AR067975A1 - Derivados de la n-bencil, n-arilcarbonilpiperazina - Google Patents
Derivados de la n-bencil, n-arilcarbonilpiperazinaInfo
- Publication number
- AR067975A1 AR067975A1 ARP080103603A ARP080103603A AR067975A1 AR 067975 A1 AR067975 A1 AR 067975A1 AR P080103603 A ARP080103603 A AR P080103603A AR P080103603 A ARP080103603 A AR P080103603A AR 067975 A1 AR067975 A1 AR 067975A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- halogen
- alkyloxy
- optionally substituted
- optionally
- Prior art date
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Classifications
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
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- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
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- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
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- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
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- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
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Abstract
A composiciones farmacéuticas comprendiendo la misma, y al uso de estos derivados de la N-bencil, N'-arilcarbonilpiperazina para la fabricacion de un medicamento para tratar o prevenir arterosclerosis y trastornos relacionados asociados con el colesterol y el trasporte y metabolismo de los ácidos biliares. Reivindicacion 1: Un derivado de la N-bencil, N'-arilcarbonilpiperazina caracterizado porque tiene la formula general (1) donde n es 1 o 2; A es un anillo aromático de 6 miembros conteniendo opcionalmente 1 o 2 átomos de nitrogeno; X es NR8, O o un enlace; R1 es H, alquilo C1-8) [sustituido opcionalmente con halogeno, (C1-4) alquiloxi, (C1-4) alquiloxicarbonilo, (C3-8) cicloalquilo, OH, CF3, ciano o NR9R10], (C2-6) alquenilo, (C2-6) alquinilo, (C3-8) cicloalquilo, fenilo [sustituido opcionalmente con (C1-4) alquilo, (C1-4) alquiloxi, halogeno, CN, CF3, OCF3 o NO2], un grupo heterocíclico saturado de 5 o 6 miembros que contiene 1 o 2 heteroátomos seleccionados de O y S, o un grupo heteroarilo de 5 o 6 miembros que contiene 1-3 heteroátomos seleccionados de O, S y N [sustituido opcionalmente con (C14 alquilo, (C1-4) alquiloxi, halogeno o CF3]; o R1 es (C1-3) alquilo sustituido con fenilo [sustituido opcionalmente con (C1-4) alquilo, (C1-4) alquiloxi, halogeno o con 2 sustitutos en posiciones adyacentes formando O - (CH2)n - O, donde n es 1 o 2], un grupo heteroarilo de 5 o 6 miembros que contiene 1-3 heteroátomos seleccionados de O, S y N [sustituido opcionalmente con (C1-3) alquilo, (C1-3) alquiloxi o halogeno], un grupo heterocíclico saturado de 5 o 6 miembros que contiene 1 o 2 heteroátomos seleccionados de O y S y N [sustituido opcionalmente con (C1-4) alquilo, (C1-4) alquiloxi, oxo, OH o halogeno]; o cuando X es NR8, R1 puede, junto con R8 y el N al cual están enlazados, formar un anillo de 4-8 miembros que contienen opcionalmente un heteroátomo opcional seleccionado de O y S [y cuyo anillo es sustituido opcionalmente con OH, (C1-4) alquilo, (C1-4) alquiloxi o halogeno]; R2 representa opcionalmente 1-3 sustitutos seleccionados independientemente de (C1-4) alquilo, (C1-4) alquiloxi, CF3 y halogeno; R3 representa opcionalmente 1-4 sustitutos seleccionados independientemente de (C1-4) alquilo y (C1-4) alquilo sustituido por OH o 1 o más halogenos; R4 es H o (C1-6) alquilo; R5 representa opcionalmente 1-3 sustitutos seleccionados independientemente de (C1-3) alquilo, (C1-3) alquiloxi y halogeno; R6 es H, (C1-6) alquilo [sustituido opcionalmente con halogeno, CF3 o CN], (C3-6) cicloalquilo [que contiene opcionalmente un heteroátomo seleccionado de O y S, y [sustituido opcionalmente por CN o fenilo], (C3-6) cicloalquilo (C1-4) alquilo, o un grupo (hetero) arilo de 5 o 6 miembros, enlazado opcionalmente a través de un grupo metileno, y sustituido opcionalmente con (C1-4) alquilo, (C1-4), alquiloxi (C1-4) alquilosulfonilo, halogeno, CN, CF3, CF3O o NO2]; R7 es H o (C1-3)alquilo; R8, cuando está presente, es H o (C1-3) alquilo; o R8, junto con R1 y el N al cual están enlazados, forman un anillo de 4-8 miembros conteniendo opcionalmente un heteroátomo adicional seleccionado de O y S [y cuyo anillo es sustituido opcionalmente con OH, (C1-3) alquilo, (C1-3) alquiloxi o halogeno]; R9 y R10 son seleccionados independientemente de H, (C1-3) alquilo o (C1-3) alquilcarbonilo; o R9 y R10, juntos con el N al cual están enlazados forman un anillo de 4-8 miembros que contiene opcionalmente un heteroátomo adicional seleccionado de O y S; o una sal farmacéuticamente aceptable del mismo.
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EP07114602 | 2007-08-20 |
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ARP080103603A AR067975A1 (es) | 2007-08-20 | 2008-08-19 | Derivados de la n-bencil, n-arilcarbonilpiperazina |
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EP (1) | EP2190827B1 (es) |
JP (1) | JP5444547B2 (es) |
CN (1) | CN101848899B (es) |
AR (1) | AR067975A1 (es) |
AT (1) | ATE495161T1 (es) |
CA (1) | CA2694604C (es) |
CL (1) | CL2008002429A1 (es) |
DE (1) | DE602008004562D1 (es) |
MX (1) | MX2010001847A (es) |
PE (1) | PE20091241A1 (es) |
TW (1) | TW200922582A (es) |
WO (1) | WO2009024550A1 (es) |
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US8314091B2 (en) | 2007-08-20 | 2012-11-20 | Msd Oss B.V. | N-benzyl,N'-arylcarbonylpiperazine derivatives |
TW201022230A (en) | 2008-08-28 | 2010-06-16 | Organon Nv | 1-(4-ureidobenzoyl)piperazine derivatives |
CN102438991B (zh) * | 2009-04-29 | 2015-08-26 | 兴和株式会社 | 具有杂环连接基的甲醇化合物 |
US8242260B2 (en) | 2009-08-28 | 2012-08-14 | Novartis Ag | Compounds and compositions as protein kinase inhibitors |
JP2013542183A (ja) | 2010-09-07 | 2013-11-21 | エスエヌユー アールアンドディービー ファウンデーション | セスタテルペン化合物およびこれらの物質の用途 |
EP2882496B1 (en) | 2012-08-13 | 2019-10-09 | The Rockefeller University | Treatment and diagnosis of melanoma |
CN103159687A (zh) * | 2013-04-12 | 2013-06-19 | 苏州科捷生物医药有限公司 | 一种2-胺基吡嗪-5甲酸的合成方法 |
JP7025022B2 (ja) | 2016-01-11 | 2022-02-24 | ザ ロックフェラー ユニバーシティー | 骨髄系由来抑制細胞関連障害の治療のための方法 |
US11214536B2 (en) | 2017-11-21 | 2022-01-04 | Inspirna, Inc. | Polymorphs and uses thereof |
WO2021119397A1 (en) | 2019-12-13 | 2021-06-17 | Rgenix, Inc. | Metal salts and uses thereof |
WO2023240376A1 (zh) * | 2022-06-12 | 2023-12-21 | 中国医学科学院药物研究所 | 肠道上皮细胞核受体抑制子NCoR作为靶标在筛选药物中的应用 |
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EP0742208A1 (en) * | 1995-05-05 | 1996-11-13 | Grelan Pharmaceutical Co., Ltd. | 2-Ureido-benzamide derivatives |
WO2002094799A2 (en) * | 2001-05-22 | 2002-11-28 | Neurogen Corporation | Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues |
SE0102764D0 (sv) * | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
FR2892722B1 (fr) * | 2005-11-02 | 2008-08-15 | Clinigenetics Sa | Composes de type methanone et leur utilisation dans des compositions pharmaceutiques notamment pour le traitement des maladies cardiovasculaires |
CN101309915A (zh) * | 2005-11-14 | 2008-11-19 | Irm责任有限公司 | 作为lxr调节剂的化合物和组合物 |
KR20080081321A (ko) * | 2005-12-21 | 2008-09-09 | 쉐링 코포레이션 | H3 길항제/역 작용제 및 식욕 억제제의 조합물 |
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- 2008-08-18 CL CL2008002429A patent/CL2008002429A1/es unknown
- 2008-08-18 EP EP08787281A patent/EP2190827B1/en active Active
- 2008-08-18 DE DE602008004562T patent/DE602008004562D1/de active Active
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WO2009024550A1 (en) | 2009-02-26 |
CA2694604A1 (en) | 2009-02-26 |
JP5444547B2 (ja) | 2014-03-19 |
JP2010536821A (ja) | 2010-12-02 |
PE20091241A1 (es) | 2009-07-16 |
MX2010001847A (es) | 2010-03-11 |
CA2694604C (en) | 2016-02-09 |
CL2008002429A1 (es) | 2009-01-02 |
CN101848899B (zh) | 2016-03-02 |
EP2190827A1 (en) | 2010-06-02 |
CN101848899A (zh) | 2010-09-29 |
ATE495161T1 (de) | 2011-01-15 |
DE602008004562D1 (de) | 2011-02-24 |
TW200922582A (en) | 2009-06-01 |
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