JPS5625149A - Keto ester derivative and its preparation - Google Patents

Keto ester derivative and its preparation

Info

Publication number
JPS5625149A
JPS5625149A JP10031079A JP10031079A JPS5625149A JP S5625149 A JPS5625149 A JP S5625149A JP 10031079 A JP10031079 A JP 10031079A JP 10031079 A JP10031079 A JP 10031079A JP S5625149 A JPS5625149 A JP S5625149A
Authority
JP
Japan
Prior art keywords
formula
keto ester
preparation
fluorine
reacted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10031079A
Other languages
Japanese (ja)
Other versions
JPS621392B2 (en
Inventor
Sei Kondo
Kiyohide Matsui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Priority to JP10031079A priority Critical patent/JPS5625149A/en
Publication of JPS5625149A publication Critical patent/JPS5625149A/en
Publication of JPS621392B2 publication Critical patent/JPS621392B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:The titled compound shown by the formula I (X1 and X2 are H or halogen; R is alkyl; R1 is H, halogen, or arylthio; Ar is aryl).
EXAMPLE: 5-(4-Chlorophenyl)-5-benzenesulfonyl-2-oxocyclohexanecarboxylic acid methyl ester.
USE: A preparative intermediate for flufenisal which is a compound substitued by fluorine at para position and for diflunisal which is an acetyl derivative substituted by fluorine at ortho position, useful as pain-killing agents.
PROCESS: A benzylsulfone derivative shown by the formula II is reacted with an acrylate shown by formula III in the presence of a base of give a keto ester shown by the formula IV, which is reacted with a compound shown by the formula R1Y to give a compound shown by the formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP10031079A 1979-08-08 1979-08-08 Keto ester derivative and its preparation Granted JPS5625149A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10031079A JPS5625149A (en) 1979-08-08 1979-08-08 Keto ester derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10031079A JPS5625149A (en) 1979-08-08 1979-08-08 Keto ester derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS5625149A true JPS5625149A (en) 1981-03-10
JPS621392B2 JPS621392B2 (en) 1987-01-13

Family

ID=14270592

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10031079A Granted JPS5625149A (en) 1979-08-08 1979-08-08 Keto ester derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5625149A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4667055A (en) * 1983-12-29 1987-05-19 Merck Frosst Canada, Inc. Leukotriene antagonists
US4871756A (en) * 1985-03-20 1989-10-03 Merck Frosst Canada, Inc. Leukotriene antagonists
JP2004533428A (en) * 2001-04-05 2004-11-04 メルク シャープ エンド ドーム リミテッド Sulfone regulating the action of γ-secretase
US7101895B2 (en) 2002-10-04 2006-09-05 Merck Sharp & Dohme Limited Cyclohexyl sulphone derivatives as gamma-secretase inhibitors
US7304094B2 (en) 2001-08-21 2007-12-04 Merck Sharp + Dohme Cyclohexyl sulphones

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4667055A (en) * 1983-12-29 1987-05-19 Merck Frosst Canada, Inc. Leukotriene antagonists
US4871756A (en) * 1985-03-20 1989-10-03 Merck Frosst Canada, Inc. Leukotriene antagonists
JP2004533428A (en) * 2001-04-05 2004-11-04 メルク シャープ エンド ドーム リミテッド Sulfone regulating the action of γ-secretase
US7595344B2 (en) 2001-04-05 2009-09-29 Merck Sharp & Dohme Limited Sulphones which modulate the action of gamma secretase
US7598386B2 (en) 2001-04-05 2009-10-06 Merck Sharp & Dohme Limited Sulphones which modulate the action of gamma-secretase
US7304094B2 (en) 2001-08-21 2007-12-04 Merck Sharp + Dohme Cyclohexyl sulphones
US7101895B2 (en) 2002-10-04 2006-09-05 Merck Sharp & Dohme Limited Cyclohexyl sulphone derivatives as gamma-secretase inhibitors

Also Published As

Publication number Publication date
JPS621392B2 (en) 1987-01-13

Similar Documents

Publication Publication Date Title
JPS5278848A (en) Preparation of novel propionic acid ester derivatives
JPS5625149A (en) Keto ester derivative and its preparation
JPS55130991A (en) Pyrazole phosphate esters, their preparation and insecticide and acaricide
JPS55380A (en) Preparation of dibenzoxepin derivative
JPS5618989A (en) Imidazole derivative and its preparation
JPS5579395A (en) Novel germanium compound
JPS5289642A (en) Preparation of dihydroxybenzoic acid esters
JPS5373566A (en) 7,8,9,10,-tetrahydrophenanthridone-3-acetic acids
JPS5273842A (en) Preparation of 2,2-dimethyl-3-)alpha-hydroxy-alphe-trihalogenomethylme thyl) -cyclopropane carboxylic acid derivatives
JPS5721321A (en) Antihyperlipemic agent
JPS5566592A (en) 7-alkoxythiazolo 3,2-a pyrimidine derivative, its preparation, and drug containing the same
JPS5439042A (en) Preparation of 2-(4-iso butylphenyl)-propionic acid
JPS5511536A (en) Reproduction controller against algae and mold
JPS52118445A (en) 2-cyano-3-methyl-3-(4-isobutylphenyl)acrylic acid derivatives and met hod of preparing the same
JPS55120591A (en) Phosphinoethylmalonic acid derivative, and preparation thereof
JPS5365882A (en) 1,4-dihydro-4-oxonicotinic acids and process for preparation of the same
JPS5353638A (en) Alpha-acetyl cinnamic acid ester derivatives, their preparation and theirherbicides containing the same
JPS5718648A (en) Cyclopropanecarboxylic acid ester derivative, preparation of cyclopropanecarboxylic acid ester derivative, and insecticidal and miticidal agent containing cyclopropanecarboxylic acid ester derivative
JPS55105643A (en) Novel cyclohexanecarboxylic acid derivative
JPS5283714A (en) Novel alkyl ester derivatives of 16-alkyl-20-alkoxyprostadienoic acids
JPS52133959A (en) 2-cyano-3-methyl-3-(naphthyl)acrylic acids and method of preparing the same
JPS55100372A (en) 5-fluorouracil derivative and its preparation
JPS5643271A (en) Production of 4-benzoyl-5-hydroxypyrazole
JPS52133960A (en) 2-cyano-3-methyl-3-(6-methoxy-2-naphthyl)-glycidic acid and method of preparing the same
JPS5663977A (en) Secoprostaglandin i2 derivative and its preparation