SG11202000077RA - Methods of treating behavior alterations - Google Patents

Methods of treating behavior alterations

Info

Publication number
SG11202000077RA
SG11202000077RA SG11202000077RA SG11202000077RA SG11202000077RA SG 11202000077R A SG11202000077R A SG 11202000077RA SG 11202000077R A SG11202000077R A SG 11202000077RA SG 11202000077R A SG11202000077R A SG 11202000077RA SG 11202000077R A SG11202000077R A SG 11202000077RA
Authority
SG
Singapore
Prior art keywords
llobregat
ferran
cornelia
sant
international
Prior art date
Application number
SG11202000077RA
Inventor
Tamara Maes
Pozo David Rottlant
Ferre Christian Griñán
Lliberia Mercè Pallàs
Alemany Roser Nadal
García Antonio Armario
Original Assignee
Oryzon Genomics Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oryzon Genomics Sa filed Critical Oryzon Genomics Sa
Publication of SG11202000077RA publication Critical patent/SG11202000077RA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau omit omoioninim Imo oimIE (43) International Publication Date 07 February 2019 (07.02.2019) (10) International Publication Number WO 2019/025588 Al WIPO I PCT (51) International Patent Classification: A61K 31/44 (2006.01) A61P 25/28 (2006.01) A61P 25/00 (2006.01) A61P 25/18 (2006.01) A61P 25/24 (2006.01) A61P 25/30 (2006.01) A61P 25/16 (2006.01) A61P 25/08 (2006.01) A61P 25/14 (2006.01) TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: 17382544.9 03 August 2017 (03.08.2017) 17382545.6 03 August 2017 (03.08.2017) 18382299.8 30 April 2018 (30.04.2018) Published: — with international search report (Art. 21(3)) PCT/EP2018/071120 03 August 2018 (03.08.2018) English English EP EP EP (71) Applicant: ORYZON GENOMICS, S.A. [ES/ES]; Car- rera de San Jeronimo 15, 2a planta, 28014 Madrid (ES). = (72) Inventors: MAES, Tamara; Oryzon Genomics, S.A., Sant Ferran 74, 08940 Cornelia de Llobregat (ES). ROTTLANT POZO, David; Oryzon Genomics, S.A., Sant Ferran 74, 08940 Cornelia de Llobregat (ES). GRISAN FERRE, Christian; Oryzon Genomics, S.A., Sant Ferran 74, 08940 Cornelia de Llobregat (ES). PALLAS LLIBERIA, Meree; Oryzon Genomics, S.A., Sant Ferran 74, 08940 Cornelia de Llobregat (ES). NADAL ALEMANY, Roser; Oryzon Ge- nomics, S.A., Sant Ferran 74, 08940 Cornelia de Llobregat (ES). ARMARIO GARCIA, Antonio; Oryzon Genomics, S.A., Sant Ferran 74, 08940 Cornelia de Llobregat (ES). (74) Agent: OSWIN RIDDERBUSCH, VOSSIUS & PART- NER; Patentanwalte Rechtsanwalte mbB, SiebertstraBe 3, 81675 Miinchen (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 1-1 O \" (57) : Provided herein are methods for treating behavior alterations using KDM1A inhibitors, particularly 5-((((1R,2S)- 2-(4- 0 (benzyloxy)phenyi)cyclopropyl)amino)methyl)-1,3,4-oxadiazol-2-amine. (54) Title: METHODS OF TREATING BEHAVIOR ALTERATIONS
SG11202000077RA 2017-08-03 2018-08-03 Methods of treating behavior alterations SG11202000077RA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP17382544 2017-08-03
EP17382545 2017-08-03
EP18382299 2018-04-30
PCT/EP2018/071120 WO2019025588A1 (en) 2017-08-03 2018-08-03 Methods of treating behavior alterations

Publications (1)

Publication Number Publication Date
SG11202000077RA true SG11202000077RA (en) 2020-02-27

Family

ID=63077881

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202000077RA SG11202000077RA (en) 2017-08-03 2018-08-03 Methods of treating behavior alterations

Country Status (13)

Country Link
US (1) US20200323828A1 (en)
EP (1) EP3661510A1 (en)
JP (2) JP2020529995A (en)
KR (1) KR20200036920A (en)
CN (1) CN110996949A (en)
AU (1) AU2018309372A1 (en)
BR (1) BR112020000827A2 (en)
CA (1) CA3071804A1 (en)
IL (1) IL272092A (en)
MX (2) MX2020001323A (en)
PH (1) PH12020500211A1 (en)
SG (1) SG11202000077RA (en)
WO (1) WO2019025588A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017157813A1 (en) 2016-03-15 2017-09-21 F. Hoffmann-La Roche Ag Combinations of lsd1 inhibitors for the treatment of hematological malignancies
US20220151998A1 (en) * 2019-03-20 2022-05-19 Oryzon Genomics, S.A. Methods of treating borderline personality disorder
JP2022526755A (en) * 2019-03-20 2022-05-26 オリソン ヘノミクス，ソシエダ アノニマ Treatment of Attention Deficit Hyperactivity Disorder Using KDM1A Inhibitors such as Compound Bafidemstat
CN114615979A (en) * 2019-09-03 2022-06-10 奥莱松基因组股份有限公司 Valfelast for the treatment of autism spectrum disorders
CN114502561B (en) * 2019-09-29 2023-12-26 南昌弘益药业有限公司 LSD1 inhibitors

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
WO2007021839A2 (en) 2005-08-10 2007-02-22 Johns Hopkins University Polyamines useful as anti-parasitic and anti-cancer therapeutics and as lysine-specific demethylase inhibitors
JP2010523685A (en) 2007-04-13 2010-07-15 ザ・ジョンズ・ホプキンス・ユニバーシティー Lysine-specific demethylase inhibitor
EP2361242B1 (en) 2008-10-17 2018-08-01 Oryzon Genomics, S.A. Oxidase inhibitors and their use
US8993808B2 (en) 2009-01-21 2015-03-31 Oryzon Genomics, S.A. Phenylcyclopropylamine derivatives and their medical use
US8389580B2 (en) 2009-06-02 2013-03-05 Duke University Arylcyclopropylamines and methods of use
JPWO2010143582A1 (en) 2009-06-11 2012-11-22 公立大学法人名古屋市立大学 Phenylcyclopropylamine derivatives and LSD1 inhibitors
WO2011022489A2 (en) 2009-08-18 2011-02-24 The Johns Hopkins University (bis) urea and (bis) thiourea compounds as epigenic modulators of lysine-specific demethylase 1 and methods of treating disorders
CA2812683C (en) 2009-09-25 2017-10-10 Oryzon Genomics S.A. Lysine specific demethylase-1 inhibitors and their use
WO2011042217A1 (en) 2009-10-09 2011-04-14 Oryzon Genomics S.A. Substituted heteroaryl- and aryl- cyclopropylamine acetamides and their use
CN102947265B (en) 2010-04-19 2015-07-29 奥瑞泽恩基因组学股份有限公司 Methionin specific demethylase-1 inhibitor and application thereof
EP2560949B1 (en) 2010-04-20 2015-12-02 Università degli Studi di Roma "La Sapienza" Tranylcypromine derivatives as inhibitors of histone demethylase lsd1 and/or lsd2
WO2012013728A1 (en) * 2010-07-29 2012-02-02 Oryzon Genomics S.A. Arylcyclopropylamine based demethylase inhibitors of lsd1 and their medical use
US9006449B2 (en) 2010-07-29 2015-04-14 Oryzon Genomics, S.A. Cyclopropylamine derivatives useful as LSD1 inhibitors
US9527805B2 (en) 2010-09-10 2016-12-27 Robert A. Casero Small molecules as epigenetic modulators of lysine-specific demethylase 1 and methods of treating disorders
US9061966B2 (en) 2010-10-08 2015-06-23 Oryzon Genomics S.A. Cyclopropylamine inhibitors of oxidases
WO2012071469A2 (en) 2010-11-23 2012-05-31 Nevada Cancer Institute Histone demethylase inhibitors and uses thereof for treatment o f cancer
MY165620A (en) 2011-03-25 2018-04-18 Glaxosmithkline Ip No 2 Ltd Cyclopropylamines as lsd1 inhibitors
AP2014007488A0 (en) 2011-08-09 2014-03-31 Takeda Pharmaceutical Cyclopropaneamine compound
US8987335B2 (en) 2011-08-15 2015-03-24 University Of Utah Research Foundation Substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors
WO2013033688A1 (en) 2011-09-01 2013-03-07 The Brigham And Women's Hospital, Inc. Treatment of cancer
EP3736265A1 (en) 2011-10-20 2020-11-11 Oryzon Genomics, S.A. (hetero)aryl cyclopropylamine compounds as lsd1 inhibitors
RS58475B1 (en) 2011-10-20 2019-04-30 Oryzon Genomics Sa (hetero)aryl cyclopropylamine compounds as lsd1 inhibitors
JP6325449B2 (en) 2012-10-12 2018-05-16 武田薬品工業株式会社 Cyclopropanamine compounds and uses thereof
JP6238908B2 (en) 2012-11-28 2017-11-29 京都府公立大学法人 LSD1 selective inhibitor having lysine structure
EP2925307B1 (en) 2012-11-30 2020-10-28 McCord, Darlene E. Hydroxytyrosol and oleuropein compositions for induction of dna damage, cell death and lsd1 inhibition
EP2740474A1 (en) 2012-12-05 2014-06-11 Instituto Europeo di Oncologia S.r.l. Cyclopropylamine derivatives useful as inhibitors of histone demethylases kdm1a
CN103054869A (en) 2013-01-18 2013-04-24 郑州大学 Application of amino dithio formic ester compound with triazolyl in preparing medicine taking LSD1 (Lysine Specificity Demethylase 1) as target
WO2014164867A1 (en) 2013-03-11 2014-10-09 Imago Biosciences Kdm1a inhibitors for the treatment of disease
WO2014205213A1 (en) 2013-06-19 2014-12-24 University Of Utah Research Foundation Substituted (e)-n'-(1-phenylethylidene) benzohydrazide analogs as histone demethylase inhibitors
CN103319466B (en) 2013-07-04 2016-03-16 郑州大学 Containing the 1,2,3-triazoles-dithiocarbamates compound of tonka bean camphor parent nucleus, preparation method and application thereof
CN105592888A (en) 2013-08-06 2016-05-18 伊美格生物科学公司 Kdm1a inhibitors for the treatment of disease
US9186391B2 (en) 2013-08-29 2015-11-17 Musc Foundation For Research Development Cyclic peptide inhibitors of lysine-specific demethylase 1
US9556170B2 (en) 2013-08-30 2017-01-31 University Of Utah Research Foundation Substituted-1H-benzo[d]imidazole series compounds as lysine-specific demethylase 1 (LSD1) inhibitors
CA2933480C (en) 2013-12-11 2022-08-23 Celgene Quanticel Research, Inc. Inhibitors of lysine specific demethylase-1
US10118903B2 (en) 2014-02-07 2018-11-06 Musc Foundation For Research Development Aminotriazole-based KDM1A inhibitors as epigenetic modulators
HUE045725T2 (en) 2014-02-13 2020-01-28 Incyte Corp Cyclopropylamines as lsd1 inhibitors
US9527835B2 (en) 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
ES2672797T3 (en) 2014-02-13 2018-06-18 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
ES2760261T3 (en) 2014-02-13 2020-05-13 Incyte Corp Cyclopropylamines as LSD1 inhibitors
CA2941716A1 (en) 2014-03-07 2015-09-11 The Johns Hopkins University Inhibitors of histone lysine specific demethylase (lsd1) and histone deacetylases (hdacs)
CN103893163B (en) 2014-03-28 2016-02-03 中国药科大学 The application of 2-([1,1 '-biphenyl]-4-base) 2-oxoethyl 4-((the chloro-4-aminomethyl phenyl of 3-) is amino)-4-oxobutanoic acid esters in preparation LSD1 inhibitor medicaments
CN106459024B (en) 2014-04-11 2019-11-05 武田药品工业株式会社 Cyclopropyl amine compounds and application thereof
CN103961340B (en) 2014-04-30 2019-06-25 南通中国科学院海洋研究所海洋科学与技术研究发展中心 A kind of LSD1 inhibitor and its application
PE20161438A1 (en) 2014-05-01 2017-01-18 Celgene Quanticel Res Inc DESMETILASE INHIBITORS 1 SPECIFIC TO LYSINE
EP3148974B1 (en) 2014-05-30 2018-09-26 Istituto Europeo di Oncologia S.r.l. Cyclopropylamine compounds as histone demethylase inhibitors
MX2017000179A (en) 2014-06-27 2017-05-01 Celgene Quanticel Res Inc Inhibitors of lysine specific demethylase-1.
CN104119280B (en) 2014-06-27 2016-03-16 郑州大学 Containing the pyrimidine derivatives of amino urea and Terminal Acetylenes structural unit, preparation method and application
PT3164380T (en) 2014-07-03 2022-03-02 Celgene Quanticel Res Inc Inhibitors of lysine specific demethylase-1
CA2954060A1 (en) 2014-07-03 2016-01-07 Celgene Quanticel Research, Inc. Inhibitors of lysine specific demethylase-1
WO2016007722A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
US9695168B2 (en) 2014-07-10 2017-07-04 Incyte Corporation Substituted imidazo[1,5-α]pyridines and imidazo[1,5-α]pyrazines as LSD1 inhibitors
US9758523B2 (en) 2014-07-10 2017-09-12 Incyte Corporation Triazolopyridines and triazolopyrazines as LSD1 inhibitors
WO2016007736A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Imidazopyrazines as lsd1 inhibitors
BR112017004334A2 (en) 2014-09-05 2018-08-07 Celgene Quanticel Res Inc lysine-1 specific demethylase inhibitors.
EP2993175A1 (en) 2014-09-05 2016-03-09 IEO - Istituto Europeo di Oncologia Srl Thienopyrroles as histone demethylase inhibitors
EP3250552B1 (en) 2015-01-30 2019-03-27 Genentech, Inc. Therapeutic compounds and uses thereof
JP6727216B2 (en) 2015-02-12 2020-07-22 イマーゴ バイオサイエンシーズ インコーポレイテッド KDM1A inhibitors for the treatment of diseases
CN106146361A (en) 2015-03-16 2016-11-23 四川大学 Indenes-1-subunit sulfonyl benzoyl hydrazine derivant and its production and use
MX2017012699A (en) 2015-04-03 2018-02-09 Incyte Corp Heterocyclic compounds as lsd1 inhibitors.
CN106045862B (en) 2015-04-10 2019-04-23 上海迪诺医药科技有限公司 Cyclopropyl amine spiral shell (miscellaneous) cycle compound, its pharmaceutical composition and application
WO2016172496A1 (en) 2015-04-23 2016-10-27 Constellation Pharmaceuticals, Inc. Lsd1 inhibitors and uses thereof
EP3090998A1 (en) 2015-05-06 2016-11-09 F. Hoffmann-La Roche AG Solid forms
US20170001970A1 (en) 2015-07-02 2017-01-05 University Of Utah Research Foundation Substituted benzohydrazide analogs as histone demethylase inhibitors
KR20180051523A (en) 2015-08-12 2018-05-16 인사이트 코포레이션 Salt of LSD1 inhibitor
EP3371152B1 (en) 2015-11-05 2020-12-23 Celgene Quanticel Research, Inc. Compositions comprising an inhibitor of lysine specific demethylase-1 having a pyrimidine ring and its use in the treatment of cancer
US10059668B2 (en) 2015-11-05 2018-08-28 Mirati Therapeutics, Inc. LSD1 inhibitors
JP6510068B2 (en) 2015-11-27 2019-05-08 大鵬薬品工業株式会社 Novel biphenyl compound or salt thereof
WO2017109061A1 (en) 2015-12-23 2017-06-29 Ieo - Istituto Europeo Di Oncologia S.R.L. Spirocyclopropylamine derivatives useful as inhibitors of histone demethylases kdm1a
WO2017116558A1 (en) 2015-12-29 2017-07-06 Mirati Therapeutics, Inc. Lsd1 inhibitors
WO2017114497A1 (en) 2015-12-30 2017-07-06 Novartis Ag Immune effector cell therapies with enhanced efficacy
WO2017149463A1 (en) 2016-03-01 2017-09-08 Novartis Ag Cyano-substituted indole compounds and uses thereof as lsd1 inhibitors
CN107200706A (en) 2016-03-16 2017-09-26 中国科学院上海药物研究所 Cyclopropylamine class compound of one class fluorine substitution and preparation method thereof, pharmaceutical composition and purposes
US20170283397A1 (en) 2016-03-31 2017-10-05 University Of Utah Research Foundation Substituted 1-h-indol-3-yl-benzamide and 1, 1'-biphenyl analogs as histone demethylase inhibitors
CN109153636B (en) 2016-05-09 2021-10-22 朱比连特埃皮科尔有限责任公司 Cyclopropyl-amide compounds as dual LSD1/HDAC inhibitors
EP3246330A1 (en) 2016-05-18 2017-11-22 Istituto Europeo di Oncologia S.r.l. Imidazoles as histone demethylase inhibitors
CN107513068A (en) 2016-06-16 2017-12-26 中国科学院上海药物研究所 A kind of new compound and its preparation and application with FGFR inhibitory activity
CN106478639B (en) 2016-09-05 2018-09-18 郑州大学 LSD1 inhibitor, preparation method and the application of 1,2,4-triazole of pyrimido
CN106432248B (en) 2016-09-27 2018-11-27 郑州大学 The LSD1 of triazole containing pyrimido inhibitor, preparation method and application
HRP20231369T1 (en) 2016-10-26 2024-02-16 Constellation Pharmaceuticals, Inc. Lsd1 inhibitors and medical uses thereof
WO2018081342A1 (en) 2016-10-26 2018-05-03 Constellation Pharmaceuticals, Inc. Lsd1 inhibitors and uses thereof
CN106831489B (en) 2017-03-23 2018-04-17 郑州大学 Tranylcypromine acylhydrazone, preparation method and applications
CN106928235A (en) 2017-05-03 2017-07-07 郑州大学 The LSD1 of triazole containing pyrimido inhibitor, its preparation method and application

Also Published As

Publication number Publication date
IL272092A (en) 2020-03-31
KR20200036920A (en) 2020-04-07
US20200323828A1 (en) 2020-10-15
MX2020001323A (en) 2020-03-20
PH12020500211A1 (en) 2020-10-19
AU2018309372A1 (en) 2020-01-30
CA3071804A1 (en) 2019-02-07
RU2020109167A3 (en) 2022-02-10
EP3661510A1 (en) 2020-06-10
RU2020109167A (en) 2021-09-03
JP2020529995A (en) 2020-10-15
BR112020000827A2 (en) 2020-07-21
JP2023159354A (en) 2023-10-31
CN110996949A (en) 2020-04-10
MX2023009388A (en) 2023-08-23
WO2019025588A1 (en) 2019-02-07

Similar Documents

Publication Publication Date Title
SG11202000077RA (en) Methods of treating behavior alterations
SG11201907744QA (en) Replacement of cytotoxic preconditioning before cellular immunotherapy
SG11201811470PA (en) Pyrazolopyrimidine derivatives as kinase inhibitor
SG11201804098TA (en) Purinones as ubiquitin-specific protease 1 inhibitors
SG11201808125RA (en) Methods for solid tumor treatment
SG11201811431VA (en) Multispecific antibodies against cd40 and cd137
SG11201810983PA (en) Novel heterocyclic derivatives useful as shp2 inhibitors
SG11201908532UA (en) Macrocyclic compounds as ros1 kinase inhibitors
SG11201810600WA (en) Fxr (nr1h4) modulating compounds
SG11201808710UA (en) Novel immunogenic cd1d binding peptides
SG11201808990QA (en) Compositions for topical application of compounds
SG11201808709VA (en) T cell receptors
SG11201906431UA (en) Method for the treatment of thromboembolism
SG11201907855QA (en) Multispecific binding proteins targeting caix, ano1, mesothelin,trop2, cea, or claudin-18.2
SG11201906885TA (en) Methods for the administration of certain vmat2 inhibitors
SG11201908604YA (en) Fused imidazo-piperidine jak inhibitor compound
SG11201900400QA (en) Bispecific antibody-like binding proteins specifically binding to cd3 and cd123
SG11201900501RA (en) Cannabis composition
SG11201407580YA (en) Composition comprising two antibodies engineered to have reduced and increased effector function
SG11201908326YA (en) Methods of treating neurodegenerative diseases
SG11201909376TA (en) Crystalline forms of a jak inhibitor compound
SG11201804123VA (en) Modulators of kv3 channels to treat pain
SG11201909520VA (en) Rna for treatment of autoimmune diseases
SG11201901347UA (en) Compositions and methods for cancer immunotherapy
SG11201908325PA (en) Process for the preparation of glucuronide drug-linkers and intermediates thereof