SG11201907744QA - Replacement of cytotoxic preconditioning before cellular immunotherapy - Google Patents
Replacement of cytotoxic preconditioning before cellular immunotherapyInfo
- Publication number
- SG11201907744QA SG11201907744QA SG11201907744QA SG11201907744QA SG11201907744QA SG 11201907744Q A SG11201907744Q A SG 11201907744QA SG 11201907744Q A SG11201907744Q A SG 11201907744QA SG 11201907744Q A SG11201907744Q A SG 11201907744QA SG 11201907744Q A SG11201907744Q A SG 11201907744QA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- pct
- cytotoxic preconditioning
- cellular
- cytotoxic
- Prior art date
Links
- 230000001413 cellular effect Effects 0.000 title abstract 4
- 231100000433 cytotoxic Toxicity 0.000 title abstract 4
- 230000001472 cytotoxic effect Effects 0.000 title abstract 4
- 238000009169 immunotherapy Methods 0.000 title abstract 4
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 102220240796 rs553605556 Human genes 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4613—Natural-killer cells [NK or NK-T]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/46433—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/26—Universal/off- the- shelf cellular immunotherapy; Allogenic cells or means to avoid rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
ACTBIND IGFICHE DECREASE ACT SWUNG NICHE CO*{: ANT/ age ,1 a i0 t%) Ermr bAr, SEA hF 4r! mtr, nor (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) W I PO I PCT ill~~~~~~~~ 011101010VIIIOH olo HE mil moiolommo oimIE (10) International Publication Number WO 2018/183927 Al N cr (51) International Patent Classification: A61K 45/00 (2006.01) A61P 35/00 (2006.01) A61K 31/573 (2006.01) (21) International Application Number: PCT/US2018/025517 (22) International Filing Date: 30 March 2018 (30.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/480,414 01 April 2017 (01.04.2017) US 62/613,697 04 January 2018 (04.01.2018) US 62/624,454 31 January 2018 (31.01.2018) US (71) Applicant: AVM BIOTECHNOLOGY, LLC [US/US]; 1749 Dexter Avenue N, Seattle, WA 98109 (US). (72) Inventor: DEISHER, Theresa Ann; 8226 23rd Ave NE., Seattle, WA 98115 (US). (74) Agent: BAUMGARTNER, Marc; Baumgartner Patent Law, 3344 NE 30th Ave, Portland, OR 97212 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: REPLACEMENT OF CYTOTOXIC PRECONDITIONING BEFORE CELLULAR IMMUNOTHERAPY Figure 1 CONTROL 1s 114.9 MG/ DEX MED 9.3 NIGIKG1 c)1: 1-1 (57) : Provided herein are novel therapeutic compositions and methods that keep cellular immunotherapies in the circulation or at the site of injection for extended periods of time without resorting to the use of cytotoxic preconditioning. More specifically the c)1: 1-1 compositions and methods herein lymphodeplete and reduce or ablate sites in the secondary lymphatics where the cellular immunother- apy is bound and sequestered, without the use of cytotoxic preconditioning. O [Continued on next page] WO 2018/183927 Al MIDEDIMOIMEMIEHNOMOINIIIMEIDEHMOVOIMIE TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762480414P | 2017-04-01 | 2017-04-01 | |
US201862613697P | 2018-01-04 | 2018-01-04 | |
US201862624454P | 2018-01-31 | 2018-01-31 | |
PCT/US2018/025517 WO2018183927A1 (en) | 2017-04-01 | 2018-03-30 | Replacement of cytotoxic preconditioning before cellular immunotherapy |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201907744QA true SG11201907744QA (en) | 2019-09-27 |
Family
ID=62111173
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201907744QA SG11201907744QA (en) | 2017-04-01 | 2018-03-30 | Replacement of cytotoxic preconditioning before cellular immunotherapy |
Country Status (13)
Country | Link |
---|---|
US (2) | US11219628B2 (en) |
EP (1) | EP3490605B1 (en) |
JP (2) | JP6748221B2 (en) |
KR (1) | KR102509006B1 (en) |
CN (1) | CN110475571B (en) |
AU (1) | AU2018243753A1 (en) |
BR (1) | BR112019020214A2 (en) |
CA (1) | CA3054443A1 (en) |
ES (1) | ES2954311T3 (en) |
IL (1) | IL269209B2 (en) |
MX (1) | MX2019011679A (en) |
SG (1) | SG11201907744QA (en) |
WO (1) | WO2018183927A1 (en) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10426740B1 (en) | 2010-08-18 | 2019-10-01 | Avm Biotechnology, Llc | Compositions and methods to inhibit stem cell and progenitor cell binding to lymphoid tissue and for regenerating germinal centers in lymphatic tissues |
CN110475571B (en) | 2017-04-01 | 2023-04-04 | Avm生物技术有限责任公司 | Replacement for cellular immunotherapy pre-conditioning for cytotoxicity |
JP7414529B2 (en) | 2017-06-07 | 2024-01-16 | シファメド・ホールディングス・エルエルシー | Intravascular fluid transfer devices, systems, and methods of use |
WO2019094963A1 (en) | 2017-11-13 | 2019-05-16 | Shifamed Holdings, Llc | Intravascular fluid movement devices, systems, and methods of use |
US10722631B2 (en) | 2018-02-01 | 2020-07-28 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of use and manufacture |
US11459393B2 (en) | 2018-04-17 | 2022-10-04 | Celldex Therapeutics, Inc. | Anti-CD27 and anti-PD-L1 antibodies and bispecific constructs |
EP3488851A1 (en) | 2018-10-03 | 2019-05-29 | AVM Biotechnology, LLC | Immunoablative therapies |
EP3632446B3 (en) | 2018-10-03 | 2024-01-24 | AVM Biotechnology, LLC | Immunoablative therapies |
CN111918645A (en) * | 2018-11-14 | 2020-11-10 | Avm生物技术有限责任公司 | Stable glucocorticoid formulations |
US20220016168A1 (en) * | 2018-12-11 | 2022-01-20 | Celldex Therapeutics, Inc. | Methods of using cd27 antibodies as conditioning treatment for adoptive cell therapy |
WO2021011473A1 (en) | 2019-07-12 | 2021-01-21 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of manufacture and use |
US11654275B2 (en) | 2019-07-22 | 2023-05-23 | Shifamed Holdings, Llc | Intravascular blood pumps with struts and methods of use and manufacture |
US11724089B2 (en) | 2019-09-25 | 2023-08-15 | Shifamed Holdings, Llc | Intravascular blood pump systems and methods of use and control thereof |
US20210161959A1 (en) * | 2019-11-06 | 2021-06-03 | Kite Pharma, Inc. | Chimeric antigen receptor t cell therapy |
CN113189340A (en) * | 2020-01-14 | 2021-07-30 | 中国医学科学院基础医学研究所 | Use of cellular apoptosis pathway in cell therapy |
EP4106775A4 (en) * | 2020-02-20 | 2024-03-06 | Kite Pharma Inc | Chimeric antigen receptor t cell therapy |
EP4110902A1 (en) | 2020-02-28 | 2023-01-04 | AVM Biotechnology, LLC | Lypmphocyte population and methods for producing same |
US20230136350A1 (en) * | 2020-04-10 | 2023-05-04 | North Carolina State University | Enhanced viral transduction of mammalian cells using material scaffolds |
CN111443210B (en) * | 2020-04-10 | 2023-09-22 | 青海大学附属医院 | Bubble type echinococcosis early diagnosis and treatment biomarker and application thereof |
US20230172950A1 (en) | 2020-04-29 | 2023-06-08 | Avm Biotechnology, Llc | Glucocorticoid Receptor (GR) Modulators for Treating a SARS-COV-2 Virus |
AU2020451285A1 (en) | 2020-06-01 | 2022-12-22 | Avm Biotechnology, Llc | Methods of treatment using ICAM-modulating agents |
WO2022049572A1 (en) * | 2020-09-01 | 2022-03-10 | The National Institute for Biotechnology in the Negev Ltd. | Immune system restoration by cell therapy |
CN113322233A (en) * | 2021-04-19 | 2021-08-31 | 格源致善(上海)生物科技有限公司 | Improved preparation method and application of reactive T cells based on neoantigens |
CN116063401B (en) * | 2021-08-13 | 2023-12-01 | 中国人民解放军总医院 | Blocking type PD-L1 targeted ultra-high affinity small protein and application thereof |
WO2023034377A1 (en) | 2021-09-01 | 2023-03-09 | Avm Biotechnology, Llc | Lymphocyte population and methods for producing same |
CN114031678A (en) * | 2021-12-08 | 2022-02-11 | 中国科学院新疆理化技术研究所 | Preparation method and application of polypeptide component of scorpion venom polypeptide |
CN115785203B (en) * | 2022-06-10 | 2024-03-12 | 河北博海生物工程开发有限公司 | Lung cancer specific molecular target 10 and application thereof |
CN116606352B (en) * | 2023-07-14 | 2023-09-29 | 诺赛联合(北京)生物医学科技有限公司 | Application of composition gel with antibacterial and repairing functions in gynecological diseases |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5728388A (en) | 1989-10-03 | 1998-03-17 | Terman; David S. | Method of cancer treatment |
GB9323199D0 (en) | 1993-11-10 | 1994-01-05 | Falkenberg J H F | Leukaemia treatment |
ES2320314T3 (en) | 1997-12-16 | 2009-05-21 | University Of Zurich | DIAGNOSIS FOR TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHY. |
US6406699B1 (en) | 1999-10-05 | 2002-06-18 | Gary W. Wood | Composition and method of cancer antigen immunotherapy |
US20030099621A1 (en) * | 2001-11-29 | 2003-05-29 | Robert Chow | Stem cell screening and transplantation therapy for HIV infection |
IL146970A0 (en) | 2001-12-06 | 2002-08-14 | Yeda Res & Dev | Migration of haematopoietic stem cells and progenitor cells to the liver |
WO2003077865A2 (en) | 2002-03-15 | 2003-09-25 | Baxter International Inc. | Methods and compositions for directing cells to target organs |
CN103393681B (en) | 2002-05-17 | 2017-04-12 | 细胞基因公司 | Methodand composition for treatment and management of multiple myeloma |
GB0310593D0 (en) | 2003-05-08 | 2003-06-11 | Leuven K U Res & Dev | Peptidic prodrugs |
US20040247574A1 (en) | 2003-05-27 | 2004-12-09 | Christopherson Kent W. | Methods for enhancing stem cell engraftment during transplantation |
US7875273B2 (en) | 2004-12-23 | 2011-01-25 | Ethicon, Incorporated | Treatment of Parkinson's disease and related disorders using postpartum derived cells |
JP5129122B2 (en) * | 2005-04-26 | 2013-01-23 | トリオン ファーマ ゲーエムベーハー | Combination of antibodies and glucocorticoids for cancer treatment |
JP4997239B2 (en) | 2005-07-22 | 2012-08-08 | ワイズ・エー・シー株式会社 | Anti-CD26 antibody and method of use thereof |
US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
GB0700058D0 (en) | 2007-01-03 | 2007-02-07 | Scancell Aps | Anti-tumor vaccine based on normal cells |
US20100247491A1 (en) | 2007-02-01 | 2010-09-30 | Christof Westenfelder | Potentiation of Stem Cell Homing and Treatment of Organ Dysfunction or Organ Failure |
KR101679084B1 (en) * | 2008-05-23 | 2016-11-24 | 아고스 쎄라퓨틱스, 인코포레이티드 | Novel soluble cd83 polypeptides, formulations and methods of use |
US20090299269A1 (en) | 2008-05-29 | 2009-12-03 | John Foley | Vascular stimulation to aid intravascular cell replacement therapy |
WO2009152187A1 (en) | 2008-06-09 | 2009-12-17 | American Stem Cell, Inc. | Augmentation of cell therapy efficacy including treatment with alpha 1-3 fucoslytransferase |
WO2009152186A1 (en) | 2008-06-09 | 2009-12-17 | American Stem Cell, Inc. | Methods for enhancing cell therapy efficacy including treatment with cd26 peptidase inhibitors |
US20100055107A1 (en) * | 2008-07-31 | 2010-03-04 | Defu Zeng | Methods for preventing hematological malignancies and graft versus host disease by anti-cd3 preconditioning |
KR101833204B1 (en) * | 2010-08-18 | 2018-03-02 | 테레사 데이셔 | Compositions and methods to inhibit stem cell and progenitor cell binding to lymphoid tissue and for regenerating germinal centers in lymphatic tissues |
US10426740B1 (en) * | 2010-08-18 | 2019-10-01 | Avm Biotechnology, Llc | Compositions and methods to inhibit stem cell and progenitor cell binding to lymphoid tissue and for regenerating germinal centers in lymphatic tissues |
EP3305798A1 (en) | 2010-12-09 | 2018-04-11 | The Trustees of The University of Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
CA2824997C (en) | 2011-01-18 | 2023-01-17 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treating cancer |
EP2532740A1 (en) | 2011-06-11 | 2012-12-12 | Michael Schmück | Antigen-specific CD4+ and CD8+ central-memory T cell preparations for adoptive T cell therapy |
KR20140060541A (en) | 2011-09-16 | 2014-05-20 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Rna engineered t cells for the treatment of cancer |
WO2014055657A1 (en) | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Use of a trans-signaling approach in chimeric antigen receptors |
DK3129470T3 (en) * | 2014-04-07 | 2021-07-05 | Novartis Ag | Treatment of cancer using anti-CD19 chimeric antigen receptor |
AU2016212162A1 (en) * | 2015-01-26 | 2017-07-13 | Cellectis | T cell receptor knock out engineered immune cells, endowed with chimeric antigen receptors binding to CD123 for the treatment of relapsed/refractory acute myeloid lymphoma or blastic plasmacytoid dendritic cell neoplasm |
JP7197979B2 (en) | 2015-05-28 | 2022-12-28 | カイト ファーマ インコーポレイテッド | Methods of conditioning a patient for T cell therapy |
CA3044261A1 (en) * | 2016-11-30 | 2018-06-07 | Intrexon Corporation | Steroid administration and immunotherapy |
CN110475571B (en) | 2017-04-01 | 2023-04-04 | Avm生物技术有限责任公司 | Replacement for cellular immunotherapy pre-conditioning for cytotoxicity |
-
2018
- 2018-03-30 CN CN201880021900.0A patent/CN110475571B/en active Active
- 2018-03-30 KR KR1020197031661A patent/KR102509006B1/en active IP Right Grant
- 2018-03-30 MX MX2019011679A patent/MX2019011679A/en unknown
- 2018-03-30 SG SG11201907744QA patent/SG11201907744QA/en unknown
- 2018-03-30 BR BR112019020214A patent/BR112019020214A2/en unknown
- 2018-03-30 JP JP2018551293A patent/JP6748221B2/en active Active
- 2018-03-30 CA CA3054443A patent/CA3054443A1/en active Pending
- 2018-03-30 AU AU2018243753A patent/AU2018243753A1/en not_active Abandoned
- 2018-03-30 WO PCT/US2018/025517 patent/WO2018183927A1/en unknown
- 2018-03-30 IL IL269209A patent/IL269209B2/en unknown
- 2018-03-30 ES ES18722262T patent/ES2954311T3/en active Active
- 2018-03-30 EP EP18722262.5A patent/EP3490605B1/en active Active
- 2018-05-10 US US15/976,630 patent/US11219628B2/en active Active
-
2020
- 2020-03-19 JP JP2020049116A patent/JP7162632B2/en active Active
-
2021
- 2021-12-06 US US17/542,712 patent/US20220160729A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP6748221B2 (en) | 2020-08-26 |
MX2019011679A (en) | 2019-11-01 |
BR112019020214A2 (en) | 2020-04-22 |
US20180296572A1 (en) | 2018-10-18 |
EP3490605B1 (en) | 2023-06-07 |
CA3054443A1 (en) | 2018-10-14 |
ES2954311T3 (en) | 2023-11-21 |
IL269209B2 (en) | 2023-11-01 |
JP2019515888A (en) | 2019-06-13 |
EP3490605A1 (en) | 2019-06-05 |
IL269209B1 (en) | 2023-07-01 |
IL269209A (en) | 2019-11-28 |
WO2018183927A1 (en) | 2018-10-04 |
KR20190130624A (en) | 2019-11-22 |
US20220160729A1 (en) | 2022-05-26 |
CN110475571B (en) | 2023-04-04 |
KR102509006B1 (en) | 2023-03-13 |
CN110475571A (en) | 2019-11-19 |
AU2018243753A1 (en) | 2019-10-10 |
JP7162632B2 (en) | 2022-10-28 |
EP3490605C0 (en) | 2023-06-07 |
JP2020114837A (en) | 2020-07-30 |
US11219628B2 (en) | 2022-01-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG11201907744QA (en) | Replacement of cytotoxic preconditioning before cellular immunotherapy | |
SG11201811431VA (en) | Multispecific antibodies against cd40 and cd137 | |
SG11201808990QA (en) | Compositions for topical application of compounds | |
SG11201900135YA (en) | N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors | |
SG11201906763RA (en) | Pyrrolo [1,2-b] pyridazine derivatives | |
SG11201811074RA (en) | Nant cancer vaccine | |
SG11201900163PA (en) | Macrocycle kinase inhibitors | |
SG11201810983PA (en) | Novel heterocyclic derivatives useful as shp2 inhibitors | |
SG11201808222RA (en) | Methods of treatment of cholestatic diseases | |
SG11201903483VA (en) | Compositions and methods for treating ezh2-mediated cancer | |
SG11201808108XA (en) | Synthesis of indazoles | |
SG11201810525XA (en) | Anti-gitr antibodies and uses thereof | |
SG11201407200TA (en) | Liquid formulation | |
SG11201810965YA (en) | 1h-pyrazolo[4,3-b]pyridines as pde1 inhibitors | |
SG11201906853QA (en) | Anti-rsv monoclonal antibody formulation | |
SG11201908325PA (en) | Process for the preparation of glucuronide drug-linkers and intermediates thereof | |
SG11201901251SA (en) | Aminopyrimidines as alk inhibitors | |
SG11201804704PA (en) | Compositions and methods for decreasing tau expression | |
SG11201805001UA (en) | Method of treating influenza a | |
SG11201808221QA (en) | 1,5-dihydro-4h-pyrazolo[3,4-d]pyrimidin-4-ones and 1,5-dihydro-4h-pyrazolo[4,3-c]pyridin-4-ones as pde1 inhibitors | |
SG11202000333UA (en) | Bicyclic ketone compounds and methods of use thereof | |
SG11201900043TA (en) | Antibody formulations | |
SG11201900361RA (en) | Methods of treating prostate cancer | |
SG11201810940XA (en) | Methods of treating pancreatic cancer | |
SG11201809882XA (en) | Pharmaceutical combinations for treating cancer |