|
US4522811A
(en)
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
|
EP1940773B1
(en)
|
2005-08-10 |
2015-03-18 |
Johns Hopkins University |
Polyamines useful as anti-parasitic and anti-cancer therapeutics and as lysine-specific demethylase inhibitors
|
|
EP2142287A4
(en)
|
2007-04-13 |
2012-05-23 |
Univ Johns Hopkins |
INHIBITORS OF LYSINPECIFIC DEMETHYLASE
|
|
WO2010043721A1
(en)
|
2008-10-17 |
2010-04-22 |
Oryzon Genomics, S.A. |
Oxidase inhibitors and their use
|
|
US8993808B2
(en)
|
2009-01-21 |
2015-03-31 |
Oryzon Genomics, S.A. |
Phenylcyclopropylamine derivatives and their medical use
|
|
US8389580B2
(en)
|
2009-06-02 |
2013-03-05 |
Duke University |
Arylcyclopropylamines and methods of use
|
|
JPWO2010143582A1
(ja)
|
2009-06-11 |
2012-11-22 |
公立大学法人名古屋市立大学 |
フェニルシクロプロピルアミン誘導体及びｌｓｄ１阻害剤
|
|
AU2010284221B2
(en)
|
2009-08-18 |
2016-09-22 |
Casero, Robert A |
(bis) urea and (bis) thiourea compounds as epigenic modulators of lysine-specific demethylase 1 and methods of treating disorders
|
|
WO2011035941A1
(en)
|
2009-09-25 |
2011-03-31 |
Oryzon Genomics S.A. |
Lysine specific demethylase-1 inhibitors and their use
|
|
US8946296B2
(en)
|
2009-10-09 |
2015-02-03 |
Oryzon Genomics S.A. |
Substituted heteroaryl- and aryl-cyclopropylamine acetamides and their use
|
|
RS55348B1
(sr)
|
2010-04-19 |
2017-03-31 |
Oryzon Gnomics S A |
Inhibitori lizin specifične demetilaze-1 i njihova upotreba
|
|
US8765820B2
(en)
|
2010-04-20 |
2014-07-01 |
Universita Degli Studi Di Roma “La Sapienza” |
Tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and/or LSD2
|
|
DK2598482T3
(en)
*
|
2010-07-29 |
2018-06-14 |
Oryzon Genomics Sa |
ARYLCYCLOPROPYLAMINE-BASED DEMETHYLASE INHIBITORS OF LSD1 AND THEIR MEDICAL USE
|
|
EP2598480B1
(en)
|
2010-07-29 |
2019-04-24 |
Oryzon Genomics, S.A. |
Cyclopropylamine derivatives useful as lsd1 inhibitors
|
|
WO2012034116A2
(en)
|
2010-09-10 |
2012-03-15 |
The Johns Hopkins University |
Small molecules as epigenetic modulators of lysine-specific demethylase 1 and methods of treating disorders
|
|
WO2012045883A1
(en)
|
2010-10-08 |
2012-04-12 |
Oryzon Genomics S.A. |
Cyclopropylamine inhibitors of oxidases
|
|
WO2012071469A2
(en)
|
2010-11-23 |
2012-05-31 |
Nevada Cancer Institute |
Histone demethylase inhibitors and uses thereof for treatment o f cancer
|
|
MX347913B
(es)
|
2011-03-25 |
2017-05-17 |
Glaxosmithkline Intellectual Property (No 2) Ltd |
Ciclopropilaminas como inhibidores de desmetilasa 1 especifica de lisina.
|
|
BR112014002939A2
(pt)
|
2011-08-09 |
2017-03-01 |
Takeda Pharmaceuticals Co |
composto, medicamento, método para profilaxia ou tratamento de doença, a doença sendo esquizofrenia, alzheimer, parkinson ou huntington, uso do composto, e, método para inibir o lsd1
|
|
AU2012296639B2
(en)
|
2011-08-15 |
2016-06-09 |
University Of Utah Research Foundation |
Substituted (E)-N'-(1-phenylethylidene) benzohydrazide analogs as histone demethylase inhibitors
|
|
US9289415B2
(en)
|
2011-09-01 |
2016-03-22 |
The Brigham And Women's Hospital, Inc. |
Treatment of cancer
|
|
US9469597B2
(en)
|
2011-10-20 |
2016-10-18 |
Oryzon Genomics S.A. |
(Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors
|
|
AU2012324803B9
(en)
|
2011-10-20 |
2017-08-24 |
Oryzon Genomics, S.A. |
(hetero)aryl cyclopropylamine compounds as LSD1 inhibitors
|
|
EP2907802B1
(en)
|
2012-10-12 |
2019-08-07 |
Takeda Pharmaceutical Company Limited |
Cyclopropanamine compound and use thereof
|
|
WO2014084298A1
(ja)
|
2012-11-28 |
2014-06-05 |
京都府公立大学法人 |
リシン構造を有するｌｓｄ1選択的阻害薬
|
|
US9144555B2
(en)
|
2012-11-30 |
2015-09-29 |
Darlene E. McCord |
Hydroxytyrosol and oleuropein compositions for induction of DNA damage, cell death and LSD1 inhibition
|
|
EP2740474A1
(en)
|
2012-12-05 |
2014-06-11 |
Instituto Europeo di Oncologia S.r.l. |
Cyclopropylamine derivatives useful as inhibitors of histone demethylases kdm1a
|
|
CN103054869A
(zh)
|
2013-01-18 |
2013-04-24 |
郑州大学 |
含三唑基的氨基二硫代甲酸酯化合物在制备以lsd1为靶标药物中的应用
|
|
WO2014164867A1
(en)
|
2013-03-11 |
2014-10-09 |
Imago Biosciences |
Kdm1a inhibitors for the treatment of disease
|
|
CN105555784B
(zh)
|
2013-06-19 |
2019-03-15 |
犹他大学研究基金会 |
作为组蛋白去甲基化酶抑制剂的被取代的(e)-n’-(1-苯亚乙基)苯甲酰肼类似物
|
|
CN103319466B
(zh)
|
2013-07-04 |
2016-03-16 |
郑州大学 |
含香豆素母核的1,2,3-三唑-氨基二硫代甲酸酯化合物、制备方法及其应用
|
|
JP6521967B2
(ja)
|
2013-08-06 |
2019-05-29 |
イマーゴ バイオサイエンシーズ インコーポレイテッド |
疾患の治療のためのｋｄｍ１ａ阻害剤
|
|
US9186391B2
(en)
|
2013-08-29 |
2015-11-17 |
Musc Foundation For Research Development |
Cyclic peptide inhibitors of lysine-specific demethylase 1
|
|
WO2015031564A2
(en)
|
2013-08-30 |
2015-03-05 |
University Of Utah |
Substituted-1h-benzo[d]imidazole series compounds as lysine-specfic demethylase 1 (lsd1) inhibitors
|
|
CA3161836A1
(en)
|
2013-12-11 |
2015-06-18 |
Celgene Quanticel Research, Inc. |
Inhibitors of lysine specific demethylase-1
|
|
WO2015120281A1
(en)
|
2014-02-07 |
2015-08-13 |
Musc Foundation For Research Development |
Aminotriazole- and aminotetrazole-based kdm1a inhibitors as epigenetic modulators
|
|
US9527835B2
(en)
|
2014-02-13 |
2016-12-27 |
Incyte Corporation |
Cyclopropylamines as LSD1 inhibitors
|
|
EP3392244A1
(en)
|
2014-02-13 |
2018-10-24 |
Incyte Corporation |
Cyclopropylamines as lsd1 inhibitors
|
|
WO2015123424A1
(en)
|
2014-02-13 |
2015-08-20 |
Incyte Corporation |
Cyclopropylamines as lsd1 inhibitors
|
|
LT3105218T
(lt)
|
2014-02-13 |
2019-12-10 |
Incyte Corp |
Ciklopropilaminai kaip lsd1 inhibitoriai
|
|
JP2017508798A
(ja)
|
2014-03-07 |
2017-03-30 |
ザ ジョンズ ホプキンス ユニバーシティ |
ヒストンリジン特異的デメチラーゼ（ｌｓｄ１）およびヒストンデアセチラーゼ（ｈｄａｃ）の阻害剤
|
|
CN103893163B
(zh)
|
2014-03-28 |
2016-02-03 |
中国药科大学 |
2-([1，1′-联苯]-4-基)2-氧代乙基4-((3-氯-4-甲基苯基)氨基)-4-氧代丁酸酯在制备lsd1抑制剂药物中的应用
|
|
NZ725262A
(en)
|
2014-04-11 |
2023-01-27 |
Takeda Pharmaceuticals Co |
Cyclopropanamine compound and use thereof
|
|
CN103961340B
(zh)
|
2014-04-30 |
2019-06-25 |
南通中国科学院海洋研究所海洋科学与技术研究发展中心 |
一类lsd1抑制剂及其应用
|
|
WO2015168466A1
(en)
|
2014-05-01 |
2015-11-05 |
Quanticel Pharmaceuticals, Inc. |
Inhibitors of lysine specific demethylase-1
|
|
MX375102B
(es)
|
2014-05-30 |
2025-03-06 |
Ieo St Europeo Di Oncologia S R L |
Compuestos de ciclopropilamina como inhibidores de histona demetilasa
|
|
CN104119280B
(zh)
|
2014-06-27 |
2016-03-16 |
郑州大学 |
含氨基类脲与端炔结构单元的嘧啶衍生物、制备方法及应用
|
|
PL3160956T3
(pl)
|
2014-06-27 |
2020-11-30 |
Celgene Quanticel Research, Inc. |
Inhibitory demetylazy-1 specyficznej dla lizyny
|
|
WO2016003917A1
(en)
|
2014-07-03 |
2016-01-07 |
Quanticel Pharmaceuticals, Inc. |
Inhibitors of lysine specific demethylase-1
|
|
EA201790082A1
(ru)
|
2014-07-03 |
2017-08-31 |
Селджен Квонтисел Рисёрч, Инк. |
Ингибиторы лизин-специфической демитилазы-1
|
|
US9758523B2
(en)
|
2014-07-10 |
2017-09-12 |
Incyte Corporation |
Triazolopyridines and triazolopyrazines as LSD1 inhibitors
|
|
WO2016007722A1
(en)
|
2014-07-10 |
2016-01-14 |
Incyte Corporation |
Triazolopyridines and triazolopyrazines as lsd1 inhibitors
|
|
WO2016007736A1
(en)
|
2014-07-10 |
2016-01-14 |
Incyte Corporation |
Imidazopyrazines as lsd1 inhibitors
|
|
WO2016007731A1
(en)
|
2014-07-10 |
2016-01-14 |
Incyte Corporation |
Imidazopyridines and imidazopyrazines as lsd1 inhibitors
|
|
EP2993175A1
(en)
|
2014-09-05 |
2016-03-09 |
IEO - Istituto Europeo di Oncologia Srl |
Thienopyrroles as histone demethylase inhibitors
|
|
ES2935114T3
(es)
|
2014-09-05 |
2023-03-01 |
Celgene Quanticel Res Inc |
Inhibidores de la desmetilasa 1 específica de lisina
|
|
EP3250552B1
(en)
|
2015-01-30 |
2019-03-27 |
Genentech, Inc. |
Therapeutic compounds and uses thereof
|
|
JP6727216B2
(ja)
|
2015-02-12 |
2020-07-22 |
イマーゴ バイオサイエンシーズ インコーポレイテッド |
疾患の治療のためのｋｄｍ１ａ阻害剤
|
|
CN106146361A
(zh)
|
2015-03-16 |
2016-11-23 |
四川大学 |
茚-1-亚基磺酰基苯甲酰肼衍生物及其制备方法和用途
|
|
EA201792205A1
(ru)
|
2015-04-03 |
2018-02-28 |
Инсайт Корпорейшн |
Гетероциклические соединения как ингибиторы lsd1
|
|
CN106045862B
(zh)
|
2015-04-10 |
2019-04-23 |
上海迪诺医药科技有限公司 |
环丙胺类螺(杂)环化合物、其药物组合物及应用
|
|
EP3286172B1
(en)
|
2015-04-23 |
2019-06-12 |
Constellation Pharmaceuticals, Inc. |
Lsd1 inhibitors and uses thereof
|
|
EP3090998A1
(en)
|
2015-05-06 |
2016-11-09 |
F. Hoffmann-La Roche AG |
Solid forms
|
|
US20170001970A1
(en)
|
2015-07-02 |
2017-01-05 |
University Of Utah Research Foundation |
Substituted benzohydrazide analogs as histone demethylase inhibitors
|
|
DK3334709T3
(da)
|
2015-08-12 |
2025-02-03 |
Incyte Holdings Corp |
Salte af en lsd1-hæmmer
|
|
WO2017079476A1
(en)
|
2015-11-05 |
2017-05-11 |
Mirati Therapeutics, Inc. |
Lsd1 inhibitors
|
|
MX373363B
(es)
|
2015-11-05 |
2020-05-21 |
Celgene Quanticel Res Inc |
Composiciones que comprenden un inhibidor de demetilasa-1 específico de lisina.
|
|
FI3381896T3
(fi)
|
2015-11-27 |
2023-04-21 |
Taiho Pharmaceutical Co Ltd |
Bifenyyliyhdiste tai sen suola
|
|
WO2017109061A1
(en)
|
2015-12-23 |
2017-06-29 |
Ieo - Istituto Europeo Di Oncologia S.R.L. |
Spirocyclopropylamine derivatives useful as inhibitors of histone demethylases kdm1a
|
|
KR102720551B1
(ko)
|
2015-12-29 |
2024-10-21 |
미라티 테라퓨틱스, 인크. |
Lsd1 억제제
|
|
KR20180099768A
(ko)
|
2015-12-30 |
2018-09-05 |
노파르티스 아게 |
증진된 효능을 갖는 면역 이펙터 세포 요법
|
|
WO2017149463A1
(en)
|
2016-03-01 |
2017-09-08 |
Novartis Ag |
Cyano-substituted indole compounds and uses thereof as lsd1 inhibitors
|
|
CN107200706A
(zh)
|
2016-03-16 |
2017-09-26 |
中国科学院上海药物研究所 |
一类氟取代的环丙胺类化合物及其制备方法、药物组合物和用途
|
|
US20170283397A1
(en)
|
2016-03-31 |
2017-10-05 |
University Of Utah Research Foundation |
Substituted 1-h-indol-3-yl-benzamide and 1, 1'-biphenyl analogs as histone demethylase inhibitors
|
|
AU2017263361B2
(en)
|
2016-05-09 |
2021-08-05 |
Jubilant Epicore LLC |
Cyclopropyl-amide compounds as dual LSD1/HDAC inhibitors
|
|
EP3246330A1
(en)
|
2016-05-18 |
2017-11-22 |
Istituto Europeo di Oncologia S.r.l. |
Imidazoles as histone demethylase inhibitors
|
|
CN107513068A
(zh)
|
2016-06-16 |
2017-12-26 |
中国科学院上海药物研究所 |
一种具有fgfr抑制活性的新型化合物及其制备和应用
|
|
CN106478639B
(zh)
|
2016-09-05 |
2018-09-18 |
郑州大学 |
嘧啶并1,2,4–三氮唑类的lsd1抑制剂、其制备方法及应用
|
|
CN106432248B
(zh)
|
2016-09-27 |
2018-11-27 |
郑州大学 |
含嘧啶并三氮唑类lsd1抑制剂、其制备方法及应用
|
|
WO2018081342A1
(en)
|
2016-10-26 |
2018-05-03 |
Constellation Pharmaceuticals, Inc. |
Lsd1 inhibitors and uses thereof
|
|
LT3532459T
(lt)
|
2016-10-26 |
2023-11-10 |
Constellation Pharmaceuticals, Inc. |
Lsd1 inhibitoriai ir jų medicininis panaudojimas
|
|
CN106831489B
(zh)
|
2017-03-23 |
2018-04-17 |
郑州大学 |
苯环丙胺酰腙类化合物、制备方法及其应用
|
|
CN106928235A
(zh)
|
2017-05-03 |
2017-07-07 |
郑州大学 |
含嘧啶并三氮唑类lsd1抑制剂、其制备方法及应用
|
|
AU2018309372B2
(en)
*
|
2017-08-03 |
2024-08-15 |
Oryzon Genomics, S.A. |
Methods of treating behavior alterations
|