JP2019507179A5 - - Google Patents
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- Publication number
- JP2019507179A5 JP2019507179A5 JP2018546584A JP2018546584A JP2019507179A5 JP 2019507179 A5 JP2019507179 A5 JP 2019507179A5 JP 2018546584 A JP2018546584 A JP 2018546584A JP 2018546584 A JP2018546584 A JP 2018546584A JP 2019507179 A5 JP2019507179 A5 JP 2019507179A5
- Authority
- JP
- Japan
- Prior art keywords
- alkylene
- alkyl
- phenyl
- carboxamide
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662301678P | 2016-03-01 | 2016-03-01 | |
| US62/301,678 | 2016-03-01 | ||
| PCT/CA2017/050271 WO2017147701A1 (en) | 2016-03-01 | 2017-03-01 | Inhibitors of wdr5 protein-protein binding |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019507179A JP2019507179A (ja) | 2019-03-14 |
| JP2019507179A5 true JP2019507179A5 (enExample) | 2020-04-09 |
Family
ID=59743040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018546584A Pending JP2019507179A (ja) | 2016-03-01 | 2017-03-01 | Ｗｄｒ５タンパク質−タンパク質結合の阻害剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11174250B2 (enExample) |
| EP (1) | EP3423437A4 (enExample) |
| JP (1) | JP2019507179A (enExample) |
| AU (1) | AU2017226005A1 (enExample) |
| CA (1) | CA3015417A1 (enExample) |
| WO (1) | WO2017147701A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109195965B (zh) | 2016-03-01 | 2022-07-26 | 普罗佩纶治疗公司 | Wdr5蛋白质-蛋白质结合的抑制剂 |
| EP3532464A4 (en) | 2016-10-28 | 2020-07-08 | Icahn School of Medicine at Mount Sinai | COMPOSITIONS AND METHODS FOR THE TREATMENT OF EZH2 MEDIATION CANCER |
| AU2017370694A1 (en) | 2016-12-08 | 2019-07-25 | Icahn School Of Medicine At Mount Sinai | Compositions and methods for treating CDK4/6-mediated cancer |
| JP2020532561A (ja) * | 2017-09-06 | 2020-11-12 | プロペロン セラピューティクス インコーポレイテッド | Ｗｄｒ５タンパク質−タンパク質結合の阻害剤 |
| US10501466B2 (en) | 2017-09-19 | 2019-12-10 | Vanderbilt University | WDR5 inhibitors and modulators |
| AU2019231689A1 (en) | 2018-03-06 | 2020-09-24 | Icahn School Of Medicine At Mount Sinai | Serine threonine kinase (AKT) degradation / disruption compounds and methods of use |
| CN108715585A (zh) | 2018-04-23 | 2018-10-30 | 中国药科大学 | 苯基联三氮唑类mll1-wdr5蛋白-蛋白相互作用抑制剂 |
| US10844044B2 (en) | 2018-06-14 | 2020-11-24 | Vanderbilt University | WDR5 inhibitors and modulators |
| CA3104298A1 (en) * | 2018-06-21 | 2019-12-26 | Icahn School Of Medicine At Mount Sinai | Wd40 repeat domain protein 5 (wdr5) degradation / disruption compounds and methods of use |
| US10807959B2 (en) | 2018-08-16 | 2020-10-20 | Vanderbilt University | WDR5-MLL1 inhibitors and modulators |
| CN109734674B (zh) | 2019-02-26 | 2022-08-26 | 中国药科大学 | 苯胺类wdr5蛋白-蛋白相互作用抑制剂及其制法和用途 |
| CA3137916A1 (en) | 2019-05-06 | 2020-11-12 | Ichan School Of Medicine At Mount Sinai | Heterobifunctional compounds as degraders of hpk1 |
| US12103924B2 (en) | 2020-06-01 | 2024-10-01 | Icahn School Of Medicine At Mount Sinai | Mitogen-activated protein kinase kinase (MEK) degradation compounds and methods of use |
| US20230286948A1 (en) * | 2022-03-14 | 2023-09-14 | Huyabio International, Llc | Haloalkylpyridyl triazole mll1-wdr5 protein-protein interaction inhibitor |
| CN119365449A (zh) * | 2022-07-01 | 2025-01-24 | 甘李药业股份有限公司 | 一种用作wdr5抑制剂的化合物或其可药用盐及其应用 |
| CN117486791A (zh) * | 2023-10-18 | 2024-02-02 | 南通敏言生物医药科技有限公司 | 一种5-甲氧基-4-(三氟甲基)吡啶-2-甲酸甲酯的合成方法 |
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| AU698625B2 (en) | 1993-11-12 | 1998-11-05 | Pharmacia & Upjohn Company | Pyrimidine-thioalkyl and alkylether compounds |
| JPH0959236A (ja) | 1995-08-23 | 1997-03-04 | Dai Ichi Seiyaku Co Ltd | ベンズアミド化合物 |
| US20010051719A1 (en) | 1996-12-19 | 2001-12-13 | Smithkline Beecham P.L.C. | Novel compounds |
| US6541669B1 (en) | 1998-06-08 | 2003-04-01 | Theravance, Inc. | β2-adrenergic receptor agonists |
| DE19952146A1 (de) | 1999-10-29 | 2001-06-07 | Boehringer Ingelheim Pharma | Arylalkane, Arylalkene und Aryl-azaalkane, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| IL151946A0 (en) | 2000-03-29 | 2003-04-10 | Cyclacel Ltd | 2-substituted 4-heteroaryl-pyrimidines and their use in the treatment of proliferative disorders |
| JP2002193938A (ja) * | 2000-12-01 | 2002-07-10 | Bayer Ag | ４−アリールピリジン誘導体 |
| JP2004534017A (ja) | 2001-04-27 | 2004-11-11 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ｂａｃｅのインヒビター |
| GB0215676D0 (en) | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| KR20050029209A (ko) | 2002-07-15 | 2005-03-24 | 미리어드 제네틱스, 인크. | 화합물, 조성물 및 이의 사용방법 |
| WO2004022562A1 (en) | 2002-09-09 | 2004-03-18 | Cellular Genomics, Inc. | 6-ARYL-IMIDAZO[1,2-a]PYRAZIN-8-YLAMINES, METHOD OF MAKING, AND METHOD OF USE THEREOF |
| GB0412072D0 (en) | 2004-05-28 | 2004-06-30 | Syngenta Participations Ag | Chemical compounds |
| RU2401265C2 (ru) | 2004-06-10 | 2010-10-10 | Айрм Ллк | Соединения и композиции в качестве ингибиторов протеинкиназы |
| CN101106990B (zh) | 2005-01-26 | 2010-12-08 | Irm责任有限公司 | 用作蛋白激酶抑制剂的化合物和组合物 |
| WO2006124731A2 (en) | 2005-05-12 | 2006-11-23 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| DE102005022977A1 (de) | 2005-05-19 | 2006-12-07 | Merck Patent Gmbh | Phenylchinazolinderivate |
| US20070254894A1 (en) | 2006-01-10 | 2007-11-01 | Kane John L Jr | Novel small molecules with selective cytotoxicity against human microvascular endothelial cell proliferation |
| AU2007212345A1 (en) | 2006-02-06 | 2007-08-16 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| MX2008012728A (es) | 2006-04-05 | 2008-10-14 | Novartis Ag | Combinaciones de agentes terapeuticos para el tratamiento de cancer. |
| US8822497B2 (en) | 2007-03-01 | 2014-09-02 | Novartis Ag | PIM kinase inhibitors and methods of their use |
| CA2690653A1 (en) | 2007-06-15 | 2008-12-24 | Irm Llc | Protein kinase inhibitors and methods for using thereof |
| CN101875617B (zh) | 2009-03-23 | 2015-05-20 | 中国医学科学院药物研究所 | 烷氧基取代芳环的氨甲酰基类芳酸化合物及其制法和用途 |
| JP2012526093A (ja) | 2009-05-07 | 2012-10-25 | アストラゼネカ・アクチエボラーグ | 置換１−シアノエチルヘテロシクリルカルボキサミド化合物７５０ |
| CN107441097A (zh) | 2010-04-16 | 2017-12-08 | 阿西纳斯公司 | 用于预防和治疗癌症的组合物以及方法 |
| EP2627650A2 (en) | 2010-05-26 | 2013-08-21 | Merck Sharp & Dohme Corp. | N-phenyl imidazole carboxamide inhibitors of 3-phosphoinositide-dependent protein kinase-1 |
| WO2011156557A2 (en) | 2010-06-11 | 2011-12-15 | Thomas James B | Compounds active at the neurotensin receptor |
| CN103189067A (zh) | 2010-06-16 | 2013-07-03 | 密执安大学评议会 | Wdr5与其结合配偶体的相互作用的抑制及治疗方法 |
| CN201802360U (zh) | 2010-06-29 | 2011-04-20 | 中国石油化工股份有限公司胜利油田分公司采油工艺研究院 | 曲柄无游梁抽油机 |
| WO2012066065A1 (en) | 2010-11-17 | 2012-05-24 | Novartis Ag | Phenyl-heteroaryl amine compounds and their uses |
| AR091586A1 (es) * | 2012-06-28 | 2015-02-11 | Fujifilm Corp | Derivado de amida o su sal como inhibidor de la produccion de colageno |
| WO2014048878A1 (en) | 2012-09-26 | 2014-04-03 | Evotec (Uk) Ltd. | Phenyl- or pyridyl- pyrrolo[2,3b]pyrazine derivatives useful in the treatment or prevention of proliferative disorders or dysplasia |
| WO2014058071A1 (ja) | 2012-10-12 | 2014-04-17 | 武田薬品工業株式会社 | シクロプロパンアミン化合物およびその用途 |
| US9745328B2 (en) | 2013-02-04 | 2017-08-29 | Janssen Pharmaceutica Nv | Flap modulators |
| US9908872B2 (en) | 2013-12-13 | 2018-03-06 | Dana-Farber Cancer Institute, Inc. | Methods to treat lymphoplasmacytic lymphoma |
| AU2014361798B2 (en) | 2013-12-13 | 2020-06-11 | Dana-Farber Cancer Institute, Inc. | Methods to treat lymphoplasmacytic lymphoma |
| CN104926801B (zh) | 2014-03-22 | 2019-06-04 | 浙江大学 | 取代氮杂环类衍生物、含其的药物组合物及其在抗肿瘤中的应用 |
| CN105585565B (zh) | 2014-10-23 | 2019-10-01 | 中国医学科学院药物研究所 | 含2-苯胺基-4-噻唑基吡啶衍生物及其制法和药物组合物与用途 |
| CN105837575B (zh) | 2015-01-13 | 2019-01-15 | 四川大学 | 3-乙炔基吡唑并嘧啶衍生物及其制备方法和用途 |
| CN105175284B (zh) | 2015-07-21 | 2017-06-16 | 中国药科大学 | 酰胺类化合物、制备方法及其医药用途 |
| IL302705A (en) | 2016-03-01 | 2023-07-01 | Immatics Biotechnologies Gmbh | Peptides, combination of peptides, and cell-based medicaments for use in immunotherapy against urinary bladder cancer and other cancers |
| CN109195965B (zh) | 2016-03-01 | 2022-07-26 | 普罗佩纶治疗公司 | Wdr5蛋白质-蛋白质结合的抑制剂 |
| CN109906224B (zh) | 2016-06-20 | 2022-02-25 | 诺华股份有限公司 | 三唑吡啶化合物及其应用 |
| US10160763B2 (en) | 2016-09-13 | 2018-12-25 | Vanderbilt University | WDR5 inhibitors and modulators |
| JP2020532561A (ja) | 2017-09-06 | 2020-11-12 | プロペロン セラピューティクス インコーポレイテッド | Ｗｄｒ５タンパク質−タンパク質結合の阻害剤 |
| US10501466B2 (en) | 2017-09-19 | 2019-12-10 | Vanderbilt University | WDR5 inhibitors and modulators |
| US11999716B2 (en) | 2018-10-24 | 2024-06-04 | Vanderbilt University | WDR5 inhibitors and modulators |
| WO2021026672A1 (en) | 2019-08-09 | 2021-02-18 | Novartis Ag | Heterocyclic wdr5 inhibitors as anti-cancer compounds |
-
2017
- 2017-03-01 CA CA3015417A patent/CA3015417A1/en active Pending
- 2017-03-01 WO PCT/CA2017/050271 patent/WO2017147701A1/en not_active Ceased
- 2017-03-01 US US16/080,851 patent/US11174250B2/en not_active Expired - Fee Related
- 2017-03-01 AU AU2017226005A patent/AU2017226005A1/en not_active Abandoned
- 2017-03-01 EP EP17759040.3A patent/EP3423437A4/en not_active Withdrawn
- 2017-03-01 JP JP2018546584A patent/JP2019507179A/ja active Pending
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