SG11201805950UA - Self-assembled nanostructures and separation membranes comprising aquaporin water channels and methods of making and using them - Google Patents

Self-assembled nanostructures and separation membranes comprising aquaporin water channels and methods of making and using them

Info

Publication number
SG11201805950UA
SG11201805950UA SG11201805950UA SG11201805950UA SG11201805950UA SG 11201805950U A SG11201805950U A SG 11201805950UA SG 11201805950U A SG11201805950U A SG 11201805950UA SG 11201805950U A SG11201805950U A SG 11201805950UA SG 11201805950U A SG11201805950U A SG 11201805950UA
Authority
SG
Singapore
Prior art keywords
bold
international
self
aquaporin
pct
Prior art date
Application number
SG11201805950UA
Inventor
Mariana Spulber
Krzysztof Trzaskus
Original Assignee
Aquaporin As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aquaporin As filed Critical Aquaporin As
Publication of SG11201805950UA publication Critical patent/SG11201805950UA/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/08—Hollow fibre membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3496—Plasmapheresis; Leucopheresis; Lymphopheresis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/002—Forward osmosis or direct osmosis
    • B01D61/0022—Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/24—Dialysis ; Membrane extraction
    • B01D61/243—Dialysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0081—After-treatment of organic or inorganic membranes
    • B01D67/0093—Chemical modification
    • B01D67/00931—Chemical modification by introduction of specific groups after membrane formation, e.g. by grafting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/12—Composite membranes; Ultra-thin membranes
    • B01D69/1213—Laminated layers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/12—Composite membranes; Ultra-thin membranes
    • B01D69/125—In situ manufacturing by polymerisation, polycondensation, cross-linking or chemical reaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/12—Composite membranes; Ultra-thin membranes
    • B01D69/125—In situ manufacturing by polymerisation, polycondensation, cross-linking or chemical reaction
    • B01D69/1251—In situ manufacturing by polymerisation, polycondensation, cross-linking or chemical reaction by interfacial polymerisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/14—Dynamic membranes
    • B01D69/141—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes
    • B01D69/142—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes with "carriers"
    • B01D69/144—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes with "carriers" containing embedded or bound biomolecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y40/00—Manufacture or treatment of nanostructures
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00—Treatment of water, waste water, or sewage
    • C02F1/44—Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis
    • C02F1/441—Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis by reverse osmosis
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F03—MACHINES OR ENGINES FOR LIQUIDS; WIND, SPRING, OR WEIGHT MOTORS; PRODUCING MECHANICAL POWER OR A REACTIVE PROPULSIVE THRUST, NOT OTHERWISE PROVIDED FOR
    • F03G—SPRING, WEIGHT, INERTIA OR LIKE MOTORS; MECHANICAL-POWER PRODUCING DEVICES OR MECHANISMS, NOT OTHERWISE PROVIDED FOR OR USING ENERGY SOURCES NOT OTHERWISE PROVIDED FOR
    • F03G7/00—Mechanical-power-producing mechanisms, not otherwise provided for or using energy sources not otherwise provided for
    • F03G7/04—Mechanical-power-producing mechanisms, not otherwise provided for or using energy sources not otherwise provided for using pressure differences or thermal differences occurring in nature
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/34—Molecular weight or degree of polymerisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/002—Forward osmosis or direct osmosis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/02—Reverse osmosis; Hyperfiltration ; Nanofiltration
    • B01D61/025—Reverse osmosis; Hyperfiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/56—Polyamides, e.g. polyester-amides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A20/00—Water conservation; Efficient water supply; Efficient water use
    • Y02A20/124—Water desalination
    • Y02A20/131—Reverse-osmosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Water Supply & Treatment (AREA)
  • Nanotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Manufacturing & Machinery (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Combustion & Propulsion (AREA)
  • Inorganic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Mechanical Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrology & Water Resources (AREA)
  • Environmental & Geological Engineering (AREA)
  • Organic Chemistry (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Peptides Or Proteins (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11111111011110111010101111101011111011101111111110011011011111101111011111 International Bureau r..... .Yi j (10) International Publication Number (43) International Publication Date ...... ... WO 2017/137361 Al 17 August 2017 (17.08.2017) WIPO I PCT (51) International Patent Classification: AO, BOlD 61/02 (2006.01) BOlD 69/12 (2006.01) BZ, BOlD 63/02 (2006.01) BOlD 69/14 (2006.01) DO, BOlD 69/08 (2006.01) BOlD 71/56 (2006.01) HN, KP, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (21) International Application Number: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, PCT/EP2017/052567 NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (22) International Filing Date: RU, 6 February 2017 (06.02.2017) TH, ZA, ZM, ZW. RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (25) Filing Language: English (84) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of regional protection available): ARIPO (BW, GH, (30) Priority Data: GM, PA201600079 8 February 2016 (08.02.2016) DK TZ, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, PA201600249 27 April 2016 (27.04.2016) DK TJ, DK, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (71) Applicant: AQUAPORIN A/S [DK/DK]; Nymollevej 78, LV, DK-2800 Kongens Lyngby (DK). SM, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (72) Inventors: SPULBER, Mariana; Schioldannsvej 3, 1-N, GW, KM, ML, MR, NE, SN, TD, TG). 2920 Charlottenlund (DK). TRZASKUS, Krzysztof; Er- Declarations under Rule 4.17: emitageparken 363, 1D, 2800 Kongens Lyngby (DK). — of inventorship (Rule 4.17(iv)) (74) Agent: RASMUSSEN, Torben Ravn; Nordic Patent Ser- Published: vice, Bredgade 30, 1260 Copenhagen K (DK). - — — with Designated States (unless otherwise indicated, for every (81) international search report (Art. 21(3)) kind of national protection available): AE, AG, AL, AM, _ = = = = = = = = = = = = = 1-1 11 cr) IN cr) 1-1 IN 1-1 © (54) Title: SELF-ASSEMBLED NANOSTRUCTURES AND SEPARATION MEMBRANES COMPRISING AQUAPORIN WA- \" TER CHANNELS AND METHODS OF MAKING AND USING THEM C ) „,.. (57) : The present invention relates to self-assembled nano structures comprising polyalkyleneimine (PAI) and a detergent solubilized transmembrane protein, such as an aquaporin protein.
SG11201805950UA 2016-02-08 2017-02-06 Self-assembled nanostructures and separation membranes comprising aquaporin water channels and methods of making and using them SG11201805950UA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201600079 2016-02-08
DKPA201600249 2016-04-27
PCT/EP2017/052567 WO2017137361A1 (en) 2016-02-08 2017-02-06 Self-assembled nanostructures and separation membranes comprising aquaporin water channels and methods of making and using them

Publications (1)

Publication Number Publication Date
SG11201805950UA true SG11201805950UA (en) 2018-08-30

Family

ID=57963242

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201805950UA SG11201805950UA (en) 2016-02-08 2017-02-06 Self-assembled nanostructures and separation membranes comprising aquaporin water channels and methods of making and using them
SG10202007455VA SG10202007455VA (en) 2016-02-08 2017-02-06 Self-assembled nanostructures and separation membranes comprising aquaporin water channels and methods of making and using them

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10202007455VA SG10202007455VA (en) 2016-02-08 2017-02-06 Self-assembled nanostructures and separation membranes comprising aquaporin water channels and methods of making and using them

Country Status (11)

Country Link
US (1) US20190076789A1 (en)
EP (1) EP3413998B1 (en)
JP (1) JP7072509B2 (en)
CN (1) CN108697984B (en)
AU (1) AU2017217591B2 (en)
CA (1) CA3011002A1 (en)
IL (1) IL261049B (en)
MX (1) MX2018009617A (en)
RU (1) RU2749848C2 (en)
SG (2) SG11201805950UA (en)
WO (1) WO2017137361A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK177696B1 (en) 2013-02-25 2014-03-17 Aquaporin As Systems for water extraction
US11000809B2 (en) 2017-02-06 2021-05-11 Aquaporin A/S Diblock copolymer vesicles and separation membranes comprising aquaporin water channels and methods of making and using them
WO2018141985A1 (en) * 2017-02-06 2018-08-09 Aquaporin A/S Diblock copolymer vesicles and separation membranes comprising aquaporin water channels and methods of making and using them
DK180051B1 (en) * 2017-03-16 2020-02-05 Aquaporin A/S A method of producing a hollow fiber membrane
WO2019154831A1 (en) * 2018-02-06 2019-08-15 Aquaporin A/S Tubular membrane, method for preparation thereof, and tubular membrane module
DE102018105120A1 (en) * 2018-03-06 2019-09-12 Fresenius Medical Care Deutschland Gmbh Apparatus and method for regenerating a dialysis solution
KR20210003782A (en) 2018-04-06 2021-01-12 아쿠아포린 에이에스 Membrane protein manufacturing process
EP3790648A1 (en) 2018-05-09 2021-03-17 Aquaporin A/S Method for enriching aqueous ethanolic solution in ethanol
CN113423488B (en) 2018-12-12 2023-12-29 水通道蛋白有限公司 Hollow fiber module
CN109794175A (en) * 2018-12-26 2019-05-24 浙江大学 Graphene oxide composite membrane and its preparation method and application with pH responsiveness
CN113795328A (en) 2019-02-28 2021-12-14 水通道蛋白有限公司 Generation of concentrated spent dialysate
CN115461136A (en) 2019-12-12 2022-12-09 水通道蛋白有限公司 Antifouling and semi-permeable membranes
CN111636195B (en) * 2020-04-30 2022-12-30 武汉纺织大学 Layer-by-layer self-assembly composite conductive fiber bundle and preparation method thereof
CN115867374A (en) 2020-06-29 2023-03-28 水通道蛋白有限公司 Hollow fiber and method for producing same
WO2022152748A1 (en) 2021-01-13 2022-07-21 Aquaporin A/S Membrane for water filtration
WO2022254032A1 (en) * 2021-06-03 2022-12-08 Aquaporin A/S Plant-derived vesicles incorporating trans-membrane proteins
WO2023139121A1 (en) 2022-01-18 2023-07-27 Aquaporin A/S Interfacially polymerised polyamide membrane for reverse osmosis with silane additive
CN115007004B (en) * 2022-05-16 2023-12-26 天津工业大学 Preparation method of hydrophilic charged high-voltage reverse osmosis membrane based on egg albumin/aromatic polyamide

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4219218A1 (en) * 1992-06-12 1994-01-13 Gambro Dialysatoren Membrane and process for its manufacture
US20060014013A1 (en) * 2001-03-10 2006-01-19 Saavedra Steven S Stabilized biocompatible supported lipid membrane
KR20070114316A (en) * 2002-07-29 2007-11-30 엠티 테크날러지스, 인코포레이션 Biomimetic membranes
US20060062982A1 (en) * 2004-09-17 2006-03-23 Massachusetts Institute Of Technology Carbon-polymer electrochemical systems and methods of fabricating them using layer-by-layer technology
CA2621807C (en) * 2005-09-20 2013-08-06 Aquaporin Aps Biomimetic water membrane comprising aquaporins used in the production of salinity power
US8378003B2 (en) * 2007-12-05 2013-02-19 The Board Of Trustees Of The University Of Illinois Highly permeable polymeric membranes
SG173165A1 (en) * 2009-02-03 2011-08-29 Aquaz As Nanofabricated membrane using polymerized proteoliposomes
DK177144B1 (en) * 2009-06-19 2012-02-06 Aquaporin As A liquid membrane suitable for water extraction
US20110084026A1 (en) * 2009-06-30 2011-04-14 B.G. Negev Technologies Ltd. Biomimetic membranes, their production and uses thereof in water purification
US9067180B2 (en) * 2010-03-05 2015-06-30 Stichting Voor De Technische Wetenschappen Hollow fibre membrane
US20130112618A1 (en) * 2011-08-08 2013-05-09 Mamadou S. Diallo Filtration membranes, related nano and/or micro fibers, composites methods and systems
CN104144737B (en) * 2011-09-21 2017-03-29 南洋理工大学 Thin-film composite membrane based on aquaporin
WO2013180659A1 (en) * 2012-06-01 2013-12-05 National University Of Singapore Method of making a membrane and a membrane for water filtration
WO2014063097A1 (en) * 2012-10-19 2014-04-24 Danisco Us Inc. Stabilization of biomimetic membranes
GB201300465D0 (en) * 2013-01-11 2013-02-27 Aquaporin As A hollow fiber module having tfc-aquaporin modified membranes
DK177696B1 (en) * 2013-02-25 2014-03-17 Aquaporin As Systems for water extraction
CN103721572B (en) * 2014-01-10 2015-09-30 中国海洋大学 A kind of preparation method of the phospholipid biomimic membrane containing aquaporin
DK179128B1 (en) * 2014-02-24 2017-11-20 Aquaporin As Systems for utilizing the water content in fluid from a renal replacement therapy process
DK178227B1 (en) * 2014-05-01 2015-09-07 Aquaporin As A novel synthetic process of a block copolymer and a novel use
CN105013334A (en) * 2014-11-01 2015-11-04 中国海洋大学 Preparation method for double-skin forward permeable membrane with aquaporin

Also Published As

Publication number Publication date
AU2017217591A1 (en) 2018-07-26
JP2019507673A (en) 2019-03-22
MX2018009617A (en) 2019-05-02
SG10202007455VA (en) 2020-09-29
RU2018130885A (en) 2020-03-10
KR20180104158A (en) 2018-09-19
EP3413998A1 (en) 2018-12-19
WO2017137361A1 (en) 2017-08-17
IL261049A (en) 2018-10-31
CN108697984B (en) 2022-03-15
CN108697984A (en) 2018-10-23
US20190076789A1 (en) 2019-03-14
EP3413998B1 (en) 2024-05-15
JP7072509B2 (en) 2022-05-20
CA3011002A1 (en) 2017-08-17
RU2749848C2 (en) 2021-06-17
IL261049B (en) 2022-06-01
AU2017217591B2 (en) 2022-12-15
RU2018130885A3 (en) 2020-06-26

Similar Documents

Publication Publication Date Title
SG11201805950UA (en) Self-assembled nanostructures and separation membranes comprising aquaporin water channels and methods of making and using them
SG11201807252QA (en) Anti-lag-3 antibodies
SG11201808622SA (en) Chimeric receptors to flt3 and methods of use thereof
SG11201907857RA (en) Edible and biodegradable utensils
SG11201810116VA (en) Exosomes comprising therapeutic polypeptides
SG11201811431VA (en) Multispecific antibodies against cd40 and cd137
SG11201804161VA (en) Compositions comprising bacterial strains
SG11201804185VA (en) Features on a porous membrane
SG11201804758QA (en) Aqueous pharmaceutical formulation comprising anti-pd-1 antibody avelumab
SG11201808476SA (en) Recycling of polymer matrix composite
SG11201808525UA (en) Anti-complement factor bb antibodies and uses thereof
SG11201807827VA (en) Process for the preparation of pegylated drug-linkers and intermediates thereof
SG11201804916PA (en) Three-dimensional polymer networks with channels situated therein
SG11201901438VA (en) Solid forms of cenicriviroc mesylate and processes of making solid forms of cenicriviroc mesylate
SG11201407800SA (en) Selective binding of biological targets to solid phase ureides
SG11201908082UA (en) A method of producing a hollow fiber membrane
SG11201809594WA (en) Nicotine particles and compositions
SG11201903012RA (en) Anti-c1s antibodies and methods of use thereof
SG11201805204WA (en) Nicotine particle capsule
SG11201407801VA (en) Methods for use of mixed multifunctional surfaces for reducing aggregate content in protein preparations
SG11201809882XA (en) Pharmaceutical combinations for treating cancer
SG11201809356YA (en) Multilayer coating and process of preparing the multilayer coating
SG11201903329WA (en) Method for preparing electrocompetent yeast cells, and method for using said cells
SG11201805149XA (en) Compositions comprising 15-hepe and methods of using the same
SG11201806127XA (en) Pharmaceutical or nutritional combination comprising beta-hydroxy-betamethylbutyrate