003-11-13

Publications (1)

Publication Number Publication Date
ATE356124T1 true ATE356124T1 (de) 2007-03-15

Family

ID=34590444

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04797601T ATE356124T1 (de) 2003-11-13 2004-11-04 Hydroxyalkylsubstituierte pyrido-7-pyrimidin-7- one

Country Status (27)

Country Link
US (2) US7348331B2 (de)
EP (1) EP1685131B1 (de)
JP (1) JP4616839B2 (de)
KR (1) KR100816321B1 (de)
CN (1) CN100455582C (de)
AR (1) AR046705A1 (de)
AT (1) ATE356124T1 (de)
AU (1) AU2004289428B2 (de)
BR (1) BRPI0416030A (de)
CA (1) CA2544247A1 (de)
CO (1) CO5690600A2 (de)
DE (1) DE602004005238T2 (de)
DK (1) DK1685131T3 (de)
ES (1) ES2281843T3 (de)
HK (1) HK1099021A1 (de)
HR (1) HRP20070132T3 (de)
IL (1) IL175284A0 (de)
MY (1) MY141011A (de)
NO (1) NO20062256L (de)
NZ (1) NZ546634A (de)
PL (1) PL1685131T3 (de)
PT (1) PT1685131E (de)
RU (1) RU2348632C2 (de)
SI (1) SI1685131T1 (de)
TW (1) TWI349670B (de)
WO (1) WO2005047284A1 (de)
ZA (1) ZA200603829B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2400695T3 (es) 2006-07-17 2013-04-11 Amgen Inc. Derivados de quinazolina y piridopirimidina como inhibidores de la cinasa p38
CN101568518A (zh) * 2006-12-22 2009-10-28 霍夫曼-拉罗奇有限公司 用于氨基亚烷基二醇合成的化合物和方法
CN101679211A (zh) * 2007-06-15 2010-03-24 霍夫曼-拉罗奇有限公司 用于制备3-氨基-戊-1,5-二醇的新方法
US8889696B2 (en) * 2009-12-18 2014-11-18 Temple University—Of the Commonwealth System of Higher Education Substituted pyrido[2,3-d]pyrimidin-7(8H)-ones and therapeutic uses thereof
PT3102577T (pt) 2014-02-07 2018-10-23 Principia Biopharma Inc Derivados de quinolona como inibidores do recetor do fator de crescimento de fibroblastos
MX2018001350A (es) 2015-08-11 2018-05-22 Principia Biopharma Inc Procesos para preparar un inhibidor de fgfr.
CN105418609B (zh) * 2015-12-31 2017-06-23 山东大学 4‑(1,2,3‑三氮唑取代苯胺基)‑吡啶骈嘧啶酮衍生物及其制备方法与应用
US20190060286A1 (en) 2016-02-29 2019-02-28 University Of Florida Research Foundation, Incorpo Chemotherapeutic Methods
MY194619A (en) 2016-06-02 2022-12-07 Abbvie Inc Glucocorticoid receptor agonist and immunoconjugates thereof
MY195671A (en) 2016-06-08 2023-02-03 Support Venture Gmbh Pharmaceutical Combinations for Treating Cancer
EP3500258A1 (de) 2016-08-17 2019-06-26 Support-Venture GmbH Verfahren zur vorbeugung oder behandlung von gehörverlust
EA201992004A1 (ru) * 2017-04-04 2020-02-20 Кинарус Аг Способы предотвращения или лечения офтальмологических заболеваний
LT3691620T (lt) 2017-10-05 2022-09-26 Fulcrum Therapeutics, Inc. P38 kinazės inhibitoriai, sumažinantys dux4 ir pasrovinių genų raišką, skirti fshd gydymui
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
CN111417410B (zh) 2017-12-01 2023-06-23 艾伯维公司 糖皮质激素受体激动剂及其免疫缀合物
PL3797107T3 (pl) 2018-05-21 2022-12-05 Nerviano Medical Sciences S.R.L. Heteroskondensowane związki pirydonów oraz ich zastosowanie jako inhibitory idh
JP2021524493A (ja) 2018-07-13 2021-09-13 キナラス アーゲー 線維性疾患を予防または処置するためのＰＰＡＲアゴニストおよびｐ３８キナーゼ阻害剤の組合せ物
JP2022554364A (ja) 2019-11-08 2022-12-28 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ ｇｅｍ－二置換複素環式化合物及びＩＤＨ阻害剤としてのその使用
US20230263803A1 (en) 2020-08-11 2023-08-24 Kinarus Ag Methods of preventing or treating covid-19 and related viral diseases or disorders

Family Cites Families (19)

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Publication number Priority date Publication date Assignee Title
US4215216A (en) 1979-04-18 1980-07-29 American Home Products Corporation 7,8-Dihydro-2,5,8-trisubstituted-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxylic acid derivatives
US5037826A (en) 1986-10-15 1991-08-06 Schering Corporation 1-substituted naphthyridine and pyridopyrazine derivatives
AU598093B2 (en) 1987-02-07 1990-06-14 Wellcome Foundation Limited, The Pyridopyrimidines, methods for their preparation and pharmaceutical formulations thereof
WO1993017682A1 (en) 1992-03-04 1993-09-16 Abbott Laboratories Angiotensin ii receptor antagonists
GEP20012444B (en) 1994-11-14 2001-05-25 Warner Lambert Company Us 6-Aryl Pyrido[2,3-d]Pyrimidines and Naphthyridines, Pharmaceutical Composition on Their Basis and Application for Inhibiting Cellular Proliferation
IL115256A0 (en) 1994-11-14 1995-12-31 Warner Lambert Co 6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
IL117923A (en) 1995-05-03 2000-06-01 Warner Lambert Co Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds
US5620981A (en) 1995-05-03 1997-04-15 Warner-Lambert Company Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
EP0964864B1 (de) 1997-02-05 2008-04-09 Warner-Lambert Company LLC Pyrido (2,3-d) pyrimidine und 4-amino-primidine als inhibitoren der zellulären proliferation
US5945422A (en) 1997-02-05 1999-08-31 Warner-Lambert Company N-oxides of amino containing pyrido 2,3-D! pyrimidines
YU73300A (sh) 1998-05-26 2003-08-29 Warner-Lambert Company Biciklični pirimidini i biciklični 3,4-dihidropirimidini kao inhibitori ćelijske proliferacije
US7053070B2 (en) 2000-01-25 2006-05-30 Warner-Lambert Company Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors
BR0017075A (pt) 2000-01-27 2002-11-05 Warner Lambert Co Derivados de piridopirimidinona para tratamento de doença neurodegenerativa
CA2401368A1 (en) 2000-03-06 2001-09-27 Warner-Lambert Company 5-alkylpyrido[2,3-d]pyrimidines tyrosine kinase inhibitors
US6518276B2 (en) 2000-08-31 2003-02-11 Syntex (U.S.A.) Llc 7-oxo-pyridopyrimidines (II)
BR0113628A (pt) * 2000-08-31 2003-07-01 Hoffmann La Roche 7-oxo-piridopirimidinas como inibidores de uma proliferação celular
MXPA03007166A (es) * 2001-02-12 2003-11-18 Hoffmann La Roche Pirido-pirimidinas 6-sustituidas.
WO2003062236A1 (en) 2002-01-22 2003-07-31 Warner-Lambert Company Llc 2-(PYRIDIN-2-YLAMINO)-PYRIDO[2,3d]PYRIMIDIN-7-ONES
FR2897336B1 (fr) 2006-02-10 2010-07-30 Ranger France Support d'aile pour vehicule automobile

Also Published As

Publication number Publication date
NZ546634A (en) 2010-01-29
PT1685131E (pt) 2007-05-31
CN1882585A (zh) 2006-12-20
JP4616839B2 (ja) 2011-01-19
DE602004005238D1 (de) 2007-04-19
DE602004005238T2 (de) 2007-11-08
EP1685131A1 (de) 2006-08-02
HRP20070132T3 (en) 2007-05-31
US20080119497A1 (en) 2008-05-22
NO20062256L (no) 2006-06-06
DK1685131T3 (da) 2007-07-09
US20050107408A1 (en) 2005-05-19
TW200526657A (en) 2005-08-16
ZA200603829B (en) 2007-10-31
RU2006120486A (ru) 2008-01-20
AU2004289428A1 (en) 2005-05-26
WO2005047284A1 (en) 2005-05-26
CA2544247A1 (en) 2005-05-26
AR046705A1 (es) 2005-12-21
SI1685131T1 (sl) 2007-06-30
BRPI0416030A (pt) 2007-01-02
CO5690600A2 (es) 2006-10-31
RU2348632C2 (ru) 2009-03-10
TWI349670B (en) 2011-10-01
HK1099021A1 (en) 2007-08-03
US7750016B2 (en) 2010-07-06
KR100816321B1 (ko) 2008-03-24
MY141011A (en) 2010-02-25
CN100455582C (zh) 2009-01-28
PL1685131T3 (pl) 2007-08-31
AU2004289428B2 (en) 2010-06-03
IL175284A0 (en) 2006-09-05
EP1685131B1 (de) 2007-03-07
JP2007510686A (ja) 2007-04-26
ES2281843T3 (es) 2007-10-01
KR20060086417A (ko) 2006-07-31
US7348331B2 (en) 2008-03-25

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