JP2015536306A5 - - Google Patents
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- Publication number
- JP2015536306A5 JP2015536306A5 JP2015536951A JP2015536951A JP2015536306A5 JP 2015536306 A5 JP2015536306 A5 JP 2015536306A5 JP 2015536951 A JP2015536951 A JP 2015536951A JP 2015536951 A JP2015536951 A JP 2015536951A JP 2015536306 A5 JP2015536306 A5 JP 2015536306A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- methyl
- phenyl
- carbonyl
- benzenesulfonamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- -1 C 1-6 alkyl-OH Chemical group 0.000 claims description 67
- 150000001875 compounds Chemical class 0.000 claims description 45
- 125000000217 alkyl group Chemical group 0.000 claims description 42
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 40
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 29
- 230000035772 mutation Effects 0.000 claims description 20
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 20
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 19
- 125000000623 heterocyclic group Chemical group 0.000 claims description 18
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 18
- 125000003118 aryl group Chemical group 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 15
- 206010028980 Neoplasm Diseases 0.000 claims description 13
- 201000011510 cancer Diseases 0.000 claims description 13
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 12
- 125000001072 heteroaryl group Chemical group 0.000 claims description 12
- 101000599886 Homo sapiens Isocitrate dehydrogenase [NADP], mitochondrial Proteins 0.000 claims description 10
- 102100037845 Isocitrate dehydrogenase [NADP], mitochondrial Human genes 0.000 claims description 10
- 101001042041 Bos taurus Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Proteins 0.000 claims description 9
- 101000960234 Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic Proteins 0.000 claims description 9
- 102100039905 Isocitrate dehydrogenase [NADP] cytoplasmic Human genes 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 9
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims description 8
- 201000007224 Myeloproliferative neoplasm Diseases 0.000 claims description 8
- 125000003545 alkoxy group Chemical group 0.000 claims description 8
- 125000005843 halogen group Chemical group 0.000 claims description 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
- OEYGXEYESNDHQS-UHFFFAOYSA-N 1-(2-methyl-5-piperidin-1-ylsulfonylphenyl)-3-(3,5,7-trimethyl-1-adamantyl)urea Chemical compound C1=C(NC(=O)NC23CC4(C)CC(C)(CC(C4)(C)C2)C3)C(C)=CC=C1S(=O)(=O)N1CCCCC1 OEYGXEYESNDHQS-UHFFFAOYSA-N 0.000 claims description 6
- CYCFHZPFMAXQRB-UHFFFAOYSA-N 1-(4-chlorophenyl)-3-[5-morpholin-4-ylsulfonyl-2-(2-oxopyrrolidin-1-yl)phenyl]urea Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC(S(=O)(=O)N2CCOCC2)=CC=C1N1C(=O)CCC1 CYCFHZPFMAXQRB-UHFFFAOYSA-N 0.000 claims description 6
- JADAACJWFPKJSC-UHFFFAOYSA-N 1-[2-(diethylamino)-5-morpholin-4-ylsulfonylphenyl]-3-(3-methylphenyl)urea Chemical compound CCN(CC)C1=CC=C(S(=O)(=O)N2CCOCC2)C=C1NC(=O)NC1=CC=CC(C)=C1 JADAACJWFPKJSC-UHFFFAOYSA-N 0.000 claims description 6
- RSIFRBLCVZDPFI-UHFFFAOYSA-N 1-[3-(azepan-1-ylsulfonyl)-4-methylphenyl]-3-[2-(3-prop-1-en-2-ylphenyl)propan-2-yl]urea Chemical compound CC(=C)C1=CC=CC(C(C)(C)NC(=O)NC=2C=C(C(C)=CC=2)S(=O)(=O)N2CCCCCC2)=C1 RSIFRBLCVZDPFI-UHFFFAOYSA-N 0.000 claims description 6
- GUNQZZMJRXGITI-UHFFFAOYSA-N 1-[3-[(2-methoxyphenyl)sulfamoyl]-4-piperidin-1-ylphenyl]-3-[2-(3-prop-1-en-2-ylphenyl)propan-2-yl]urea Chemical compound COC1=CC=CC=C1NS(=O)(=O)C1=CC(NC(=O)NC(C)(C)C=2C=C(C=CC=2)C(C)=C)=CC=C1N1CCCCC1 GUNQZZMJRXGITI-UHFFFAOYSA-N 0.000 claims description 6
- AQEFBMVFUWQQGA-UHFFFAOYSA-N 1-[3-[(3-chlorophenyl)sulfamoyl]-4-methylphenyl]-3-[2-(3-prop-1-en-2-ylphenyl)propan-2-yl]urea Chemical compound CC(=C)C1=CC=CC(C(C)(C)NC(=O)NC=2C=C(C(C)=CC=2)S(=O)(=O)NC=2C=C(Cl)C=CC=2)=C1 AQEFBMVFUWQQGA-UHFFFAOYSA-N 0.000 claims description 6
- JMMZFYORIQSJKO-UHFFFAOYSA-N 1-[4-(diethylamino)-3-[(2-methoxyphenyl)sulfamoyl]phenyl]-3-[2-(3-prop-1-en-2-ylphenyl)propan-2-yl]urea Chemical compound C1=C(S(=O)(=O)NC=2C(=CC=CC=2)OC)C(N(CC)CC)=CC=C1NC(=O)NC(C)(C)C1=CC=CC(C(C)=C)=C1 JMMZFYORIQSJKO-UHFFFAOYSA-N 0.000 claims description 6
- XOFACLCJHFUIDE-UHFFFAOYSA-N 1-[4-chloro-3-[(4-ethoxyphenyl)sulfamoyl]phenyl]-3-[2-(3-prop-1-en-2-ylphenyl)propan-2-yl]urea Chemical compound C1=CC(OCC)=CC=C1NS(=O)(=O)C1=CC(NC(=O)NC(C)(C)C=2C=C(C=CC=2)C(C)=C)=CC=C1Cl XOFACLCJHFUIDE-UHFFFAOYSA-N 0.000 claims description 6
- VAZOYARPRLVOKK-UHFFFAOYSA-N 1-[5-(butylsulfamoyl)-2-methoxyphenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea Chemical compound CCCCNS(=O)(=O)C1=CC=C(OC)C(NC(=O)NC=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=C1 VAZOYARPRLVOKK-UHFFFAOYSA-N 0.000 claims description 6
- HRKRDXGIYSURLR-UHFFFAOYSA-N 1-[5-[(2,5-dichlorophenyl)sulfamoyl]-2-(diethylamino)phenyl]-3-(4-nitrophenyl)urea Chemical compound CCN(CC)C1=CC=C(S(=O)(=O)NC=2C(=CC=C(Cl)C=2)Cl)C=C1NC(=O)NC1=CC=C([N+]([O-])=O)C=C1 HRKRDXGIYSURLR-UHFFFAOYSA-N 0.000 claims description 6
- JDUBSDSPWVKMFO-UHFFFAOYSA-N 1-[5-[3-[2,4-bis(2-methylbutan-2-yl)phenoxy]propylsulfamoyl]-2-chlorophenyl]-3-(3,5-dichloro-2-hydroxy-4-methylphenyl)urea Chemical compound CCC(C)(C)C1=CC(C(C)(C)CC)=CC=C1OCCCNS(=O)(=O)C1=CC=C(Cl)C(NC(=O)NC=2C(=C(Cl)C(C)=C(Cl)C=2)O)=C1 JDUBSDSPWVKMFO-UHFFFAOYSA-N 0.000 claims description 6
- DVNJUHFYDMTVCU-UHFFFAOYSA-N 1-[5-[[4-[bis(2-hydroxyethyl)amino]-2-methylphenyl]methylidene]-2-phenylimidazol-4-yl]-3-[5-(hexadecylsulfamoyl)-2-methoxyphenyl]urea Chemical compound CCCCCCCCCCCCCCCCNS(=O)(=O)C1=CC=C(OC)C(NC(=O)NC=2C(N=C(N=2)C=2C=CC=CC=2)=CC=2C(=CC(=CC=2)N(CCO)CCO)C)=C1 DVNJUHFYDMTVCU-UHFFFAOYSA-N 0.000 claims description 6
- GSPWDUPQFBOLPX-UHFFFAOYSA-N 1-[6-[4-[bis(2-cyanoethyl)amino]-2-methylphenyl]imino-3,4-dicyano-5-(trifluoromethyl)pyrrolo[1,2-b]pyrazol-2-yl]-3-[2-chloro-5-(hexadecylsulfamoyl)phenyl]urea Chemical compound CCCCCCCCCCCCCCCCNS(=O)(=O)c1ccc(Cl)c(NC(=O)Nc2nn3C(=Nc4ccc(cc4C)N(CCC#N)CCC#N)C(=C(C#N)c3c2C#N)C(F)(F)F)c1 GSPWDUPQFBOLPX-UHFFFAOYSA-N 0.000 claims description 6
- KRYZQVQMDSSVHM-UHFFFAOYSA-N 3-(4-chloro-3-pyrrolidin-1-ylsulfonylphenyl)-1-methyl-1-[(2-methyl-1,3-thiazol-5-yl)methyl]urea Chemical compound C=1C=C(Cl)C(S(=O)(=O)N2CCCC2)=CC=1NC(=O)N(C)CC1=CN=C(C)S1 KRYZQVQMDSSVHM-UHFFFAOYSA-N 0.000 claims description 6
- YLOIWATYZNZGIC-UHFFFAOYSA-N 3-(4-methoxy-3-piperidin-1-ylsulfonylphenyl)-1-methyl-1-[(2-methyl-1,3-thiazol-5-yl)methyl]urea Chemical compound C1=C(S(=O)(=O)N2CCCCC2)C(OC)=CC=C1NC(=O)N(C)CC1=CN=C(C)S1 YLOIWATYZNZGIC-UHFFFAOYSA-N 0.000 claims description 6
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 6
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 claims description 6
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 6
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 6
- LDZOUHCRTQBWTF-UHFFFAOYSA-O n-[4-[[5-[3-(4-butyl-3,5-dimethylpyridin-1-ium-1-yl)propylcarbamoylamino]-2-chlorophenyl]sulfonylamino]anilino]formamide Chemical compound C1=C(C)C(CCCC)=C(C)C=[N+]1CCCNC(=O)NC1=CC=C(Cl)C(S(=O)(=O)NC=2C=CC(NNC=O)=CC=2)=C1 LDZOUHCRTQBWTF-UHFFFAOYSA-O 0.000 claims description 6
- IJAIFRUQXADQJV-UHFFFAOYSA-N n-[4-[[5-[3-(4-butyl-3,5-dimethylpyridin-1-ium-1-yl)propylcarbamoylamino]-2-chlorophenyl]sulfonylamino]anilino]formamide;chloride Chemical compound [Cl-].C1=C(C)C(CCCC)=C(C)C=[N+]1CCCNC(=O)NC1=CC=C(Cl)C(S(=O)(=O)NC=2C=CC(NNC=O)=CC=2)=C1 IJAIFRUQXADQJV-UHFFFAOYSA-N 0.000 claims description 6
- RIHISJPMISXXNE-UHFFFAOYSA-N n-[5-chloro-3-[[4-chloro-3-(dodecylsulfamoyl)phenyl]carbamoylamino]-2-hydroxyphenyl]acetamide Chemical compound C1=C(Cl)C(S(=O)(=O)NCCCCCCCCCCCC)=CC(NC(=O)NC=2C(=C(NC(C)=O)C=C(Cl)C=2)O)=C1 RIHISJPMISXXNE-UHFFFAOYSA-N 0.000 claims description 6
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 6
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 6
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 4
- HWXBTNAVRSUOJR-UHFFFAOYSA-N 2-hydroxyglutaric acid Chemical compound OC(=O)C(O)CCC(O)=O HWXBTNAVRSUOJR-UHFFFAOYSA-N 0.000 claims description 4
- CTJVLIALFREFQS-UHFFFAOYSA-N 3-(4-ethoxy-3-pyrrolidin-1-ylsulfonylphenyl)-1-methyl-1-(4-methylcyclohexyl)urea Chemical compound C1=C(S(=O)(=O)N2CCCC2)C(OCC)=CC=C1NC(=O)N(C)C1CCC(C)CC1 CTJVLIALFREFQS-UHFFFAOYSA-N 0.000 claims description 4
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 4
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 4
- 208000005243 Chondrosarcoma Diseases 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 4
- 102000004190 Enzymes Human genes 0.000 claims description 4
- 208000032612 Glial tumor Diseases 0.000 claims description 4
- 206010018338 Glioma Diseases 0.000 claims description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims description 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 4
- 208000006990 cholangiocarcinoma Diseases 0.000 claims description 4
- 230000001419 dependent effect Effects 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 208000005017 glioblastoma Diseases 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 201000001441 melanoma Diseases 0.000 claims description 4
- 102200116484 rs121913502 Human genes 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims description 2
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims description 2
- 206010004593 Bile duct cancer Diseases 0.000 claims description 2
- 206010009944 Colon cancer Diseases 0.000 claims description 2
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims description 2
- 206010039491 Sarcoma Diseases 0.000 claims description 2
- 125000004104 aryloxy group Chemical group 0.000 claims description 2
- 125000004429 atom Chemical group 0.000 claims description 2
- 125000003725 azepanyl group Chemical group 0.000 claims description 2
- 208000026900 bile duct neoplasm Diseases 0.000 claims description 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 125000004475 heteroaralkyl group Chemical group 0.000 claims description 2
- 102200069708 rs121913499 Human genes 0.000 claims description 2
- 102200069690 rs121913500 Human genes 0.000 claims description 2
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims description 2
- 125000005309 thioalkoxy group Chemical group 0.000 claims description 2
- 125000004001 thioalkyl group Chemical group 0.000 claims description 2
- 230000002792 vascular Effects 0.000 claims description 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 3
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 description 12
- KNPYUBYMGCLBEJ-UHFFFAOYSA-N 1-[5-(azepan-1-ylsulfonyl)-2-chlorophenyl]-3-(4-nitrophenyl)urea Chemical compound C1=CC([N+](=O)[O-])=CC=C1NC(=O)NC1=CC(S(=O)(=O)N2CCCCCC2)=CC=C1Cl KNPYUBYMGCLBEJ-UHFFFAOYSA-N 0.000 description 3
- KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261714179P | 2012-10-15 | 2012-10-15 | |
| US61/714,179 | 2012-10-15 | ||
| PCT/US2013/064601 WO2014062511A1 (en) | 2012-10-15 | 2013-10-11 | Therapeutic compounds and compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018130743A Division JP2018199677A (ja) | 2012-10-15 | 2018-07-10 | 治療化合物および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015536306A JP2015536306A (ja) | 2015-12-21 |
| JP2015536306A5 true JP2015536306A5 (enExample) | 2016-11-24 |
| JP6385352B2 JP6385352B2 (ja) | 2018-09-05 |
Family
ID=50488660
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015536951A Expired - Fee Related JP6385352B2 (ja) | 2012-10-15 | 2013-10-11 | 治療化合物および組成物 |
| JP2018130743A Withdrawn JP2018199677A (ja) | 2012-10-15 | 2018-07-10 | 治療化合物および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018130743A Withdrawn JP2018199677A (ja) | 2012-10-15 | 2018-07-10 | 治療化合物および組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10202339B2 (enExample) |
| EP (1) | EP2906212A4 (enExample) |
| JP (2) | JP6385352B2 (enExample) |
| CN (1) | CN104822373B (enExample) |
| AU (1) | AU2013331626B2 (enExample) |
| CA (1) | CA2888360A1 (enExample) |
| HK (1) | HK1213798A1 (enExample) |
| MX (1) | MX365747B (enExample) |
| NZ (1) | NZ706999A (enExample) |
| WO (1) | WO2014062511A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20120693A1 (es) | 2009-06-29 | 2012-07-04 | Agios Pharmaceuticals Inc | Compuestos heterociclos como moduladores de la piruvato cinasa m2 (pkm2) |
| CN102827170A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| US9474779B2 (en) | 2012-01-19 | 2016-10-25 | Agios Pharmaceuticals, Inc. | Therapeutically active compositions and their methods of use |
| WO2015003360A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| CN105593215B (zh) | 2013-07-11 | 2019-01-15 | 安吉奥斯医药品有限公司 | 用于治疗癌症的作为idh2突变体抑制剂的2,4-或4,6-二氨基嘧啶化合物 |
| WO2015003355A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| WO2015010297A1 (en) | 2013-07-25 | 2015-01-29 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| PH12021551647A1 (en) | 2014-03-14 | 2022-06-06 | Agios Pharmaceuticals Inc | Pharmaceutical compositions of therapeutically active compounds |
| US20150273088A1 (en) * | 2014-03-28 | 2015-10-01 | Washington University | Zaprinast analogues as glutaminase inhibitors and methods to predict response thereto |
| EP3303286B1 (en) * | 2015-06-01 | 2023-10-04 | Cedars-Sinai Medical Center | Compounds that bind to rela of nf-kb for use in treating cancer |
| WO2017016523A1 (zh) * | 2015-07-30 | 2017-02-02 | 正大天晴药业集团股份有限公司 | 靶向idh2突变的抗肿瘤化合物及其使用方法 |
| MD3362066T2 (ro) | 2015-10-15 | 2022-08-31 | Les Laboratoires Servier Sas | Terapie combinată pentru tratamentul tumorilor maligne |
| HUE067449T2 (hu) | 2015-10-15 | 2024-10-28 | Servier Lab | Ivozidenib, citarabin és daunorubicin vagy idarubicin kombinációs terápa akut mielogén leukémia kezelésére |
| WO2017135399A1 (ja) * | 2016-02-04 | 2017-08-10 | 塩野義製薬株式会社 | ＴｒｋＡ阻害活性を有する含窒素複素環および炭素環誘導体 |
| WO2017140758A1 (en) | 2016-02-19 | 2017-08-24 | Debiopharm International S.A. | Derivatives of 2-amino-4-(2-oxazolidinon-3-yl)-pyrimidine fused with a five-membered heteroaromatic ring in 5,6-position which are useful for the treatment of various cancers |
| EP3444237B1 (en) | 2016-03-22 | 2020-10-28 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Iridinesulfonamide compound and use method thereof |
| CN107556366B (zh) * | 2016-06-30 | 2025-02-07 | 上海海和药物研究开发股份有限公司 | 具有突变型异柠檬酸脱氢酶抑制活性的化合物、其制备方法及用途 |
| CN107973748A (zh) * | 2017-12-22 | 2018-05-01 | 潘劲松 | 含磺酸酯基或磺酰胺基的吡啶酮类偶氮分散染料及其合成方法 |
| CA3096424A1 (en) * | 2018-04-12 | 2019-10-17 | Eisai R&D Management Co., Ltd. | Pladienolide derivatives as spliceosome targeting agents for treating cancer |
| US10980788B2 (en) | 2018-06-08 | 2021-04-20 | Agios Pharmaceuticals, Inc. | Therapy for treating malignancies |
| IT201900001009A1 (it) | 2019-01-23 | 2020-07-23 | Torino Politecnico | Vettore nanoporoso biomimetico comprendente un inibitore diretto verso la forma nativa della proteina IDH2 |
| CA3166379A1 (en) | 2020-01-21 | 2021-07-29 | Emory University | Inhibitors of glutathione s-transferases (gsts) and nad(p)h:quinone oxidoreductase 1 (nqo1), pharmaceutical compositions, and uses in managing cancer |
| CN112375069B (zh) * | 2020-11-20 | 2022-09-13 | 湖北民族大学 | 一种4-脲基嘧啶类化合物及其用途 |
Family Cites Families (116)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2390529A (en) | 1942-02-03 | 1945-12-11 | Ernst A H Friedheim | Hydrazino-1,3,5-triazino derivatives of substituted phenylarsenic compounds |
| BE754242A (fr) | 1970-07-15 | 1971-02-01 | Geigy Ag J R | Diamino-s-triazines et dinitro-s-triazines |
| US3867383A (en) | 1971-03-29 | 1975-02-18 | Ciba Geigy Corp | Monoanthranilatoanilino-s-triazines |
| CH606334A5 (enExample) | 1974-06-21 | 1978-10-31 | Ciba Geigy Ag | |
| DE2928485A1 (de) * | 1979-07-14 | 1981-01-29 | Bayer Ag | Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen |
| JPS58186682A (ja) | 1982-04-27 | 1983-10-31 | 日本化薬株式会社 | セルロ−ス又はセルロ−ス含有繊維材料の染色法 |
| DE3512630A1 (de) | 1985-04-06 | 1986-10-23 | Hoechst Ag, 6230 Frankfurt | Verfahren zum faerben oder bedrucken von cellulosefasern oder cellulosemischfasern |
| JP2588711B2 (ja) * | 1987-04-06 | 1997-03-12 | 富士写真フイルム株式会社 | ハロゲン化銀写真感光材料 |
| US5041443A (en) | 1989-02-21 | 1991-08-20 | Dainippon Pharmaceutical Co., Ltd. | Medicament for treating cerebral insufficiency diseases, novel 2-(1-piperazinyl)-4-phenylcycloalkanopyrimidine derivatives, and process for the production thereof |
| DK0385237T3 (da) | 1989-03-03 | 1994-07-25 | Dainippon Pharmaceutical Co | 2-(1-Piperazinyl)-4-phenylcycloalkanopyridinderivater, fremgangsmåde til fremstilling deraf og farmaceutisk præparat indeholdende dem |
| JPH0499768A (ja) | 1990-08-17 | 1992-03-31 | Dainippon Pharmaceut Co Ltd | ４―（４―フェニルピリジン―２―イル）ピペラジン―１―オキシド誘導体 |
| AU665238B2 (en) | 1992-02-28 | 1995-12-21 | Zenyaku Kogyo Kabushiki Kaisha | S-triazine derivative and remedy for estrogen-dependent diseases containing the same as active ingredient |
| IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
| FR2735127B1 (fr) | 1995-06-09 | 1997-08-22 | Pf Medicament | Nouvelles piperazines heteroaromatiques utiles comme medicaments. |
| US6313127B1 (en) | 1996-02-02 | 2001-11-06 | Zeneca Limited | Heterocyclic compounds useful as pharmaceutical agents |
| GB9602166D0 (en) | 1996-02-02 | 1996-04-03 | Zeneca Ltd | Aminoheterocyclic derivatives |
| US5807876A (en) * | 1996-04-23 | 1998-09-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme |
| JPH09291034A (ja) | 1996-02-27 | 1997-11-11 | Yoshitomi Pharmaceut Ind Ltd | 縮合ピリジン化合物およびその医薬としての用途 |
| US6262113B1 (en) * | 1996-03-20 | 2001-07-17 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| JP2000510866A (ja) | 1996-05-20 | 2000-08-22 | ダーウィン・ディスカバリー・リミテッド | Ｔｎｆとｐｄｅ―ｉｖのインヒビターとしてのキノリンスルホンアミド |
| US5984882A (en) | 1996-08-19 | 1999-11-16 | Angiosonics Inc. | Methods for prevention and treatment of cancer and other proliferative diseases with ultrasonic energy |
| EP0945446A4 (en) | 1996-11-14 | 1999-12-08 | Nissan Chemical Ind Ltd | CYANOETHYLMELAMINE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME |
| US6399358B1 (en) | 1997-03-31 | 2002-06-04 | Thomas Jefferson University | Human gene encoding human chondroitin 6-sulfotransferase |
| JPH11158073A (ja) | 1997-09-26 | 1999-06-15 | Takeda Chem Ind Ltd | アデノシンａ３拮抗剤 |
| DE69830513T2 (de) * | 1997-12-22 | 2006-03-16 | Bayer Pharmaceuticals Corp., West Haven | HEMMUNG DER p38 KINASE UNTER VERWENDUNG VON SYMMETRISCHEN UND ASYMMETRISCHEN DIPHENYLHARNSTOFFEN |
| US7517880B2 (en) * | 1997-12-22 | 2009-04-14 | Bayer Pharmaceuticals Corporation | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
| UY25842A1 (es) | 1998-12-16 | 2001-04-30 | Smithkline Beecham Corp | Antagonistas de receptores de il-8 |
| US6500817B1 (en) * | 1999-03-08 | 2002-12-31 | Bayer Aktiengesellschaft | Thiazolyl urea derivatives and their utilization as antiviral agents |
| WO2000075129A1 (en) | 1999-06-07 | 2000-12-14 | Shire Biochem Inc. | Thiophene integrin inhibitors |
| DE60023920T2 (de) | 1999-08-27 | 2006-07-20 | Sugen, Inc., South San Francisco | Phosphatmimetika und Verfahren zur Behandlung mit Phosphataseinhibitoren HIBITOREN |
| IL153884A0 (en) | 2000-07-20 | 2003-07-31 | Neurogen Corp | Capsaicin receptor ligands |
| US6525091B2 (en) | 2001-03-07 | 2003-02-25 | Telik, Inc. | Substituted diarylureas as stimulators for Fas-mediated apoptosis |
| JP2004534017A (ja) | 2001-04-27 | 2004-11-11 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ｂａｃｅのインヒビター |
| CA2450934A1 (en) | 2001-06-19 | 2002-12-27 | Marco Dodier | Pyrimidine inhibitors of phosphodiesterase (pde) 7 |
| JP4344241B2 (ja) | 2001-08-17 | 2009-10-14 | チバ ホールディング インコーポレーテッド | トリアジン誘導体、およびサンスクリーンとしてのその使用 |
| JP4753336B2 (ja) | 2001-09-04 | 2011-08-24 | 日本化薬株式会社 | 新規アリル化合物及びその製法 |
| JP2003098643A (ja) * | 2001-09-26 | 2003-04-04 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料 |
| DE10155684A1 (de) * | 2001-11-13 | 2003-05-22 | Bayer Ag | Thiazolharnstoffe |
| US6878196B2 (en) | 2002-01-15 | 2005-04-12 | Fuji Photo Film Co., Ltd. | Ink, ink jet recording method and azo compound |
| DE10210319A1 (de) * | 2002-03-08 | 2003-09-18 | Bayer Ag | Thiazolylcarbonyl-Derivate |
| CA2744893A1 (en) * | 2002-06-27 | 2004-01-08 | Novo Nordisk A/S | Aryl carbonyl derivatives as glucokinase activators |
| US20040067234A1 (en) | 2002-07-11 | 2004-04-08 | Paz Einat | Isocitrate dehydrogenase and uses thereof |
| SI2256108T1 (sl) | 2002-07-18 | 2016-05-31 | Janssen Pharmaceutica N.V. | Substituirani triazinski kinazni inhibitorji |
| JP2004107220A (ja) | 2002-09-13 | 2004-04-08 | Mitsubishi Pharma Corp | ＴＮＦ−α産生抑制剤 |
| AR042052A1 (es) | 2002-11-15 | 2005-06-08 | Vertex Pharma | Diaminotriazoles utiles como inhibidores de proteinquinasas |
| US7361691B2 (en) | 2002-12-02 | 2008-04-22 | Arqule, Inc. | Method of treating cancers using β-lapachone or analogs or derivatives thereof |
| NZ541050A (en) | 2002-12-16 | 2010-06-25 | Genmab As | Human monoclonal antibodies against interleukin 8 (IL-8) |
| AU2004204778B2 (en) | 2003-01-10 | 2008-05-22 | Threshold Pharmaceuticals, Inc. | Treatment of cancer with 2-deoxyglucose |
| US7358262B2 (en) | 2003-01-29 | 2008-04-15 | Whitehead Institute For Biomedical Research | Identification of genotype-selective anti-tumor agents |
| WO2004073619A2 (en) | 2003-02-14 | 2004-09-02 | Smithkline Beecham Corporation | Ccr8 antagonists |
| WO2004074438A2 (en) | 2003-02-14 | 2004-09-02 | Smithkline Beecham Corporation | Ccr8 antagonists |
| EP1689722A2 (en) | 2003-10-10 | 2006-08-16 | Bayer Pharmaceuticals Corporation | 4-aminopyrimidine derivatives for treatment of hyperproliferative disorders |
| JP4099768B2 (ja) | 2003-11-10 | 2008-06-11 | 富士電機デバイステクノロジー株式会社 | 電子写真感光体および該電子写真感光体に起因する干渉縞有無の判定方法 |
| US20070196395A1 (en) | 2003-12-12 | 2007-08-23 | Mackerell Alexander | Immunomodulatory compounds that target and inhibit the py'binding site of tyrosene kinase p56 lck sh2 domain |
| CA2551524A1 (en) | 2003-12-24 | 2005-07-21 | Scios, Inc. | Treatment of malignant gliomas with tgf-beta inhibitors |
| CN1984899B (zh) * | 2004-05-12 | 2011-07-27 | 先灵公司 | Cxcr1和cxcr2趋化因子拮抗剂 |
| EP1805142A4 (en) | 2004-09-23 | 2009-06-10 | Reddy Us Therapeutics Inc | PYRIDINE-BASED COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING SAME |
| WO2006038594A1 (ja) | 2004-10-04 | 2006-04-13 | Ono Pharmaceutical Co., Ltd. | Ｎ型カルシウムチャネル阻害薬 |
| EP1836188A1 (en) | 2004-12-30 | 2007-09-26 | Astex Therapeutics Limited | Pyrazole derivatives as that modulate the activity of cdk, gsk and aurora kinases |
| WO2006079791A1 (en) | 2005-01-25 | 2006-08-03 | Astrazeneca Ab | Chemical compounds |
| EP2687608B1 (en) | 2005-06-08 | 2017-02-08 | Millennium Pharmaceuticals, Inc. | Methods for the identification, assessment, and treatment of patients with cancer therapy |
| AU2006261954A1 (en) * | 2005-06-28 | 2007-01-04 | Merck & Co., Inc. | Non-nucleoside reverse transcriptase inhibitors |
| ZA200801822B (en) | 2005-08-26 | 2009-09-30 | Serono Lab | Pyrazine derivatives and use as p13k inhibitors |
| US8133900B2 (en) | 2005-11-01 | 2012-03-13 | Targegen, Inc. | Use of bi-aryl meta-pyrimidine inhibitors of kinases |
| TW200815426A (en) | 2006-06-28 | 2008-04-01 | Astrazeneca Ab | New pyridine analogues II 333 |
| HUP0600810A3 (en) | 2006-10-27 | 2008-09-29 | Richter Gedeon Nyrt | New sulfonamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them |
| WO2008070661A1 (en) | 2006-12-04 | 2008-06-12 | Neurocrine Biosciences, Inc. | Substituted pyrimidines as adenosine receptor antagonists |
| JP5622393B2 (ja) | 2006-12-15 | 2014-11-12 | アブラクシスバイオサイエンス リミテッド ライアビリティー カンパニー | トリアジン誘導体類及びそれらの治療応用 |
| WO2008131547A1 (en) | 2007-04-30 | 2008-11-06 | Prometic Biosciences Inc. | 'triazine derivatives, compositions containing such derivatives, and methods of treatment of cancer and autoimmune diseases using such derivatives' |
| JP2010529193A (ja) | 2007-06-11 | 2010-08-26 | ミイカナ セラピューティクス インコーポレイテッド | 置換ピラゾール化合物 |
| EA018503B1 (ru) | 2007-07-20 | 2013-08-30 | НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. | Замещенные производные индазола, активные как ингибиторы киназы |
| TW200906818A (en) | 2007-07-31 | 2009-02-16 | Astrazeneca Ab | Chemical compounds |
| CL2008002998A1 (es) | 2007-10-10 | 2009-11-20 | Takeda Pharmaceuticals Co | Compuestos derivados de piperazina-1-carboxamida, inhibidor de faah; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del dolor inflamatorio o neuropatico, ansiedad y depresion. |
| AU2008345225A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| GB0805477D0 (en) | 2008-03-26 | 2008-04-30 | Univ Nottingham | Pyrimidines triazines and their use as pharmaceutical agents |
| JP5277685B2 (ja) | 2008-03-26 | 2013-08-28 | 富士ゼロックス株式会社 | 電子写真感光体、画像形成装置、プロセスカートリッジ及び画像形成方法 |
| US20090281089A1 (en) | 2008-04-11 | 2009-11-12 | Genentech, Inc. | Pyridyl inhibitors of hedgehog signalling |
| UY31770A1 (es) * | 2008-04-18 | 2009-09-30 | Inhibidores de catepsina c | |
| CN101575408B (zh) | 2008-05-09 | 2013-10-30 | Mca技术有限公司 | 用作阻燃剂和光稳定剂的聚三嗪基化合物 |
| FR2932483A1 (fr) | 2008-06-13 | 2009-12-18 | Cytomics Systems | Composes utiles pour le traitement des cancers. |
| TW201028381A (en) | 2008-07-14 | 2010-08-01 | Shionogi & Co | Pyridine derivative having ttk inhibition activity |
| US20100144722A1 (en) | 2008-09-03 | 2010-06-10 | Dr. Reddy's Laboratories Ltd. | Novel heterocyclic compounds as gata modulators |
| US8685660B2 (en) | 2008-09-03 | 2014-04-01 | The Johns Hopkins University | Genetic alterations in isocitrate dehydrogenase and other genes in malignant glioma |
| JP2010079130A (ja) | 2008-09-29 | 2010-04-08 | Fuji Xerox Co Ltd | 電子写真感光体、プロセスカートリッジ、及び画像形成装置 |
| EP2370417A2 (en) | 2008-11-21 | 2011-10-05 | Millennium Pharmaceuticals, Inc. | Lactate salt of 4-[6-methoxy-7-(3-piperidin-1-yl-propoxy)quinazolin-4-yl]piperazine-1-carboxylic acid(4-isopropoxyphenyl)-amide and pharmaceutical compositions thereof for the treatment of cancer and other diseases or disorders |
| JP2010181540A (ja) | 2009-02-04 | 2010-08-19 | Fuji Xerox Co Ltd | 電子写真感光体、プロセスカートリッジ、及び画像形成装置 |
| JP5263304B2 (ja) | 2009-02-06 | 2013-08-14 | 日本新薬株式会社 | アミノピラジン誘導体及び医薬 |
| CN102985557B (zh) | 2009-03-13 | 2018-06-15 | 安吉奥斯医药品有限公司 | 用于细胞增殖相关病症的方法和组合物 |
| PL2427441T3 (pl) | 2009-05-04 | 2017-06-30 | Agios Pharmaceuticals, Inc. | Aktywatory PKM2 do stosowania w leczeniu raka |
| CA2764785C (en) | 2009-06-08 | 2015-10-27 | California Capital Equity, Llc | Triazine derivatives and their therapeutical applications |
| CN102573487A (zh) | 2009-06-09 | 2012-07-11 | 加利福尼亚资本权益有限责任公司 | Hedgehog信号传导的吡啶基-三嗪抑制剂 |
| CN102573481A (zh) | 2009-06-09 | 2012-07-11 | 加利福尼亚资本权益有限责任公司 | 脲基苯基取代的三嗪衍生物及其治疗应用 |
| PE20120693A1 (es) | 2009-06-29 | 2012-07-04 | Agios Pharmaceuticals Inc | Compuestos heterociclos como moduladores de la piruvato cinasa m2 (pkm2) |
| WO2011005208A1 (en) | 2009-07-10 | 2011-01-13 | Milux Holding S.A. | Knee joint device and method |
| BR112012004149A2 (pt) * | 2009-08-25 | 2016-03-22 | Abraxis Bioscience Llc | terapia de combinação com composições de nanopartículas de taxano e inibidores de hedgehog |
| JP5473851B2 (ja) | 2009-09-30 | 2014-04-16 | 富士フイルム株式会社 | 高分子フィルム、位相差フィルム、偏光板及び液晶表示装置 |
| US8652534B2 (en) | 2009-10-14 | 2014-02-18 | Berry Pharmaceuticals, LLC | Compositions and methods for treatment of mammalian skin |
| WO2011050210A1 (en) * | 2009-10-21 | 2011-04-28 | Agios Pharmaceuticals, Inc. | Methods and compositions for cell-proliferation-related disorders |
| WO2011072174A1 (en) | 2009-12-09 | 2011-06-16 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds for use in the treatment of cancer characterized as having an idh mutation |
| US20130109643A1 (en) | 2010-05-10 | 2013-05-02 | The Johns Hopkins University | Metabolic inhibitor against tumors having an idh mutation |
| CN103097340B (zh) | 2010-07-16 | 2018-03-16 | 安吉奥斯医药品有限公司 | 治疗活性组合物及其使用方法 |
| CN106986856A (zh) * | 2010-09-03 | 2017-07-28 | 福马Tm有限责任公司 | 作为用于治疗疾病诸如癌症的nampt抑制剂的4‑{[(吡啶‑3‑基‑甲基)氨基羰基]氨基}苯‑砜衍生物 |
| CN103282365B (zh) | 2010-10-21 | 2017-12-29 | 麦迪韦逊科技有限公司 | 结晶的(8S,9R)‑5‑氟‑8‑(4‑氟苯基)‑9‑(1‑甲基‑1H‑1,2,4‑三唑‑5‑基)‑8,9‑二氢‑2H‑吡啶并[4,3,2‑de]酞嗪‑3(7H)‑酮甲苯磺酸盐 |
| SG10201601507YA (en) | 2010-11-29 | 2016-04-28 | Galleon Pharmaceuticals Inc | Novel compounds as respiratory stimulants for treatment of breathing control disorders or diseases |
| TW201636330A (zh) | 2011-05-24 | 2016-10-16 | 拜耳知識產權公司 | 含有硫醯亞胺基團之４－芳基－ｎ－苯基－１，３，５－三氮雜苯－２－胺 |
| CN102827170A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| ES2698847T3 (es) | 2011-07-07 | 2019-02-06 | Merck Patent Gmbh | Azaheterociclos sustituidos para el tratamiento del cáncer |
| CN102659765B (zh) | 2011-12-31 | 2014-09-10 | 沈阳药科大学 | 嘧啶及三嗪类化合物的制备方法和应用 |
| SMT201800334T1 (it) | 2012-01-06 | 2018-09-13 | Agios Pharmaceuticals Inc | Composti terapeuticamente attivi e loro metodi di utilizzo |
| US9474779B2 (en) | 2012-01-19 | 2016-10-25 | Agios Pharmaceuticals, Inc. | Therapeutically active compositions and their methods of use |
| ES2698625T3 (es) | 2012-01-19 | 2019-02-05 | Agios Pharmaceuticals Inc | Compuestos terapéuticamente activos y sus métodos de uso |
| EP2634259A1 (en) | 2012-03-01 | 2013-09-04 | Deutsches Krebsforschungszentrum | Means and methods for the determination of (D)-2-hydroxyglutarate (D2HG) |
| CN104169260A (zh) | 2012-03-09 | 2014-11-26 | 卡尔那生物科学株式会社 | 新三嗪衍生物 |
| WO2014015422A1 (en) | 2012-07-27 | 2014-01-30 | Ontario Institute For Cancer Research | Cellulose-based nanoparticles for drug delivery |
| WO2015003360A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| WO2015010297A1 (en) | 2013-07-25 | 2015-01-29 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
-
2013
- 2013-10-11 WO PCT/US2013/064601 patent/WO2014062511A1/en not_active Ceased
- 2013-10-11 HK HK16101848.4A patent/HK1213798A1/zh unknown
- 2013-10-11 AU AU2013331626A patent/AU2013331626B2/en not_active Ceased
- 2013-10-11 US US14/435,674 patent/US10202339B2/en not_active Expired - Fee Related
- 2013-10-11 CN CN201380062951.5A patent/CN104822373B/zh not_active Expired - Fee Related
- 2013-10-11 MX MX2015004762A patent/MX365747B/es active IP Right Grant
- 2013-10-11 NZ NZ706999A patent/NZ706999A/en not_active IP Right Cessation
- 2013-10-11 JP JP2015536951A patent/JP6385352B2/ja not_active Expired - Fee Related
- 2013-10-11 CA CA2888360A patent/CA2888360A1/en active Pending
- 2013-10-11 EP EP13846787.3A patent/EP2906212A4/en not_active Withdrawn
-
2018
- 2018-07-10 JP JP2018130743A patent/JP2018199677A/ja not_active Withdrawn
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