JP2016512825A5 - - Google Patents
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- JP2016512825A5 JP2016512825A5 JP2016501110A JP2016501110A JP2016512825A5 JP 2016512825 A5 JP2016512825 A5 JP 2016512825A5 JP 2016501110 A JP2016501110 A JP 2016501110A JP 2016501110 A JP2016501110 A JP 2016501110A JP 2016512825 A5 JP2016512825 A5 JP 2016512825A5
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- optionally substituted
- compound
- sbc
- lower alkyl
- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims description 30
- 125000000217 alkyl group Chemical group 0.000 claims 22
- 239000003814 drug Substances 0.000 claims 22
- -1 hydroxysulfonyloxy Chemical group 0.000 claims 21
- 125000001072 heteroaryl group Chemical group 0.000 claims 17
- 125000000623 heterocyclic group Chemical group 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 13
- 125000003118 aryl group Chemical group 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 125000000753 cycloalkyl group Chemical group 0.000 claims 9
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 8
- 201000001320 Atherosclerosis Diseases 0.000 claims 7
- 208000024172 Cardiovascular disease Diseases 0.000 claims 7
- 208000032928 Dyslipidaemia Diseases 0.000 claims 7
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 7
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 7
- 208000029078 coronary artery disease Diseases 0.000 claims 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 7
- 208000024891 symptom Diseases 0.000 claims 7
- 230000002265 prevention Effects 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 125000000304 alkynyl group Chemical group 0.000 claims 5
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 4
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical compound NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 claims 4
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims 4
- 125000005138 alkoxysulfonyl group Chemical group 0.000 claims 4
- 125000004688 alkyl sulfonyl alkyl group Chemical group 0.000 claims 4
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 claims 4
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 claims 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 4
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 claims 4
- 125000004472 dialkylaminosulfonyl group Chemical group 0.000 claims 4
- 125000001475 halogen functional group Chemical group 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 125000004104 aryloxy group Chemical group 0.000 claims 3
- 150000003857 carboxamides Chemical class 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000003107 substituted aryl group Chemical group 0.000 claims 3
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000005518 carboxamido group Chemical group 0.000 claims 2
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims 2
- VVYIXKBHQQSREP-ORIPQNMZSA-N (4e)-4-[hydroxy-(3-methyl-4-phenylmethoxyphenyl)methylidene]-1-(3-morpholin-4-ylpropyl)-5-pyridin-4-ylpyrrolidine-2,3-dione Chemical compound CC1=CC(C(\O)=C\2C(C(=O)N(CCCN3CCOCC3)C/2C=2C=CN=CC=2)=O)=CC=C1OCC1=CC=CC=C1 VVYIXKBHQQSREP-ORIPQNMZSA-N 0.000 claims 1
- UURZBASXTXQHLN-UHFFFAOYSA-N 2-(3-chlorophenyl)-4-hydroxy-3-(7-methoxy-1-benzofuran-2-carbonyl)-1-(3-morpholin-4-ylpropyl)-2h-pyrrol-5-one Chemical compound O1C=2C(OC)=CC=CC=2C=C1C(=O)C(C1C=2C=C(Cl)C=CC=2)=C(O)C(=O)N1CCCN1CCOCC1 UURZBASXTXQHLN-UHFFFAOYSA-N 0.000 claims 1
- 125000006179 2-methyl benzyl group Chemical group [H]C1=C([H])C(=C(C([H])=C1[H])C([H])([H])*)C([H])([H])[H] 0.000 claims 1
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims 1
- 125000006180 3-methyl benzyl group Chemical group [H]C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])* 0.000 claims 1
- MTSHYYTUXDJHNZ-UHFFFAOYSA-N 4-[[2-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]acetyl]amino]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1NC(=O)CSC(N1C2CC2)=NN=C1C1=CC=CS1 MTSHYYTUXDJHNZ-UHFFFAOYSA-N 0.000 claims 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- QZFTVSQWMKGSGR-UHFFFAOYSA-N C(C1=CC=CC=C1)OC1=C(C=C(C(=O)C2=C(C(N(C2C=2C=NC=CC=2)CCCN2CCOCC2)=O)O)C=C1)C Chemical compound C(C1=CC=CC=C1)OC1=C(C=C(C(=O)C2=C(C(N(C2C=2C=NC=CC=2)CCCN2CCOCC2)=O)O)C=C1)C QZFTVSQWMKGSGR-UHFFFAOYSA-N 0.000 claims 1
- LRPOVGDWHIMCNX-UHFFFAOYSA-N C(C1=CC=CC=C1)OC1=C(C=C(C(=O)C2=C(C(N(C2C=2SC=CC=2)CCCN2CCOCC2)=O)O)C=C1)C Chemical compound C(C1=CC=CC=C1)OC1=C(C=C(C(=O)C2=C(C(N(C2C=2SC=CC=2)CCCN2CCOCC2)=O)O)C=C1)C LRPOVGDWHIMCNX-UHFFFAOYSA-N 0.000 claims 1
- VTPCAPXHOATEKH-UHFFFAOYSA-N C(C1=CC=CC=C1)OC1=CC(=C(C(=O)C2=C(C(N(C2C=2C=NC=CC=2)CCCN2CCOCC2)=O)O)C=C1)C Chemical compound C(C1=CC=CC=C1)OC1=CC(=C(C(=O)C2=C(C(N(C2C=2C=NC=CC=2)CCCN2CCOCC2)=O)O)C=C1)C VTPCAPXHOATEKH-UHFFFAOYSA-N 0.000 claims 1
- MZRVHLINDADTSP-UHFFFAOYSA-N CN(CCCN1C(C(=C(C1C1=CC(=CC=C1)O)C(C1=CC=C(C=C1)OCC1=CC(=CC=C1)C)=O)O)=O)C Chemical compound CN(CCCN1C(C(=C(C1C1=CC(=CC=C1)O)C(C1=CC=C(C=C1)OCC1=CC(=CC=C1)C)=O)O)=O)C MZRVHLINDADTSP-UHFFFAOYSA-N 0.000 claims 1
- FZDSYMVTJPUUJC-UHFFFAOYSA-N OC=1C(N(C(C=1C(C1=CC=C(C=C1)OCC1=C(C=CC=C1)C)=O)C1=CC(=CC=C1)O)CCCN1C=NC=C1)=O Chemical compound OC=1C(N(C(C=1C(C1=CC=C(C=C1)OCC1=C(C=CC=C1)C)=O)C1=CC(=CC=C1)O)CCCN1C=NC=C1)=O FZDSYMVTJPUUJC-UHFFFAOYSA-N 0.000 claims 1
- IMYDWFQXINAZRH-UHFFFAOYSA-N OC=1C(N(C(C=1C(C1=CC=C(C=C1)OCC1=CC(=CC=C1)C)=O)C1=CC=NC=C1)CCCN1CCOCC1)=O Chemical compound OC=1C(N(C(C=1C(C1=CC=C(C=C1)OCC1=CC(=CC=C1)C)=O)C1=CC=NC=C1)CCCN1CCOCC1)=O IMYDWFQXINAZRH-UHFFFAOYSA-N 0.000 claims 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000005418 aryl aryl group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
- 238000009423 ventilation Methods 0.000 claims 1
- 101001098868 Homo sapiens Proprotein convertase subtilisin/kexin type 9 Proteins 0.000 description 10
- 102100038955 Proprotein convertase subtilisin/kexin type 9 Human genes 0.000 description 10
- 101001051093 Homo sapiens Low-density lipoprotein receptor Proteins 0.000 description 9
- 102100024640 Low-density lipoprotein receptor Human genes 0.000 description 9
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 4
- 239000002299 complementary DNA Substances 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000012894 fetal calf serum Substances 0.000 description 3
- 235000009200 high fat diet Nutrition 0.000 description 3
- 230000003827 upregulation Effects 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 230000003833 cell viability Effects 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 235000021590 normal diet Nutrition 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 238000013218 HFD mouse model Methods 0.000 description 1
- 108010028554 LDL Cholesterol Proteins 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361788061P | 2013-03-15 | 2013-03-15 | |
| US61/788,061 | 2013-03-15 | ||
| PCT/US2014/022957 WO2014150326A1 (en) | 2013-03-15 | 2014-03-11 | Anti-proprotein convertase subtilisin kexin type 9 (anti-pcsk9) compounds and methods of using the same in the treatment and/or prevention of cardiovascular diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018190991A Division JP6691948B2 (ja) | 2013-03-15 | 2018-10-09 | 抗プロタンパク質転換酵素サブチリシン／ケキシン９型（抗ｐｃｓｋ９）化合物および心血管疾患の治療および／または予防におけるその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016512825A JP2016512825A (ja) | 2016-05-09 |
| JP2016512825A5 true JP2016512825A5 (enExample) | 2017-04-13 |
Family
ID=51580740
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501110A Pending JP2016512825A (ja) | 2013-03-15 | 2014-03-11 | 抗プロタンパク質転換酵素サブチリシン／ケキシン９型（抗ｐｃｓｋ９）化合物および心血管疾患の治療および／または予防におけるその使用方法 |
| JP2018190991A Expired - Fee Related JP6691948B2 (ja) | 2013-03-15 | 2018-10-09 | 抗プロタンパク質転換酵素サブチリシン／ケキシン９型（抗ｐｃｓｋ９）化合物および心血管疾患の治療および／または予防におけるその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018190991A Expired - Fee Related JP6691948B2 (ja) | 2013-03-15 | 2018-10-09 | 抗プロタンパク質転換酵素サブチリシン／ケキシン９型（抗ｐｃｓｋ９）化合物および心血管疾患の治療および／または予防におけるその使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20160256467A1 (enExample) |
| EP (1) | EP2968266B1 (enExample) |
| JP (2) | JP2016512825A (enExample) |
| CN (1) | CN105228616B (enExample) |
| AU (1) | AU2014237312B2 (enExample) |
| BR (1) | BR112015023294A2 (enExample) |
| CA (1) | CA2904660C (enExample) |
| WO (1) | WO2014150326A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017528448A (ja) | 2014-08-21 | 2017-09-28 | エスアールエックス カーディオ，エル エル シー | プロタンパク質コンバターゼであるスブチリシン／ケキシンタイプ９（ｐｃｓｋ９）のタンパク質活性のモジュレーションのための、結合リガンドとしての小分子の組成物およびその使用方法 |
| WO2016040305A1 (en) * | 2014-09-08 | 2016-03-17 | Temple University-Of The Commonwealth System Of Higher Education | Pcsk9 inhibitors and methods of use thereof |
| CA2960274A1 (en) * | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Isoxazole carboxamide compounds |
| GB201504763D0 (en) | 2015-03-20 | 2015-05-06 | Mironid Ltd | Compounds and uses |
| CA2985542C (en) | 2015-05-20 | 2023-10-10 | Amgen Inc. | Triazole agonists of the apj receptor |
| JP2018531924A (ja) | 2015-09-24 | 2018-11-01 | ファイザー・インク | テトラヒドロピラノ［３，４−ｄ］［１，３］オキサジン誘導体、およびｂａｃｅ阻害剤としてのその使用 |
| CN105214087B (zh) | 2015-10-29 | 2017-12-26 | 陈敏 | Pcsk9单克隆抗体在制备治疗炎症免疫性疾病药物中的应用 |
| WO2017192485A1 (en) | 2016-05-03 | 2017-11-09 | Amgen Inc. | Heterocyclic triazole compounds as agonists of the apj receptor |
| JP7097828B2 (ja) * | 2016-06-21 | 2022-07-08 | シファ バイオメディカル コーポレーション | 抗プロタンパク質変換酵素サブチリシン ケキシン タイプ９（Ｓｕｂｔｉｌｉｓｉｎ Ｋｅｘｉｎ Ｔｙｐｅ ９）（抗ＰＣＳＫ９）化合物および心血管疾患の治療および／または予防にこれを使用する方法 |
| KR102449308B1 (ko) | 2016-06-24 | 2022-10-04 | 에프. 호프만-라 로슈 아게 | 심혈관 질환의 치료를 위한 조성물 및 방법 |
| GB201616439D0 (en) | 2016-09-28 | 2016-11-09 | Mironid Limited | Compounds and uses |
| EP3541805B1 (en) | 2016-11-16 | 2020-10-14 | Amgen Inc. | Heteroaryl-substituted triazoles as apj receptor agonists |
| WO2018097944A1 (en) | 2016-11-16 | 2018-05-31 | Amgen Inc. | Triazole furan compounds as agonists of the apj receptor |
| US11020395B2 (en) | 2016-11-16 | 2021-06-01 | Amgen Inc. | Cycloalkyl substituted triazole compounds as agonists of the APJ receptor |
| US10689367B2 (en) | 2016-11-16 | 2020-06-23 | Amgen Inc. | Triazole pyridyl compounds as agonists of the APJ receptor |
| US11191762B2 (en) | 2016-11-16 | 2021-12-07 | Amgen Inc. | Alkyl substituted triazole compounds as agonists of the APJ Receptor |
| WO2018093579A1 (en) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Triazole phenyl compounds as agonists of the apj receptor |
| TW201823222A (zh) * | 2016-12-23 | 2018-07-01 | 財團法人生物技術開發中心 | 化合物、醫藥組成物及其用途 |
| US11091466B2 (en) | 2017-03-17 | 2021-08-17 | Cardio Therapeutics Pty Ltd | Heterocyclic inhibitors of PCSK9 |
| CN107596373A (zh) * | 2017-09-28 | 2018-01-19 | 韩庆亮 | 一种用于治疗心血管疾病的方法 |
| MA50509A (fr) | 2017-11-03 | 2021-06-02 | Amgen Inc | Agonistes de triazole fusionnés du récepteur apj |
| US11724997B2 (en) | 2018-03-01 | 2023-08-15 | Annapurna Bio, Inc. | Compounds and compositions for treating conditions associated with APJ receptor activity |
| GB201805527D0 (en) | 2018-04-04 | 2018-05-16 | Mironid Ltd | Compounds and their use as pde4 activators |
| MA52487A (fr) | 2018-05-01 | 2021-03-10 | Amgen Inc | Pyrimidinones substituées en tant qu'agonistes du récepteur apj |
| ES3015132T3 (en) | 2018-06-21 | 2025-04-29 | Ucb Holdings Inc | Cyclic polypeptides for pcsk9 inhibition |
| WO2019246386A1 (en) | 2018-06-21 | 2019-12-26 | Ra Pharmaceuticals Inc. | Cyclic polypeptides for pcsk9 inhibition |
| JOP20190150A1 (ar) * | 2018-06-21 | 2019-12-21 | Merck Sharp & Dohme | مركبات مناهضة لـ pcsk9 |
| CN112969684B (zh) | 2018-11-05 | 2023-11-10 | 实发生物医学公司 | 抗前蛋白转化酶枯草杆菌蛋白酶Kexin 9型(抗PCSK9)纳米制剂化合物及使用其的方法 |
| RS66416B1 (sr) | 2019-01-18 | 2025-02-28 | Astrazeneca Ab | 6'-[[(1s,3s)-3-[[5-(difluorometoksi)-2-pirimidinil]amino]ciklopentil]amino][1(2h),3'-bipiridin]-2-on kao inhibitor pcsk9 i metode njegove primene |
| EP4076492A4 (en) | 2019-12-20 | 2024-01-17 | Merck Sharp & Dohme LLC | PCSK9 ANTAGONIST COMPOUNDS |
| WO2022251533A1 (en) * | 2021-05-27 | 2022-12-01 | Protego Biopharma, Inc. | Heteroaryl diamide ire1/xbp1s activators |
| JP2025534174A (ja) | 2022-10-14 | 2025-10-14 | 上▲海▼翰森生物医▲薬▼科技有限公司 | 窒素含有複素環系誘導体阻害剤、その製造方法及び応用 |
| EP4626865A1 (en) * | 2022-11-30 | 2025-10-08 | Protego Biopharma, Inc. | Cyclic pyrazole diamide ire1/xbp1s activators |
| WO2025007915A1 (zh) | 2023-07-04 | 2025-01-09 | 上海翰森生物医药科技有限公司 | 一类含氮杂环类衍生物抑制剂、其制备方法和应用 |
| AU2024298043A1 (en) * | 2023-07-27 | 2026-02-19 | Tuojie Biotech (Shanghai) Co., Ltd. | Diaminocyclopentyl substituted heteroaryl derivatives, use thereof and preparation method therefor |
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2014
- 2014-03-11 EP EP14770138.7A patent/EP2968266B1/en active Active
- 2014-03-11 BR BR112015023294A patent/BR112015023294A2/pt not_active IP Right Cessation
- 2014-03-11 JP JP2016501110A patent/JP2016512825A/ja active Pending
- 2014-03-11 AU AU2014237312A patent/AU2014237312B2/en not_active Ceased
- 2014-03-11 WO PCT/US2014/022957 patent/WO2014150326A1/en not_active Ceased
- 2014-03-11 CN CN201480016193.8A patent/CN105228616B/zh not_active Expired - Fee Related
- 2014-03-11 CA CA2904660A patent/CA2904660C/en active Active
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2016
- 2016-05-12 US US15/152,703 patent/US20160256467A1/en not_active Abandoned
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2018
- 2018-10-09 JP JP2018190991A patent/JP6691948B2/ja not_active Expired - Fee Related
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