SG11201808710UA - Novel immunogenic cd1d binding peptides - Google Patents

Novel immunogenic cd1d binding peptides

Info

Publication number
SG11201808710UA
SG11201808710UA SG11201808710UA SG11201808710UA SG11201808710UA SG 11201808710U A SG11201808710U A SG 11201808710UA SG 11201808710U A SG11201808710U A SG 11201808710UA SG 11201808710U A SG11201808710U A SG 11201808710UA SG 11201808710U A SG11201808710U A SG 11201808710UA
Authority
SG
Singapore
Prior art keywords
international
peptides
pct
rule
cd1d binding
Prior art date
Application number
SG11201808710UA
Inventor
Elst Luc Vander
Original Assignee
Imcyse Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imcyse Sa filed Critical Imcyse Sa
Publication of SG11201808710UA publication Critical patent/SG11201808710UA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4613—Natural-killer cells [NK or NK-T]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/46433—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111101111 0 DOI 010111110101111 0 111 01111101011101011111011111011 OEN Organization 0 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2017/182528 Al 26 October 2017 (26.10.2017) WIPO I PCT (51) International Patent Classification: A61K 39/00 (2006.01) C07K 14/74 (2006.01) (21) International Application Number: PCT/EP2017/059302 (22) International Filing Date: 19 April 2017 (19.04.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16166054.3 19 April 2016 (19.04.2016) EP (71) Applicant: IMCYSE SA [BE/BE]; GIGA B34 - Avenue de l'Hopital 1, 4000 Liege (BE). (72) Inventor: VANDER ELST, Luc; 48 rue du Village, 6230 Obaix (BE). (74) Agent: DE CLERCQ & PARTNERS; Edgard Gevaert- dreef 10a, 9830 Sint-Martens-Latem (BE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = = _ = — = _ — (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, _ = = = _ _ EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, = MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, = TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, = KM, ML, MR, NE, SN, TD, TG). = — Declarations under Rule 4.17: = — — of inventorship (Rule 4.17(iv)) Published: — — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) \"It - I4 ot ei in ei of (54) Title: NOVEL IMMUNOGENIC CD1D BINDING PEPTIDES 1-1 ---- (57) : The invention relates to isolated immunogenic peptides comprising a CD1d binding peptide, and immediately adjacent IN ,_ 1 or separated from said CD binding peptide, a redox motif sequence which is further flanked by a histidine or tryptophan amino acids. C::::) The invention further relates to these peptides for use as a medicament The invention further relates to methods wherein these peptides N are used for generating NKT cells which are cytolytic against cells presenting the cognate antigen. C
SG11201808710UA 2016-04-19 2017-04-19 Novel immunogenic cd1d binding peptides SG11201808710UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16166054 2016-04-19
PCT/EP2017/059302 WO2017182528A1 (en) 2016-04-19 2017-04-19 Novel immunogenic cd1d binding peptides

Publications (1)

Publication Number Publication Date
SG11201808710UA true SG11201808710UA (en) 2018-11-29

Family

ID=56024090

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201808710UA SG11201808710UA (en) 2016-04-19 2017-04-19 Novel immunogenic cd1d binding peptides

Country Status (13)

Country Link
US (2) US11485768B2 (en)
EP (1) EP3445390A1 (en)
JP (2) JP7320947B2 (en)
KR (3) KR20180134935A (en)
CN (1) CN109069605B (en)
AU (2) AU2017252192C1 (en)
BR (1) BR112018071466A2 (en)
CA (1) CA3019266A1 (en)
IL (1) IL262286B2 (en)
RU (1) RU2018136760A (en)
SG (1) SG11201808710UA (en)
WO (1) WO2017182528A1 (en)
ZA (1) ZA201806860B (en)

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TW202340224A (en) * 2021-11-10 2023-10-16 美商帝斯肯醫療公司 Magea1 immunogenic peptides, binding proteins recognizing magea1 immunogenic peptides, and uses thereof
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US11485768B2 (en) 2022-11-01
CA3019266A1 (en) 2017-10-26
AU2017252192A1 (en) 2018-10-18
IL262286B2 (en) 2023-12-01
ZA201806860B (en) 2021-05-26
AU2022203627A1 (en) 2022-06-16
IL262286B1 (en) 2023-08-01
RU2018136760A3 (en) 2020-05-27
BR112018071466A2 (en) 2019-03-19
KR20220132023A (en) 2022-09-29
AU2017252192C1 (en) 2023-06-08
KR20240015731A (en) 2024-02-05
AU2017252192B2 (en) 2022-03-03
RU2018136760A (en) 2020-05-19
CN109069605A (en) 2018-12-21
JP2022022423A (en) 2022-02-03
CN109069605B (en) 2022-11-29
US20230265156A1 (en) 2023-08-24
IL262286A (en) 2018-11-29
WO2017182528A1 (en) 2017-10-26
US20190106477A1 (en) 2019-04-11
KR20180134935A (en) 2018-12-19
JP2019514895A (en) 2019-06-06
EP3445390A1 (en) 2019-02-27
JP7320947B2 (en) 2023-08-04

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