CN113784970A - Erk抑制剂及其应用 - Google Patents
Erk抑制剂及其应用 Download PDFInfo
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- CN113784970A CN113784970A CN202080027279.6A CN202080027279A CN113784970A CN 113784970 A CN113784970 A CN 113784970A CN 202080027279 A CN202080027279 A CN 202080027279A CN 113784970 A CN113784970 A CN 113784970A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
一类作为ERK抑制剂的化合物，及其在制备治疗ERK相关疾病的药物中的应用。具体涉及式(III)所示化合物、其异构体或其药学上可接受的盐。
Description
PCT国内申请，说明书已公开。
Claims (17)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910404679 | 2019-05-15 | ||
| CN2019104046793 | 2019-05-15 | ||
| CN201910761813 | 2019-08-16 | ||
| CN2019107618135 | 2019-08-16 | ||
| CN201911248182 | 2019-12-06 | ||
| CN2019112481823 | 2019-12-06 | ||
| CN2020103097930 | 2020-04-17 | ||
| CN202010309793 | 2020-04-17 | ||
| PCT/CN2020/090494 WO2020228817A1 (zh) | 2019-05-15 | 2020-05-15 | Erk抑制剂及其应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113784970A true CN113784970A (zh) | 2021-12-10 |
| CN113784970B CN113784970B (zh) | 2022-11-29 |
Family
ID=73289819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080027279.6A Active CN113784970B (zh) | 2019-05-15 | 2020-05-15 | Erk抑制剂及其应用 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN113784970B (zh) |
| WO (1) | WO2020228817A1 (zh) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI765451B (zh) | 2019-12-06 | 2022-05-21 | 大陸商南京明德新藥研發有限公司 | 作為erk抑制劑的螺環類化合物及其應用 |
| WO2022100586A1 (zh) * | 2020-11-11 | 2022-05-19 | 南京明德新药研发有限公司 | 一种含氧杂环丁烷的螺环类化合物的晶型、制备方法及其应用 |
| WO2022253186A1 (zh) * | 2021-06-02 | 2022-12-08 | 南京明德新药研发有限公司 | 一种二甲基取代的噻唑并吡咯酮类化合物的晶型及其制备方法 |
| IL309706A (en) * | 2021-06-28 | 2024-02-01 | D3 Bio Wuxi Co Ltd | Dimethyl-converted thiazololactam compound and its uses |
| CN117561266A (zh) * | 2021-06-28 | 2024-02-13 | 德昇济医药(无锡)有限公司 | 噻唑并内酰胺并螺杂环类化合物及其应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008153947A2 (en) * | 2007-06-07 | 2008-12-18 | Amgen Inc. | Heterocyclic compounds as raf kinase modulators |
| CN103189369A (zh) * | 2010-09-01 | 2013-07-03 | 吉利德康涅狄格有限公司 | 吡啶酮/吡嗪酮、其制备方法及使用方法 |
| WO2013130976A1 (en) * | 2012-03-01 | 2013-09-06 | Array Biopharma Inc. | Serine/threonine kinase inhibitors |
| CN107074874A (zh) * | 2014-12-22 | 2017-08-18 | 伊莱利利公司 | Erk抑制剂 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103201277B (zh) * | 2010-09-01 | 2015-11-25 | 吉利德康涅狄格有限公司 | 哒嗪酮、其制备方法及使用方法 |
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2020
- 2020-05-15 CN CN202080027279.6A patent/CN113784970B/zh active Active
- 2020-05-15 WO PCT/CN2020/090494 patent/WO2020228817A1/zh active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008153947A2 (en) * | 2007-06-07 | 2008-12-18 | Amgen Inc. | Heterocyclic compounds as raf kinase modulators |
| CN103189369A (zh) * | 2010-09-01 | 2013-07-03 | 吉利德康涅狄格有限公司 | 吡啶酮/吡嗪酮、其制备方法及使用方法 |
| WO2013130976A1 (en) * | 2012-03-01 | 2013-09-06 | Array Biopharma Inc. | Serine/threonine kinase inhibitors |
| CN107074874A (zh) * | 2014-12-22 | 2017-08-18 | 伊莱利利公司 | Erk抑制剂 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN113784970B (zh) | 2022-11-29 |
| WO2020228817A1 (zh) | 2020-11-19 |
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