ATE354562T1 - Cyclohexylsulfon-derivate als gamma-secretase- inhibitoren - Google Patents
Cyclohexylsulfon-derivate als gamma-secretase- inhibitorenInfo
- Publication number
- ATE354562T1 ATE354562T1 AT03748306T AT03748306T ATE354562T1 AT E354562 T1 ATE354562 T1 AT E354562T1 AT 03748306 T AT03748306 T AT 03748306T AT 03748306 T AT03748306 T AT 03748306T AT E354562 T1 ATE354562 T1 AT E354562T1
- Authority
- AT
- Austria
- Prior art keywords
- sup
- sub
- cyclohexylsulfone
- derivatives
- gamma secretase
- Prior art date
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
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- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Furan Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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GBGB0223039.9A GB0223039D0 (en) | 2002-10-04 | 2002-10-04 | Therapeutic compounds |
Publications (1)
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ATE354562T1 true ATE354562T1 (de) | 2007-03-15 |
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AT03748306T ATE354562T1 (de) | 2002-10-04 | 2003-09-25 | Cyclohexylsulfon-derivate als gamma-secretase- inhibitoren |
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US (1) | US7101895B2 (de) |
EP (1) | EP1551797B1 (de) |
JP (1) | JP4653485B2 (de) |
AT (1) | ATE354562T1 (de) |
AU (1) | AU2003267614B2 (de) |
CA (1) | CA2500964C (de) |
DE (1) | DE60312016T2 (de) |
ES (1) | ES2280774T3 (de) |
GB (1) | GB0223039D0 (de) |
WO (1) | WO2004031137A1 (de) |
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RU2304140C2 (ru) | 2001-12-27 | 2007-08-10 | Дайити Фармасьютикал Ко., Лтд. | ИНГИБИТОРЫ ПРОДУЦИРОВАНИЯ / СЕКРЕЦИИ β-АМИЛОИДНОГО БЕЛКА |
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US20090215775A1 (en) * | 2005-05-17 | 2009-08-27 | Huw David Lewis | Sulphonamido-Substituted Cyclohexyl Sulphones for Treatment of Cancer |
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JP5281395B2 (ja) * | 2005-06-06 | 2013-09-04 | メルク シャープ エンド ドーム リミテッド | 統合失調症の治療用のglyt1阻害剤としてのシクロヘキサンスルホニル誘導体 |
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CN110461335A (zh) | 2017-02-17 | 2019-11-15 | 弗雷德哈钦森癌症研究中心 | 用于治疗bcma相关癌症和自身免疫性失调的联合疗法 |
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-
2002
- 2002-10-04 GB GBGB0223039.9A patent/GB0223039D0/en not_active Ceased
-
2003
- 2003-09-25 DE DE60312016T patent/DE60312016T2/de not_active Expired - Lifetime
- 2003-09-25 WO PCT/GB2003/004102 patent/WO2004031137A1/en active IP Right Grant
- 2003-09-25 JP JP2004540927A patent/JP4653485B2/ja not_active Expired - Fee Related
- 2003-09-25 CA CA2500964A patent/CA2500964C/en not_active Expired - Fee Related
- 2003-09-25 EP EP03748306A patent/EP1551797B1/de not_active Expired - Lifetime
- 2003-09-25 AU AU2003267614A patent/AU2003267614B2/en not_active Ceased
- 2003-09-25 AT AT03748306T patent/ATE354562T1/de not_active IP Right Cessation
- 2003-09-25 ES ES03748306T patent/ES2280774T3/es not_active Expired - Lifetime
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Also Published As
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EP1551797A1 (de) | 2005-07-13 |
AU2003267614B2 (en) | 2010-02-18 |
WO2004031137A1 (en) | 2004-04-15 |
JP2006501292A (ja) | 2006-01-12 |
CA2500964C (en) | 2011-01-18 |
DE60312016T2 (de) | 2007-10-31 |
EP1551797B1 (de) | 2007-02-21 |
AU2003267614A1 (en) | 2004-04-23 |
GB0223039D0 (en) | 2002-11-13 |
CA2500964A1 (en) | 2004-04-15 |
US20040122050A1 (en) | 2004-06-24 |
ES2280774T3 (es) | 2007-09-16 |
DE60312016D1 (en) | 2007-04-05 |
JP4653485B2 (ja) | 2011-03-16 |
US7101895B2 (en) | 2006-09-05 |
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