JP2010536821A5 - - Google Patents
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- Publication number
- JP2010536821A5 JP2010536821A5 JP2010521405A JP2010521405A JP2010536821A5 JP 2010536821 A5 JP2010536821 A5 JP 2010536821A5 JP 2010521405 A JP2010521405 A JP 2010521405A JP 2010521405 A JP2010521405 A JP 2010521405A JP 2010536821 A5 JP2010536821 A5 JP 2010536821A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- piperazin
- benzamide
- tert
- butyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 38
- 125000000217 alkyl group Chemical group 0.000 claims 23
- 229910052736 halogen Inorganic materials 0.000 claims 15
- 150000002367 halogens Chemical class 0.000 claims 12
- 125000003545 alkoxy group Chemical group 0.000 claims 10
- 125000005842 heteroatom Chemical group 0.000 claims 9
- 229910052760 oxygen Inorganic materials 0.000 claims 8
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000001424 substituent group Chemical group 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- BMBANPOHPFKVTA-UHFFFAOYSA-N benzamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.NC(=O)C1=CC=CC=C1 BMBANPOHPFKVTA-UHFFFAOYSA-N 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims 1
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 1
- 125000006163 5-membered heteroaryl group Chemical group 0.000 claims 1
- 125000006164 6-membered heteroaryl group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- -1 or O Chemical group 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07114602.1 | 2007-08-20 | ||
| EP07114602 | 2007-08-20 | ||
| PCT/EP2008/060788 WO2009024550A1 (en) | 2007-08-20 | 2008-08-18 | N-benzyl, n' -arylcarbonylpiperazine derivatives as lxr modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010536821A JP2010536821A (ja) | 2010-12-02 |
| JP2010536821A5 true JP2010536821A5 (enExample) | 2013-12-05 |
| JP5444547B2 JP5444547B2 (ja) | 2014-03-19 |
Family
ID=40032504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010521405A Expired - Fee Related JP5444547B2 (ja) | 2007-08-20 | 2008-08-18 | Ｌｘｒ調節因子としてのｎ−ベンジル，ｎ’−アリールカルボニルピペラジン誘導体 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP2190827B1 (enExample) |
| JP (1) | JP5444547B2 (enExample) |
| CN (1) | CN101848899B (enExample) |
| AR (1) | AR067975A1 (enExample) |
| AT (1) | ATE495161T1 (enExample) |
| CA (1) | CA2694604C (enExample) |
| CL (1) | CL2008002429A1 (enExample) |
| DE (1) | DE602008004562D1 (enExample) |
| MX (1) | MX2010001847A (enExample) |
| PE (1) | PE20091241A1 (enExample) |
| TW (1) | TW200922582A (enExample) |
| WO (1) | WO2009024550A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8314091B2 (en) | 2007-08-20 | 2012-11-20 | Msd Oss B.V. | N-benzyl,N'-arylcarbonylpiperazine derivatives |
| TW201022230A (en) * | 2008-08-28 | 2010-06-16 | Organon Nv | 1-(4-ureidobenzoyl)piperazine derivatives |
| BRPI1016232A2 (pt) * | 2009-04-29 | 2023-04-11 | Kowa Co | Composto de carbinol, medicamento, regulador de lxr, composição farmacêutica, método para prevenir e/ou tratar doenças, e, uso do composto de carbinol |
| US8242260B2 (en) | 2009-08-28 | 2012-08-14 | Novartis Ag | Compounds and compositions as protein kinase inhibitors |
| US20130274212A1 (en) | 2010-09-07 | 2013-10-17 | Snu R&Db Foundation | Sesterterpene Compounds and Use Thereof |
| EP3626309B1 (en) | 2012-08-13 | 2023-03-08 | The Rockefeller University | Lxrbeta agonist for the treatment of cancer |
| CN103159687A (zh) * | 2013-04-12 | 2013-06-19 | 苏州科捷生物医药有限公司 | 一种2-胺基吡嗪-5甲酸的合成方法 |
| CA3010883A1 (en) | 2016-01-11 | 2017-07-20 | The Rockefeller University | Methods for the treatment of myeloid derived suppressor cells related disorders |
| AU2018373028A1 (en) | 2017-11-21 | 2020-04-30 | Inspirna, Inc. | Polymorphs and uses thereof |
| WO2021119397A1 (en) | 2019-12-13 | 2021-06-17 | Rgenix, Inc. | Metal salts and uses thereof |
| WO2023240376A1 (zh) * | 2022-06-12 | 2023-12-21 | 中国医学科学院药物研究所 | 肠道上皮细胞核受体抑制子NCoR作为靶标在筛选药物中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0742208A1 (en) * | 1995-05-05 | 1996-11-13 | Grelan Pharmaceutical Co., Ltd. | 2-Ureido-benzamide derivatives |
| BR0209932A (pt) * | 2001-05-22 | 2004-10-13 | Neurogen Corp | Composto ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, preparação farmacêutica embalada, métodos para modular ligação de mch a um receptor de mch e de mvc, para alterar a atividade de transdução de sinal de um receptor de mch em uma célula, para tratar uma doença ou distúrbio associado com a ativação de receptor de mch patogênico obesidade e para determinar a presença ou ausência de receptor de mch em uma amostra, e, uso de um composto |
| SE0102764D0 (sv) * | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
| FR2892722B1 (fr) * | 2005-11-02 | 2008-08-15 | Clinigenetics Sa | Composes de type methanone et leur utilisation dans des compositions pharmaceutiques notamment pour le traitement des maladies cardiovasculaires |
| WO2007092065A2 (en) * | 2005-11-14 | 2007-08-16 | Irm Llc | Compounds and compositions as lxr modulators |
| CN101378807A (zh) * | 2005-12-21 | 2009-03-04 | 先灵公司 | H3拮抗剂/反相激动剂与食欲抑制剂的组合 |
-
2008
- 2008-08-04 TW TW097129557A patent/TW200922582A/zh unknown
- 2008-08-18 MX MX2010001847A patent/MX2010001847A/es active IP Right Grant
- 2008-08-18 EP EP08787281A patent/EP2190827B1/en active Active
- 2008-08-18 PE PE2008001401A patent/PE20091241A1/es not_active Application Discontinuation
- 2008-08-18 JP JP2010521405A patent/JP5444547B2/ja not_active Expired - Fee Related
- 2008-08-18 AT AT08787281T patent/ATE495161T1/de not_active IP Right Cessation
- 2008-08-18 DE DE602008004562T patent/DE602008004562D1/de active Active
- 2008-08-18 CN CN200880101573.6A patent/CN101848899B/zh not_active Expired - Fee Related
- 2008-08-18 WO PCT/EP2008/060788 patent/WO2009024550A1/en not_active Ceased
- 2008-08-18 CL CL2008002429A patent/CL2008002429A1/es unknown
- 2008-08-18 CA CA2694604A patent/CA2694604C/en not_active Expired - Fee Related
- 2008-08-19 AR ARP080103603A patent/AR067975A1/es unknown
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