CO5690600A2 - Pirido-7-pirimidin-7-onas substituidas con hidroxialquilo - Google Patents

Pirido-7-pirimidin-7-onas substituidas con hidroxialquilo

Info

Publication number
CO5690600A2
CO5690600A2 CO06045585A CO06045585A CO5690600A2 CO 5690600 A2 CO5690600 A2 CO 5690600A2 CO 06045585 A CO06045585 A CO 06045585A CO 06045585 A CO06045585 A CO 06045585A CO 5690600 A2 CO5690600 A2 CO 5690600A2
Authority
CO
Colombia
Prior art keywords
hydroxialquil
pirido
pirimidin
waves
substituted
Prior art date
Application number
CO06045585A
Other languages
English (en)
Inventor
David Michael Goldstein
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO5690600A2 publication Critical patent/CO5690600A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1.- Un compuesto de fórmula Ien donde X1 es O, C=O ó S(O)n, en donde n es 0, 1 ó 2;Ar1 es arilo ó heteroarilo;R1 es alcoxialquilo, alquilo, cicloalquilo, cicloalquilalquilo, heterociclilo, hidroxialquilo, ó hidroxicicloalquilo; y R2 es hidroxialquilo, oxoalquilo o hidroxicicloalquilo.
CO06045585A 2003-11-13 2006-05-12 Pirido-7-pirimidin-7-onas substituidas con hidroxialquilo CO5690600A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51978903P 2003-11-13 2003-11-13

Publications (1)

Publication Number Publication Date
CO5690600A2 true CO5690600A2 (es) 2006-10-31

Family

ID=34590444

Family Applications (1)

Application Number Title Priority Date Filing Date
CO06045585A CO5690600A2 (es) 2003-11-13 2006-05-12 Pirido-7-pirimidin-7-onas substituidas con hidroxialquilo

Country Status (27)

Country Link
US (2) US7348331B2 (es)
EP (1) EP1685131B1 (es)
JP (1) JP4616839B2 (es)
KR (1) KR100816321B1 (es)
CN (1) CN100455582C (es)
AR (1) AR046705A1 (es)
AT (1) ATE356124T1 (es)
AU (1) AU2004289428B2 (es)
BR (1) BRPI0416030A (es)
CA (1) CA2544247A1 (es)
CO (1) CO5690600A2 (es)
DE (1) DE602004005238T2 (es)
DK (1) DK1685131T3 (es)
ES (1) ES2281843T3 (es)
HK (1) HK1099021A1 (es)
HR (1) HRP20070132T3 (es)
IL (1) IL175284A0 (es)
MY (1) MY141011A (es)
NO (1) NO20062256L (es)
NZ (1) NZ546634A (es)
PL (1) PL1685131T3 (es)
PT (1) PT1685131E (es)
RU (1) RU2348632C2 (es)
SI (1) SI1685131T1 (es)
TW (1) TWI349670B (es)
WO (1) WO2005047284A1 (es)
ZA (1) ZA200603829B (es)

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WO2008011032A1 (en) 2006-07-17 2008-01-24 Amgen Inc. Quinazoline and pyridopyrimidine derivatives as p38 kinase inhibitors
CA2672848A1 (en) * 2006-12-22 2008-07-03 F. Hoffmann-La Roche Ag Compounds and methods for amino-alkylenediol synthesis
EP2158182A2 (en) * 2007-06-15 2010-03-03 F. Hoffmann-Roche AG A novel process for the preparation of 3-amino-pentan-1,5-diol
KR101754664B1 (ko) * 2009-12-18 2017-07-06 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 치환된 피리도〔2,3-ｄ〕피리미딘-7(8ｈ)-온스 및 이의 치료 용도
JP6553629B2 (ja) 2014-02-07 2019-07-31 プリンシピア バイオファーマ インコーポレイテッド 線維芽細胞増殖因子受容体阻害剤としてのキノロン誘導体
JP6940480B2 (ja) 2015-08-11 2021-09-29 プリンシピア バイオファーマ インコーポレイテッド Ｆｇｆｒ阻害剤の合成方法
CN105418609B (zh) * 2015-12-31 2017-06-23 山东大学 4‑(1,2,3‑三氮唑取代苯胺基)‑吡啶骈嘧啶酮衍生物及其制备方法与应用
WO2017151409A1 (en) 2016-02-29 2017-09-08 University Of Florida Research Foundation, Incorporated Chemotherapeutic methods
KR20220119529A (ko) 2016-06-02 2022-08-29 애브비 인코포레이티드 글루코코르티코이드 수용체 작용제 및 이의 면역접합체
PE20190376A1 (es) 2016-06-08 2019-03-08 Support Venture Gmbh Combinaciones farmaceuticas para el tratamiento del cancer
EA201990220A1 (ru) 2016-08-17 2019-08-30 Суппорт-Венче Гмбх Способ предотвращения или лечения потери слуха
US11576916B2 (en) * 2017-04-04 2023-02-14 Kinarus Ag Methods of preventing or treating ophthalmic diseases
WO2019071147A1 (en) 2017-10-05 2019-04-11 Fulcrum Therapeutics, Inc. INHIBITORS OF KINASE P38 REDUCING EXPRESSION OF DUX4 GENE AND DOWNSTREAM GENES FOR THE TREATMENT OF FSHD
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
WO2019106609A1 (en) 2017-12-01 2019-06-06 Abbvie Inc. Glucocorticoid receptor agonist and immunoconjugates thereof
WO2019224096A1 (en) 2018-05-21 2019-11-28 Nerviano Medical Sciences S.R.L. Heterocondensed pyridones compounds and their use as idh inhibitors
WO2020011661A1 (en) 2018-07-13 2020-01-16 Kinarus Ag Combinations of ppar agonists and p38 kinase inhibitors for preventing or treating fibrotic diseases
EP4055015A1 (en) 2019-11-08 2022-09-14 Nerviano Medical Sciences S.r.l. Gem-disubstituted heterocyclic compounds and their use as idh inhibitors
US20230263803A1 (en) 2020-08-11 2023-08-24 Kinarus Ag Methods of preventing or treating covid-19 and related viral diseases or disorders

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US4215216A (en) * 1979-04-18 1980-07-29 American Home Products Corporation 7,8-Dihydro-2,5,8-trisubstituted-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxylic acid derivatives
US5037826A (en) * 1986-10-15 1991-08-06 Schering Corporation 1-substituted naphthyridine and pyridopyrazine derivatives
EP0278686A1 (en) 1987-02-07 1988-08-17 The Wellcome Foundation Limited Pyridopyrimidines methods for their preparation and pharmaceutical formulations thereof
WO1993017682A1 (en) 1992-03-04 1993-09-16 Abbott Laboratories Angiotensin ii receptor antagonists
MD1861G2 (ro) 1994-11-14 2002-09-30 Уорнер-Ламберт Кампэни Derivaţi ai 6-arilpirido[2,3-d]pirimidinelor şi naftiridinelor, compoziţie farmaceutică pe baza lor, metode de tratament şi de inhibare a proliferării şi migraţiei celulei receptorului tirozinkinazei
IL115256A0 (en) * 1994-11-14 1995-12-31 Warner Lambert Co 6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
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BR9911590A (pt) 1998-05-26 2001-02-13 Warner Lambert Co Pirimidinas bicìclicas e 3,4-diidropirimidinas bicìclicas como inibidores da proliferação celular
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Also Published As

Publication number Publication date
JP2007510686A (ja) 2007-04-26
US20080119497A1 (en) 2008-05-22
DK1685131T3 (da) 2007-07-09
IL175284A0 (en) 2006-09-05
EP1685131A1 (en) 2006-08-02
AR046705A1 (es) 2005-12-21
ATE356124T1 (de) 2007-03-15
RU2006120486A (ru) 2008-01-20
US20050107408A1 (en) 2005-05-19
HK1099021A1 (en) 2007-08-03
HRP20070132T3 (en) 2007-05-31
US7348331B2 (en) 2008-03-25
CN1882585A (zh) 2006-12-20
PT1685131E (pt) 2007-05-31
CA2544247A1 (en) 2005-05-26
KR100816321B1 (ko) 2008-03-24
ES2281843T3 (es) 2007-10-01
TWI349670B (en) 2011-10-01
NZ546634A (en) 2010-01-29
AU2004289428B2 (en) 2010-06-03
BRPI0416030A (pt) 2007-01-02
SI1685131T1 (sl) 2007-06-30
NO20062256L (no) 2006-06-06
CN100455582C (zh) 2009-01-28
WO2005047284A1 (en) 2005-05-26
MY141011A (en) 2010-02-25
DE602004005238D1 (de) 2007-04-19
PL1685131T3 (pl) 2007-08-31
KR20060086417A (ko) 2006-07-31
ZA200603829B (en) 2007-10-31
DE602004005238T2 (de) 2007-11-08
EP1685131B1 (en) 2007-03-07
RU2348632C2 (ru) 2009-03-10
JP4616839B2 (ja) 2011-01-19
TW200526657A (en) 2005-08-16
AU2004289428A1 (en) 2005-05-26
US7750016B2 (en) 2010-07-06

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Legal Events

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