AR047666A1 - Sintesis estereoselectiva del acido ciclohexanopropanoico 4,4-disubstituido - Google Patents
Sintesis estereoselectiva del acido ciclohexanopropanoico 4,4-disubstituidoInfo
- Publication number
- AR047666A1 AR047666A1 ARP050100482A ARP050100482A AR047666A1 AR 047666 A1 AR047666 A1 AR 047666A1 AR P050100482 A ARP050100482 A AR P050100482A AR P050100482 A ARP050100482 A AR P050100482A AR 047666 A1 AR047666 A1 AR 047666A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- sulfide
- cis
- acid
- estereoselective
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/62—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/16—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by addition of hydrogen sulfide or its salts to unsaturated compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/58—Preparation of carboxylic acid halides
- C07C51/60—Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/09—Geometrical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Se proporciona una ruta estereoselectiva para un compuesto de formula (1) donde R representa H o un metal álcali; Ar1 representa 4-clorofenil; y Ar2 representa 2,5-difluorofenil. Un procedimiento para la preparacion de un compuesto de formula (1) donde R representa H o un metal álcali; Ar1 representa 4-clorofenil; y Ar2 representa 2,5-difluorofenil; comprendiendo los pasos de: (a) agitar una mezcla de un cis-sulfuro de formula (2) y un trans-sulfuro de formula (3) con 4-clorobencenotiol en un medio ácido en el cual dicha mezcla de sulfuros es parcialmente soluble, causando preferentemente la cristalizacion del cis-sulfuro de formula (2); (b) recoger el cis-sulfuro de formula (2); (c) oxidar el cis-sulfuro de formula (2) a la correspondiente sulfona; y opcionalmente (d) neutralizar el producto del paso (c) con un álcali.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54634304P | 2004-02-20 | 2004-02-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR047666A1 true AR047666A1 (es) | 2006-02-01 |
Family
ID=34886259
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050100482A AR047666A1 (es) | 2004-02-20 | 2005-02-10 | Sintesis estereoselectiva del acido ciclohexanopropanoico 4,4-disubstituido |
Country Status (17)
Country | Link |
---|---|
US (1) | US7411088B2 (es) |
EP (1) | EP1718593B1 (es) |
JP (1) | JP4719162B2 (es) |
CN (1) | CN100443458C (es) |
AR (1) | AR047666A1 (es) |
AT (1) | ATE368024T1 (es) |
AU (1) | AU2005214131B2 (es) |
CA (1) | CA2556348C (es) |
CY (1) | CY1108519T1 (es) |
DE (1) | DE602005001766T2 (es) |
DK (1) | DK1718593T3 (es) |
ES (1) | ES2290887T3 (es) |
PL (1) | PL1718593T3 (es) |
PT (1) | PT1718593E (es) |
SI (1) | SI1718593T1 (es) |
TW (1) | TWI352075B (es) |
WO (1) | WO2005080309A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0120347D0 (en) * | 2001-08-21 | 2001-10-17 | Merck Sharp & Dohme | Therapeutic agents |
CN111393253B (zh) * | 2019-01-02 | 2022-11-29 | 江苏广域化学有限公司 | 一种含有反式取代环己基的化合物的合成方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3601197A (en) * | 1970-04-29 | 1971-08-24 | Exxon Production Research Co | Treatment of formations with aryl sulfonic acid |
US4612254A (en) * | 1985-03-07 | 1986-09-16 | Occidental Chemical Corporation | Aromatic carboxylic acid and metal-modified phenolic resins and methods of preparation |
US6214331B1 (en) * | 1995-06-06 | 2001-04-10 | C. R. Bard, Inc. | Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained |
GB0108591D0 (en) * | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
GB0108592D0 (en) * | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
GB0120347D0 (en) * | 2001-08-21 | 2001-10-17 | Merck Sharp & Dohme | Therapeutic agents |
MXPA04001607A (es) | 2001-08-21 | 2004-07-08 | Merck Sharp & Dohme | Ciclohexilsulfonas novedosas. |
GB0218041D0 (en) * | 2002-08-02 | 2002-09-11 | Merck Sharp & Dohme | Chemical process |
GB0223039D0 (en) * | 2002-10-04 | 2002-11-13 | Merck Sharp & Dohme | Therapeutic compounds |
GB0318447D0 (en) * | 2003-08-05 | 2003-09-10 | Merck Sharp & Dohme | Therapeutic agents |
-
2005
- 2005-02-10 AR ARP050100482A patent/AR047666A1/es not_active Application Discontinuation
- 2005-02-16 WO PCT/GB2005/000544 patent/WO2005080309A1/en active IP Right Grant
- 2005-02-16 CA CA2556348A patent/CA2556348C/en not_active Expired - Fee Related
- 2005-02-16 DK DK05708359T patent/DK1718593T3/da active
- 2005-02-16 SI SI200530065T patent/SI1718593T1/sl unknown
- 2005-02-16 AU AU2005214131A patent/AU2005214131B2/en not_active Ceased
- 2005-02-16 EP EP05708359A patent/EP1718593B1/en active Active
- 2005-02-16 AT AT05708359T patent/ATE368024T1/de active
- 2005-02-16 JP JP2006553651A patent/JP4719162B2/ja not_active Expired - Fee Related
- 2005-02-16 CN CNB2005800050033A patent/CN100443458C/zh not_active Expired - Fee Related
- 2005-02-16 ES ES05708359T patent/ES2290887T3/es active Active
- 2005-02-16 DE DE602005001766T patent/DE602005001766T2/de active Active
- 2005-02-16 US US10/589,098 patent/US7411088B2/en active Active
- 2005-02-16 PL PL05708359T patent/PL1718593T3/pl unknown
- 2005-02-16 PT PT05708359T patent/PT1718593E/pt unknown
- 2005-02-18 TW TW094104921A patent/TWI352075B/zh not_active IP Right Cessation
-
2007
- 2007-09-24 CY CY20071101228T patent/CY1108519T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
JP2007523141A (ja) | 2007-08-16 |
EP1718593A1 (en) | 2006-11-08 |
CN1918106A (zh) | 2007-02-21 |
DK1718593T3 (da) | 2007-10-22 |
DE602005001766T2 (de) | 2008-04-30 |
CY1108519T1 (el) | 2012-05-23 |
CA2556348A1 (en) | 2005-09-01 |
JP4719162B2 (ja) | 2011-07-06 |
TW200602309A (en) | 2006-01-16 |
US7411088B2 (en) | 2008-08-12 |
ATE368024T1 (de) | 2007-08-15 |
CA2556348C (en) | 2013-01-08 |
PL1718593T3 (pl) | 2007-12-31 |
DE602005001766D1 (de) | 2007-09-06 |
AU2005214131A1 (en) | 2005-09-01 |
WO2005080309A8 (en) | 2005-11-03 |
WO2005080309A1 (en) | 2005-09-01 |
SI1718593T1 (sl) | 2007-12-31 |
TWI352075B (en) | 2011-11-11 |
PT1718593E (pt) | 2007-10-17 |
ES2290887T3 (es) | 2008-02-16 |
US20070225520A1 (en) | 2007-09-27 |
EP1718593B1 (en) | 2007-07-25 |
AU2005214131B2 (en) | 2010-12-16 |
CN100443458C (zh) | 2008-12-17 |
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FA | Abandonment or withdrawal |