JPS5625149A - Keto ester derivative and its preparation - Google Patents
Keto ester derivative and its preparationInfo
- Publication number
- JPS5625149A JPS5625149A JP10031079A JP10031079A JPS5625149A JP S5625149 A JPS5625149 A JP S5625149A JP 10031079 A JP10031079 A JP 10031079A JP 10031079 A JP10031079 A JP 10031079A JP S5625149 A JPS5625149 A JP S5625149A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- keto ester
- preparation
- fluorine
- reacted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:The titled compound shown by the formula I (X1 and X2 are H or halogen; R is alkyl; R1 is H, halogen, or arylthio; Ar is aryl).
EXAMPLE: 5-(4-Chlorophenyl)-5-benzenesulfonyl-2-oxocyclohexanecarboxylic acid methyl ester.
USE: A preparative intermediate for flufenisal which is a compound substitued by fluorine at para position and for diflunisal which is an acetyl derivative substituted by fluorine at ortho position, useful as pain-killing agents.
PROCESS: A benzylsulfone derivative shown by the formula II is reacted with an acrylate shown by formula III in the presence of a base of give a keto ester shown by the formula IV, which is reacted with a compound shown by the formula R1Y to give a compound shown by the formula I.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10031079A JPS5625149A (en) | 1979-08-08 | 1979-08-08 | Keto ester derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10031079A JPS5625149A (en) | 1979-08-08 | 1979-08-08 | Keto ester derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5625149A true JPS5625149A (en) | 1981-03-10 |
JPS621392B2 JPS621392B2 (en) | 1987-01-13 |
Family
ID=14270592
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10031079A Granted JPS5625149A (en) | 1979-08-08 | 1979-08-08 | Keto ester derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5625149A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4667055A (en) * | 1983-12-29 | 1987-05-19 | Merck Frosst Canada, Inc. | Leukotriene antagonists |
US4871756A (en) * | 1985-03-20 | 1989-10-03 | Merck Frosst Canada, Inc. | Leukotriene antagonists |
JP2004533428A (en) * | 2001-04-05 | 2004-11-04 | メルク シャープ エンド ドーム リミテッド | Sulfone regulating the action of γ-secretase |
US7101895B2 (en) | 2002-10-04 | 2006-09-05 | Merck Sharp & Dohme Limited | Cyclohexyl sulphone derivatives as gamma-secretase inhibitors |
US7304094B2 (en) | 2001-08-21 | 2007-12-04 | Merck Sharp + Dohme | Cyclohexyl sulphones |
-
1979
- 1979-08-08 JP JP10031079A patent/JPS5625149A/en active Granted
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4667055A (en) * | 1983-12-29 | 1987-05-19 | Merck Frosst Canada, Inc. | Leukotriene antagonists |
US4871756A (en) * | 1985-03-20 | 1989-10-03 | Merck Frosst Canada, Inc. | Leukotriene antagonists |
JP2004533428A (en) * | 2001-04-05 | 2004-11-04 | メルク シャープ エンド ドーム リミテッド | Sulfone regulating the action of γ-secretase |
US7595344B2 (en) | 2001-04-05 | 2009-09-29 | Merck Sharp & Dohme Limited | Sulphones which modulate the action of gamma secretase |
US7598386B2 (en) | 2001-04-05 | 2009-10-06 | Merck Sharp & Dohme Limited | Sulphones which modulate the action of gamma-secretase |
US7304094B2 (en) | 2001-08-21 | 2007-12-04 | Merck Sharp + Dohme | Cyclohexyl sulphones |
US7101895B2 (en) | 2002-10-04 | 2006-09-05 | Merck Sharp & Dohme Limited | Cyclohexyl sulphone derivatives as gamma-secretase inhibitors |
Also Published As
Publication number | Publication date |
---|---|
JPS621392B2 (en) | 1987-01-13 |
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